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5. Treatment of acute urticaria: A systematic review.

Author

Badloe, Fariza M. S., Grosber, Martine, Ring, Johannes, Kortekaas Krohn, Inge, and Gutermuth, Jan

Abstract

There are only a few clinical trials which address the treatment of acute urticaria (AU). Especially, the added value of systemic corticosteroids to antihistamines is unclear in treatment of severe AU. To review the existing evidence‐based approaches for AU treatment. A systematic electronic search was done in PubMed and Web of Science to retrieve all studies on the treatment of patients with AU. A descriptive synthesis was conducted based on the PRISMA statement. Quality assessment was independently performed by both reviewers ('Cochrane risk‐of‐bias tool' for RCTs). Ten randomized controlled trials (RCTs) (n = 857 participants) were included. Four studies assessed corticosteroid effectiveness added to antihistamines and six studies compared the efficacy of H1 and/ or H2‐antihistamines. The addition of corticosteroid (prednisone) to an antihistamine (levo)cetirizine did not improve symptoms of AU compared to antihistamine alone in two out of three RCTs. The combination of diphenhydramine (50 mg, IV) and ranitidine (50 mg, IV) or cimetidine (300 mg, IV) was most efficient for relief of urticaria in two out of five studies. Most frequent adverse effects were sedation and drowsiness. Recent guidelines on urticaria treatment mainly focus on chronic urticaria rather than on AU. Moreover, only few, small RCTs provide evidence for the management of AU. Thus, the state‐of‐the‐art management of this frequent condition remains unclear. The addition of corticosteroids to an antihistamine as treatment for AU needs to be further investigated. Well‐designed, high‐quality interventional trials are needed to establish evidence‐based treatment guidelines for AU. [ABSTRACT FROM AUTHOR]

Published
2024
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7. White paper on peanut allergy – part 1: Epidemiology, burden of disease, health economic aspects

Author

Lange, Lars, Klimek, Ludger, Beyer, Kirsten, Blümchen, Katharina, Novak, Natalija, Hamelmann, Eckard, Bauer, Andrea, Merk, Hans, Rabe, Uta, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Jakob, Thilo, Ankermann, Tobias, Schmidt, Sebastian M., Gerstlauer, Michael, Zuberbier, Torsten, Spindler, Thomas, and Vogelberg, Christian

Published
2021
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8. Messages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis

Author

Ring, Johannes, Beyer, Kirsten, Biedermann, Tilo, Bircher, Andreas, Fischer, Matthias, Fuchs, Thomas, Heller, Axel, Hoffmann, Florian, Huttegger, Isidor, Jakob, Thilo, Klimek, Ludger, Kopp, Matthias V., Kugler, Claudia, Lange, Lars, Pfaar, Oliver, Rietschel, Ernst, Rueff, Franziska, Schnadt, Sabine, Seifert, Roland, Stöcker, Britta, Treudler, Regina, Vogelberg, Christian, Werfel, Thomas, Worm, Margitta, Sitter, Helmut, and Brockow, Knut

Published
2021
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10. Immunologically relevant aspects of the new COVID-19 vaccines—an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper

Author

Untersmayr, Eva, Förster-Waldl, Elisabeth, Bonelli, Michael, Boztug, Kaan, Brunner, Patrick M., Eiwegger, Thomas, Eller, Kathrin, Göschl, Lisa, Grabmeier-Pfistershammer, Katharina, Hötzenecker, Wolfram, Jordakieva, Galateja, Moschen, Alexander R., Pfaller, Birgit, Pickl, Winfried, Reinisch, Walter, Wiedermann, Ursula, Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Pfützner, Wolfgang, Novak, Natalija, Merk, Hans, Rabe, Uta, Schlenter, Wolfgang, Ring, Johannes, Wehrmann, Wolfgang, Mülleneisen, Norbert, Wrede, Holger, Fuchs, Thomas, and Jensen-Jarolim, Erika

Published
2021
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11. Practical handling of allergic reactions to COVID-19 vaccines: A position paper from German and Austrian Allergy Societies AeDA, DGAKI, GPA and ÖGAI

Author

Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Pfützner, Wolfgang, Zuberbier, Torsten, Hartmann, Karin, Jakob, Thilo, Novak, Natalija, Ring, Johannes, Merk, Hans, Hamelmann, Eckard, Ankermann, Tobias, Schmidt, Sebastian, Untersmayr, Eva, Hötzenecker, Wolfram, Jensen-Jarolim, Erika, Brockow, Knut, Mahler, Vera, and Worm, Margitta

Published
2021
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12. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA)

Author

Klimek, Ludger, Novak, Natalija, Hamelmann, Eckard, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Bauer, Andrea, Merk, Hans, Rabe, Uta, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Jakob, Thilo, Ankermann, Tobias, Schmidt, Sebastian M., Gerstlauer, Michael, Vogelberg, Christian, Zuberbier, Thomas, Hartmann, Karin, and Worm, Margitta

Published
2021
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13. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE)

Author

Ring, Johannes, Beyer, Kirsten, Biedermann, Tilo, Bircher, Andreas, Fischer, Matthias, Fuchs, Thomas, Heller, Axel, Hoffmann, Florian, Huttegger, Isidor, Jakob, Thilo, Klimek, Ludger, Kopp, Matthias V., Kugler, Claudia, Lange, Lars, Pfaar, Oliver, Rietschel, Ernst, Rueff, Franziska, Schnadt, Sabine, Seifert, Roland, Stöcker, Britta, Treudler, Regina, Vogelberg, Christian, Werfel, Thomas, Worm, Margitta, Sitter, Helmut, and Brockow, Knut

Published
2021
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14. Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients: A position paper of the Medical Association of German Allergists (AEDA) in cooperation with the ENT section of the European Academy of Allergy and Clinical Immunology (EAACI), the German ARIA (Allergic Rhinitis and its Impact on Asthma) Group and the Working Group Clinical Immunology, Allergology and Environmental Medicine of the German Society for Otorhinolaryngology, Head and Neck Surgery (DGHNO-KHC)

Author

Klimek, Ludger, Casper, Ingrid, Bergmann, Karl-Christian, Biedermann, Tilo, Bousquet, Jean, Hellings, Peter, Jung, Kirsten, Merk, Hans, Olze, Heidi, Mösges, Ralph, Schlenter, Wolfgang, Gröger, Moritz, Ring, Johannes, Chaker, Adam, Pfaar, Oliver, Wehrmann, Wolfgang, Zuberbier, Torsten, and Becker, Sven

Published
2020
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16. Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”

Author

Klimek, Ludger, Bachert, Claus, Pfaar, Oliver, Becker, Sven, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Casper, Ingrid, Chaker, Adam, Czech, Wolfgang, Fischer, Jörg, Fuchs, Thomas, Gerstlauer, Michael, Hörmann, Karl, Jakob, Thilo, Jung, Kirsten, Kopp, Matthias V., Mahler, Vera, Merk, Hans, Mülleneisen, Norbert, Nemat, Katja, Rabe, Uta, Ring, Johannes, Saloga, Joachim, Schlenter, Wolfgang, Schmidt-Weber, Carsten, Seyfarth, Holger, Sperl, Annette, Spindler, Thomas, Staubach, Petra, Strieth, Sebastian, Treudler, Regina, Vogelberg, Christian, Wallrafen, Andrea, Wehrmann, Wolfgang, Wrede, Holger, Zuberbier, Torsten, Bedbrook, Anna, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas B., Czarlewski, Wienczylawa, Fokkens, Wytske J., Hamelmann, Eckard, Hellings, Peter W., Jutel, Marek, Larenas-Linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikolaos G., Toppila-Salmi, Sanna, Werfel, Thomas, and Bousquet, Jean

Published
2020
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17. ARIA guideline 2019: treatment of allergic rhinitis in the German health system

Author

Klimek, Ludger, Bachert, Claus, Pfaar, Oliver, Becker, Sven, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Casper, Ingrid, Chaker, Adam, Czech, Wolfgang, Fischer, Jörg, Fuchs, Thomas, Gerstlauer, Michael, Hörmann, Karl, Jakob, Thilo, Jung, Kirsten, Kopp, Matthias V., Mahler, Vera, Merk, Hans, Mülleneisen, Norbert, Nemat, Katja, Rabe, Uta, Ring, Johannes, Saloga, Joachim, Schlenter, Wolfgang, Schmidt-Weber, Carsten, Seyfarth, Holger, Sperl, Annette, Spindler, Thomas, Staubach, Petra, Strieth, Sebastian, Treudler, Regina, Vogelberg, Christian, Wallrafen, Andrea, Wehrmann, Wolfgang, Wrede, Holger, Zuberbier, Torsten, Bedbrook, Anna, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas B., Czarlewski, Wienczylawa, Fokkens, Wytske J., Hamelmann, Eckard, Hellings, Peter W., Jutel, Marek, Larenas-Linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikolaos G., Toppila-Salmi, Sanna, Werfel, Thomas, and Bousquet, Jean

Published
2019
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22. Progress in Dermatology and Venereology in 2023 as reflected in the Journal of the European Academy of Dermatology and Venereology.

Author

Ring, Johannes

Subjects
*DERMATOLOGY, *ACQUISITION of manuscripts, *EDUCATIONAL objectives, *AUTOIMMUNE diseases, *CANCER prevention
Abstract

The article provides a summary of some notable articles published in the Journal of the European Academy of Dermatology & Venereology in 2023. The topics covered include advancements in oncology and cancer prevention, pigmentary disturbances, autoimmune diseases, allergy/eczema, acne/rosacea, psoriasis, hair disorders, venereology, and historical perspectives. The article also mentions the publication of European guidelines on various dermatological conditions. The journal received a significant number of manuscript submissions and maintained a stable impact factor. The summary encourages readers to explore the journal for educational purposes and to stay updated on developments in the field. [Extracted from the article]

Published
2024
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23. Pioneers in Dermatology and Venereology: An interview with Professor Johannes Ring.

Author

Ring, Johannes

Subjects
*FRAUD in science, *PREDATORY publishing, *DERMATOLOGY, *COLLEGE teachers
Abstract

This document is an interview with Professor Johannes Ring, a renowned figure in the field of dermatology and venereology. The interview provides insights into Professor Ring's background, career, and influential mentors, as well as his passion for writing and editing. Professor Ring shares his experiences as the Editor-in-Chief of the Journal of the European Academy of Dermatology & Venereology (JEADV), discussing the challenges faced in managing a high volume of manuscripts and improving the journal's impact factor. The interview also touches on issues of scientific misconduct and predatory journals. Overall, the interview offers valuable perspectives on the field of dermatology and the importance of creating a journal that is both informative and engaging. [Extracted from the article]

Published
2023
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24. 2013–2023: A decade of progress and challenges in dermatology as reflected in JEADV.

Author

Ring, Johannes

Subjects
*PREDATORY publishing, *DERMATOLOGY, *CLIMATE change
Abstract

The article reflects on the past 10 years of the Journal of the European Academy of Dermatology & Venereology (JEADV). The journal has undergone various changes, including restructuring the table of contents, introducing new sections, and revamping its cover design. It has also addressed issues such as predatory journals, transparency in the review process, and the impact of climate change on dermatology. The journal has seen an increase in article downloads and its impact factor, and it continues to attract good authors and maintain a fair and fast review process. The article concludes with expressions of gratitude to the authors, reviewers, editorial team, publisher, and support from the European Academy of Dermatology & Venereology. [Extracted from the article]

Published
2023
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25. Immunoglobulin E autoantibodies in atopic dermatitis associate with Type‐2 comorbidities and the atopic march.

Author

Kortekaas Krohn, Inge, Badloe, Fariza Mishaal Saiema, Herrmann, Nadine, Maintz, Laura, De Vriese, Shauni, Ring, Johannes, Schmid‐Grendelmeier, Peter, Traidl‐Hoffmann, Claudia, Akdis, Cezmi, Lauener, Roger, Brüggen, Marie‐Charlotte, Rhyner, Claudio, Bersuch, Eugen, Dreher, Anita, Hammel, Gertrud, Luschkova, Daria, Lang, Claudia, Reiger, Matthias, Bieber, Thomas, and Gutermuth, Jan

Subjects
IMMUNOGLOBULIN E, AUTOANTIBODIES, ATOPIC dermatitis, ALLERGIC rhinitis, FOOD allergy
Abstract

Background: Autoreactive immunoglobulin E (IgE) antibodies to self‐peptides within the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence, concomitant diseases, patient characteristics, and risk factors of IgE autoantibody development remain elusive. We aimed to determine IgE autoantibodies in serum samples (n = 672) from well‐characterized patients with AD and controls (1.2–88.9 years). Methods: Atopic dermatitis patients were sub‐grouped in AD with comorbid Type‐2 diseases ("AD + Type 2"; asthma, allergic rhinitis, food allergy, n = 431) or "solely AD" (n = 115). Also, subjects without AD but with Type‐2 diseases ("atopic controls," n = 52) and non‐atopic "healthy controls" (n = 74) were included. Total proteins from primary human keratinocytes were used for the immunoassay to detect IgE autoantibodies. Values were compared to already known positive and negative serum samples. Results: Immunoglobulin E autoantibodies were found in 15.0% (82/546) of all analyzed AD‐patients. "AD + Type 2" showed a higher prevalence (16.4%) than "solely AD" (9.6%). "Atopic controls" (9.6%) were comparable with "solely AD" patients, while 2.7% of healthy controls showed IgE autoantibodies. Of those with high levels of IgE autoantibodies, 15 out of 16 were patients with "AD + Type 2". AD patients with IgE autoantibodies were younger than those without. Patients with IgE autoreactivity also displayed higher total serum IgE levels. Factors that affected IgE autoantibody development were as follows: birth between January and June, cesarean‐section and diversity of domestic pets. Conclusions: Immunoglobulin E autoantibodies in AD seem to associate with the presence of atopic comorbidities and environmental factors. The potential value of IgE autoantibodies as a predictive biomarker for the course of AD, including the atopic march, needs further exploration. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice.

Author

Worm, Margitta, Fox, Adam T., Wickman, Magnus, Ring, Johannes, Ebisawa, Motohiro, Pouessel, Guillaume, and Smith, Pete

Subjects
ADRENALINE, EPINEPHRINE autoinjectors, PHARMACOKINETICS, INJECTORS, ALLERGIES, ANAPHYLAXIS
Abstract

Background: Anaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the first‐line treatment for anaphylaxis outside a perioperative reaction. Adrenaline autoinjectors (AAIs) are widely used self‐administrable devices, especially in community settings. Different commercial AAIs have been authorized to be marketed in Europe. For an AAI to be efficacious, a rapid adrenaline delivery in patients, including those who are overweight or obese, resulting in an optimal cardiovascular (CV) response, is a key feature. AAIs are designed to achieve this requirement, which is reflected in their differing functional properties such as primary container selection, drug delivery mechanism (cartridge‐or syringe‐based), needle length, needle gauge, and adrenaline dose (150 μg, 300 μg, or 500 μg). However, the differences in functional properties across these devices may play a critical role in achieving these requirements as well as the differences in ergonomics in the handling of these devices. The purpose of this review: Considering the dynamic pharmacokinetic/pharmacodynamic (PK/PD) profiles of different AAIs marketed in Europe and their effect on adrenaline delivery, the expert panel, also serving as author for this paper have carried out a detailed analysis of the PK/PD profiles of four AAIs, namely, Anapen, Emerade, EpiPen, and Jext, to delineate the adrenaline delivery and their subsequent physiological effects on the backdrop of device characteristics, dose strength, and the skin‐to‐muscle distances of the participants. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Atopic Dermatitis in Children and Adults: Diagnosis and Treatment

Author

Wollenberg, Andreas, Werfel, Thomas, Ring, Johannes, Ott, Hagen, Gieler, Uwe, and Weidinger, Stephan

Subjects
Continuing Medical Education
Abstract

BACKGROUND: Atopic dermatitis is a common, chronically recurring inflammatory skin disease. It gives rise to a high disease burden and is of major importance in social medicine. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed, including the current German and European guidelines. RESULTS: Basic therapy with drug-free topical agents markedly improves the barrier function of the skin. Adults should apply at least 250 g per week. Patient-specific trigger factors such as allergens, stress, microbial pathogens, or skin irritants should be eliminated or avoided. In mild and moderately severe forms, external treatment with topical glucocorticosteroids and topical calcineurin inhibitors usually suffices; proactive therapy is given to patients with frequent recurrences or a long course of disease. Systemic anti-inflammatory treatment with biological agents such as dupilumab and tralokinumab, Janus kinase inhibitors such as baricitinib, upadacitinib, and abrocitinib, or conventional immunosuppressant drugs is indicated particularly in severe cases. The patient should be actively involved in the choice and planning of treatment; the patient’s age and the cutaneous findings should be taken into account. Interdisciplinary patient education yields a sustained benefit. CONCLUSION: A combination of baseline therapy, reactive and proactive anti-inflammatory therapy, and systemic therapy as needed is the foundation of successful interdisciplinary treatment for atopic dermatitis.

Published
2023

32. Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Author

Bousquet, Jean, Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula, and uBibliorum

Subjects
IL-33, Multimorbidity, Asthma, Toll-like receptors, Rhinitis
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

Published
2023

34. Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: Position Paper of the German Society of Allergology (AeDA) and the German Society of Allergy and Clinical Immunology (DGAKI), ENT Section, in collaboration with the working group on Clinical Immunology, Allergology and Environmental Medicine of the German Society of Otorhinolaryngology, Head and Neck Surgery (DGHNOKHC)

Author

Klimek, Ludger, Bergmann, Karl-Christian, Biedermann, Tilo, Bousquet, Jean, Hellings, Peter, Jung, Kirsten, Merk, Hans, Olze, Heidi, Schlenter, Wolfgang, Stock, Philippe, Ring, Johannes, Wagenmann, Martin, Wehrmann, Wolfgang, Mösges, Ralph, and Pfaar, Oliver

Published
2017
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35. Correction to: Guideline for the diagnosis of drug hypersensitivity reactions

Author

Brockow, Knut, Przybilla, Bernhard, Aberer, Werner, Bircher, Andreas J., Brehler, Randolf, Dickel, Heinrich, Fuchs, Thomas, Jakob, Thilo, Lange, Lars, Pfützner, Wolfgang, Mockenhaupt, Maja, Ott, Hagen, Pfaar, Oliver, Ring, Johannes, Sachs, Bernhardt, Sitter, Helmut, Trautmann, Axel, Treudler, Regina, Wedi, Bettina, Worm, Margitta, Wurpts, Gerda, Zuberbier, Torsten, and Merk, Hans F.

Published
2017
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37. Immunologisch relevante Aspekte der neuen COVID-19-Impfstoffe

Author

Untersmayr, Eva, Förster-Waldl, Elisabeth, Bonelli, Michael, Boztug, Kaan, Brunner, Patrick M., Eiwegger, Thomas, Eller, Kathrin, Göschl, Lisa, Grabmeier-Pfistershammer, Katharina, Hötzenecker, Wolfram, Jordakieva, Galateja, Moschen, Alexander R., Pfaller, Birgit, Pickl, Winfried, Reinisch, Walter, Wiedermann, Ursula, Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Novak, Natalija, Merk, Hans F., Rabe, Uta, Schlenter, Wolfgang W., Ring, Johannes, Wehrmann, Wolfgang, Mülleneisen, Norbert K., Wrede, Holger, Fuchs, Thomas, and Jensen-Jarolim, Erika

Subjects
Immunsuppression, Impfwirkung, COVID-19, Immunantwort, COVID-19-Impfung, Immunmodulation, Leitlinie
Published
2021

39. Supportive care of patients with anaphylaxis — options and shortcomings: an assessment on behalf of the working group on anaphylaxis training and education (AGATE), Germany

Author

Brockow, Knut, Beyer, Kirsten, Biedermann, Tilo, Fischer, Jörg, Gieler, Uwe, Giessler-Fichtner, Oliver, Gebert, Norbert, Jakob, Thilo, Klimek, Ludger, Kugler, Claudia, Reese, Imke, Rietschel, Ernst, Ruëff, Franziska, Schnadt, Sabine, Siemens, Cäcilia, Szczepanski, Rüdiger, Worm, Margitta, Ring, Johannes, Lange, Lars, and the working group on anaphylaxis training and education (AGATE), Germany

Published
2016
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40. Praktischer Umgang mit allergischen Reaktionen auf COVID-19-Impfstoffe

Author

Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Pfützner, Wolfgang, Worm, Margitta, Hartmann, Karin, Jakob, Thilo, Novak, Natalija, Ring, Johannes, Hamelmann, Eckard, Ankermann, Tobias, Schmidt, Sebastian M., Untersmayr, Eva, Hötzenecker, Wolfram, Jensen-Jarolim, Erika, and Zuberbier, Torsten

Subjects
mRNA-1273, mRNA-Impfstoff, Anaphylaxie, SARS-CoV-2, allergische Reaktion, COVID-19, BNT162b2, Leitlinie
Abstract

Hintergrund: Zur vorbeugenden Behandlung von COVID-19 (Coronaviruserkrankung 2019) wurden in einer beispiellosen weltweiten Forschungsanstrengung Sicherheit und Wirksamkeit neuer Impfstoffplattformen studiert, die noch nie zuvor am Menschen eingesetzt wurden. Weniger als ein Jahr nach der Entdeckung der SARS-CoV-2-Virussequenz (SARS-CoV-2, "severe acute respiratory syndrome coronavirus type 2") wurden diese in zahlreichen Ländern für den Einsatz zugelassen und es wurde mit Massenimpfungen begonnen. Die bislang in der Europäischen Union (EU) zugelassenen mRNA-Impfstoffe (mRNA, "messenger"-RNA) gegen SARS-CoV-2 BNT162b2 und mRNA-1273 basieren auf einer ähnlichen lipidbasierten Nanopartikelträgertechnologie; die Lipidkomponenten unterscheiden sich jedoch. Schwere allergische Reaktionen und Anaphylaxien nach COVID-19-Impfungen sind sehr seltene unerwünschte Nebenwirkungen, die aber aufgrund potenziell letaler Ausgänge viel Aufmerksamkeit erhalten und ein hohes Maß an Verunsicherung ausgelöst haben. Methoden: Das aktuelle Wissen zu anaphylaktischen Reaktionen auf Impfstoffe und speziell zu den derzeit neuen mRNA-COVID-19-Impfstoffen wurde zusammengestellt mittels einer Literaturanalyse durch Recherchen in Medline, Pubmed sowie den nationalen und internationalen Studien- und Leitlinienregistern, der Cochrane Library und dem Internet unter besonderer Berücksichtigung offizieller Webseiten der World Health Oranization (WHO), der Centers for Disease Control and Prevention (CDC), der European Medicines Agency (EMA), des Robert-Koch-Instituts (RKI) und des Paul-Ehrlich-Instituts (PEI). Ergebnisse: Basierend auf der internationalen Literatur und bisheriger Erfahrungen zu schweren allergischen Reaktionen im Kontext der COVID-19-Impfungen werden von einem Expertengremium Empfehlungen für Prophylaxe, Diagnostik und Therapie dieser allergischen Reaktionen gegeben. Schlussfolgerung: Vor einer COVID-19-Impfung mit den derzeit zugelassenen Impfstoffen sind Allergietests für die allermeisten Allergiker nicht notwendig. Bei allergischer/anaphylaktischer Reaktion auf den verabreichten COVID-19-Impfstoff wird eine allergologische Abklärung empfohlen, wie auch für eine kleine potenzielle Risikopopulation vor der ersten Impfung. Die Evaluierung und Zulassung von Testverfahren sollten hierfür erfolgen. Zitierweise: Klimek L, Bergmann K-C, Brehler R, Pfützner W, Zuberbier T, Hartmann K, Jakob T, Novak N, Ring J, Merk H; Hamelmann E, Ankermann T, Schmidt S, Untersmayr E, Hötzenecker W, Jensen-Jarolim E, Brockow K, Mahler V, Worm M. Practical Handling of Allergic Reactions to COVID-19 vaccines. A Position Paper from German and Austrian Allergy Societies AeDA, DGAKI, GPA and ÖGAI. Allergo J Int 2021;30:79-95 https: //doi.org/10.1007/s40629-021-00165-7

Published
2021

41. Schwere allergische Reaktionen nach COVID-19-Impfung mit dem Impfstoff von Pfizer/BioNTech in Großbritannien und USA

Author

Klimek, Ludger, Novak, Natalija, Hamelmann, Eckard, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Bauer, Andrea, Merk, Hans F., Rabe, Uta, Jung, Kirsten, Schlenter, Wolfgang W., Ring, Johannes, Chaker, Adam M., Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert K., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Jakob, Thilo, Ankermann, Tobias, Schmidt, Sebastian M., Gerstlauer, Michael, Vogelberg, Christian, Zuberbier, Torsten, Hartmann, Karin, and Worm, Margitta

Subjects
Anaphylaxie, mRNA, Umschlag, BNT162b2, schwere allergische Reaktion, Impfstoffe
Abstract

Zwei Mitarbeiter des National Health Service (NHS) in England entwickelten nach der Verabreichung des BNT162b2-Impfstoffs von BionNTech gegen COVID-19 schwere allergische Reaktionen. Die britische Fachinformation für den BNT162b2-Impfstoff enthält bereits Hinweise auf eine Kontraindikation zur Anwendung bei Personen, die allergisch auf den Impfstoff oder einen seiner Bestandteile reagiert haben. Als Vorsichtsmaßnahme hat die englische Regulationsbehörde für Arzneimittel und Gesundheitsprodukte (MHRA) eine vorläufige Anleitung herausgegeben, "Patienten mit schweren Allergien" grundsätzlich nicht zu impfen. Allergische Reaktionen auf Impfstoffe sind sehr selten, aber Impfstoffkomponenten verursachen bekanntermaßen allergische Reaktionen. BNT162b2 ist ein Impfstoff, der auf einer in Lipidnanopartikel eingebetteten mRNA basiert und mit weiteren Substanzen angereichert wird, um den Transport in die Zellen zu ermöglichen. In der zentralen klinischen Phase-III-Studie wurde der BNT162b2-Impfstoff im Allgemeinen gut vertragen. Impfstoffe gelten als eine der wirksamsten Maßnahmen im Bereich der öffentlichen Gesundheit. Schwere allergische Reaktionen auf Impfstoffe sind selten, können jedoch lebensbedrohlich sein. Es ist ratsam, die Impfteams auf diese Gefahr aufmerksam zu machen und angemessene Vorsichtsmaßnahmen zu treffen, während mehr Erfahrungen mit dem neuen Impfstoff gesammelt werden.

Published
2021

42. Difficult to control atopic dermatitis

Author

Darsow, Ulf, Wollenberg, Andreas, Simon, Dagmar, Taïeb, Alain, Werfel, Thomas, Oranje, Arnold, Gelmetti, Carlo, Svensson, Ake, Deleuran, Mette, Calza, Anne-Marie, Giusti, Francesca, Lübbe, Jann, Seidenari, Stefania, and Ring, Johannes

Published
2013
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46. Guideline for the diagnosis of drug hypersensitivity reactions: S2K-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Dermatological Society (DDG) in collaboration with the Association of German Allergologists (AeDA), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Swiss Society for Allergy and Immunology (SGAI), the Austrian Society for Allergology and Immunology (ÖGAI), the German Academy of Allergology and Environmental Medicine (DAAU), the German Center for Documentation of Severe Skin Reactions and the German Federal Institute for Drugs and Medical Products (BfArM)

Author

Brockow, Knut, Przybilla, Bernhard, Aberer, Werner, Bircher, Andreas J., Brehler, Randolf, Dickel, Heinrich, Fuchs, Thomas, Jakob, Thilo, Lange, Lars, Pfützner, Wolfgang, Mockenhaupt, Maja, Ott, Hagen, Pfaar, Oliver, Ring, Johannes, Sachs, Bernhardt, Sitter, Helmut, Trautmann, Axel, Treudler, Regina, Wedi, Bettina, Worm, Margitta, Wurpts, Gerda, Zuberbier, Torsten, and Merk, Hans F.

Published
2015
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49. Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemiea, b, c

Author

Klimek, Ludger, Pfaar, Oliver, Worm, Margitta, Eiwegger, Thomas, Hagemann, Jan, Ollert, Markus, Untersmayr, Eva, Hoffmann-Sommergruber, Karin, Vultaggio, Alessandra, Agache, Ioana, Bavbek, Sevim, Bossios, Apostolos, Casper, Ingrid, Chan, Susan, Chatzipetrou, Alexia, Vogelberg, Christian, Firinu, Davide, Kauppi, Paula, Kolios, Antonios, Kothari, Akash, Matucci, Andrea, Palomares, Oscar, Szépfalusi, Zsolt, Pohl, Wolfgang, Hötzenecker, Wolfram, Rosenkranz, Alexander, Bergmann, Karl-Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen, Darsow, Ulf, Keil, Thomas, Kleine-Tebbe, Jörg, Lau, Susanne, Maurer, Marcus, Merk, Hans, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Jappe, Uta, Rabe, Claus, Rabe, Uta, Vogelmeier, Claus, Biedermann, Tilo, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Freudelsperger, Laura, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Tomazic, Peter-Valentin, Aberer, Werner, Fink Wagner, Antje, Horak, Fritz, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Roller-Wirnsberger, Regina, Spranger, Otto, Valenta, Rudolf, Akdis, Mübecell, Matricardi, Paolo M., Spertini, François, Khaltaev, Nikolai, Michel, Jean-Pierre, Nicod, Larent, Schmid-Grendelmeier, Peter, Idzko, Marco, Hamelmann, Eckard, Jakob, Thilo, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Jensen-Jarolim, Erika, Korn, Stephanie, Hentges, Francois, Schwarze, Jürgen, O´Mahony, Liam, Knol, Edward, del Giacco, Stefano, Chivato, Tomás, Bousquet, Jean, Zuberbier, Torsten, Akdis, Cezmi, and Jutel, Marek

Subjects
Titel, SARS-CoV-2, Medizin, Immunology and Allergy, Omalizumab, Benralizumab, Dupilumab, Reslizumab, Covid-19, Telemedizin, Mepolizumab
Published
2020

50. Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration

Author

Nebelung, Sven, D��tsch, Lisa, Shah, Dhaval, Abrar, Daniel Benjamin, Linka, Kevin, Knobe, Matthias, Sewerin, Philipp, Th��ring, Johannes, Kuhl, Christiane, and Truhn, Daniel

Subjects
Adult, Aged, 80 and over, Male, Compressive Strength, 600: Technik, lcsh:R, lcsh:Medicine, Diagnostic markers, Translational research, Middle Aged, musculoskeletal system, Magnetic Resonance Imaging, Article, Cartilage, Osteoarthritis, Humans, Female, Meniscus, lcsh:Q, Arthroplasty, Replacement, Knee, lcsh:Science, ddc:600, Technik [600], Biomedical engineering, Aged
Abstract

Scientific reports 10, 2499 (2020). doi:10.1038/s41598-020-59573-4, Published by Macmillan Publishers Limited, part of Springer Nature, [London]

Published
2020

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