49 results on '"Reis, Carolina"'
Search Results
2. Drivers of degradation of pastures in the Cerrado north of Minas Gerais - BR /Vetores de degradação das pastagens no Cerrado norte mineiro--Minas Gerais - BR
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Silva, Lucas Augusto Pereira da, Sena-Souza, João Paulo, Souza, Cristiano Marcelo Pereira, Silva, Claudionor Ribeiro da, Bolfe, Edson Luis, Chagas-Reis, Carolina Cabral, and Leite, Marcos Esdras
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- 2023
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3. Probing and restoring disrupted thalamocortical interactions during Parkinson's disease and essential tremor
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Reis, Carolina, Brown, Peter, Cagnan, Hayriye, and Sharott, Andrew
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Neurology ,Neurosciences - Abstract
Parkinson's disease (PD) and Essential Tremor (ET) are two movement disorders where impaired motor function can lead to severe disability. In conjunction with motor impairments, both disorders display augmented frequency-specific activity patterns across brain networks that converge at the thalamocortical (TC) level. In treating motor symptoms, the available therapies for PD and ET modulate these pathologically increased activity patterns. However, therapeutic interventions can also lead to the disruption of physiological brain activity and cause undesirable secondary effects. A major challenge delaying the development of selective neuromodulatory therapies is our limited understanding of the impact of neural activity on function and dysfunction. This thesis contributes to addressing this knowledge gap by probing the TC network dynamics that underlie aberrant synchrony in PD, and by exploring ways of restoring motor function in ET through temporally-specific perturbations of tremor-related TC interactions. By using a combination of tools that span from computational modelling, signal analysis and closed-loop stimulation algorithms we have found that: 1) transient events of high-power beta synchrony in PD are promoted by synaptic dynamics across the TC circuit; 2) the temporal patterning of beta activity in PD is mediated by unit and ensemble dynamic changes in TC temporal alignment; 3) phase-specific stimulation (Cagnan et al., 2017a) can bring kinetic and postural tremor control in ET patients with stable tremor properties, and 4) closed-loop algorithms using online estimates of phase and amplitude to trigger median nerve stimulation might be more effective in yielding tremor suppression in ET patients. Overall, the findings of this thesis contribute to the fields of neuroscience and neurotechnology by deepening our understanding on the dynamics of pathological neural synchrony and shedding light on the key features underlying the efficacy of selective neuromodulatory therapies.
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- 2021
4. Effects of dredging activities and seasonal variation on coastal plankton assemblages: results from 10 years of environmental monitoring
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Fernandes, Lohengrin D. A., Corte, Guilherme N., Moura, Laura, Reis, Carolina, Matos, Thiago, Moreno, Danubia, Cortez, Pedro Sant’ Anna, de Carvalho, Wanderson Fernandes, Monteiro-Ribas, Wanda, Gonçalves, José Eduardo A., Ribeiro, Fernando, Thomazelli, Fernanda, Rizzini-Ansari, Nafisa, Neto, Eduardo Barros Fagundes, Gaelzer, Luiz Ricardo, de Souza Martins, Elizabeth, Lobão, Márcio Martins, Baeta-Neves, Maria Helena, and Coutinho, Ricardo
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- 2023
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5. Sequence stratigraphy and paleoenvironmental significance of the Neoproterozoic Bambui Group, Central Brazil
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DaSilva, Leandro G., Pufahl, Peir K., James, Noel P., Guimaraes, Edi M., and Reis, Carolina
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- 2022
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6. How do data scientists and managers influence machine learning value creation?
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Ferreira, Humberto, Ruivo, Pedro, and Reis, Carolina
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- 2021
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7. Assessing the drivers of machine learning business value
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Reis, Carolina, Ruivo, Pedro, Oliveira, Tiago, and Faroleiro, Paulo
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- 2020
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8. Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor
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Arruda, Beatriz S., Reis, Carolina, Sermon, James J., Pogosyan, Alek, Brown, Peter, and Cagnan, Hayriye
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- 2021
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9. Essential tremor amplitude modulation by median nerve stimulation
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Reis, Carolina, Arruda, Beatriz S., Pogosyan, Alek, Brown, Peter, and Cagnan, Hayriye
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- 2021
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10. Systematic review of quality of life in Turner syndrome
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Reis, Carolina Trombeta, de Assumpção, Maíra Seabra, Guerra-Junior, Gil, and de Lemos-Marini, Sofia Helena Valente
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- 2018
11. Sources and settings of Ediacaran post-collisional syenite-monzonite-diorite shoshonitic magmatism from southernmost Brazil
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Padilha, Dionatan Ferri, Bitencourt, Maria de Fátima, Nardi, Lauro Valentim Stoll, Florisbal, Luana Moreira, Reis, Carolina, Geraldes, Mauro, and Almeida, Bruna Saar
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- 2019
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12. Financial Reporting Quality Impact on Firms' Capital Structure.
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Pereira Reis, Carolina, Cadima Lisboa, Inês Margarida, and Pedro Costa, Magali
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FINANCIAL statements ,CAPITAL structure ,FINANCE ,CORPORATE finance - Abstract
Purpose: Past literature on capital structure has demonstrated that firms' financing decisions play a crucial role in their performance and longevity. Accordingly, researchers have often addressed this subject to understand why firms opt for either debt or equity financing. Most research suggests that capital structure is predominantly determined by two elements: the firms' internal and external characteristics. In this study, we investigate the possible impact, that has been frequently neglected, the quality of financial information. Since financial reports are the principal basis for most financial decisions, their quality and information can influence capital structure choices. Some managers have been known to resort to earnings management practices during times of financial hardship, to conceal difficulties and mask their financial situation for stakeholders. Such practices compromise the quality of financial information, possibly hindering financial decisions. Therefore, this study aims to investigate the potential impact of financial reporting quality on firms' capital structure. Methodology: To our research, we assembled a sample of non-financial firms listed on the main stock exchanges of Portugal, Italy, Greece, and Spain; this is, the PSI, the FTSE/MIB, the FTSE/ATHEX, and the IBEX 35. After removing financial firms and those with insufficient data, our final sample compiled observations from 414 companies over the period between 2013 and 2022. All the data regarding the observed companies was obtained from the Orbis database, with further data on macroeconomic variables being sourced from Eurostat. To obtain our findings, we use an unbalanced panel data methodology on our sample and estimated the regressions using both fixed effects and Ordinary Least Squares (OLS) models. Capital structure is measured through six different proxies: the total debt ratio, the short-term debt ratio, and the long-term debt ratio based on both accounting and market values. We apply all these measures to gain a more comprehensive understanding of the capital structure and its influencing factors. To assess the quality of financial reporting, we employed four measures, namely, accruals quality (that measures the lack of earnings management - misreporting to hide the real financial situation of the firm), smoothness (hiding fluctuations in earnings), timeliness (measures if earnings are timelier recognized), and accounting conservatism (related with the recognition of bad news in earnings earlier than good news). Prior research has predominantly focused on accruals quality, with smoothness and accounting conservatism being acknowledged to a lesser extent. However, as far as we are aware, the effect of timeliness on debt was not study till now. Our goal is to enhance the understanding of the relationship between financial reporting quality and capital structure, by using various proxies that address different aspects of reporting quality. Finally, to ensure consistency and accuracy among the findings, firm-specific and macroeconomic variables were incorporated into the empirical models. The firm-specific factors, included to mitigate the differences between the analyzed companies, consist of age, size, assets' collateral value, profitability, and market-to-book value. To decrease macroeconomic disparities, we added inflation and gross domestic product (GDP) per capita to the empirical model. Besides the global analysis, our research also investigates two sub-samples to understand the differences between firms that were under the influence of Troika policies and those that were not. Results: Our primary research revealed mixed findings, as three variables of financial reporting quality exhibited a positive impact on debt (accruals quality, smoothness and conservatism), whereas the remaining measure had an adverse effect (timeliness). According to our results, financial information quality as a positive and a negative impact on debt. Resorting to earnings management practices, which reduce accruals quality, to smoothness, or accounting conservatism practices results in a decline in financial reporting quality, subsequently leading to decreased indebtedness. In contrast, engaging in timeliness practices also results in a reduction of financial reporting quality; however, in this case it is prone to increase debt. Our additional analysis investigated the effect of financial reporting quality on debt in companies that were impacted by Troika policies compared to those that were not. While our main findings were upheld for companies not subject to Troika's intervention, the Portuguese and Greek companies, impacted by Troika policies, exhibited significant differences in their results. First, neither discretionary accruals nor smoothness yielded any statistical significance in explaining capital structure. Subsequently, we found that timeliness has a negative impact on Portuguese and Greek companies' debt. Therefore, accounting conservatism is the only variable that provides a consistent outcome throughout all analyses. Moreover, our data indicates that both firm-specific and macroeconomic control variables demonstrate substantial statistical relevance when explaining capital structure, despite not all variables being relevant. Furthermore, the control variables seem to combine elements of both the pecking order and trade-off theories, as demonstrated by the conflicting results, suggesting that neither of these theories completely clarify the models. These observations also apply when analyzing the subsamples. Therefore, it is necessary to consider both approaches to fully comprehend the findings. Research limitations: Despite aiming for listed companies to comprehend the capital structure at an accounting and market-based level, it is important to note that listed companies tend to only make up a small portion of the total market and are, as a result, not a representative sample of all companies in the countries reviewed. Therefore, further research could investigate a wider sample compiling listed and non-listed companies to gain a deeper understanding of how multiple capital structures are affected by financial reporting quality. Our study was also limited to four stock exchanges from developed countries with similar financial environments, which restricts the possibility of generalizing our findings to companies from other countries with distinct macroeconomic backgrounds. Further investigation could tackle this limitation to obtain a more detailed understanding of the potential impact of the macroeconomic context on this relationship between debt and financial reporting quality. Lastly, we only applied four financial reporting quality measures, three already used in previous research, and one new, but more measures can be explored. Therefore, our findings on reporting quality are restricted to the variables that were applied in our empirical model. A more thorough investigation, encompassing additional or even all the variables of financial information quality, may produce more complete findings regarding its influence on capital structure. Originality: This study makes a significant contribution to the existing literature. First, it examines additional determinants of the capital structure ratio, as financial reporting quality proxies are frequently overlooked, as well as the impact of the proxy timeliness which has not previously been addressed. Second, it enhances the understanding of financial reporting quality and its importance by demonstrating its impact on other financial aspects of the company. Third, it extends the scope of previous research by investigating four economies that are often neglected. Lastly, it improves our understanding on how reformative measures impact companies. Therefore, this study aims to provide generalizable conclusions that can be applied to other samples and generate informative insights for the stakeholders of the examined firms. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism
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Reis, Carolina, Sharott, Andrew, Magill, Peter J., van Wijk, Bernadette C.M., Parr, Thomas, Zeidman, Peter, Friston, Karl J., and Cagnan, Hayriye
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- 2019
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14. Low Ankle-Brachial Index is a Simple Physical Exam Sign Predicting Intracranial Atherosclerotic Stenosis in Ischemic Stroke Patients
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Barreto-Neto, Nestor, Barros, Alexandre D., Jesus, Pedro A.P., Reis, Carolina C., Jesus, Morgana L., Ferreira, Isadora L.O., Fernandes, Rodrigo D., Resende, Lucas L., Andrade, Alisson L., Gonçalves, Beatriz M., Ventura, Lais M.B., Jesus, Adriano A., Fonseca, Luana F., Mueller, Mila C., and Oliveira-Filho, Jamary
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- 2016
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15. Electrochemical behavior and determination of major phenolic antioxidants in selected coffee samples
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Oliveira-Neto, Jerônimo Raimundo, Rezende, Stefani Garcia, de Fátima Reis, Carolina, Benjamin, Stephen Rathinaraj, Rocha, Matheus Lavorenti, and de Souza Gil, Eric
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- 2016
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16. Electrocoagulation treatment of furniture industry wastewater : economic analy0sis and environmental impact evaluation
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Reis, Carolina Vicente and Castro, Luís Miguel Moura Neves de
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Scale-up ,Otimização ,Eletrocoagulação ,Indústria de mobiliário ,Tratamento de águas residuais - Abstract
O efluente da indústria de mobiliário é altamente contaminado e pouco biodegradável. Este projeto pretende avaliar o desempenho da eletrocoagulação (EC) no tratamento de um efluente com acetato de polivinilo (PVAc). Com esse objetivo, realizaram-se testes em escala laboratorial e piloto que demonstram a adequabilidade da EC na diminuição de carência química de oxigénio (CQO) e sólidos. Em escala laboratorial avaliaram-se os efeitos da distância entre elétrodos (d), densidade e modo de corrente. Estudaram-se três valores de d (0.3, 0.6 e 0.9 cm), mostrando que este fator não afeta significativamente a performance em termos de tratamento. Contudo, valores mais baixos resultaram na redução do consumo energético, devido à diminuição da voltagem aplicada. Testaram-se três valores de densidade (132, 158 e 197 A.m-2), usando dois modos de corrente elétrica, corrente contínua (DC, do inglês direct current) e corrente de pulso alternado (APC, do inglês alternating pulsed current). Para DC, o melhor tratamento ocorreu usando 158 A.m-2. A utilização de APC permitiu melhorar a eficiência de tratamento para 197 A.m-2. APC provou ser uma escolha economicamente vantajosa, reduzindo o consumo de ânodo e a passivação. Em escala piloto avaliaram-se dois modos de operação, descontínuo e contínuo. Em descontínuo, testaram-se dois caudais de ar (1452 e 287 L.h-1). Em ambos os casos, verificou-se remoção de CQO acima de 90%, com uma ligeira melhoria para o caudal de ar mais baixo. A aplicação de carvão ativado como pós-tratamento permitiu reduzir a CQO para valores legalmente permitidos. Durante o teste realizado em modo contínuo, com a duração de quatro horas, atingiu-se o estado estacionário. A performance de tratamento não foi afetada pela alteração do modo de operação. Em escala piloto, o custo de operação considerando apenas o consumo energético não excedeu 2.65 €.m-3. Os resultados da análise ambiental mostraram que a aplicação da EC não afeta o desempenho ambiental da unidade fabril.
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- 2023
17. Bioproducts from Passiflora cincinnata Seeds: The Brazilian Caatinga Passion Fruit.
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Reis, Carolina Cruzeiro, Freitas, Suely Pereira, Lorentino, Carolline Margot Albanez, Fagundes, Thayssa da Silva Ferreira, da Matta, Virgínia Martins, dos Santos, André Luis Souza, Moreira, Davyson de Lima, Kunigami, Claudete Norie, Jung, Eliane Przytyk, and Ribeiro, Leilson de Oliveira
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PASSION fruit ,ETHANOL ,PASSIFLORA ,FRUIT seeds ,ESSENTIAL fatty acids ,LINOLEIC acid ,OILSEEDS - Abstract
The present work aimed to obtain bioproducts from Passiflora cincinnata seeds, the Brazilian Caatinga passion fruit, as well as to determine their physical, chemical and biological properties. The seeds were pressed in a continuous press to obtain the oil, which showed an oxidative stability of 5.37 h and a fatty profile rich in linoleic acid. The defatted seeds were evaluated for the recovery of antioxidant compounds by a central rotation experimental design, varying temperature (32–74 °C), ethanol (13–97%) and solid–liquid ratio (1:10–1:60 m/v). The best operational condition (74 °C, 58% ethanol, 1:48) yielded an extract composed mainly of lignans, which showed antioxidant capacity and antimicrobial activity against Gram-positive and Gram-negative bacteria. The microencapsulation of linoleic acid-rich oil through spray drying has proven to be an effective method for protecting the oil. Furthermore, the addition of the antioxidant extract to the formulation increased the oxidative stability of the product to 30% (6.97 h), compared to microencapsulated oil without the addition of the antioxidant extract (5.27 h). The microparticles also exhibited favorable technological characteristics, such as low hygroscopicity and high water solubility. Thus, it was possible to obtain three bioproducts from the Brazilian Caatinga passion fruit seeds: the oil rich in linoleic acid (an essential fatty acid), antioxidant extract from the defatted seeds and the oil microparticles added from the antioxidant extract. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Seasonal Changes in the Size Distribution of Copepods Is Affected by Coastal Upwelling.
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Rosa, Judson da Cruz Lopes da, Matos, Thiago da Silva, da Silva, Débora Costa Brito, Reis, Carolina, Dias, Cristina de Oliveira, Konno, Tatiana Ungaretti Paleo, and Fernandes, Lohengrin Dias de Almeida
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UPWELLING (Oceanography) ,COPEPODA ,PLANKTON populations ,OCEAN temperature ,SEASONS - Abstract
Water temperature controls the physiology, growth rate, distribution, and behavior of most plankton populations in the sea and thus affects the energy transfer in marine ecosystems. The present study focuses on the influence of seasonal changes in sea surface temperature on phytoplankton and the size distribution of copepods in the Arraial do Cabo Upwelling System (Brazil), where a wind-driven coastal upwelling can lead to multiple distinct bottom-up cascade effects on the food web. To address the potential effect of the seasonal changes, environmental data were obtained and the abundance of plankton determined from monthly samples collected in triplicate from 2010 to 2014. The samples were analyzed on a Benchtop FlowCAM (FC), and copepods (<1000 µm) were classified according to their Ellipses Equivalent Major Axis using image analysis software ImageJ (IJ). For IJ analysis, a batch-processing macro was built to open all FC raw images and then crop each copepod individually into a single picture. Using these images, prosome and urosome lengths were manually measured with the straight-line tool in IJ. With the combinations of measurements obtained in the IJ adjusted as FC measurements, we established a new, faster, and more effective way to measure copepods. With the copepod size classification, we found that there is a cycle in copepod size combined with the upwelling cycle that is related to temperature rather than to phytoplankton growth. Copepod abundance as a whole peaked during the autumn, winter, and spring seasons. The method performed here proved that FC is an effective tool for classifying copepod sizes and detecting seasonal variation. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Impact of lipid dynamic behavior on physical stability, in vitro release and skin permeation of genistein-loaded lipid nanoparticles
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Andrade, Lígia Marquez, de Fátima Reis, Carolina, Maione-Silva, Lorena, Anjos, Jorge Luiz V., Alonso, Antonio, Serpa, Rafael Caixeta, Marreto, Ricardo Neves, Lima, Eliana Martins, and Taveira, Stephânia Fleury
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- 2014
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20. Long-term follow-up of a case of choroidal neovascularization secondary to reticular pigmentary retinal dystrophy
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Reis, Carolina Campos, Casella, Antônio Marcelo Barbante, Chong, Lawrence Paul, and Rocha, Jorge Carlos Pessoa
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Choroidal neovascularization ,Transtornos da pigmentação ,genetic structures ,Pigmentation disorders ,Distrofias retinianas ,Sjogren’s syndrome ,sense organs ,Neovascularização de coroide ,Retinal dystrophies ,Síndrome de Sjogren ,eye diseases - Abstract
Reticular pigmentary retinal dystrophy, also known as Sjögren’s reticular dystrophy, is a rare condition characterized by macular lesions with a reticular pattern, which are best seen on fluorescein angiogram. Choroidal neovascularization secondary to this type of dystrophy is even less common. This report describes a case of reticular pigmentary retinal dystrophy with vision loss due to neovascular membrane, which responded well to treatment with anti-vascular endothelial growth factor. RESUMO A distrofia reticular pigmentar da retina, também conhecida como distrofia reticular de Sjögren, é uma doença rara, caracterizada por lesões maculares com um padrão reticular, que são mais bem visualizadas na angiografia com fluoresceína. A neovascularização de coroide secundária a este tipo de distrofia é ainda menos comum. Este relato descreve um caso de distrofia reticular pigmentar da retina, com perda de visão devido à membrana neovascular, que respondeu bem ao tratamento com fator de crescimento endotelial antivascular.
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- 2022
21. An antibody-like peptide that recognizes malignancy among thyroid nodules
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Reis, Carolina Fernandes, Carneiro, Ana Paula, Vieira, Carlos Ueira, Fujimura, Patrícia Tiemi, Morari, Elaine Cristina, Silva, Sindeval José da, Goulart, Luiz Ricardo, and Ward, Laura Sterian
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- 2013
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22. Relaxing effect of a new ruthenium complex nitric oxide donor on airway smooth muscle of an experimental model of asthma in rats
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Castro, Patrícia Ferreira da Silva, de Andrade, Daniela Lobo, Reis, Carolina de Fátima, Costa, Sérgio Henrique Nascente, Batista, Aline Carvalho, da Silva, Roberto Santana, and Rocha, Matheus Lavorenti
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- 2016
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23. How Portuguese consumers perceive the sustainable dimension of the brand1?
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Reis, Carolina Raquel Almeida and Silveira, Catherine da
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Sustainability ,Garnier ,Bio products ,Beauty and personal care market ,Brand architecture ,Plastic packaging ,Ciências Sociais::Economia e Gestão [Domínio/Área Científica] - Abstract
The Beauty and Personal Care Market has been moving towards a sustainable path. During the past few years, companies have taken on initiatives to reduce their environmental footprint, and Brand 1is at its forefront in the mass market. This Field Lab Project aims to analyse how Portuguese consumers perceive the sustainable dimension of the Brand 1. We concluded that most Portuguese consumers are not up-to-date with sustainability, showing incongruencies between their stated opinions and their actions. Their misunderstanding of the topic extends to their reliability of the sustainability concept on packaging, granting it greater importance than any other factors.
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- 2021
24. Cidadania e igualdade de género em crianças e adolescentes
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Dias, António Madureira, Cunha, Madalena, Oliveira, Adriana, Reis, Carolina, Oliveira, Inês, Maltez, Leonardo, Fernandes, Leonor, Nogueira, Mariana, and Osório, Stefanie
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LC8-6691 ,participação da comunidade ,05 social sciences ,criança ,050602 political science & public administration ,adolescente ,Public aspects of medicine ,RA1-1270 ,Special aspects of education ,050601 international relations ,género ,0506 political science - Abstract
Introdução: O direito à educação da criança/adolescente em relação à sua preparação para o desempenho da cidadania é um dos objetivos da educação inclusiva, que deve promover o respeito pela dignidade das crianças/adolescentes, apoiando-os de igual forma, independentemente do seu género. Objetivos: Avaliar os conhecimentos dos agentes educativos sobre cidadania e igualdade de género em crianças e adolescentes. Métodos: Estudo quantitativo, descritivo, transversal, realizado numa amostra não probabilística de conveniência, constituída por 136 participantes, professores (62,5%), enfermeiros (32,4%) e polícias (5,1%), com uma média de idades de 48,34 anos (±7,49 anos), sendo 70,6% do género feminino. Foi utilizado o questionário ad hoc, Cidadania e Igualdade de Género em Crianças e Adolescentes (CIG-CA) de Cunha (2017), constituído por 2 escalas, uma referente à educação e linguagem inclusiva e outra aos conhecimentos sobre cidadania e igualdade de género, tendo em conta dois fatores: tarefas domésticas e cuidar dos filhos. Resultados: Apurou-se que as percentagens mais elevadas correspondem aos participantes que referem ter conhecimento sobre cidadania e igualdade de género no que se refere à linguagem inclusiva (O Ser Humano 89.7% vs. O(A) Professor(a) 75,0%). Na globalidade, há uma prevalência de bons conhecimentos (40,4%), seguindo-se os razoáveis conhecimentos sobre cidadania e igualdade de género. Conclusões: Os resultados permitiram reconhecer um foco de interesse para a intervenção da enfermagem no âmbito do projecto MaiSaúdeMental, e para a definição de estratégias para a promoção da cidadania das crianças / adolescentes no contexto escolar e comunitário, mobilizando os recursos dos agentes educativos para uma inclusão mais efetiva., Millenium - Journal of Education, Technologies, and Health, No. 5e (2020): Serie 2, n.º 05e
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- 2020
25. Second-hand fashion : the effect of nostalgia on purchase intentions and shopping behaviour
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Reis, Carolina Lopes da Silva and Braga, João Pedro Niza
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Nostalgia ,Second-hand ,Consumer behaviour ,Vintage ,Comportamento do consumidor ,Segunda mão ,Fashion ,Moda ,Ciências Sociais::Economia e Gestão [Domínio/Área Científica] - Abstract
Submitted by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2020-10-30T09:04:20Z No. of bitstreams: 1 152118045_Carolina Reis_DPDFA.pdf: 1255816 bytes, checksum: 5eb945e228484ce0f470da4cc15b200f (MD5) Approved for entry into archive by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2020-10-30T09:04:33Z (GMT) No. of bitstreams: 1 152118045_Carolina Reis_DPDFA.pdf: 1255816 bytes, checksum: 5eb945e228484ce0f470da4cc15b200f (MD5) Made available in DSpace on 2020-10-30T09:04:33Z (GMT). No. of bitstreams: 1 152118045_Carolina Reis_DPDFA.pdf: 1255816 bytes, checksum: 5eb945e228484ce0f470da4cc15b200f (MD5) Previous issue date: 2020-07-06
- Published
- 2020
26. Effect of Transcranial random noise stimulation on medial prefrontal cortex governing inhibitory control
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Mandali, Alekhya, Torrecillos, Flavie, Reis, Carolina, Wiest, Christoph, Pogosyan, Alek, Tan, Huiling, and Cagnan, Hayriye
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- 2023
- Full Text
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27. Long-term follow-up of a case of choroidal neovascularization secondary to reticular pigmentary retinal dystrophy.
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Campos Reis, Carolina, Barbante Casella, Antônio Marcelo, Chong, Lawrence Paul, and Pessoa Rocha, Jorge Carlos
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RETINAL degeneration , *PATHOLOGIC neovascularization , *ENDOTHELIAL growth factors , *NEOVASCULARIZATION , *VISION disorders , *SJOGREN'S syndrome - Abstract
Reticular pigmentary retinal dystrophy, also known as Sjögren's reticular dystrophy, is a rare condition characterized by macular lesions with a reticular pattern, which are best seen on fluorescein angiogram. Choroidal neovascularization secondary to this type of dystrophy is even less common. This report describes a case of reticular pigmentary retinal dystrophy with vision loss due to neovascular membrane, which responded well to treatment with anti-vascular endothelial growth factor. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
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28. Multi-scale temporal variation of marine femtoplankton and picophytoplankton: the role of size and environment.
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Reis, Carolina, Corte, Guilherme, and Fernandes, Lohengrin
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VIRUS-like particles ,UPWELLING (Oceanography) ,SYNECHOCOCCUS ,FLOW cytometry ,PHYTOPLANKTON ,STATISTICAL models ,OCEAN - Abstract
Femtoplankton and picophytoplankton organisms exert a major role in the balance between producers and consumers and are responsible for a large part of net primary production in the ocean. However, despite their ecological importance, the magnitude and drivers of their temporal dynamics remain largely unexplored. To address this significant knowledge gap, we performed weekly sampling over ten months in a wind-driven coastal upwelling area in the subtropical South Atlantic Ocean. We combined this intensive fieldwork with multi-color flow cytometry and statistical modeling to investigate the temporal changes of both femto- and picophytoplankton at multiple temporal scales. We found that femtoplanktonic organisms (including virus-like particles) responded faster (i.e., without a temporal lag) to environmental changes, mainly related to chlorophyll-a (chl-a) and phaeopigment variations. On the other hand, picophytoplanktonic organisms showed a slower response to environmental changes, with positive responses to variation in pH and NH4 concentrations after a one-week lag. Overall, our results demonstrate that the speed of response of planktonic organisms to environmental changes may be dependent on their size, which highlights the importance of environmental variables and biological interactions as drivers of their temporal dynamics. [ABSTRACT FROM AUTHOR]
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- 2022
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29. Brewery spent grain: a potential biosorbent for hexavalent chromium.
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Vendruscolo, Francielo, Reis, Carolina Leandra Fantt de Sousa e, and Silva, Jessica Guimarães
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HEXAVALENT chromium , *SOLID waste , *BREWERIES , *HYDROGEN peroxide , *PH effect - Abstract
Spent grain is a solid waste from the brewery process which is used as feed for ruminants or as organic fertiliser. Due to the large scale generation of spent grain, new technological and industrial applications are being developed. In this work, spent grain was modified by chemical treatments for use in the biosorption of hexavalent chromium. For spent grain treated with acid, alkali, petroleum ether and hydrogen peroxide, the amount of hexavalent chromium removed was respectively 97, 21, 0.9 and 0.5%. The kinetic data of spent grain biosorbent treated with acid, untreated and treated with alkali were applied to pseudo‐first order, pseudo‐second order and intraparticle diffusion models. The pseudo‐second order model showed the best fit to the kinetic data, indicating chemisorption in the biosorption processes. The effects of pH and biosorbent concentration were analysed for spent grain treated with acid. The optimum values for pH and concentration of the biosorbent were pH 2 and 2 g/L. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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30. Gold mineralization in veins of massive pyrite at Serra da Paciência, Bahia state, Brazil - a different tipology from that of Au-U conglomerates of the Jacobina Group
- Author
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MIRANDA, Daniel Augusto de, SANTOS, Fabrício Pereira dos, REIS, Carolina, and OLIVEIRA, Rita Cunha Leal Menezes de
- Subjects
SERRA DA PACIÊNCIA ,SERRA DE JACOBINA ,GEOLOGIA ECONÔMICA ,BAHIA ,ECONOMIA MINERAL ,OURO - Published
- 2017
31. A group of Brazilian Turner syndrome patients: Better quality of life than the control group.
- Author
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Reis, Carolina T., Macedo, Marina C., Morcillo, André M., Guerra‐Junior, Gil, and Lemos‐Marini, Sofia Helena V.
- Abstract
Current literature presents no consensus regarding which aspects influence health‐related quality of life (HRQoL) of women with Turner syndrome (TS). The objective of the present study was to compare HRQoL in the TS and control group, using components and domains of the Medical Outcomes Study 36‐Item Short Form Health Survey (SF‐36). Observational, descriptive, and cross‐sectional study with 44 women with TS aged between 18 and 30 years (TS group) and 44 healthy women of the same age which were sisters, relatives, or friends of the TS group (control group). A registration form and the SF‐36 questionnaire were used to analyze HRQoL in TS in relation to the control group. The TS group presented better scores in the mental component summary and in the role physical, bodily pain, general health, social function, and role emotional domains compared to the control group. This study presented some unexpected results, different from those found in the current literature, showing the possibility of TS patients presenting better coping strategies. It is necessary to develop a specific questionnaire to assess QoL in TS and analyze in great detail which factors may influence the HRQoL of these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
32. Chlamydia trachomatis: um importante agente de infecções respiratórias em lactentes de famílias de baixa renda
- Author
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Souza, Edna Lucia, Girão, Renata Silva, Simões, Juçara Magalhães, Reis, Carolina Ferraz, Galvão, Naiara Araújo, Andrade, Sandra Cristina S., Werneck, Denise Mattedi F., Araújo-Neto, César A., and Souza, Leda Solano F.
- Subjects
bronquiolite ,respiratory tract infection ,lactente ,lcsh:RJ1-570 ,pneumonia ,bronchiolitis ,Chlamydia trachomatis ,lcsh:Pediatrics ,infant ,infecção do trato respiratório - Abstract
OBJETIVOS: Determinar a prevalência de infecção do trato respiratório inferior (ITRI) por Chlamydia trachomatis em lactentes internados e descrever as características clínicas, laboratoriais e radiológicas da doença. MÉTODOS: Este foi um estudo do tipo corte transversal, realizado durante um período de 12 meses. Foram incluídos todos os lactentes de até 6 meses internados consecutivamente no Centro Pediátrico Professor Hosannah de Oliveira da Universidade Federal da Bahia, em Salvador, BA, com diagnóstico clínico ou clínico-radiológico de ITRI. O diagnóstico de infecção por C. trachomatis foi realizado através da pesquisa de anticorpos da classe IgM, utilizando-se o ensaio imunoenzimático (ELISA). A prevalência de ITRI por C. trachomatis foi determinada, e foram calculadas as razões de prevalência para essa infecção e variáveis clínicas e laboratoriais. RESULTADOS: Cento e cinquenta e um lactentes realizaram sorologia para C. trachomatis, das quais 15 (9,9%) foram positivas. A infecção por C. trachomatis ocorreu unicamente entre os menores de 5 meses, principalmente naqueles menores de 2 meses. Três crianças com infecção por C. trachomatis nasceram de parto cesáreo. Conjuntivite e eosinofilia ocorreram em 33,3% dos casos. As radiografias de tórax se mostraram alteradas em 92% dos casos. Demonstrou-se associação da infecção por C. trachomatis com duração de internação superior a 15 dias (p = 0,0398) e com oxigenoterapia (p = 0,0484). CONCLUSÕES: Houve alta prevalência de ITRI por C. trachomatis na população estudada. A infecção por esta bactéria foi associada a uma forma mais grave da doença, demonstrando a importância de se investigar essa infecção na gestante de forma a evitar o adoecimento de recém-nascidos. OBJECTIVES: To determine the prevalence of lower respiratory tract infection (LRTI) due to Chlamydia trachomatis in newborn infants and to describe the clinical, laboratory, and radiological characteristics of the disease. METHODS: A cross-sectional study carried out over a 12-month period. All infants up to 6 months of age admitted consecutively at the Centro Pediátrico Professor Hosannah de Oliveira of the Universidade Federal da Bahia in Salvador, Brazil, and diagnosed with LRTI according to clinical and/or radiological criteria were included in the study. C. trachomatis infection was diagnosed by the enzyme-linked immunosorbent assay (ELISA) for the detection of IgM-class antibodies. The prevalence of LRTI by C. trachomatis was determined and the prevalence ratios for the infection and clinical or laboratory variables were calculated. RESULTS: One hundred and fifty-one infants were submitted to serology for C. trachomatis and 15 (9.9%) tested positive. Chlamydial infection was found only in infants under 5 months of age, mainly in those aged under 2 months. Three of the infants with C. trachomatis infection were born by cesarean section. Conjunctivitis and eosinophilia had occurred in 33.3% of the cases. Chest X rays were abnormal in 92.0% of cases. There was an association between C. trachomatis infection and the duration of hospitalization exceeding 15 days (p = 0.0398) and oxygen therapy (p = 0.0484). CONCLUSIONS: There was a high prevalence of C. trachomatis respiratory infection in the population studied. The infection was associated with a more severe form of the disease, emphasizing the importance of testing pregnant women for this infection to avoid infection in the newborn infant.
- Published
- 2012
33. Patulin: A mycotoxin in apples
- Author
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Reis, Carolina, Couto, Daniela, Tomás, Joana, Moreira, Patrícia, Santos, Ana Lúcia Baltazar, and Joaquim, João
- Published
- 2017
- Full Text
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34. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
- Author
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Chun-Yi Wu, Don-Hong Wang, Xiaobing Wang, Dixon, Seth M., Liping Meng, Ahadi, Sara, Enter, Daniel H., Chao-Yu Chen, Jason Kato, Leon, Leonardo J., Ramirez, Laura M., Yoshiko Maeda, Reis, Carolina F., Ribeiro, Brianna, Weems, Brittany, Hsing-Jien Kung, and Lam, Kit S.
- Published
- 2016
- Full Text
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35. 15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells.
- Author
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Trindade-da-Silva, Carlos Antônio, Reis, Carolina Fernandes, Vecchi, Lara, Napimoga, Marcelo Henrique, Sperandio, Marcelo, Matias Colombo, Bruna França, Alves, Patrícia Terra, Ward, Laura Sterian, Ueira-Vieira, Carlos, and Goulart, Luiz Ricardo
- Subjects
- *
THYROID cancer treatment , *APOPTOSIS , *CANCER cells , *CYCLOPENTENONE , *INTERLEUKIN-6 , *PEROXISOME proliferator-activated receptors , *PROSTAGLANDINS - Abstract
The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TPC-1) using different doses of 15d-PGJ2 (0.6 to 20 μM) to determine IC50 (9.3 μM) via the MTT assay. The supernatant culture medium of the TPC-1 cells that was treated either with 15d-PGJ2 or with vehicle (control) for 24 hours was assessed for IL-6 secretion via CBA assay. RT-qPCR was used to evaluate mRNA expression of IL-6, SOCS1, SOCS3, and STAT3. TPC-1 cells treated with 15d-PGJ2 decreased the secretion and expression of IL-6 and STAT3, while it increased SOCS1 and SOCS3. Overall, we demonstrated that 15d-PGJ2 downregulated IL-6 signaling pathway and led TPC-1 cells into apoptosis. In conclusion, 15d-PGJ2 shows the potential to become a new therapeutic approach for thyroid tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
36. Preventing Juvenile Delinquency: Compulsory Hospitalization as a Public Security Tool.
- Author
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dos Reis, Carolina and de Fátima Guareschi, Neuza Maria
- Published
- 2016
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37. Chromosomal disruption and rearrangements during murine sarcoma development converge to stable karyotypic formation kept by telomerase overexpression.
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de Oliveira-Júnior, Robson José, Ueira-Vieira, Carlos, Servino Sena, Angela Aparecida, Fernandes Reis, Carolina, Roberto Mineo, José, Ricardo Goulart, Luiz, and Morelli, Sandra
- Subjects
CHROMOSOMES ,CELL nuclei ,SARCOMA ,CANCER ,TELOMERASE - Abstract
Background: Tumor initiation presents a complex and unstable genomic landscape; one of the earliest hallmark events of cancer, and its progression is probably based on selection mechanisms under specific environments that lead to functional tumor cell speciation. We hypothesized that viable tumor phenotypes possess common and highly stable karyotypes and their proliferation is facilitated by an attuned high telomerase activity. Very few investigations have focused on the evolution of common chromosomal rearrangements associated to molecular events that result in functional phenotypes during tumor development. Results: We have used cytogenetic, flow cytometry and cell culture tools to investigate chromosomal rearrangements and clonality during cancer development using the murine sarcoma TG180 model, and also molecular biology techniques to establish a correlation between chromosome instability and telomerase activity, since telomeres are highly affected during cancer evolution. Cytogenetic analysis showed a near-tetraploid karyotype originated by endoreduplication. Chromosomal rearrangements were random events in response to in vitro conditions, but a stable karyotypic equilibrium was achieved during tumor progression in different in vivo conditions, suggesting that a specific microenvironment may stabilize the chromosomal number and architecture. Specific chromosome aberrations (marker chromosomes) and activated regions (rDNAs) were ubiquitous in the karyotype, suggesting that the conservation of these patterns may be advantageous for tumor progression. High telomerase expression was also correlated with the chromosomal rearrangements stabilization. Conclusions: Our data reinforce the notion that the sarcoma cell evolution converges from a highly unstable karyotype to relatively stable and functional chromosome rearrangements, which are further enabled by telomerase overexpression. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
38. Blocking the L-type Ca2+ channel (Cav 1.2) is the key mechanism for the vascular relaxing effect of Pterodon spp. and its isolated diterpene methyl-6α-acetoxy-7β-hydroxyvouacapan-17β-oate.
- Author
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de Fátima Reis, Carolina, de Andrade, Daniela Medeiros Lobo, Neves, Bruno Junior, de Almeida Ribeiro Oliveira, Leandra, Pinho, José Felippe, da Silva, Leidiane Pinha, Cruz, Jader Dos Santos, Bara, Maria Teresa Freitas, Andrade, Carolina Horta, and Rocha, Matheus Lavorenti
- Subjects
- *
CALCIUM channels , *DITERPENES , *SMOOTH muscle , *MUSCLE contraction , *PHENYLEPHRINE - Abstract
Pterodon spp. Vogel (Fabaceae), popularly known as “sucupira”, has ethnopharmacological application which is described as having antispasmodic and relaxant effects. Hence, it was hypothesized that sucupira oil-resin (SOR) could induce smooth muscle relaxation. So, this study investigated the mechanisms involved in the vasorelaxant effect of SOR and its isolated diterpene (methyl-6α-acetoxy-7β-hydroxyvouacapan-17β-oate). Vascular reactivity experiments were performed using rat aortic rings ( n = 5–8) with ( E +) or without endothelium ( E −) in an isolated bath organ. The SOR (0–56 μg/mL) relaxed phenylephrine ( E +: 86.7 ± 7.1%; E −: 92.3 ± 4.7%) and KCl contracted rings ( E −: 97.1 ± 2.8%). In the same way, diterpene (0–48μg/mL) also relaxed phenylephrine ( E +: 94.5 ± 3.6%; E −: 92.2 ± 3.4%) and KCl contracted rings ( E −: 99.7 ± 0.2%). The pre-incubation of arterial rings with cyclopiazonic acid (reticular Ca 2+ -ATPase inhibitor), tetraethylammonium (K+ channels blocker) or MDL-12,330A (adenylyl cyclesinhibitor) did not modify either SOR- or diterpeneinduced vasorelaxation. However, ODQ (guanylyl cyclase inhibitor) impaired only diterpene-induced vasorelaxation. SOR and diterpene significantly reduced CaCl 2 -induced contraction stimulated by Bay K8644 (1 μM), phenylephrine (0.1 μM) or KCl solution (40 mM). Computational molecular docking studies demonstrated that the vasodilator effect of diterpene relies on blocking the Ca v 1.2 channel, and patch clamp results showed that diterpene substantially decreased the ionic current through Ca v 1.2 in freshly dissociated vascular smooth muscle cells. These findings suggest that SOR and its isolated diterpene induce endothelium-independent vascular relaxation by blocking the L-type Ca 2+ channel (Ca v 1.2). [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
39. Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.
- Author
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Lobo de Andrade, Daniela Medeiros, Reis, Carolina de Fátima, Castro, Patrícia Ferreira da Silva, Borges, Leonardo Luiz, Amaral, Nathalia Oda, Torres, Ieda Maria Sapateiro, Rezende, Stefani Garcia, Gil, Eric de Souza, Cardoso da Conceição, Edemilson, Pedrino, Gustavo Rodrigues, and Lavorenti Rocha, Matheus
- Abstract
This study’s aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
40. Diuretic effects and urinary electrolyte excretion induced by Aspidosperma subincanum Mart. and the involvement of prostaglandins in such effects.
- Author
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Ribeiro, Emmeline Flor, de Fátima Reis, Carolina, de Carvalho, Flávio Silva, Abreu, João Pedro Silva, Arruda, Andréa Fernandes, Garrote, Clévia Ferreira Duarte, and Rocha, Matheus Lavorenti
- Subjects
- *
NONSTEROIDAL anti-inflammatory agents , *CYCLOOXYGENASE 2 , *ANIMALS , *CARDIOVASCULAR diseases , *DIURESIS , *DIURETICS , *ETHANOL , *FUROSEMIDE , *ORAL drug administration , *PHYSIOLOGIC salines , *PIROXICAM , *PROSTAGLANDINS , *RATS , *URINARY organ physiology , *PHARMACODYNAMICS , *THERAPEUTICS ,THERAPEUTIC use of plant extracts ,URINE collection & preservation - Abstract
Ethnopharmacological relevance Aspidosperma subincanum Mart. is a medicinal herb known for its diuretic properties and used for the treatment of cardiovascular-related illnesses. Although our earlier study has shown that the ethanol extract of Aspidosperma subincanum (EEAS) induces hypotension and vasodilation, no scientific data have been recorded to evaluate the diuretic effects of this Brazilian medicinal plant. The aim of this study was to evaluate the diuretic activity of EEAS, and possible mechanism of action, using Wistar rats. Material and methods EEAS (60 and 120 mg/kg), furosemide (20 mg/kg) or saline (control) were orally administered to rats individually held in metabolic cages for urine collection 1, 2, 4, 6, 8, 12 and 24 h after treatment. In order to evaluate the involvement of prostaglandins in the diuretic action of EEAS, the animals received piroxicam (5 mg/kg i.p.), a nonselective inhibitor of cyclooxygenase, before treatment with EEAS at 120 mg/kg. The control groups received only saline (NaCl, 0.9%), or saline and piroxicam. Urinary volume, electrolyte excretion and pH were measured. Results Oral administration of EEAS 60 and 120 mg/kg significantly increased diuresis and electrolyte excretion of Na + and K + on a continuous basis throughout the study period. Both EEAS 60 and 120 mg/kg caused a relative increase of around 77% and 142%, respectively, in cumulative diuresis compared with the control group. From 4th hour until the end of the experiment, the group treated with EEAS 120 mg/kg provided a greater excretion of Na + than the furosemide group. The diuretic effects of EEAS were neutralized by piroxicam between 4 and 8 h after treatment. Conclusion The results suggest that EEAS could present compound(s) responsible for diuretic activities, and the mechanism could involve the prostaglandin system. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
41. Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.
- Author
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Lobode Andrade, Daniela Medeiros, de Fátima Reis, Carolina, da Silva Castro, Patrícia Ferreira, Borges, Leonardo Luiz, Oda Amaral, Nathalia, Sapateiro Torres, Ieda Maria, Garcia Rezende, Stefani, de Souza Gil, Eric, Cardosoda Conceição, Edemilson, Rodrigues Pedrino, Gustavo, and Lavorenti Rocha, Matheus
- Subjects
- *
ANALYSIS of variance , *ANIMAL experimentation , *AORTA , *BIOPHYSICS , *BLOOD pressure , *HEART beat , *HEMODYNAMICS , *RESEARCH methodology , *RATS , *RESEARCH funding , *PLANT extracts , *REPEATED measures design , *IN vitro studies - Abstract
This study's aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
42. Effect of somatic cell count and mastitis pathogens on milk composition in Gyr cows.
- Author
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Malek dos Reis, Carolina Barbosa, Barreiro, Juliana Regina, Mestieri, Lucinéia, de Felício Porcionato, Marco Aurélio, and dos Santos, Marcos Veiga
- Subjects
- *
SOMATIC cells , *MILK yield , *BOVINE mastitis , *LACTOSE , *PATHOGENIC microorganisms - Abstract
Background: Gyr cows are well adapted to tropical conditions, resistant to some tropical diseases and have satisfactory milk production. However, Gyr dairy herds have a high prevalence of subclinical mastitis, which negatively affects their milk yield and composition. The objectives of this study were (i) to evaluate the effects of seasonality, mammary quarter location (rear x front), mastitis-causing pathogen species, and somatic cell count (SCC) on milk composition in Gyr cows with mammary quarters as the experimental units and (ii) to evaluate the effects of seasonality and somatic cell count (SCC) on milk composition in Gyr cows with cows as the experimental units. A total of 221 lactating Gyr cows from three commercial dairy farms were selected for this study. Individual foremilk quarter samples and composite milk samples were collected once a month over one year from all lactating cows for analysis of SCC, milk composition, and bacteriological culture. Results: Subclinical mastitis reduced lactose, nonfat solids and total solids content, but no difference was found in the protein and fat content between infected and uninfected quarters. Seasonality influenced milk composition both in mammary quarters and composite milk samples. Nevertheless, there was no effect of mammary quarter position on milk composition. Mastitis-causing pathogens affected protein, lactose, nonfat solids, and total solids content, but not milk fat content. Somatic cell count levels affected milk composition in both mammary quarters and composite samples of milk. Conclusions: Intramammary infections in Gyr cows alter milk composition; however, the degree of change depends on the mastitis-causing pathogen. Somatic cell count is negatively associated with reduced lactose and nonfat solids content in milk. Seasonality significantly affects milk composition, in which the concentration of lactose, fat, protein, nonfat solids and total solids differs between dry and wet seasons in Gyr cows. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
43. Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families.
- Author
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Souza, Edna Lucia, Girão, Renata Silva, Simões, Juçara Magalhães, Reis, Carolina Ferraz, Galvão, Naiara Araújo, Andrade, Sandra Cristina S., Werneck, Denise Mattedi F., Araújo-Neto, César A., and Souza, Leda Solano F.
- Subjects
RESPIRATORY infections in children ,CHLAMYDIA trachomatis ,PNEUMONIA in children ,INFANT health ,HEALTH of poor people ,POOR people ,PREVENTION ,PATIENTS - Abstract
Objectives: To determine the prevalence of lower respiratory tract infection (LRTI) due to Chlamydia trachomatis in newborn infants and to describe the clinical, laboratory, and radiological characteristics of the disease. Methods: A cross-sectional study carried out over a 12-month period. All infants up to 6 months of age admitted consecutively at the Centro Pediátrico Professor Hosannah de Oliveira of the Universidade Federal da Bahia in Salvador, Brazil, and diagnosed with LRTI according to clinical and/or radiological criteria were included in the study. C. trachomatis infection was diagnosed by the enzyme-linked immunosorbent assay (ELISA) for the detection of IgM-class antibodies. The prevalence of LRTI by C. trachomatis was determined and the prevalence ratios for the infection and clinical or laboratory variables were calculated. Results: One hundred and fifty-one infants were submitted to serology for C. trachomatis and 15 (9.9%) tested positive. Chlamydial infection was found only in infants under 5 months of age, mainly in those aged under 2 months. Three of the infants with C. trachomatis infection were born by cesarean section. Conjunctivitis and eosinophilia had occurred in 33.3% of the cases. Chest X rays were abnormal in 92.0% of cases. There was an association between C. trachomatis infection and the duration of hospitalization exceeding 15 days (p = 0.0398) and oxygen therapy (p = 0.0484). Conclusions: There was a high prevalence of C. trachomatis respiratory infection in the population studied. The infection was associated with a more severe form of the disease, emphasizing the importance of testing pregnant women for this infection to avoid infection in the newborn infant. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
44. Abstract T P361.
- Author
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Oliveira-Filho, Jamary, Reis, Carolina C, Fernandes, Rodrigo D, Jesus, Adriano A, Fonseca, Luana F, Muller, Mila C, Lordelo, Morgana J, Ventura, Laís M, Barreto-Neto, Nestor J, Ferreira, Isadora L, Resende, Lucas L, Andrade, Alisson L, Gonçalves, Beatriz M, Jesus, Pedro A, Abbehusen, Cristiane B, and Furie, Karen L
- Published
- 2014
45. Abstract W P134.
- Author
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Barros, Alexandre D, Reis, Carolina C, Jesus, Adriano A, Fernandes, Rodrigo D, Ferreira, Isadora L, Fonseca, Luana F, Resende, Lucas L, Lordelo, Morgana J, Barreto-Neto, Nestor J, Ventura, Lais M, Andrade, Alisson L, Gonçalves, Beatriz M, Martins-Neto, Gentil P, Jesus, Pedro A, and Oliveira-Filho, Jamary
- Published
- 2014
46. Anthropometry and physical appearance can be associated with quality of life in Brazilian women with Turner syndrome.
- Author
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Reis CT, Macedo MC, Morcillo AM, Guerra G Junior, and de Lemos-Marini SHV
- Subjects
- Humans, Female, Quality of Life psychology, Brazil, Cross-Sectional Studies, Surveys and Questionnaires, Anthropometry, Turner Syndrome psychology, Physical Appearance, Body
- Abstract
Objective: This study aimed to analyze if anthropometric factors and physical appearance are associated to QoL in Turner syndrome (TS)., Materials and Methods: Observational, analytical, and cross-sectional study. The SF-36 was applied along with an additional questionnaire regarding specific characteristics of TS., Results: There were no differences in quality of life (QoL) in TS women regarding median height and appropriate height according to parental target height, however, participants satisfied and who did not desire to change their height had better scores in the mental health and role emotional domains than those not satisfied and desired to change it. When comparing participants who were or were not bothered by physical appearance, the results showed that those not bothered by physical appearance had a better score in the vitality and social function domains. Considering patients who did or did not desire to change physical appearance, those who did not want to change their physical appearance had higher scores in the mental component and in the social function and mental health domains of the SF-36., Conclusion: This study indicated that anthropometric factors and physical appearance may possibly be associated to QoL in TS, and also emphasizes the need to develop and validate an official questionnaire regarding specific TS characteristics in order to assess in more detail how specific characteristics of TS interfere with their QoL.
- Published
- 2023
- Full Text
- View/download PDF
47. ARDD 2020: from aging mechanisms to interventions.
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Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, and Scheibye-Knudsen M
- Subjects
- Cellular Senescence, Congresses as Topic, Drug Discovery, Humans, Life Style, Pharmaceutical Preparations, Aging, Artificial Intelligence, Biomedical Research, Longevity
- Abstract
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7
th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.- Published
- 2020
- Full Text
- View/download PDF
48. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
- Author
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Wu CY, Wang DH, Wang X, Dixon SM, Meng L, Ahadi S, Enter DH, Chen CY, Kato J, Leon LJ, Ramirez LM, Maeda Y, Reis CF, Ribeiro B, Weems B, Kung HJ, and Lam KS
- Subjects
- Antineoplastic Agents pharmacology, Benzimidazoles chemical synthesis, Benzimidazoles pharmacology, Cell Cycle, Cell Line, Combinatorial Chemistry Techniques methods, DNA, Complementary biosynthesis, DNA, Complementary genetics, Drug Screening Assays, Antitumor, High-Throughput Screening Assays, Humans, Jurkat Cells, Ligands, Methionine metabolism, Drug Discovery methods, Peptide Library, Proteomics methods, Small Molecule Libraries
- Abstract
Identifying "druggable" targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molecules that bind to a specific target protein or elicit a specific cellular response. The phage display cDNA expression proteome library method has been employed to identify target proteins that interact with specific compounds. Here, we combined these two high-throughput approaches, efficiently interrogated approximately 10(13) possible molecular interactions, and identified 91 small molecule compound beads that interacted strongly with the phage library. Of 19 compounds resynthesized, 4 were cytotoxic against cancer cells; one of these compounds was found to interact with EIF5B and inhibit protein translation. As more binding pairs are confirmed and evaluated, the "library-against-library" screening approach and the resulting small molecule-protein domain interaction database may serve as a valuable tool for basic research and drug development.
- Published
- 2016
- Full Text
- View/download PDF
49. 15-Deoxy-Δ(12,14)-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells.
- Author
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Trindade-da-Silva CA, Reis CF, Vecchi L, Napimoga MH, Sperandio M, Matias Colombo BF, Alves PT, Ward LS, Ueira-Vieira C, and Goulart LR
- Abstract
The cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TPC-1) using different doses of 15d-PGJ2 (0.6 to 20 μM) to determine IC50 (9.3 μM) via the MTT assay. The supernatant culture medium of the TPC-1 cells that was treated either with 15d-PGJ2 or with vehicle (control) for 24 hours was assessed for IL-6 secretion via CBA assay. RT-qPCR was used to evaluate mRNA expression of IL-6, SOCS1, SOCS3, and STAT3. TPC-1 cells treated with 15d-PGJ2 decreased the secretion and expression of IL-6 and STAT3, while it increased SOCS1 and SOCS3. Overall, we demonstrated that 15d-PGJ2 downregulated IL-6 signaling pathway and led TPC-1 cells into apoptosis. In conclusion, 15d-PGJ2 shows the potential to become a new therapeutic approach for thyroid tumors.
- Published
- 2016
- Full Text
- View/download PDF
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