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2. Assessing the Effects of Metabolic Disruption, Body Mass Index and Inflammation on Depressive Symptoms in Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine

Author

Kwan, Angela T. H., Guo, Ziji, Ceban, Felicia, Le, Gia Han, Wong, Sabrina, Teopiz, Kayla M., Rhee, Taeho Greg, Ho, Roger, Di Vincenzo, Joshua D., Badulescu, Sebastian, Meshkat, Shakila, Cao, Bing, Rosenblat, Joshua D., d’Andrea, Giacomo, Dev, Donovan A., Phan, Lee, Subramaniapillai, Mehala, and McIntyre, Roger S.

Published
2024
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4. Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression

Author

Poulin, Joshua M., Bigford, Gregory E., Lanctôt, Krista L., Giacobbe, Peter, Schaffer, Ayal, Sinyor, Mark, Rabin, Jennifer S., Masellis, Mario, Singnurkar, Amit, Pople, Christopher B., Lipsman, Nir, Husain, Muhammad I., Rosenblat, Joshua D., Cao, Xingshan, MacIntosh, Bradley J., and Nestor, Sean M.

Published
2024
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14. Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis

Author

Le, Gia Han, Wong, Sabrina, Haikazian, Sipan, Johnson, Danica E., Badulescu, Sebastian, Kwan, Angela T.H., Gill, Hartej, Di Vincenzo, Joshua D., Rosenblat, Joshua D., Mansur, Rodrigo, Teopiz, Kayla M., Rhee, Taeho Greg, Ho, Roger, Liao, Sonya, Cao, Bing, Schweinfurth-Keck, Nina, Vinberg, Maj, Grande, Iria, Phan, Lee, d'Andrea, Giacomo, and McIntyre, Roger S.

Published
2024
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17. Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment-resistant depression: A systematic review

Author

Le, Gia Han, Wong, Sabrina, Badulescu, Sebastian, Au, Hezekiah, Di Vincenzo, Joshua D., Gill, Hartej, Phan, Lee, Rhee, Taeho Greg, Ho, Roger, Teopiz, Kayla M., Kwan, Angela T.H., Rosenblat, Joshua D., Mansur, Rodrigo B., and McIntyre, Roger S.

Published
2024
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20. Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin

Author

Rosenblat, Joshua D., Meshkat, Shakila, Doyle, Zoe, Kaczmarek, Erica, Brudner, Ryan M., Kratiuk, Kevin, Mansur, Rodrigo B., Schulz-Quach, Christian, Sethi, Rickinder, Abate, Amanda, Ali, Shaun, Bawks, Jordan, Blainey, Marc G., Brietzke, Elisa, Cronin, Victoria, Danilewitz, Jessica, Dhawan, Shalini, Di Fonzo, Anthony, Di Fonzo, Melissa, Drzadzewski, Pawel, Dunlop, William, Fiszter, Hajnalka, Gomes, Fabiano A., Grewal, Smrita, Leon-Carlyle, Marisa, McCallum, Marilyn, Mofidi, Niki, Offman, Hilary, Riva-Cambrin, Jeremy, Schmidt, Joel, Smolkin, Mark, Quinn, Joan M., Zumrova, Andrea, Marlborough, Michelle, and McIntyre, Roger S.

Published
2024
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21. The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

Author

d'Andrea, Giacomo, Pettorruso, Mauro, Di Lorenzo, Giorgio, Rhee, Taeho Greg, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Clerici, Massimo, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Mansur, Rodrigo B., Rosenblat, Joshua D., Martinotti, Giovanni, and McIntyre, Roger S.

Published
2024
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22. Association of SARS-CoV-2 infection with neurological impairments in pediatric population: A systematic review

Author

Kwan, Angela T.H., Portnoff, Jacob S., Al-Kassimi, Khaled, Singh, Gurkaran, Hanafimosalman, Mehrshad, Tesla, Marija, Gharibi, Nima, Ni, Tiffany, Guo, Ziji, Sonfack, Davaine J.N., Martyniuk, Julia, Arfaie, Saman, Mashayekhi, Mohammad Sadegh, Mofatteh, Mohammad, Jeremian, Richie, Ho, Kevin, Moscote-Salazar, Luis Rafael, Lee, Ángel, Jawad, Muhammad Youshay, Ceban, Felicia, Teopiz, Kayla M., Mansur, Rodrigo B., Ho, Roger, Rosenblat, Joshua D., Cao, Bing, Rhee, Taeho Greg, and McIntyre, Roger S.

Published
2024
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25. Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)

Author

Pettorruso, Mauro, Guidotti, Roberto, d'Andrea, Giacomo, De Risio, Luisa, D'Andrea, Antea, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, De Filippis, Sergio, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Nicolò, Giuseppe, Martiadis, Vassilis, Bassetti, Roberta, Nucifora, Domenica, De Fazio, Pasquale, Rosenblat, Joshua D., Clerici, Massimo, Maria Dell'Osso, Bernardo, Vita, Antonio, Marzetti, Laura, Sensi, Stefano L., Di Lorenzo, Giorgio, McIntyre, Roger S., and Martinotti, Giovanni

Published
2023
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45. Prescribed psychostimulants and other pro‐cognitive medications in bipolar disorder: A systematic review and meta‐analysis of recurrence of manic symptoms.

Author

Chiorean, Andreea, Jones, Brett D. M., Murong, Mijia, Gonzalez‐Torres, Christina, Kloiber, Stefan, Ortiz, Abigail, Rosenblat, Joshua D., Mulsant, Benoit H., and Husain, M. Ishrat

Abstract

Objectives: Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder (BD) due to concerns of inducing (hypo)mania, despite limited published evidence on associations between prescribed psychostimulant use and recurrence of mood episodes in BD. The current systematic review and meta‐analysis evaluated the emergence of (hypo)manic symptoms in patients with BD receiving prescribed psychostimulants or other pro‐cognitive medications in euthymic or depressive states. Methods: A systematic search was performed of MEDLINE, Embase, and PsychINFO from inception to April 5, 2023 and search of Clinicaltrials.gov and Clinicaltrialsregister.eu for unpublished data. References of included studies were hand‐searched. Randomized trials and prospective longitudinal studies that evaluated psychostimulants and non‐stimulant medications recommended for the treatment of ADHD by the Canadian ADHD practice guidelines were included. The review was reported in line with PRISMA guidelines and was preregistered on PROSPERO (CRD42022358588). Results: After screening 414 unique records, we included 27 studies, of which five reported data that was quantitatively synthesized (n = 1653). The use of psychostimulants in BD was not associated with increased scores on the Young Mania Rating Scale in patients who were in a euthymic or depressed state (SMD IV −0.17; 95% CI, −0.40 to 0.06) compared to placebo. There was a high degree of study‐level heterogeneity (I2 = 80%). A qualitative synthesis of studies revealed a limited risk of medication‐induced manic symptoms. Conclusions: Our review provides preliminary evidence to suggest psychostimulants and non‐stimulant ADHD medications have a limited risk of precipitating (hypo)mania symptoms. More extensive studies evaluating the safety and efficacy of these medications are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Association between fatigue and depressive symptoms in persons with post-COVID-19 condition: a post hoc analysis.

Author

Teopiz, Kayla M., Kwan, Angela T. H., Le, Gia Han, Guo, Ziji, Badulescu, Sebastian, Ceban, Felicia, Meshkat, Shakila, Di Vincenzo, Joshua D., d'Andrea, Giacomo, Cao, Bing, Ho, Roger, Rhee, Taeho Greg, Dev, Donovan A., Phan, Lee, Subramaniapillai, Mehala, Mansur, Rodrigo B., Rosenblat, Joshua D., and McIntyre, Roger S.

Subjects
FATIGUE (Physiology), MENTAL depression, CANCER fatigue, POST-acute COVID-19 syndrome, COVID-19 pandemic, SLEEP interruptions
Abstract

Post-COVID-19 Condition (PCC) is a prevalent, persistent and debilitating phenomenon occurring three or more months after resolution of acute COVID-19 infection. Fatigue and depressive symptoms are commonly reported in PCC. We aimed to further characterize PCC by assessing the relationship between fatigue and depressive symptom severity in adults with PCC. A post hoc analysis was conducted on data retrieved from a randomized, double-blinded, placebo-controlled study evaluating vortioxetine for cognitive deficits in persons with PCC. We sought to determine the relationship between baseline fatigue [i.e. Fatigue Severity Scale (FSS) total score] and baseline depressive symptom severity [i.e. 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR-16) total score] in adults with PCC. The statistical analysis included baseline data from 142 participants. After adjusting for age, sex, education, employment status, history of major depressive disorder (MDD) diagnosis, self-reported physical activity, history of documented acute SARS-CoV-2 infection and body mass index (BMI), baseline FSS was significantly correlated with baseline QIDS-SR-16 (β = 0.825, p =.001) In our sample, baseline measures of fatigue and depressive symptoms are correlated in persons living with PCC. Individuals presenting with PCC and fatigue should be screened for the presence and severity of depressive symptoms. Guideline-concordant care should be prescribed for individuals experiencing clinically significant depressive symptoms. Fatigue and depressive symptom severity scores were not pre-specified as primary objectives of the study. Multiple confounding factors (i.e. disturbance in sleep, anthropometrics and cognitive impairment) were not collected nor adjusted for in the analysis herein. Unrestricted Research Grant from H. Lundbeck A/S, Copenhagen, Denmark. ClinicalTrials.gov Identifier: NCT05047952 [ABSTRACT FROM AUTHOR]

Published
2024
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49. Ketamine for psychotic depression: An overview of the glutamatergic system and ketamine's mechanisms associated with antidepressant and psychotomimetic effects

Author

Le, Tuyen T., Di Vincenzo, Joshua D., Teopiz, Kayla M., Lee, Yena, Cha, Danielle S., Lui, Leanna M.W., Rodrigues, Nelson B., Ho, Roger C., Cao, Bing, Lin, Kangguang, Nasri, Flora, Gill, Hartej, Lipsitz, Orly, Subramaniapillai, Mehala, Mansur, Rodrigo B., Rosenblat, Joshua D., and McIntyre, Roger S.

Published
2021
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