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3. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author

Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicolas, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesús, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Plaza, Borja, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz

Published
2023
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5. Regulation of post-transcriptional gene expression in human mitochondria

Author

Rozanska, Agata

Subjects
572.8
Abstract

Mitochondria are cellular organelles that have evolved from the eubacterial ancestor into highly specialized compartment of the eukaryotic cell. They are unique among animal cells in that they retain a level of autonomy through the genetic information in their genome. Human mtDNA is built of ~16.5 kbp encoding 13 polypeptides, which are synthesised by mitoribosomes. The latter consist of two RNA species also transcribed from mtDNA and approximately 80 proteins originating from the nucleus. All 13 products of intramitochondrial translation are incorporated into the inner mitochondrial membrane where they co-build the oxidative phosphorylation (OXPHOS) system. OXPHOS is a multicomplex machinery, the final product of which is adenosine triphosphate, ATP, a carrier of energy that is necessary to sustain cell homeostasis and growth. The malfunctions of mitochondria have a severe impact on the ‘host’ organism and are the causative factor in many human diseases. Pathological changes of mitochondrial function can be triggered by mutations in the mitochondrial genome and/or defects in nuclear genes involved in mitochondrial activity. The mitochondrial gene expression pathway has been increasingly investigated during last twenty years and combines both types of factors, those translated in the cytosol and those synthesised in the mitochondrial matrix. A functional mitochondrion requires over 1500 proteins to be imported from the cytosol, a significant subset of these are devoted to the maintenance, replication, transcription and subsequently for translation of the minimal mitochondrial genome fostered within. In the course of my PhD study three of these nuclear encoded but mitochondrially destined proteins were investigated. The first of these proteins that I contributed to investigating was SLIRP. As the specificity of this RNA binding protein had not been established I performed CLIP (cross-linking immunoprecipitation) assay in order to assess the ability of SLIRP to bind RNA. The data generated from this analysis directly showed that SLIRP can interact with all mt-mRNAs apart from MTND6. This work confirmed that SLIRP participates in the stability of mt-mRNA species, as has now been subsequently published by other research groups. A main part of my PhD studies centred on characterisation of MRPL12. This protein belongs to the pool of conserved mitochondrial proteins having the bacterial orthologue 3 called L7/L12. One of the unique features of these proteins is their dynamic character and ability to exchange location between ribosomal LSU and the free pool. This has been postulated to be a regulatory mechanism of translation process in response to fluctuations in cell metabolism. To test this hypothesis I characterised immortalised fibroblasts obtained from a patient with a homozygous mutation in MRPL12 caused by c.542C to T transition in exon 5. This cell line allowed me to study the consequence of this defect on the regulation of translation in human mitochondria. I could conclude that a reduced number of MRPL12 molecules per mt-LSU in subject fibroblasts did not affect overall mitoribosome assembly, but a visible decline in mitochondrial translation was detected although the reduction in translational efficiency for different mitochondrially encoded subunits varied. The third protein that I characterised was mitochondrial RBFA. This protein was identified in my host laboratory and preliminary characterisation performed prior to my involvement. My studies included the CLIP assay that showed direct interaction of this protein with a 3’ terminal stem loop of helix 45 of the 12S mt-rRNA. The methylation status of two conserved neighbouring adenines located in helix 45 was altered by changes in steady state level of RBFA. Moreover, the CLIP data identified a second rRNA species associated with RBFA. This was an unexpected RNA species in the form of 5S rRNA. The data regarding the mitochondrial localisation and specifically any submitochondrial location has been controversial. Intriguingly my data identified a number of chimeric CLIP sequences containing both 5S and 12S rRNA fragments, strongly suggesting that within the mitochondrial matrix RBFA interacts simultaneously with both RNA species. Similarity between the 5S rRNA secondary structure and snoRNA, which guides modifications on cytosolic rRNA, led to the hypothesis proposing a novel function for 5S rRNA guiding methylation at helix 45 of the 12S mtrRNA. My data therefore assign RBFA as a new member of the group of maturation factors of the mammalian mt-SSU.

Published
2014

6. The Athena X-ray Integral Field Unit (X-IFU)

Author

Barret, Didier, Trong, Thein Lam, Den Herder, Jan-Willem, Piro, Luigi, Barcons, Xavier, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miquel, Mitsuda, Kazuhisa, Paltani, Stephane, Rauw, Gregor, Rozanska, Agata, Wilms, Joern, Barbera, Marco, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Decourchelle, Anne, Den Hartog, Roland, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Macculi, Claudio, Mendez, Mariano, Molendi, Silvano, Orleanski, Piotr, Pajot, Francois, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W, Prele, Damien, Ravera, Laurent, Renotte, Etienne, Schaye, Joop, Shinozaki, Keisuke, Valenziano, Luca, Vink, Jacco, Webb, Natalie, Yamasaki, Noriko, Delcelier-Douchin, Francoise, Le Du, Michel, Mesnager, Jean-Michel, Pradines, Alice, Branduardi-Raymont, Graziella, Dadina, Mauro, Finoguenov, Alexis, Fukazawa, Yasushi, Janiuk, Agnieszka, Miller, Jon, Naze, Yael, Nicastro, Fabrizio, Sciortino, Salvatore, Torrejon, Jose Miguel, Geoffray, Herve, Hernandez, Isabelle, Luno, Laure, Peille, Philippe, Andre, Jerome, Daniel, Christophe, Etcheverry, Christophe, Gloaguen, Emilie, Hassin, Jeremie, Hervet, Gilles, Maussang, Irwin, Moueza, Jerome, Paillet, Alexis, Vella, Bruno, Garrido, Gonzalo Campos, Damery, Jean-Charles, Panem, Chantal, Panh, Johan, Bandler, Simon, Biffi, Jean-Marc, Boyce, Kevin, Clenet, Antoine, DiPirro, Michael, Jamotton, Pierre, Lotti, Simone, Schwander, Denis, Smith, Stephen, Van Leeuwen, Bert-Joost, Van Weers, Henk, Brand, Thorsten, Cobo, Beatriz, Dauser, Thomas, De Plaa, Jelle, and Cucchetti, Eldorado

Subjects
Astrophysics
Abstract

The X-ray Integral Field Unit (X-IFU) on board the Advanced Telescope for High-ENergy Astrophysics (Athena) will provide spatially resolved high-resolution X-ray spectroscopy from 0.2 to 12 keV, with 5 pixels over a field of view of 5 arc minute equivalent diameter and a spectral resolution of 2.5 eV up to 7 keV. In this paper, we first review the core scientific objectives of Athena, driving the main performance parameters of the X-IFU, namely the spectral resolution, the field of view, the effective area, the count rate capabilities, the instrumental background. We also illustrate the breakthrough potential of the X-IFU for some observatory science goals. Then we brie y describe the X-IFU design as defined at the time of the mission consolidation review concluded in May 2016, and report on its predicted performance. Finally, we discuss some options to improve the instrument performance while not increasing its complexity and resource demands (e.g. count rate capability, spectral resolution). (2016) .

Published
2016
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7. Evidence for Fe K$_{\alpha}$ line and soft X-ray lag in NGC 7456 ULX-1

Author

Mondal, Samaresh, Rozanska, Agata, De Marco, Barbara, and Markowitz, Alex

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the first detection of a Fe K$_{\alpha}$ line and soft X-ray lag in the ultraluminous X-ray source (ULX) NGC 7456 ULX-1. The XMM-Newton spectra show the presence of the 6.4 keV Fe line at 2.6$\sigma$ confidence and an upper limit on the FWHM of 32900 km s$^{-1}$. Assuming that the line arises by reflection from a Keplerian disk, it must originate beyond $85 r_{\rm g}$ from the compact object. As a result of Fourier timing analysis we found that the soft X-ray photons lag behind the hard X-ray photons with a $\sim$1300 s delay. The covariance spectra indicate that the hard spectral component is responsible for the correlated variability and the soft X-ray lag. This is the second ULX in which a Fe K$_{\alpha}$ line is found, the fifth with a soft X-ray lag, and the first with both features detected., Comment: 5 pages, 8 figures, accepted for publication in MNRAS Letters

Published
2021

9. pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation.

Author

Rozanska, Agata, Cerna-Chavez, Rodrigo, Queen, Rachel, Collin, Joseph, Zerti, Darin, Dorgau, Birthe, Beh, Chia Shyan, Davey, Tracey, Coxhead, Jonathan, Hussain, Rafiqul, Al-Aama, Jumana, Steel, David H, Benvenisty, Nissim, Armstrong, Lyle, Parulekar, Manoj, and Lako, Majlinda

Published
2022
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10. XIPE the X-Ray Imaging Polarimetry Explorer

Author

Soffitta, Paolo, Barcons, Xavier, Bellazzini, Ronaldo, Braga, Joao, Costa, Enrico, Fraser, George W, Gburek, Szymon, Huovelin, Juhani, Matt, Giorgio, Pearce, Mark, Poutanen, Juri, Reglero, Victor, Santangelo, Andrea, Sunyaev, Rashid A, Tagliaferri, Gianpiero, Weisskopf, Martin, Aloisio, Roberto, Amato, Elena, Attina, Primo, Axelsson, Magnus, Baldini, Luca, Basso, Stefano, Bianchi, Stefano, Blasi, Pasquale, Bregeon, Johan, Brez, Alessandro, Bucciantini, Niccolo, Burderi, Luciano, Burwitz, Vadim, Casella, Piergiorgio, Churazov, Eugene, Civitani, Marta, Covino, Stefano, Curado da Silva, Rui Miguel, Cusumano, Giancarlo, Dadina, Mauro, D'Amico, Flavio, De Rosa, Alessandra, Di Cosimo, Sergio, Di Persio, Giuseppe, Di Salvo, Tiziana, Dovciak, Michal, Elsner, Ronald, Eyles, Chris J, Fabian, Andrew C, Fabiani, Sergio, Feng, Hua, Giarrusso, Salvatore, Goosmann, Rene W, Grandi, Paola, Grosso, Nicolas, Israel, Gianluca, Jackson, Miranda, Kaaret, Phillip, Karas, Vladimir, Kuss, Michael, Lai, Dong, La Rosa, Giovanni, Larsson, Josefin, Larsson, Stefan, Latronico, Luca, Maggio, Antonio, Maia, Jorge, Marin, Frederic, Massai, Marco Maria, Mineo, Teresa, Minuti, Massimo, Moretti, Elena, Muleri, Fabio, O'Dell, Stephen L, Pareschi, Giovanni, Peres, Giovanni, Pesce, Melissa, Petrucci, Pierre-Olivier, Pinchera, Michele, Porquet, Delphine, Ramsey, Brian, Rea, Nanda, Reale, Fabio, Rodrigo, Juana Maria, Rozanska, Agata, Rubini, Alda, Rudawy, Pawel, Ryde, Felix, Salvati, Marco, Santiago, Valdivino Alexandre de , Jr, Sazonov, Sergey, Sgro, Carmelo, Silver, Eric, Spandre, Gloria, Spiga, Daniele, Stella, Luigi, Tamagawa, Toru, Tamborra, Francesco, Tavecchio, Fabrizio, Teixeira Dias, Teresa, van Adelsberg, Matthew, Wu, Kinwah, Zane, Silvia, and Kallman, Timothy R

Subjects
Astrophysics, Astronomy
Abstract

X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017. The proposal was, unfortunately, not selected. To be compliant with this schedule, we designed the payload mostly with existing items. The XIPE proposal takes advantage of the completed phase A of POLARIX for an ASI small mission program that was cancelled, but is different in many aspects: the detectors, the presence of a solar flare polarimeter and photometer and the use of a light platform derived by a mass production for a cluster of satellites. XIPE is composed of two out of the three existing JET-X telescopes with two Gas Pixel Detectors (GPD) filled with a He-DME mixture at their focus. Two additional GPDs filled with a 3-bar Ar-DME mixture always face the Sun to detect polarization from solar flares. The Minimum Detectable Polarization of a 1 mCrab source reaches 14 in the 210 keV band in 105 s for pointed observations, and 0.6 for an X10 class solar flare in the 1535 keV energy band. The imaging capability is 24 arcsec Half Energy Width (HEW) in a Field of View of 14.7 arcmin 14.7 arcmin. The spectral resolution is 20 at 6 keV and the time resolution is 8 s. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut fr extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 of the net observing time.

Published
2013
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12. The ATHENA X-ray Integral Field Unit (X-IFU)

Author

Barret, Didier, Thien Lam Trong, den Herder, Jan-Willem, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Mitsuda, Kazuhisa, Paltani, Stephane, Rauw, Gregor, Rozanska, Agata, Wilms, Joern, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Decourchelle, Anne, den Hartog, Roland, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Macculi, Claudio, Mendez, Mariano, Molendi, Silvano, Orleanski, Piotr, Pajot, Francois, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prele, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Thibert, Tanguy, Valenziano, Luca, Valette, Veronique, Vink, Jacco, Webb, Natalie, Wise, Michael, Yamasaki, Noriko, Delcelier-Douchin, Francoise, Mesnager, Jean-Michel, Pontet, Bernard, Pradines, Alice, Branduardi-Raymont, Graziella, Bulbul, Esra, Dadina, Mauro, Ettori, Stefano, Finoguenov, Alexis, Fukazawa, Yasushi, Janiuk, Agnieszka, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Naze, Yael, Nicastro, Fabrizio, Sciortino, Salvatore, Simionescu, Aurora, Torrejon, Jose Miguel, Geoffray, Herve, Peille, Philippe, Aicardi, Corinne, Andre, Jerome, Garrido, Gonzalo Campos, Clenet, Antoine, Daniel, Christophe, Etcheverry, Christophe, Frezouls, Benot, Gloaguen, Emilie, Hervet, Gilles, Jolly, Antoine, Ledot, Aurelien, Maussang, Irwin, Paillet, Alexis, Schmisser, Roseline, Travert, Jean-Michel, Vella, Bruno, Damery, Jean-Charles, Boyce, Kevin, DiPirro, Michael, Lotti, Simone, Schwander, Denis, Smith, Stephen, van Leeuwen, Bert-Joost, van Weers, Henk, Clerc, Nicolas, Cobo, Beatriz, Dauser, Thomas, de Plaa, Jelle, Kirsch, Christian, Cucchetti, Edoardo, Eckart, Megan, Ferrando, Philippe, Natalucci, Lorenzo, European Commission, Ministerio de Economía y Competitividad (España), Fonds de la Recherche Scientifique (Fédération Wallonie-Bruxelles), High Energy Astrophys. & Astropart. Phys (API, FNWI), DenHerder, JWA, Nikzad, S, Nakazawa, K, Department of Physics, Barret, Didier, Lam Trong, Thien, den Herder, Jan-Willem, Piro, Luigi, Cappi, Massimo, Houvelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Mitsuda, Kazuhisa, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Wilms, Joern, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Decourchelle, Anne, den Hartog, Roland, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Macculi, Claudio, Mendez, Mariano, Molendi, Silvano, Orleanski, Piotr, Pajot, Françoi, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Thibert, Tanguy, Valenziano, Luca, Valette, Véronique, Vink, Jacco, Webb, Natalie, Wise, Michael, Yamasaki, Noriko, Douchin, Françoise, Mesnager, Jean-Michel, Pontet, Bernard, Pradines, Alice, Branduardi-Raymont, Graziella, Bulbul, Esra, Dadina, Mauro, Ettori, Stefano, Finoguenov, Alexi, Fukazawa, Yasushi, Janiuk, Agnieszka, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Naze, Yael, Nicastro, Fabrizio, Scioritino, Salavtore, Simonescu, Aurora, Torrejon, Jose Miguel, Frezouls, Benoit, Geoffray, Hervé, Peille, Philippe, Aicardi, Corinne, André, Jérôme, Daniel, Christophe, Clénet, Antoine, Etcheverry, Christophe, Gloaguen, Emilie, Hervet, Gille, Jolly, Antoine, Ledot, Aurélien, Paillet, Irwin, Schmisser, Roseline, Vella, Bruno, Damery, Jean-Charle, Boyce, Kevin, Dipirro, Mike, Lotti, Simone, Schwander, Deni, Smith, Stephen, Van Leeuwen, Bert-Joost, van Weers, Henk, Clerc, Nicola, Cobo, Beatriz, Dauser, Thoma, Kirsch, Christian, Cucchetti, Edoardo, Eckart, Megan, Ferrando, Philippe, Natalucci, Lorenzo, and Fonds de la Recherche Scientifique (Belgique)

Subjects
Point spread function, Photon, Astrophysics::High Energy Astrophysical Phenomena, Field of view, Athena, Instrumentation, Space telescopes, X-ray Integral Field Unit, X-ray spectroscopy, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, Condensed Matter Physic, Large format, 01 natural sciences, 7. Clean energy, law.invention, Telescope, Physics::Popular Physics, Settore FIS/05 - Astronomia E Astrofisica, Optics, law, Physics::Plasma Physics, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Spectral resolution, 010306 general physics, 010303 astronomy & astrophysics, Physics, Spectrometer, business.industry, Electronic, Optical and Magnetic Material, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, 115 Astronomy, Space science, Physics::History of Physics, Applied Mathematic, Space telescope, business
Abstract

Event: SPIE Astronomical Telescopes + Instrumentation, 2018, Austin, Texas, United States., The X-IFU will be provided by an international consortium led by France, The Netherlands and Italy, with further ESA member state contributions from Belgium, Finland, Germany, Poland, Spain, Switzerland and two international partners from the United States and Japan: et al., The X-ray Integral Field Unit (X-IFU) is the high resolution X-ray spectrometer of the ESA Athena X-ray observatory. Over a field of view of 5’ equivalent diameter, it will deliver X-ray spectra from 0.2 to 12 keV with a spectral resolution of 2.5 eV up to 7 keV on ∼ 5” pixels. The X-IFU is based on a large format array of super-conducting molybdenum-gold Transition Edge Sensors cooled at ∼ 90 mK, each coupled with an absorber made of gold and bismuth with a pitch of 249 μm. A cryogenic anti-coincidence detector located underneath the prime TES array enables the non X-ray background to be reduced. A bath temperature of ∼ 50 mK is obtained by a series of mechanical coolers combining 15K Pulse Tubes, 4K and 2K Joule-Thomson coolers which pre-cool a sub Kelvin cooler made of a 3He sorption cooler coupled with an Adiabatic Demagnetization Refrigerator. Frequency domain multiplexing enables to read out 40 pixels in one single channel. A photon interacting with an absorber leads to a current pulse, amplified by the readout electronics and whose shape is reconstructed on board to recover its energy with high accuracy. The defocusing capability offered by the Athena movable mirror assembly enables the X-IFU to observe the brightest X-ray sources of the sky (up to Crab-like intensities) by spreading the telescope point spread function over hundreds of pixels. Thus the X-IFU delivers low pile-up, high throughput (< 50%), and typically 10 eV spectral resolution at 1 Crab intensities, i.e. a factor of 10 or more better than Silicon based X-ray detectors. In this paper, the current X-IFU baseline is presented, together with an assessment of its anticipated performance in terms of spectral resolution, background, and count rate capability. The X-IFU baseline configuration will be subject to a preliminary requirement review that is scheduled at the end of 2018., We acknowledge support from the Athena Science Study Team, the Athena Working Group Chairs, the Athena Topical Panel Chairs and the Topical Panel members in strengthening the X-IFU top level performance requirements. Particular thanks go to: E. Rasia, V. Biffi, S. Borgani and K. Dolag for providing cosmological hydrodynamic simulations of a cluster used to produce simulation of X-IFU observation presented in Fig. 2; P.T. O'Brien for assistance with Sect. 2.2.1, A.C. Fabian and C. Pinto for providing inputs for Figure 1. We also thank the ESA project team, and in particular Mark Ayre and Ivo Ferreira, for their work on the assessment of the ToO efficiency requirement. The Italian contribution to X-IFU is supported through the ASI contractn. 2015-046-R.0. XB, MTC and BC acknowledge nancial support by MINECO through grant ESP2014-53672-C3-1-P. A.R., P.O, and A.J. were supported by Polish NSC grants: 2015/17/B/ST9/03422 and 2015/18/M/ST9/00541. GR, ER, YN, and PJ acknowledges support by FNRS and Prodex (Belspo). This work was supported by the French Space Agency (CNES).

Published
2018

13. The physics and astrophysics of X-ray outflows from Active Galactic Nuclei

Author

Laha, Sibasish, Smith, Randall, Tzanavaris, Panayiotis, Kallman, Tim, Veilleux, Sylvain, Tombesi, Francesco, Kriss, Gerard, GUAINAZZI, MATTEO, GASPARI, MASSIMO, Kaastra, Jelle, Markowitz, Alex, Crenshaw, Mike, Behar, Ehud, Fukumura, Keigo, Longinotti, Anna Lia, Rozanska, Agata, Ebrero, Jacobo, Ferland, Gary, Ricci, Claudio, Done, Chris, Proga, Daniel, Revalski, Mitchell, and Vayner, Andrey

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics of Galaxies (astro-ph.GA), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, Astrophysics::Galaxy Astrophysics
Abstract

The highly energetic outflows from Active Galactic Nuclei detected in X-rays are one of the most powerful mechanisms by which the central supermassive black hole (SMBH) interacts with the host galaxy. The last two decades of high resolution X-ray spectroscopy with XMM and Chandra have improved our understanding of the nature of these outflowing ionized absorbers and we are now poised to take the next giant leap with higher spectral resolution and higher throughput observatories to understand the physics and impact of these outflows on the host galaxy gas. The future studies on X-ray outflows not only have the potential to unravel some of the currently outstanding puzzles in astronomy, such as the physical basis behind the MBH$-\sigma$ relation, the cooling flow problem in intra-cluster medium (ICM), and the evolution of the quasar luminosity function across cosmic timescales, but also provide rare insights into the dynamics and nature of matter in the immediate vicinity of the SMBH. Higher spectral resolution ($\le 0.5$ eV at $1$ keV) observations will be required to identify individual absorption lines and study the asymmetries and shifts in the line profiles revealing important information about outflow structures and their impact. Higher effective area ($\ge 1000 \rm \,cm^{2}$) will be required to study the outflows in distant quasars, particularly at the quasar peak era (redshift $1\le z\le 3$) when the AGN population was the brightest. Thus, it is imperative that we develop next generation X-ray telescopes with high spectral resolution and high throughput for unveiling the properties and impact of highly energetic X-ray outflows. A simultaneous high resolution UV + X-ray mission will encompass the crucial AGN ionizing continuum, and also characterize the simultaneous detections of UV and X-ray outflows, which map different spatial scales along the line of sight., Comment: A Science White Paper submitted to the Astro2020 Decadal Survey

Published
2019

15. The Athena X-ray Integral Field Unit

Author

Barret, Didier, Trong, Thien Lam, Den Herder, Jan-Willem, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Miguel Mas-Hesse, J., Mitsuda, Kazuhisa, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Wilms, Joern, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Decourchelle, Anne, Den Hartog, Roland, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Macculi, Claudio, Mendez, Mariano, Molendi, Silvano, Orleanski, Piotr, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Thibert, Tanguy, Valenziano, Luca, Valette, Veronique, Vink, Jacco, Webb, Natalie, Wise, Michael, Yamasaki, Noriko, Delcelier-Douchin, Françoise, Mesnager, Jean-Michel, Pontet, Bernard, Pradines, Alice, Branduardi-Raymont, Graziella, Bulbul, Esra, Dadina, Mauro, Ettori, Stefano, Finoguenov, Alexis, Fukazawa, Yasushi, Janiuk, Agnieszka, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nazé, Yaël, Nicastro, Fabrizio, Sciortino, Salvatore, Simionescu, Aurora, Torrejon, Jose Miguel, Frezouls, Benot, Geoffray, Hervé, Peille, Philippe, Aicardi, Corinne, André, Jérôme, Clénet, Antoine, Daniel, Christophe, Etcheverry, Christophe, Gloaguen, Emilie, Hervet, Gilles, Jolly, Antoine, Ledot, Aurélien, Maussang, Irwin, Paillet, Alexis, Schmisser, Roseline, Vella, Bruno, Damery, Jean-Charles, Boyce, Kevin, Dipirro, Michael, Lotti, Simone, Schwander, Denis, Smith, Stephen, van Leeuwen, Bert-Joost, van Weers, Henk, Clerc, Nicolas, Cobo, Beatriz, Dauser, Thomas, De Plaa, Jelle, Kirsch, Christian, Cucchetti, Edoardo, Eckart, Megan, Ferrando, Philippe, Natalucci, Lorenzo, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Cosmology and Nongalactic Astrophysics (astro-ph.CO), Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Astrophysics of Galaxies, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The X-ray Integral Field Unit (X-IFU) is the high resolution X-ray spectrometer of the ESA Athena X-ray observatory. Over a field of view of 5' equivalent diameter, it will deliver X-ray spectra from 0.2 to 12 keV with a spectral resolution of 2.5 eV up to 7 keV on ~5 arcsecond pixels. The X-IFU is based on a large format array of super-conducting molybdenum-gold Transition Edge Sensors cooled at about 90 mK, each coupled with an absorber made of gold and bismuth with a pitch of 249 microns. A cryogenic anti-coincidence detector located underneath the prime TES array enables the non X-ray background to be reduced. A bath temperature of about 50 mK is obtained by a series of mechanical coolers combining 15K Pulse Tubes, 4K and 2K Joule-Thomson coolers which pre-cool a sub Kelvin cooler made of a 3He sorption cooler coupled with an Adiabatic Demagnetization Refrigerator. Frequency domain multiplexing enables to read out 40 pixels in one single channel. A photon interacting with an absorber leads to a current pulse, amplified by the readout electronics and whose shape is reconstructed on board to recover its energy with high accuracy. The defocusing capability offered by the Athena movable mirror assembly enables the X-IFU to observe the brightest X-ray sources of the sky (up to Crab-like intensities) by spreading the telescope point spread function over hundreds of pixels. Thus the X-IFU delivers low pile-up, high throughput (>50%), and typically 10 eV spectral resolution at 1 Crab intensities, i.e. a factor of 10 or more better than Silicon based X-ray detectors. In this paper, the current X-IFU baseline is presented, together with an assessment of its anticipated performance in terms of spectral resolution, background, and count rate capability. The X-IFU baseline configuration will be subject to a preliminary requirement review that is scheduled at the end of 2018., 15 pages, 5 figures, to appear in Proc. SPIE Astronomical Telescopes and Instrumentation, Austin 2018

Published
2018

16. The Hot and Energetic Universe: A White Paper presenting the science theme motivating the Athena+ mission

Author

Nandra, Kirpal, Barret, Didier, Barcons, Xavier, Fabian, Andy, Den Herder, Jan-Willem, Piro, Luigi, Watson, Mike, Adami, Christophe, Aird, James, Afonso, Jose Manuel, Alexander, Dave, Argiroffi, Costanza, Amati, Lorenzo, Arnaud, Monique, Atteia, Jean-Luc, Audard, Marc, Badenes, Carles, Ballet, Jean, Ballo, Lucia, Bamba, Aya, Bhardwaj, Anil, Stefano Battistelli, Elia, Becker, Werner, Becker, Michaël, Behar, Ehud, Bianchi, Stefano, Biffi, Veronica, Bîrzan, Laura, Bocchino, Fabrizio, Bogdanov, Slavko, Boirin, Laurence, Boller, Thomas, Borgani, Stefano, Borm, Katharina, Bouché, Nicolas, Bourdin, Hervé, Bower, Richard, Braito, Valentina, Branchini, Enzo, Branduardi-Raymont, Graziella, Bregman, Joel, Brenneman, Laura, Brightman, Murray, Brüggen, Marcus, Buchner, Johannes, Bulbul, Esra, Brusa, Marcella, Bursa, Michal, Caccianiga, Alessandro, Cackett, Ed, Campana, Sergio, Cappelluti, Nico, Cappi, Massimo, Carrera, Francisco, Ceballos, Maite, Christensen, Finn, Chu, You-Hua, Churazov, Eugene, Clerc, Nicolas, Corbel, Stephane, Corral, Amalia, Comastri, Andrea, Costantini, Elisa, Croston, Judith, Dadina, Mauro, D Ai, Antonino, Decourchelle, Anne, Della Ceca, Roberto, Dennerl, Konrad, Dolag, Klaus, Done, Chris, Dovciak, Michal, Drake, Jeremy, Eckert, Dominique, Edge, Alastair, Ettori, Stefano, Ezoe, Yuichiro, Feigelson, Eric, Fender, Rob, Feruglio, Chiara, Finoguenov, Alexis, Fiore, Fabrizio, Galeazzi, Massimiliano, Gallagher, Sarah, Gandhi, Poshak, Gaspari, Massimo, Gastaldello, Fabio, Georgakakis, Antonis, Georgantopoulos, Ioannis, Gilfanov, Marat, Gitti, Myriam, Gladstone, Randy, Goosmann, Rene, Gosset, Eric, Grosso, Nicolas, Guedel, Manuel, Guerrero, Martin, Haberl, Frank, Hardcastle, Martin, Heinz, Sebastian, Alonso Herrero, Almudena, Hervé, Anthony, Holmstrom, Mats, Iwasawa, Kazushi, Jonker, Peter, Kaastra, Jelle, Kara, Erin, Karas, Vladimir, Kastner, Joel, King, Andrew, Kosenko, Daria, Koutroumpa, Dimita, Kraft, Ralph, Kreykenbohm, Ingo, Lallement, Rosine, Lanzuisi, Giorgio, Lee, J., Lemoine-Goumard, Marianne, Lobban, Andrew, Lodato, Giuseppe, Lovisari, Lorenzo, Lotti, Simone, Mccharthy, Ian, Mcnamara, Brian, Maggio, Antonio, Maiolino, Roberto, Marco, Barbara, Martino, Domitilla, Mateos, Silvia, Matt, Giorgio, Maughan, Ben, Mazzotta, Pasquale, Mendez, Mariano, Merloni, Andrea, Micela, Giuseppina, Miceli, Marco, Mignani, Robert, Miller, Jon, Miniutti, Giovanni, Molendi, Silvano, Montez, Rodolfo, Moretti, Alberto, Motch, Christian, Nazé, Yaël, Nevalainen, Jukka, Nicastro, Fabrizio, Nulsen, Paul, Ohashi, Takaya, O Brien, Paul, Osborne, Julian, Oskinova, Lida, Pacaud, Florian, Paerels, Frederik, Page, Mat, Papadakis, Iossif, Pareschi, Giovanni, Petre, Robert, Petrucci, Pierre-Olivier, Piconcelli, Enrico, Pillitteri, Ignazio, Pinto, C., Plaa, Jelle, Pointecouteau, Etienne, Ponman, Trevor, Ponti, Gabriele, Porquet, Delphine, Pounds, Ken, Pratt, Gabriel, Predehl, Peter, Proga, Daniel, Psaltis, Dimitrios, Rafferty, David, Ramos-Ceja, Miriam, Ranalli, Piero, Rasia, Elena, Rau, Arne, Rauw, Gregor, Rea, Nanda, Read, Andy, Reeves, James, Reiprich, Thomas, Renaud, Matthieu, Reynolds, Chris, Risaliti, Guido, Rodriguez, Jerome, Rodriguez Hidalgo, Paola, Roncarelli, Mauro, Rosario, David, Rossetti, Mariachiara, Rozanska, Agata, Rovilos, Emmanouil, Salvaterra, Ruben, Salvato, Mara, Di Salvo, Tiziana, Jeremy Sanders, Sanz-Forcada, Jorge, Schawinski, Kevin, Schaye, Joop, Schwope, Axel, Sciortino, Salvatore, Severgnini, Paola, Shankar, Francesco, Sijacki, Debora, Sim, Stuart, Schmid, Christian, Smith, Randall, Steiner, Andrew, Stelzer, Beate, Stewart, Gordon, Strohmayer, Tod, Strüder, Lothar, Sun, Ming, Takei, Yoh, Tatischeff, V., Tiengo, Andreas, Tombesi, Francesco, Trinchieri, Ginevra, Tsuru, T. G., Ud-Doula, Asif, Ursino, Eugenio, Valencic, Lynne, Vanzella, Eros, Vaughan, Simon, Vignali, Cristian, Vink, Jacco, Vito, Fabio, Volonteri, Marta, Wang, Daniel, Webb, Natalie, Willingale, Richard, Wilms, Joern, Wise, Michael, Worrall, Diana, Young, Andrew, Zampieri, Luca, In T Zand, Jean, Zane, Silvia, Zezas, Andreas, Zhang, Yuying, Zhuravleva, Irina, Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Dipartimento di Fisica e Chimica (DiFC), Università degli studi di Palermo - University of Palermo, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de recherche en astrophysique et planétologie (IRAP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Columbia Astrophysics Laboratory (CAL), Columbia University [New York], Department of Astrophysical Sciences [Princeton], Princeton University, Département d'Astrophysique (ex SAP) (DAP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Cosmologie, Astrophysique Stellaire & Solaire, de Planétologie et de Mécanique des Fluides (CASSIOPEE), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institute for Computational Cosmology (ICC), Durham University, Dipartimento de Fisica Roma Tre (DF-Roma3), Università degli Studi Roma Tre, Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Technische Universität München [München] (TUM), National Space Institute [Lyngby] (DTU Space), Technical University of Denmark [Lyngby] (DTU), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), SRON Netherlands Institute for Space Research (SRON), Max-Planck-Institut für Extraterrestrische Physik (MPE), Department of Physics [Durham University], Ecole Polytechnique Fédérale de Lausanne (EPFL), Tokyo Metropolitan University [Tokyo], Department of Astronomy and Astrophysics [PennState], Pennsylvania State University (Penn State), Penn State System-Penn State System, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Department of Physics [Coral Gables], University of Miami [Coral Gables], Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Swedish Institute of Space Physics [Kiruna] (IRF), Astronomical Institute of the Czech Academy of Sciences, Czech Academy of Sciences [Prague] (ASCR), HEPPI - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Meudon (OBSPM), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Palermo (OAPa), Istituto Nazionale di Astrofisica (INAF), Cavendish Laboratory, University of Cambridge [UK] (CAM), Università degli Studi di Roma Tor Vergata [Roma], Max-Planck-Institut für Astrophysik (MPA), Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University [Cambridge]-Smithsonian Institution, PSL Research University (PSL), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], School of Physics and Astronomy [Southampton], University of Southampton, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Department of Computer Science, Penn State System, Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lawrence Livermore National Laboratory (LLNL), Max Plank Institute for Extraterrestial Life, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica e Chimica [Palermo] (DiFC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Tokyo Metropolitan University [Tokyo] (TMU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Astronomical Institute of the Czech Academy of Sciences (ASU / CAS), Czech Academy of Sciences [Prague] (CAS), HELIOS - LATMOS, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Harvard University-Smithsonian Institution, Université Paris sciences et lettres (PSL), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG ), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universiteit Leiden, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Astronomy, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Smithsonian Institution-Harvard University [Cambridge], Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Maiolino, Roberto [0000-0002-4985-3819], Reynolds, Christopher [0000-0002-1510-4860], Sijacki, Debora [0000-0002-3459-0438], Apollo - University of Cambridge Repository, Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)

Subjects
astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Earth and Planetary Astrophysics (astro-ph.EP), astro-ph.SR, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Astrophysics - Cosmology and Extragalactic Astrophysics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Solar and Stellar Astrophysics, [SDU]Sciences of the Universe [physics], astro-ph.EP, astro-ph.CO, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Solar and Stellar Astrophysics (astro-ph.SR), astro-ph.IM, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

This White Paper, submitted to the recent ESA call for science themes to define its future large missions, advocates the need for a transformational leap in our understanding of two key questions in astrophysics: 1) How does ordinary matter assemble into the large scale structures that we see today? 2) How do black holes grow and shape the Universe? Hot gas in clusters, groups and the intergalactic medium dominates the baryonic content of the local Universe. To understand the astrophysical processes responsible for the formation and assembly of these large structures, it is necessary to measure their physical properties and evolution. This requires spatially resolved X-ray spectroscopy with a factor 10 increase in both telescope throughput and spatial resolving power compared to currently planned facilities. Feedback from supermassive black holes is an essential ingredient in this process and in most galaxy evolution models, but it is not well understood. X-ray observations can uniquely reveal the mechanisms launching winds close to black holes and determine the coupling of the energy and matter flows on larger scales. Due to the effects of feedback, a complete understanding of galaxy evolution requires knowledge of the obscured growth of supermassive black holes through cosmic time, out to the redshifts where the first galaxies form. X-ray emission is the most reliable way to reveal accreting black holes, but deep survey speed must improve by a factor ~100 over current facilities to perform a full census into the early Universe. The Advanced Telescope for High Energy Astrophysics (Athena+) mission provides the necessary performance (e.g. angular resolution, spectral resolution, survey grasp) to address these questions and revolutionize our understanding of the Hot and Energetic Universe. These capabilities will also provide a powerful observatory to be used in all areas of astrophysics., Submitted in response to the call for White Papers for the definition of the L2 and L3 missions in the ESA Science program. More information: http://www.the-athena-x-ray-observatory.eu/. 19 pages, 12 figures, 4 tables

Published
2013

17. The Hot and Energetic Universe: The close environments of supermassive black holes

Author

Dovciak, Michal, Matt, Giorgio, Bianchi, Stefano, Boller, Thomas, Brenneman, Laura, Bursa, Michal, D Ai, Antonino, Di Salvo, Tiziana, Marco, Barbara, Goosmann, Rene, Karas, Vladimir, Iwasawa, Kazushi, Kara, Erin, Miller, Jon, Miniutti, Giovanni, Papadakis, Iossif, Petrucci, Pierre-Olivier, Ponti, Gabriele, Porquet, Delphine, Reynolds, Chris, Risaliti, Guido, Rozanska, Agata, Luca Zampieri, Zezas, Andreas, Young, Andrew, Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and Porquet, Delphine

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), [SDU.ASTR.CO] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [SDU.ASTR.HE] Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Earth and Planetary Astrophysics, [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract

Most of the action in Active Galactic Nuclei (AGN) occurs within a few tens of gravitational radii from the supermassive black hole, where matter in the accretion disk may lose up to almost half of its energy with a copious production of X-rays, emitted via Comptonization of the disk photons by hot electrons in a corona and partly reflected by the accretion disk. Thanks to its large effective area and excellent energy resolution, Athena+ contributions in the understanding of the physics of accretion in AGN will be fundamental - and unique - in many respects. It will allow us to map the disk-corona system - which is crucial to understand the mechanism of energy extraction and the relation of the corona with winds and jets - by studying the time lags between reflected and primary photons. These lags have been recently discovered by XMM-Newton, but only Athena+ will have the sensitivity required to fully exploit this technique. Athena+ will also be able e.g. to determine robustly the spin of the black hole in nearby sources (and to extend these measurements beyond the local Universe), to establish the nature of the soft X-ray components, and to map the circumnuclear matter within the AGN inner parsec with unprecedented details., Supporting paper for the science theme "The Hot and Energetic Universe" to be implemented by the Athena+ X-ray observatory (http://www.the-athena-x-ray-observatory.eu). 9 pages, 8 figures

Published
2013

18. Leaving the ISCO: the inner edge of a black-hole accretion disk at various luminosities

Author

Abramowicz, Marek A., Jaroszynski, Michal, Kato, Shoji, Lasota, Jean-Pierre, Rozanska, Agata, and Sadowski, Aleksander

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), General Relativity and Quantum Cosmology, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract

The "radiation inner edge" of an accretion disk is defined as the inner boundary of the region from which most of the luminosity emerges. Similarly, the "reflection edge" is the smallest radius capable of producing a significant X-ray reflection of the fluorescent iron line. For black hole accretion disks with very sub-Eddington luminosities these and all other "inner edges" locate at ISCO. Thus, in this case, one may rightly consider ISCO as the unique inner edge of the black hole accretion disk. However, even for moderate luminosities, there is no such unique inner edge as differently defined edges locate at different places. Several of them are significantly closer to the black hole than ISCO. The differences grow with the increasing luminosity. For nearly Eddington luminosities, they are so huge that the notion of the inner edge losses all practical significance., 12 pages, 15 figures, submitted to A&A

Published
2010

19. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.

Author

Rozanska, Agata, Richter-Dennerlein, Ricarda, Rorbach, Joanna, Fei Gao, Lewis, Richard J., Chrzanowska-Lightowlers, Zofia M., and Lightowlers, Robert N.

Subjects
*RIBOSOMES, *MITOCHONDRIAL RNA, *CARRIER proteins, *MITOCHONDRIAL proteins, *ADENINE
Abstract

Accurate assembly and maturation of human mitochondrial ribosomes is essential for synthesis of the 13 polypeptides encoded by the mitochondrial genome. This process requires the correct integration of 80 proteins, 1 mt (mitochondrial)-tRNA and 2 mt-rRNA species, the latter being post-transcriptionally modified at many sites. Here, we report that human ribosome-binding factor A (RBFA) is a mitochondrial RNA-binding protein that exerts crucial roles in mitoribosome biogenesis. Unlike its bacterial orthologue, RBFA associates mainly with helices 44 and 45 of the 12S rRNA in the mitoribosomal small subunit to promote dimethylation of two highly conserved consecutive adenines. Characterization of RBFA-depleted cells indicates that this dimethylation is not a prerequisite for assembly of the small ribosomal subunit. However, the RBFA-facilitated modification is necessary for completing mt-rRNA maturation and regulating association of the small and large subunits to form a functional monosome implicating RBFA in the quality control of mitoribosome formation. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Mitochondrial protein synthesis: Figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation.

Author

Lightowlers, Robert N., Rozanska, Agata, and Chrzanowska-Lightowlers, Zofia M.

Subjects
*MITOCHONDRIAL proteins, *PROTEIN synthesis, *MAMMAL genetics, *GENETIC translation, *POLYPEPTIDES, *PHOSPHORYLATION, *GENE expression
Abstract

Mitochondrial protein synthesis is essential for all mammals, being responsible for providing key components of the oxidative phosphorylation complexes. Although only thirteen different polypeptides are made, the molecular details of this deceptively simple process remain incomplete. Central to this process is a non-canonical ribosome, the mitoribosome, which has evolved to address its unique mandate. In this review, we integrate the current understanding of the molecular aspects of mitochondrial translation with recent advances in structural biology. We identify numerous key questions that we will need to answer if we are to increase our knowledge of the molecular mechanisms underlying mitochondrial protein synthesis. [ABSTRACT FROM AUTHOR]

Published
2014
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22. Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency.

Author

Serre, Valérie, Rozanska, Agata, Beinat, Marine, Chretien, Dominique, Boddaert, Nathalie, Munnich, Arnold, Rötig, Agnès, and Chrzanowska-Lightowlers, Zofia M.

Subjects
*RIBOSOMAL proteins, *MITOCHONDRIAL pathology, *DWARFISM, *GENETIC mutation, *EUBACTERIALES
Abstract

Abstract: Multiple respiratory chain deficiencies represent a common cause of mitochondrial diseases and are associated with a wide range of clinical symptoms. We report a subject, born to consanguineous parents, with growth retardation and neurological deterioration. Multiple respiratory chain deficiency was found in muscle and fibroblasts of the subject as well as abnormal assembly of complexes I and IV. A microsatellite genotyping of the family members detected only one region of homozygosity on chromosome 17q24.2–q25.3 in which we focused our attention to genes involved in mitochondrial translation. We sequenced MRPL12, encoding the mitochondrial ribosomal protein L12 and identified a c.542C>T transition in exon 5 changing a highly conserved alanine into a valine (p.Ala181Val). This mutation resulted in a decreased steady-state level of MRPL12 protein, with altered integration into the large ribosomal subunit. Moreover, an overall mitochondrial translation defect was observed in the subject's fibroblasts with a significant reduction of synthesis of COXI, COXII and COXIII subunits. Modeling of MRPL12 shows Ala181 positioned in a helix potentially involved in an interface of interaction suggesting that the p.Ala181Val change might be predicted to alter interactions with the elongation factors. These results contrast with the eubacterial orthologues of human MRPL12, where L7/L12 proteins do not appear to have a selective effect on translation. Therefore, analysis of the mutated version found in the subject presented here suggests that the mammalian protein does not function in an entirely analogous manner to the eubacterial L7/L12 equivalent. [Copyright &y& Elsevier]

Published
2013
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23. Thermal Conduction and Thermal Instability in the Transition layer between an Accretion Disc and Corona.

Author

Rozanska, Agata

Subjects
*ACCRETION (Astrophysics), *ASTROPHYSICS
Abstract

ABSTRACT We study the vertical structure of the transition layer between am accretion disc and corona in the context of the existence of two-phase medium in thermally unstable regions. The disc is illuminated by hard X-ray radiation and satisfies the condition of hydrostatic equilibrium. We take into account the energy exchange between hot corona (∼ 10[sup 8] K) and cool disc (∼ 10[sup 4] K) through the radiative processes and due to thermal conduction. We make local stability analysis of the case with conductivity and we conclude that thermal conduction does not suppress thermal instability. In spite of continuous temperature profile T(τ) there are regions with strong temperature gradient where spontaneous perturbations can lead to cloud condensation in the transition layer. We determine the minimum size λTC of such a perturbation. [ABSTRACT FROM AUTHOR]

Published
1999

24. Mitochondrial protein synthesis: Figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation

Author

Lightowlers, Robert N., Rozanska, Agata, and Chrzanowska-Lightowlers, Zofia M.

Subjects
Translation, RNA, Gene expression, Ribosomes, Mitochondria
Abstract

Mitochondrial protein synthesis is essential for all mammals, being responsible for providing key components of the oxidative phosphorylation complexes. Although only thirteen different polypeptides are made, the molecular details of this deceptively simple process remain incomplete. Central to this process is a non-canonical ribosome, the mitoribosome, which has evolved to address its unique mandate. In this review, we integrate the current understanding of the molecular aspects of mitochondrial translation with recent advances in structural biology. We identify numerous key questions that we will need to answer if we are to increase our knowledge of the molecular mechanisms underlying mitochondrial protein synthesis.

Full Text
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25. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author

Didier Barret, Vincent Albouys, Jan-Willem den Herder, Luigi Piro, Massimo Cappi, Juhani Huovelin, Richard Kelley, J. Miguel Mas-Hesse, Stéphane Paltani, Gregor Rauw, Agata Rozanska, Jiri Svoboda, Joern Wilms, Noriko Yamasaki, Marc Audard, Simon Bandler, Marco Barbera, Xavier Barcons, Enrico Bozzo, Maria Teresa Ceballos, Ivan Charles, Elisa Costantini, Thomas Dauser, Anne Decourchelle, Lionel Duband, Jean-Marc Duval, Fabrizio Fiore, Flavio Gatti, Andrea Goldwurm, Roland den Hartog, Brian Jackson, Peter Jonker, Caroline Kilbourne, Seppo Korpela, Claudio Macculi, Mariano Mendez, Kazuhisa Mitsuda, Silvano Molendi, François Pajot, Etienne Pointecouteau, Frederick Porter, Gabriel W. Pratt, Damien Prêle, Laurent Ravera, Kosuke Sato, Joop Schaye, Keisuke Shinozaki, Konrad Skup, Jan Soucek, Tanguy Thibert, Jacco Vink, Natalie Webb, Laurence Chaoul, Desi Raulin, Aurora Simionescu, Jose Miguel Torrejon, Fabio Acero, Graziella Branduardi-Raymont, Stefano Ettori, Alexis Finoguenov, Nicolas Grosso, Jelle Kaastra, Pasquale Mazzotta, Jon Miller, Giovanni Miniutti, Fabrizio Nicastro, Salvatore Sciortino, Hiroya Yamaguchi, Sophie Beaumont, Edoardo Cucchetti, Matteo D’Andrea, Megan Eckart, Philippe Ferrando, Elias Kammoun, Simone Lotti, Jean-Michel Mesnager, Lorenzo Natalucci, Philippe Peille, Jelle de Plaa, Florence Ardellier, Andrea Argan, Elise Bellouard, Jérôme Carron, Elisabetta Cavazzuti, Mauro Fiorini, Pourya Khosropanah, Sylvain Martin, James Perry, Frederic Pinsard, Alice Pradines, Manuela Rigano, Peter Roelfsema, Denis Schwander, Guido Torrioli, Joel Ullom, Isabel Vera, Eduardo Medinaceli Villegas, Monika Zuchniak, Frank Brachet, Ugo Lo Cicero, William Doriese, Malcom Durkin, Valentina Fioretti, Hervé Geoffray, Lionel Jacques, Christian Kirsch, Stephen Smith, Joseph Adams, Emilie Gloaguen, Ruud Hoogeveen, Paul van der Hulst, Mikko Kiviranta, Jan van der Kuur, Aurélien Ledot, Bert-Joost van Leeuwen, Dennis van Loon, Bertrand Lyautey, Yann Parot, Kazuhiro Sakai, Henk van Weers, Shariefa Abdoelkariem, Thomas Adam, Christophe Adami, Corinne Aicardi, Hiroki Akamatsu, Pablo Eleazar Merino Alonso, Roberta Amato, Jérôme André, Matteo Angelinelli, Manuel Anon-Cancela, Shebli Anvar, Ricardo Atienza, Anthony Attard, Natalia Auricchio, Ana Balado, Florian Bancel, Lorenzo Ferrari Barusso, Arturo Bascuñan, Vivian Bernard, Alicia Berrocal, Sylvie Blin, Donata Bonino, François Bonnet, Patrick Bonny, Peter Boorman, Charles Boreux, Ayoub Bounab, Martin Boutelier, Kevin Boyce, Daniele Brienza, Marcel Bruijn, Andrea Bulgarelli, Simona Calarco, Paul Callanan, Alberto Prada Campello, Thierry Camus, Florent Canourgues, Vito Capobianco, Nicolas Cardiel, Florent Castellani, Oscar Cheatom, James Chervenak, Fabio Chiarello, Laurent Clerc, Nicolas Clerc, Beatriz Cobo, Odile Coeur-Joly, Alexis Coleiro, Stéphane Colonges, Leonardo Corcione, Mickael Coriat, Alexandre Coynel, Francesco Cuttaia, Antonino D’Ai, Fabio D’anca, Mauro Dadina, Christophe Daniel, Lea Dauner, Natalie DeNigris, Johannes Dercksen, Michael DiPirro, Eric Doumayrou, Luc Dubbeldam, Michel Dupieux, Simon Dupourqué, Jean Louis Durand, Dominique Eckert, Valvanera Eiriz, Eric Ercolani, Christophe Etcheverry, Fred Finkbeiner, Mariateresa Fiocchi, Hervé Fossecave, Philippe Franssen, Martin Frericks, Stefano Gabici, Florent Gant, Jian-Rong Gao, Fabio Gastaldello, Ludovic Genolet, Simona Ghizzardi, Ma Angeles Alcacera Gil, Elisa Giovannini, Olivier Godet, Javier Gomez-Elvira, Raoul Gonzalez, Manuel Gonzalez, Luciano Gottardi, Dolorès Granat, Michel Gros, Nicolas Guignard, Paul Hieltjes, Adolfo Jesús Hurtado, Kent Irwin, Christian Jacquey, Agnieszka Janiuk, Jean Jaubert, Maria Jiménez, Antoine Jolly, Thierry Jourdan, Sabine Julien, Bartosz Kedziora, Andrew Korb, Ingo Kreykenbohm, Ole König, Mathieu Langer, Philippe Laudet, Philippe Laurent, Monica Laurenza, Jean Lesrel, Sebastiano Ligori, Maximilian Lorenz, Alfredo Luminari, Bruno Maffei, Océane Maisonnave, Lorenzo Marelli, Didier Massonet, Irwin Maussang, Alejandro Gonzalo Melchor, Isabelle Le Mer, Francisco Javier San Millan, Jean-Pierre Millerioux, Teresa Mineo, Gabriele Minervini, Alexeï Molin, David Monestes, Nicola Montinaro, Baptiste Mot, David Murat, Kenichiro Nagayoshi, Yaël Nazé, Loïc Noguès, Damien Pailot, Francesca Panessa, Luigi Parodi, Pascal Petit, Enrico Piconcelli, Ciro Pinto, Jose Miguel Encinas Plaza, Borja Plaza, David Poyatos, Thomas Prouvé, Andy Ptak, Simonetta Puccetti, Elena Puccio, Pascale Ramon, Manuel Reina, Guillaume Rioland, Louis Rodriguez, Anton Roig, Bertrand Rollet, Mauro Roncarelli, Gilles Roudil, Tomasz Rudnicki, Julien Sanisidro, Luisa Sciortino, Vitor Silva, Michael Sordet, Javier Soto-Aguilar, Pierre Spizzi, Christian Surace, Miguel Fernández Sánchez, Emanuele Taralli, Guilhem Terrasa, Régis Terrier, Michela Todaro, Pietro Ubertini, Michela Uslenghi, Jan Geralt Bij de Vaate, Davide Vaccaro, Salvatore Varisco, Peggy Varnière, Laurent Vibert, María Vidriales, Fabrizio Villa, Boris Martin Vodopivec, Angela Volpe, Cor de Vries, Nicholas Wakeham, Gavin Walmsley, Michael Wise, Martin de Wit, Grzegorz Woźniak, Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thoma, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, Françoi, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexi, Grosso, Nicola, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elia, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, Jame, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Deni, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Denni, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thoma, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, Françoi, Bonny, Patrick, Boorman, Peter, Boreux, Charle, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicola, Castellani, Florent, Cheatom, Oscar, Chervenak, Jame, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicola, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexi, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johanne, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Loui, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorè, Gros, Michel, Guignard, Nicola, Hieltjes, Paul, Hurtado, Adolfo Jesú, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encina, Plaza, Borja, Poyatos, David, Prouvé, Thoma, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Loui, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gille, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régi, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nichola, Walmsley, Gavin, Wise, Michael, de Wit, Martin, Woźniak, Grzegorz, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Astronomía y Astrofísica, Agencia Estatal de Investigación (AEI), Ministerio de Ciencia e Innovación (MICINN), Centre National D'Etudes Spatiales (CNES), Agenzia Spaziale Italiana (ASI), European Space Agency (ESA), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), SRON Netherlands Institute for Space Research (SRON), Department of Physics [Helsinki], Falculty of Science [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Centrum Astronomiczne im. M. Kopernika, Warszawa (CAMK), Faculty of Civil Engineering [Prague] (FSV CTU), Czech Technical University in Prague (CTU), Columbia Astrophysics Laboratory (CAL), Columbia University [New York], NASA Goddard Space Flight Center (GSFC), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)

Subjects
X-IFU: The X-ray Integral Field Unit, Cosmology and Nongalactic Astrophysics (astro-ph.CO), The X-ray Integral Field Unit [X-IFU], Solar and stellar astrophysics, FOS: Physical sciences, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Settore FIS/05 - Astronomia E Astrofisica, X-rays, SDG 7 - Affordable and Clean Energy, Instrumentation and Methods for Astrophysics (astro-ph.IM), Solar and Stellar Astrophysics (astro-ph.SR), High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics of Galaxies, Athena: the advanced telescope for high energy astrophysics, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysical phenomena, Space instrumentation, Astrophysics - Solar and Stellar Astrophysics, High energy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], the advanced telescope for high energy astrophysics [Athena], Athena: the advanced telescope for high energy astrophysics · X-IFU: The X-ray Integral Field Unit · Space instrumentation · X-rays · Observatory, Observatory, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, SDG 12 - Responsible Consumption and Production, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged)., Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editing

Published
2023

26. The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules.

Author

Zaganelli, Sofia, Rebelo-Guiomar, Pedro, Maundrell, Kinsey, Rozanska, Agata, Pierredon, Sandra, Powell, Christopher A., Jourdain, Alexis A., Hulo, Nicolas, Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M., Minczuk, Michal, and Martinou, Jean-Claude

Subjects
*PSEUDOURIDINE synthases, *MITOCHONDRIAL RNA, *GENE expression, *MOLECULAR genetics, *MOLECULAR biology
Abstract

Mitochondrial gene expression is a fundamental process that is largely dependent on nuclear-encoded proteins. Several steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modification, appear to be spatially organized into distinct foci, which we have previously termed mitochondrial RNA granules (MRGs). Although an increasing number of proteins have been localized to MRGs, a comprehensive analysis of the proteome of these structures is still lacking. Here, we have applied a microscopy-based approach that has allowed us to identify novel components of the MRG proteome. Among these, we have focused our attention on RPUSD4, an uncharacterized mitochondrial putative pseudouridine synthase. We show that RPUSD4 depletion leads to a severe reduction of the steady-state level of the 16S mitochondrial (mt) rRNA with defects in the biogenesis of the mitoribosome large subunit and consequently in mitochondrial translation. We report that RPUSD4 binds 16S mt-rRNA, mttRNA Met, and mt-tRNAPhe, and we demonstrate that it is responsible for pseudouridylation of the latter. These data provide new insights into the relevance of RNA pseudouridylation in mitochondrial gene expression. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Scientific Business Abstracts.

Author

Cooles F, Vidal-Pedrola G, Naamane N, Pratt A, Barron-Millar B, Anderson A, Hilkens C, Casement J, Bondet V, Duffy D, Zhang F, Shukla R, Isaacs J, Little M, Payne M, Coupe N, Fairfax B, Taylor CA, Mackay S, Milotay G, Bos S, Hunter B, Mcdonald D, Merces G, Sheldon G, Pradère P, Majo J, Pulle J, Vanstapel A, Vanaudenaerde BM, Vos R, Filby AJ, Fisher AJ, Collier J, Lambton J, Suomi F, Prigent M, Guissart C, Erskine D, Rozanska A, Mccorvie T, Trimouille A, Imam A, Hobson E, Mccullagh H, Frengen E, Misceo D, Bjerre A, Smeland M, Klingenberg C, Alkuraya F, Mcfarland R, Alston C, Yue W, Legouis R, Koenig M, Lako M, Mcwilliams T, Oláhová M, Taylor R, Newman W, Harkness R, McDermott J, Metcalfe K, Khan N, Macken W, Pitceathly R, Record C, Maroofian R, Sabir A, Santra S, Urquhart J, Demain L, Byers H, Beaman G, Yue W, Taylor R, Durmusalioglu E, Atik T, Isik E, Cogulu O, Reunert J, Marquardt T, Ryba L, Buchert-Lo R, Haack T, Lassuthova P, Polavarapu K, Lochmuller H, Horvath R, Jamieson P, Reilly M, O'Keefe R, Boggan R, Ng YS, Franklin I, Alston C, Blakely E, Büchner B, Bugiardini E, Colclough K, Feeney C, Hanna M, Hattersley A, Klopstock T, Kornblum C, Mancuso M, Patel K, Pitceathly R, Pizzamiglio C, Prokisch H, Schäfer J, Schaefer A, Shepherd M, Thaele A, Thomas R, Turnbull D, Gorman G, Woodward C, McFarland R, Taylor R, Cordell H, Pickett S, Tsilifis C, Pearce M, Gennery A, Daly A, Darlay R, Zatorska M, Worthington S, Anstee Q, Cordell H, Reeves H, Nizami S, Mauricio-Muir J, McCain M, Singh R, Wordsworth J, Kadharusman M, Watson R, Masson S, McPherson S, Burt A, Tiniakos D, Littler P, Nsengimana J, Zhang S, Mann D, Jamieson D, Leslie J, Shukla R, Wilson C, Betts J, Croall I, Hoggard N, Bennett J, Naamane N, Hollingsworth KG, Pratt AG, Egail M, Feeney C, Di Leo V, Taylor RW, Dodds R, Anderson AE, Sayer AA, Isaacs JD, McCracken C, Condurache DG, Szabo L, Elghazaly H, Walter F, Meade A, Chakraverty R, Harvey N, Manisty C, Petersen S, Neubauer S, Raisi-Estabragh Z, Allen L, Taylor P, Carlsson A, Hagopian W, Hedlund E, Hill A, Jones A, Ludvigsson J, Onengut-Gumuscu S, Redondo M, Rich S, Gillespie K, Dayan C, Oram R, Resteu A, Wonders K, Schattenberg J, Straub B, Ekstedt M, Berzigotti A, Geier A, Francque S, Driessen A, Boursier J, Yki-Jarvinen H, Arola J, Aithal G, Holleboom A, Verheij J, Yunis C, Trylesinski A, Papatheodoridis G, Petta S, Romero-Gomez M, Bugianesi E, Paradis V, Ratziu V, Tiniakos D, Anstee Q, Burton J, Ciminata G, Geue C, Quinn T, Glover E, Morais M, Reynolds G, Denby L, Ali S, Lennon R, Sheerin N, Yang F, Zounemat-Kermani N, Dixey P, Adcock IM, Bloom CI, Chung KF, Govaere O, Hasoon M, Alexander L, Cockell S, Tiniakos D, Ekstedt M, Schattenberg JM, Boursier J, Bugianesi E, Ratziu V, Daly AK, and Anstee QM

Published
2024
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29. Translation termination in human mitochondrial ribosomes.

Author

Richter R, Pajak A, Dennerlein S, Rozanska A, Lightowlers RN, and Chrzanowska-Lightowlers ZM

Subjects
Codon, DNA, Mitochondrial genetics, Genetic Code, Humans, Ribosomes genetics, DNA, Mitochondrial metabolism, Mitochondria genetics, Mitochondria metabolism, Peptide Chain Termination, Translational, Protein Biosynthesis, Ribosomes metabolism
Abstract

Mitochondria are ubiquitous and essential organelles for all nucleated cells of higher eukaryotes. They contain their own genome [mtDNA (mitochondrial DNA)], and this autosomally replicating extranuclear DNA encodes a complement of genes whose products are required to couple oxidative phosphorylation. Sequencing of this human mtDNA more than 20 years ago revealed unusual features that included a modified codon usage. Specific deviations from the standard genetic code include recoding of the conventional UGA stop to tryptophan, and, strikingly, the apparent recoding of two arginine triplets (AGA and AGG) to termination signals. This latter reassignment was made because of the absence of cognate mtDNA-encoded tRNAs, and a lack of tRNAs imported from the cytosol. Each of these codons only occurs once and, in both cases, at the very end of an open reading frame. The presence of both AGA and AGG is rarely found in other mammals, and the molecular mechanism that has driven the change from encoding arginine to dictating a translational stop has posed a challenging conundrum. Mitochondria from the majority of other organisms studied use only UAA and UAG, leaving the intriguing question of why human organelles appear to have added the complication of a further two stop codons, AGA and AGG, or have they? In the present review, we report recent data to show that mammalian mitochondria can utilize a -1 frameshift such that only the standard UAA and UAG stop codons are required to terminate the synthesis of all 13 polypeptides.

Published
2010
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30. Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.

Author

Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZM, and Lightowlers RN

Subjects
Blotting, Northern, Cell Line, GTP-Binding Proteins genetics, HeLa Cells, Humans, Mitochondrial Proteins biosynthesis, Molecular Chaperones genetics, Molecular Chaperones metabolism, RNA genetics, RNA Interference, RNA Stability, RNA, Mitochondrial, RNA, Ribosomal genetics, RNA, Ribosomal metabolism, RNA, Ribosomal, 28S genetics, RNA-Binding Proteins genetics, GTP-Binding Proteins metabolism, RNA metabolism, RNA, Ribosomal, 28S metabolism, RNA-Binding Proteins metabolism
Abstract

The bacterial Ras-like protein Era has been reported previously to bind 16S rRNA within the 30S ribosomal subunit and to play a crucial role in ribosome assembly. An orthologue of this essential GTPase ERAL1 (Era G-protein-like 1) exists in higher eukaryotes and although its exact molecular function and cellular localization is unknown, its absence has been linked to apoptosis. In the present study we show that human ERAL1 is a mitochondrial protein important for the formation of the 28S small mitoribosomal subunit. We also show that ERAL1 binds in vivo to the rRNA component of the small subunit [12S mt (mitochondrial)-rRNA]. Bacterial Era associates with a 3' unstructured nonanucleotide immediately downstream of the terminal stem-loop (helix 45) of 16S rRNA. This site contains an AUCA sequence highly conserved across all domains of life, immediately upstream of the anti-Shine-Dalgarno sequence, which is conserved in bacteria. Strikingly, this entire region is absent from 12S mt-rRNA. We have mapped the ERAL1-binding site to a 33 nucleotide section delineating the 3' terminal stem-loop region of 12S mt-rRNA. This loop contains two adenine residues that are reported to be dimethylated on mitoribosome maturation. Furthermore, and also in contrast with the bacterial orthologue, loss of ERAL1 leads to rapid decay of nascent 12S mt-rRNA, consistent with a role as a mitochondrial RNA chaperone. Finally, whereas depletion of ERAL1 leads to apoptosis, cell death occurs prior to any appreciable loss of mitochondrial protein synthesis or reduction in the stability of mitochondrial mRNA.

Published
2010
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31. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

Author

Daniel RA, Rozanska AL, Thomas HD, Mulligan EA, Drew Y, Castelbuono DJ, Hostomsky Z, Plummer ER, Boddy AV, Tweddle DA, Curtin NJ, and Clifford SC

Subjects
Animals, Cell Line, Tumor, Cell Proliferation drug effects, Dacarbazine pharmacology, Drug Synergism, Humans, Mice, Neuroblastoma pathology, Poly (ADP-Ribose) Polymerase-1, Temozolomide, Xenograft Model Antitumor Assays, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Dacarbazine analogs & derivatives, Enzyme Inhibitors pharmacology, Indoles pharmacology, Neuroblastoma drug therapy, Poly(ADP-ribose) Polymerase Inhibitors, Topotecan pharmacology
Abstract

Purpose: High-risk neuroblastoma is characterized by poor survival rates, and the development of improved therapeutic approaches is a priority. Temozolomide and topotecan show promising clinical activity against neuroblastoma. Poly(ADP-ribose) polymerase-1 (PARP-1) promotes DNA repair and cell survival following genotoxic insult; we postulated that its inhibition may enhance the efficacy of these DNA-damaging drugs in pediatric cancers., Experimental Design: We evaluated the chemosensitizing properties of the PARP inhibitor AG014699 (Pfizer, Inc.) in combination with temozolomide and topotecan, against human neuroblastoma cells and xenografts, alongside associated pharmacologic and toxicologic indices., Results: Addition of PARP-inhibitory concentrations of AG014699 significantly potentiated growth inhibition by both topotecan (1.5- to 2.3-fold) and temozolomide (3- to 10-fold) in vitro, with equivalent effects confirmed in clonogenic assays. In two independent in vivo models (NB1691 and SHSY5Y xenografts), temozolomide caused a xenograft growth delay, which was enhanced by co-administration of AG014699, and resulted in complete and sustained tumor regression in the majority (6 of 10; 60%) of cases. Evidence of enhanced growth delay by topotecan/AG014699 co-administration was observed in NB1691 xenografts. AG014699 metabolites distributed rapidly into the plasma (Cmax, 1.2-1.9 nmol/L at 30 min) and accumulated in xenograft tissues (Cmax, 1-2 micromol/L at 120 min), associated with a sustained suppression of PARP-1 enzyme activity. Doses of AG014699 required for potentiation were not toxic per se., Conclusions: These data show enhancement of temozolomide and topotecan efficacy by PARP inhibition in neuroblastoma. Coupled with the acceptable pharmacokinetic, pharmacodynamic, and toxicity profiles of AG014699, our findings provide strong rationale for investigation of PARP inhibitors in pediatric early clinical studies.

Published
2009
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