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3 results on '"Robert Pelletier"'

1. Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity

Author

Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, and Kristian K. Jensen

Subjects
Biochemistry, Cell biology, Cancer, Science
Abstract

Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describe the discovery of potent and specific USP7 inhibitors exemplified by FX1-5303. FX1-5303 was used as a chemical probe to study the USP7-mediated regulation of p53 signaling in cells. It demonstrates mechanistic differences compared to MDM2 antagonists, a related class of anti-tumor agents that act along the same pathway. FX1-5303 synergizes with the clinically approved BCL2 inhibitor venetoclax in acute myeloid leukemia (AML) cell lines and ex vivo patient samples and leads to strong tumor growth inhibition in in vivo mouse xenograft models of multiple myeloma and AML. This work introduces new USP7 inhibitors, differentiates their mechanism of action from MDM2 inhibition, and identifies specific opportunities for their use in the treatment of AML.

Published
2024
Full Text
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2. SNAPSHOT USA 2019: a coordinated national camera trap survey of the United States

Author

Jerrold L. Belant, Seth C. Crockett, William J. McShea, Adam Zorn, Robert A. Long, Çağan H. Şekercioğlu, Kelly Anne MacCombie, Helen I. Rowe, Jaquelyn Tleimat, Adrienne Dykstra, Kelsey A. Barnick, Tiffany A. Sprague, Connor Cincotta, Andrew J. Edelman, Marcus A. Lashley, Anthony P. Crupi, Steven Hammerich, Jennifer Sevin, Carolina Baruzzi, Jesse M. Alston, Elizabeth A. Flaherty, Christopher P. Hansen, Damon B. Lesmeister, Sean T. Giery, Caroline N. Ellison, Andrea K. Darracq, George R. Hess, Brian J. O'Neill, Matthew E. Gompper, Christopher M. Schalk, Amelia M. Bergquist, Ronald S. Revord, Brian D. Gerber, Arielle W. Parsons, Chelsey Tellez, Travis W. Knowles, Daniel G. Scognamillo, Christopher Nagy, Jan Schipper, Morgan Gray, Maximilian L. Allen, Gary W. Roemer, Tavis Forrester, Aaron N. Facka, Miranda L. Davis, Alexej P. K. Sirén, Brett A. DeGregorio, Colin E. Studds, Monica Lasky, Melissa T. R. Hawkins, La Roy S.E. Brandt, Thomas E. Lee, Sean M. King, Mark A. Linnell, Jinelle H. Sperry, John F. Benson, Katherine C. B. Weiss, Joshua J. Millspaugh, Fabiola Iannarilli, Bryn Evans, Christopher A. Lepczyk, David Mason, Mark J. Jordan, Jarred M. Brooke, Cara L. Appel, Katherine E. Andy, Jennifer L. Stenglein, Dean E. Beyer, Tru Hubbard, Marketa Zimova, Alexandra J. Bebko, Daniel J. Herrera, Cristian J. Hernandez, Petros Chrysafis, Summer D. Higdon, Caleb Durbin, Sophie L. Nasrallah, Roland Kays, Scott D. LaPoint, Kathryn R. Remine, Brandon T. Barton, Chip Ruthven, Robert C. Lonsinger, Noel Schmitz, Jorie Favreau, Stephen L. Webb, Edward Trout, Mary E. Pendergast, Brenna Wells, Christine Anhalt-Depies, Robert Horan, Christopher A. Whittier, Todd K. Fuller, M. Teague O'Mara, Hila Shamon, Jean E. Fantle-Lepczyk, Rachel M. Cliché, Sean P. Maher, Stephanie S. Coster, Joshua Sands, Kellie M. Kuhn, Helen Bontrager, Christopher T. Rota, Jaylin N. Solberg, Sarah R. Fritts, John P. Vanek, Laura S. Whipple, Erika L. Barthelmess, Alessio Mortelliti, Kodi Jo Jaspers, Daniel Davis, Renee Klann, Erin K. Kuprewicz, Melinda Fowler, Christine C. Rega-Brodsky, Haydée Hernández-Yáñez, Robert Pelletier, Daniel A. Bogan, M. Caitlin Fisher-Reid, Weston C. Thompson, Chris Sutherland, Claire Bresnan, Todd M. Kautz, Nathaniel H. Wehr, Neil H. Carter, Sharyn B. Marks, Carrie Nelson, Jessica C. Burr, Richard G. Lathrop, Austin M. Green, Robert H. Hagen, Andrea Romero, Michael S. Rentz, Matthew S. Leslie, Katarina Russell, Michael V. Cove, David S. Jachowski, Paige S. Warren, Sean A. Neiswenter, Nyeema C. Harris, Jillian R. Kilborn, Taylor Frerichs, Marius van der Merwe, Jennifer Y. Zhao, Darren A. Clark, Derek R. Risch, Jacque Williamson, Diana J. R. Lafferty, Michelle Halbur, Joanne R. Wasdin, Melissa R. Price, Justin A. Compton, Alex J. Jensen, University of St Andrews. Statistics, Cove, M. V., Kays, R., Bontrager, H., Bresnan, C., Lasky, M., Frerichs, T., Klann, R., Lee, T. E., Crockett, S. C., Crupi, A. P., Weiss, K. C. B., Rowe, H., Sprague, T., Schipper, J., Tellez, C., Lepczyk, C. A., Fantle-Lepczyk, J. E., Lapoint, S., Williamson, J., Fisher-Reid, M. C., King, S. M., Bebko, A. J., Chrysafis, P., Jensen, A. J., Jachowski, D. S., Sands, J., Maccombie, K. A., Herrera, D. J., van der Merwe, M., Knowles, T. W., Horan, R. V., Rentz, M. S., Brandt, L. S. E., Nagy, C., Barton, B. T., Thompson, W. C., Maher, S. P., Darracq, A. K., Hess, G., Parsons, A. W., Wells, B., Roemer, G. W., Hernandez, C. J., Gompper, M. E., Webb, S. L., Vanek, J. P., Lafferty, D. J. R., Bergquist, A. M., Hubbard, T., Forrester, T., Clark, D., Cincotta, C., Favreau, J., Facka, A. N., Halbur, M., Hammerich, S., Gray, M., Rega-Brodsky, C. C., Durbin, C., Flaherty, E. A., Brooke, J. M., Coster, S. S., Lathrop, R. G., Russell, K., Bogan, D. A., Cliche, R., Shamon, H., Hawkins, M. T. R., Marks, S. B., Lonsinger, R. C., O'Mara, M. T., Compton, J. A., Fowler, M., Barthelmess, E. L., Andy, K. E., Belant, J. L., Beyer, D. E., Kautz, T. M., Scognamillo, D. G., Schalk, C. M., Leslie, M. S., Nasrallah, S. L., Ellison, C. N., Ruthven, C., Fritts, S., Tleimat, J., Gay, M., Whittier, C. A., Neiswenter, S. A., Pelletier, R., Degregorio, B. A., Kuprewicz, E. K., Davis, M. L., Dykstra, A., Mason, D. S., Baruzzi, C., Lashley, M. A., Risch, D. R., Price, M. R., Allen, M. L., Whipple, L. S., Sperry, J. H., Hagen, R. H., Mortelliti, A., Evans, B. E., Studds, C. E., Siren, A. P. K., Kilborn, J., Sutherland, C., Warren, P., Fuller, T., Harris, N. C., Carter, N. H., Trout, E., Zimova, M., Giery, S. T., Iannarilli, F., Higdon, S. D., Revord, R. S., Hansen, C. P., Millspaugh, J. J., Zorn, A., Benson, J. F., Wehr, N. H., Solberg, J. N., Gerber, B. D., Burr, J. C., Sevin, J., Green, A. M., Sekercioglu, C. H., Pendergast, M., Barnick, K. A., Edelman, A. J., Wasdin, J. R., Romero, A., O'Neill, B. J., Schmitz, N., Alston, J. M., Kuhn, K. M., Lesmeister, D. B., Linnell, M. A., Appel, C. L., Rota, C., Stenglein, J. L., Anhalt-Depies, C., Nelson, C., Long, R. A., Jo Jaspers, K., Remine, K. R., Jordan, M. J., Davis, D., Hernandez-Yanez, H., Zhao, J. Y., and Mcshea, W. J.

Subjects
0106 biological sciences, Cingulata, QH301 Biology, Carnivora, Population Dynamics, Biodiversity, mammal, Information repository, 01 natural sciences, QA, biodiversity, Mammals, education.field_of_study, camera trap, Ecology, Camera traps, Environmental resource management, Species distribution modeling, Geography, Biogeography, carnivora, Extinction debt, United State, Cetartiodactyla, Didelphimorphia, Lagomorpha, Rodentia, biogeography, camera traps, mammals, occupancy modeling, species distribution modeling, Animals, Birds, United States, Animals, Wild, Occupancy modeling, Population, Wildlife, Wild, 010603 evolutionary biology, Snapshot (photography), QH301, Bird, QA Mathematics, education, Ecology, Evolution, Behavior and Systematics, Population Dynamic, Animal, business.industry, 010604 marine biology & hydrobiology, DAS, Camera trap, Survey data collection, business
Abstract

This article is protected by copyright. All rights reserved. With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August - 24 November of 2019). We sampled wildlife at 1509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the USA. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as well as future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication. Publisher PDF

Published
2021

3. IBM DB2 9.7 Advanced Administration Cookbook : Over 100 Recipes Focused on Advanced Administration Tasks to Build and Configure Powerful Databases with IBM DB2 Book and Ebook

Author

Adrian Neagu, Robert Pelletier, Adrian Neagu, and Robert Pelletier

Subjects
Relational databases, Database management
Abstract

Over 120 recipes focusing on advanced administration tasks to build and configure powerful databases.Key FeaturesMaster all the important aspects of administration from instances to IBM's newest High Availability technology pureScale with this book and e-book.Learn to implement key security features to harden your database's security against hackers and intruders.Empower your databases by building efficient data configuration using MDC and clustered tables.Book DescriptionIBM DB2 LUW is a leading relational database system developed by IBM. DB2 LUW database software offers industry leading performance, scale, and reliability on your choice of platform on various Linux distributions, leading Unix Systems like AIX, HP-UX and Solaris and MS Windows platforms. With lots of new features, DB2 9.7 delivers one the best relational database systems in the market. IBM DB2 9.7 Advanced Administration Cookbook covers all the latest features with instance creation, setup, and administration of multi-partitioned database. This practical cookbook provides step-by-step instructions to build and configure powerful databases, with scalability, safety and reliability features, using industry standard best practices. This book will walk you through all the important aspects of administration. You will learn to set up production capable environments with multi-partitioned databases and make the best use of hardware resources for maximum performance. With this guide you can master the different ways to implement strong databases with a High Availability architecture.What you will learnLearn to make best use of scalability with multi-partitioned databasesGet to grips with advanced technological breakthroughs with RBAC, and pureScale technologySharpen your troubleshooting skillsDesign and implement the best backup strategyMaster the new exciting features added to the DB2 9.7 versionGet step-by-step instructions to tune and optimize DB2 to achieve best performanceUnderstand the database objects and their integrationWho this book is forIf you are a DB2 Database Administrator who wants to understand and get hands on with the underlying aspects of database administration, then this book is for you. This book assumes that you have a basic understanding of DB2 database concepts.

Published
2012

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