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It′s well known that left ventricle (LV) geometry type is strongly associated with stroke and myocardial infarction in hypertensive patients. The most negative prognosis have persons with concentric hypertrophy of LV and concentric remodelling of LV. Both cardiomyocytes and extracellular matrix are involved in left ventricle remodelling process and their ratio determine disorders of left ventricle function and structure which result in complications.The purpose of the study is to evaluate levels of plasma markers of myocardial fibrosis in hypertensive patients with different types of left ventricle geometry models.Materials and methods: Were examined 324 patients with arterial hypertension (AH) 2-3 grade and ischemic heart disease (stable angina 2-3 functional class) complicated by CHF I-III NYHA functional class. The mean age of patients - 77 (61; 84) years. Patients with arrhythmias, diabetes mellitus were excluded from the study. As control group were enrolled 42 healthy persons (mean age - 70 (17) years). In all patients was performed ECG in 12 standard leads, EchoCG (ASE/EAE recommendations 2005) and were evaluated plasma levels of aldosteron, tissue inhibitor of metalloproteinases-1 (TIMP-1) and Insulin-like growth factor 1 (IGF-1).Statistical significance was defined at the level of methods for p<0,05.Results: As it can be seen from Table 1 The values of aldosteron (which known as interstitial fibrosis trigger) and TIMP-1 (plasma marker of interstitial fibrosis) were significant higher in patients with concentric hypertrophy and eccentric hypertrophy in comparison with hypertensive patients with normal geometry of LV and healthy persons.Conclusion: Thus, the results of the study show that levels of plasma markers of interstitial myocardial fibrosis indicate higher levels of interstitial fibrosis in hypertensive patients with such geometric models of left ventricle as concentric hypertrophy and concentric remodelling.Markers of interstitial fibrosis & LVHParametersHypertensive patientsHealthy persons with normal geometry of LV n=42Normal geometry n=57Concentric remodelling n=32Concentric hypertrophy n=166Eccentric hypertrophy n=99Aldosteron (pg/ml)121.54 (27.51)*95.8 (43.41)143.19 (38.95)*†144.5 (38.25)*†72.82 (31.39)TIMP-1 (ng/ml)276.91 (80.32)*249.82 (83.23)*403.13 (128.53)*†359.93 (119.54)*†103.44 (7.06)IGF-1 (ng/ml)162.56 (23.55)158.29 (18.91)155.51 (24.45)139.88 (19.74)*154.63 (21.69)Results are shown in M (SD).*- p<0.05 in comparison with healthy persons, †- p<0.05 in comparison with patients with normal geometry of LV [ABSTRACT FROM PUBLISHER]

Arrhythmias development determined by structural alterations of the heart, renin-angiotensin system activity and genetic factors.The purpose of our study was to evaluate angiotensin 2 receptor type 1 (AT2P1) gene polymorphism effect on development of arrhythmias in hypertensive patients.Were examined 125 patients with arterial hypertension (AH) 1-3 grade complicated by HF I-II NYHA functional class. The mean age of patients - 52.2 (6.8) years. Patients with acute myocardial infarction in history, diabetes mellitus and autoimmune diseases were excluded from the study. In all patients was performed ECG in 12 standard leads, Holter ECG monitoring, EchoCG (ASE/EAE recommendations 2005). HF NYHA functional class was determined by using the 6MWT. Extrasystoles types were determined by Lown B. classification. Genotyping of AT2P1 gene was performed by polymerase chain reaction analysis of DNA restriction fragments length.Statistical significance was defined at the level of methods for p<0,05.As it can be seen from Table 1 the presence of C allele in genotype of AT2P1 gene accompanied by a statistically significant increase of the frequency of high grade ventricular extrasystoles in comparison with homozygous AA type: 5 patients (7%) with AA and 9 patients (20%) with AC: Chi2 =3.8, p= 0.048, RR= 2.8 (95%CI 1.06 - 7.9).Thus, results of our study indicates role of C allele in genotype of AT2P1 gene in development of high grade ventricular extrasystoles in hypertensive patients.AT2P1 gene polymorphism & arrhythmiasGenotypeArrhythmia typeAA n=71AC n=44CC n=10n (%)n (%)n (%)all SVPB45 (63%)33 (75%)7 (70%) Rare SVPB33 (46%)19 (43%)4 (40%) Frequent SVPB12 (17%)14 (32%)3 (30%)Paroxysmal AF7 (10%)5 (11%)-Supraventricular tachycardia4 (6%)3 (5%)1 (10%)all ventricular extrasystoles26 (37%)21 (48%)6 (60%) Rare ventricular extrasystoles19 (27%)15 (34%)4 (40%) Frequent ventricular extrasystoles7 (10%)6 (14%)2 (20%) Ventricular extrasystole 3-4 grade5 (7%)9 (20%)2 (20%)SVPB - supraventricular premature beats, AF - atrial fibrillation [ABSTRACT FROM AUTHOR]