28 results on '"Ruan, Lian"'
Search Results
2. Current state of knowledge on intelligent-response biological and other macromolecular hydrogels in biomedical engineering: A review
- Author
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Su, Mengrong, Ruan, Lian, Dong, Xiaoyu, Tian, Shujing, Lang, Wen, Wu, Minhui, Chen, Yujie, Lv, Qizhuang, and Lei, Lanjie
- Published
- 2023
- Full Text
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3. Progress in the application of sustained-release drug microspheres in tissue engineering
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Ruan, Lian, Su, Mengrong, Qin, Xinyun, Ruan, Qingting, Lang, Wen, Wu, Minhui, Chen, Yujie, and Lv, Qizhuang
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- 2022
- Full Text
- View/download PDF
4. Leading through Partnership: How the Illinois Fire Service Institute Library Leads to Serve its User-Community.
- Author
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Habing, Kelda and Ruan, Lian
- Subjects
- *
LIBRARY users , *LIBRARY mergers , *LIBRARY services platforms , *SPECIAL libraries , *LIBRARY resources - Abstract
In the over three decades since its establishment in 1990, the Illinois Fire Service Institute (IFSI) Library has been a leader through taking the initiative in developing and maintaining partnerships for the benefit of its primary user community: the firefighters of Illinois. Partnerships at the local, state, national, and international levels have allowed the IFSI Library to respond to the unique information needs of firefighters through the creation and continued use of services and programs which have been created specifically to meet these unique needs, and the IFSI Library's place within the Illinois state fire academy allows these services and programs to be promoted and made available to firefighters across the state. By taking the initiative to create partnerships for the benefit of firefighters, the IFSI Library has established itself as a leader in partnership with both the library and information science field as well as to the fire service. The services and programs made possible through the IFSI Library's partnerships have contributed to Illinois firefighters' ability to access the information and resources that they need to continue keeping their communities safe. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Factors Defining the Development of Severe Illness in Patients with COVID-19: A Retrospective Study
- Author
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XIONG, Yi Bai, TIAN, Ya Xin, MA, Yan, YANG, Wei, LIU, Bin, RUAN, Lian Guo, LU, Cheng, and HUANG, Lu Qi
- Subjects
Male ,COVID-19 ,Middle Aged ,Risk Assessment ,Severity of Illness Index ,Nomogram ,Nomograms ,Risk factors ,Humans ,Original Article ,Female ,Severe illness ,Aged ,Retrospective Studies - Abstract
Objective Early triage of patients with coronavirus disease 2019 (COVID-19) is pivotal in managing the disease. However, studies on the clinical risk score system of the risk factors for the development of severe disease are limited. Hence, we conducted a clinical risk score system for severe illness, which might optimize appropriate treatment strategies. Methods We conducted a retrospective, single-center study at the JinYinTan Hospital from January 24, 2020 to March 31, 2020. We evaluated the demographic, clinical, and laboratory data and performed a 10-fold cross-validation to split the data into a training set and validation set. We then screened the prognostic factors for severe illness using the least absolute shrinkage and selection operator (LASSO) and logistic regression, and finally conducted a risk score to estimate the probability of severe illness in the training set. Data from the validation set were used to validate the score. Results A total of 295 patients were included. From 49 potential risk factors, 3 variables were measured as the risk score: neutrophil to lymphocyte ratio (OR, 1.27; 95% CI, 1.15–1.39), albumin (OR, 0.76; 95% CI, 0.70–0.83), and chest computed tomography abnormalities (OR, 2.01; 95% CI, 1.41–2.86) and the AUC of the validation cohort was 0.822 (95% CI, 0.7667–0.8776). Conclusion This report may help define the potential of developing severe illness in patients with COVID-19 at an early stage, which might be related to the neutrophil to lymphocyte ratio, albumin, and chest computed tomography abnormalities.
- Published
- 2022
6. Introduction.
- Author
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Ruan, Lian J. and Xia, Shengping
- Subjects
- *
DIGITAL humanities , *MASSIVE open online courses , *INFORMATION resources management , *DIGITAL libraries - Abstract
This article is the second part of a special issue of Library Trends that focuses on the cultural heritage of China and the digital scholarship being applied to it. The first part covered various aspects of cultural heritage digital scholarship work in China, including international collaboration, technology, and diversity. The second part includes seven articles that highlight international collaboration, technology, and access and application in the study and preservation of China's cultural heritage. These articles demonstrate how digital scholarship can make cultural heritage more accessible and usable for scholars, students, and the general public. The authors hope that readers will gain a deeper understanding of China's cultural heritage and be inspired to explore innovative applications of digital scholarship in their own countries. [Extracted from the article]
- Published
- 2023
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7. Introduction: Cultural Heritage and Digital Scholarship in China.
- Author
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Ruan, Lian J. and Xia, Shengping
- Subjects
- *
CULTURAL property , *SCHOLARLY method , *DIGITAL humanities , *PROTECTION of cultural property , *WORLD Heritage Sites , *ETHNIC groups , *CULTURAL pluralism - Abstract
This article is an introduction to a special issue of Library Trends that focuses on cultural heritage and digital scholarship in China. It highlights the richness and diversity of China's cultural heritage, including well-known sites like the Great Wall and Forbidden City, as well as the artifacts and knowledge of ethnic minority and underserved communities. The article emphasizes the importance of preserving and protecting cultural heritage, as well as the innovative use of digital scholarship in this endeavor. The special issue covers a wide range of topics, including international collaboration, technology, diversity, and access to cultural heritage resources. It concludes by calling for continued efforts to safeguard and share Chinese cultural heritage for the benefit of the world. [Extracted from the article]
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- 2023
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8. A leadership model for Chinese American Librarians: an oral history of Dr. Hwa-Wei Lee
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He, Yan and Ruan, Lian
- Subjects
United States. Library of Congress ,Ohio University Press ,Academic libraries -- Political aspects ,Librarians -- Political activity -- Political aspects -- Achievements and awards ,Book publishing ,Chinese Americans ,Cultural history ,Ethnic, cultural, racial issues/studies ,History ,University of Pittsburgh - Abstract
Hwa-Wei Lee, former chief of the Library of Congress's Asian Division and dean emeritus of Ohio University Libraries, was born in China, did his undergraduate studies in Taiwan, and completed [...]
- Published
- 2016
9. Information-Seeking and Sharing Behaviors among Fire Service Field Staff Instructors: A Qualitative Study
- Author
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Ruan, Lian J.
- Abstract
Fire service field staff instructors seek and share information and use information sources during their instructional work of teaching, training and curriculum development. This study is the first attempt to study their information-seeking and sharing behaviors, which have not previously been investigated empirically. Twenty-five fire service instructors who are field staff instructors of the Fire Academy were recruited to participate in the study. Semi-structured interviews as primary data along with secondary data were employed and examined to answer the research questions. Today's firefighters' responsibilities cover a wide range of emergencies in areas such as firefighting, emergency medical care, hazardous materials incidents, rescue operations, terrorism and other emergency responses. The increasing complexity of the fire service requires firefighters to continually hone their skills and improve their knowledge of various hazards through training. This study's findings reveal that the field staff instructor participants rely extensively on multiple types of information sources, while seeking and sharing information during the instructional process. These sources include formal/institutional, informal/personal and group network-mediated sources of information. This study identifies three collaborative information-seeking forms of joint, tag team, and intra-group and categorizes sequences of information activities the instructor participants undertake. It also characterizes their unique attributes as information seekers. Fire service knowledge structures of KSA--(Knowledge [cognitive], Skills [psychomotor] and Affective [attitude])--influence the changing needs of instructor participants, define the boundaries of information sources in these three required domain areas that firefighters learn and train, and dictate multiple types of information sources that are used and needed by the instructor participants. The dynamic nature and uncertainty of the fire service business as well as the task complexity are basic catalysts for the instructor participants' information-seeking and sharing behaviors, which motivate them to keep seeking the best piece of information to ensure the safety of firefighters. The Recognition-Primed Decision model leads instructor participants toward a heavy reliance on experiential knowledge. Furthermore, the selection of information sources is determined by the quality of the source, and multiple types of sources of information are constantly integrated to meet the field staff instructors' constantly changing needs. Armed with new evidence, this study revises and expands Leckie's model of information-seeking of professionals. This study recognizes the critical roles of field staff instructors in fire service training as they create, retain and share knowledge, skills and experience. The study also conceptualizes their multi-dimensional information environment with a cyclical and interactive information-seeking process that would best support their work activities. It makes suggestions for future research and lays out recommendations to improve library and information services, so fire librarians and information professionals can better provide more timely services to support fire service field staff instructors' information-seeking and sharing in a complex information use environment for their daily work, practices, and routines. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2011
10. Genetic Variation Analysis of Porcine Circovirus Type 4 in South China in 2019 to 2021.
- Author
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Wu, Minhui, Chen, Yujie, Lang, Wen, Qin, Xinyun, Ruan, Lian, Su, Mengrong, and Lv, Qizhuang
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GENETIC variation ,COVID-19 ,WHOLE genome sequencing ,CAPPING proteins ,MOLECULAR epidemiology ,SEQUENCE alignment ,BIOINFORMATICS software - Abstract
Porcine circovirus type 4 (PCV4) is a novel virus associated with porcine dermatitis and nephropathy syndrome (PDNS)-like signs identified firstly in China in 2019. However, the details of the molecular epidemiology of PCV4 are unclear at this time. A total of forty-two related sequences were selected from the GenBank database to explore the spread of PCV4 and its rule in genetic evolution. Of the selected strains, 41 were from south China in 2019 to 2021 and the other was a foreign representative strain. Phylogenetic tree construction, nucleotide and amino acid (aa) sequence alignment, gene recombination and antigen structure prediction were performed on the collected sequences using bioinformatics softwares. The 42 PCV4 strains were divided into two subgenotypes: PCV4a (35/42) and PCV4b (7/42), according to the constructed genetic evolution tree. PCV4a is the main epidemic strain, and it can be further divided into two different gene clusters: PCV4a-1 (22/35) and PCV4a-2 (13/35). The pairwise comparison analysis showed that the complete genome sequence similarity of the 42 PCV4 strains ranged between 97.9% and 100%, and the aa sequences of the Cap proteins of 42 PCV4 strains had three major heterogenic or hypervariable regions—27–28, 96 and 212—all located near the antigenic epitope of the Cap protein. The results of this study can provide some basis for further studying the spread and epidemic growth of PCV4, and the prevention and control of PCV4 infection in China. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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11. Illinois Fire Service Institute Library Initiatives During the COVID-19 Pandemic.
- Author
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Ruan, Lian, Ehrenhart, David, Richardson, Diane, and Shuyi Liu
- Subjects
- *
COVID-19 pandemic , *ACADEMIC libraries , *ACADEMIC librarians , *COLLEGE students , *LECTURES & lecturing - Abstract
The Illinois Fire Service Institute (IFSI) Library provides fire and emergency library and information assistance and services to the Institute's instructional staff, students, Illinois fire departments and firefighters, and other fire/emergency-related users in the successful and effective performance of their jobs. In response to the COVID pandemic, IFSI Librarians have developed new services and resources to continue serving patrons. At the same time, new procedures and services were adopted. With the staff's return to the library's physical location, IFSI's Learning Resource and Research Center building, new COVID-19-related safety measures have been instituted. IFSI Librarians worked with IFSI staff to create the COVID-19 Archives Collection to preserve important documents about the pandemic as it occurs. The Library received grant awards respectively from IMLS and ALA. During the pandemic, the IFSI International Programs continued to provide information resources and access to international users. The Library organized online academic activities via Zoom on a variety of workshops, lectures, and discussions to ensure that users were able to receive enough resources to continue their study and research. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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12. Illinois Firefighter Line of Duty Deaths Digital Image Collection Database: A Knowledge Management Initiative
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Ruan, Lian and Groves, Adam
- Published
- 2013
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13. Factors Defining the Development of Severe Illness in Patients with COVID-19: A Retrospective Study.
- Author
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XIONG, Yi Bai, TIAN, Ya Xin, MA, Yan, YANG, Wei, LIU, Bin, RUAN, Lian Guo, LU, Cheng, and HUANG, Lu Qi
- Subjects
COVID-19 ,DISEASE risk factors ,NEUTROPHIL lymphocyte ratio ,PROGNOSIS ,MEDICAL triage - Abstract
Early triage of patients with coronavirus disease 2019 (COVID-19) is pivotal in managing the disease. However, studies on the clinical risk score system of the risk factors for the development of severe disease are limited. Hence, we conducted a clinical risk score system for severe illness, which might optimize appropriate treatment strategies. We conducted a retrospective, single-center study at the JinYinTan Hospital from January 24, 2020 to March 31, 2020. We evaluated the demographic, clinical, and laboratory data and performed a 10-fold cross-validation to split the data into a training set and validation set. We then screened the prognostic factors for severe illness using the least absolute shrinkage and selection operator (LASSO) and logistic regression, and finally conducted a risk score to estimate the probability of severe illness in the training set. Data from the validation set were used to validate the score. A total of 295 patients were included. From 49 potential risk factors, 3 variables were measured as the risk score: neutrophil to lymphocyte ratio (OR, 1.27; 95% CI, 1.15–1.39), albumin (OR, 0.76; 95% CI, 0.70–0.83), and chest computed tomography abnormalities (OR, 2.01; 95% CI, 1.41–2.86) and the AUC of the validation cohort was 0.822 (95% CI, 0.7667–0.8776). This report may help define the potential of developing severe illness in patients with COVID-19 at an early stage, which might be related to the neutrophil to lymphocyte ratio, albumin, and chest computed tomography abnormalities. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Nonmyopic Game Analysis on Quality Control of Construction Project.
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Ruan Lian-fa and Chen Yi
- Published
- 2011
- Full Text
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15. Analysis of influence factors of the popularization of green buildings based on fuzzy DEMATEL method.
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Ruan Lian-fa and Fang Hong-wei
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- 2011
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16. Comparison and selection of green building programs based on fuzzy VIKOR method.
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Ruan Lian-fa and Chen Jialing
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- 2011
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17. Automated generation of reliability test-data for real-time software with object-oriented technology.
- Author
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Chen Xuesong, Lu Minyan, and Ruan Lian
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- 2001
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18. Designing and Developing Internet Reference Services to Support Firefighter Distance Learners in Illinois.
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Ruan, Lian
- Subjects
- *
COLLECTION development in libraries , *COMPUTER assisted instruction , *INFORMATION services , *UNIVERSITIES & colleges , *ACADEMIC libraries , *INFORMATION technology - Abstract
This article discusses issues surrounding the development of a small special library's Internet reference services to support firefighter distance learners for the University of Illinois Fire Service Institute's (IFSI) online Firefighter II Certification Program, the first of its kind in the nation. Planning for the Internet reference services involves consideration of user needs, funding, staff management, and collection development. In addition, this article explores how the IFSI Library has established a collaboration and partnership with the online course and Information Technology teams, and local public and community college libraries. [ABSTRACT FROM AUTHOR]
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- 2004
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19. Providing Better Subject Access to Nonprint Fire Emergency Materials for Illinois Firefighters.
- Author
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Ruan, Lian
- Subjects
LIBRARIES ,CATALOGING ,LIBRARY materials ,ONLINE databases ,DOCUMENTATION ,LIBRARY of Congress subject headings ,MEDICAL subject headings ,DATABASE searching ,WEBSITES - Abstract
The Illinois Fire Service Institute Library (FSI Library) has the most comprehensive and popular nonprofit fire emergency collection in Illinois. Besides providing providing descriptive cataloging for nonprint materials, the Library assigns in-depth subject terms and modified Library of Congress Classification to the catalog records. The Library reviewed its subject list and found numerous inconsistencies and duplications, because catalog records are acquired from sources using different subject vocabularies. The Library began a project in August 1999 to map the Library of Congress Subject Headings (LCSH), Medical Subject Headings (MeSH) from the National Library of Medicine, and other fire vocabulary systems. The project developers created FireTalk, a new FSI thesaurus with a mix of LCSH, MeSH terms (identified as such), plus more specific fire science terms. FireTalk is used with the Library's Online Public Access Catalog at the Institute's website to enhance retrieval of relevant bibliographic citations and facilitate multiple database searching. [ABSTRACT FROM PUBLISHER]
- Published
- 2001
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20. Aiming high.
- Author
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Ruan, Lian
- Subjects
- *
LIBRARY associations , *ACADEMIC library associations , *RESEARCH library associations - Abstract
The article looks at the achievements and accomplishments of the Association of College and Research Libraries (ACRL) from 1940 to 2015. Topics discussed include the ACRL's relationship with the American Library Association (ALA), changes to the ACRL constitution and bylaws to better align with that of ALA and the role of ACRL representatives in shaping federal legislation that affect the academic libraries.
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- 2014
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21. Introduction.
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Ruan, Lian and Du, Xingye
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- 2020
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22. Strategic Planning for the Chinese American Library Association: From Process to Implementation.
- Author
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Gao, Wenli, Pun, Raymond, and Ruan, Lian
- Subjects
- *
STRATEGIC planning , *COVID-19 pandemic , *EVALUATION , *CASE studies - Abstract
This report explored the Chinese American Librarians Association (CALA)'s strategic planning process for 2020-2025 during COVID-19. The paper introduced CALA's mission statement, values, and discussed the importance of the strategic plan. A strategic planning task force was formed to create an opportunity for membership input in virtual town hall meetings and surveys. The authors presented a case study on the process of revising a strategic plan and discussed the implementation phases. The authors also shared the challenges and recommendations in organizing strategic planning for a library association. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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23. Path to Leadership: National Forum on Advancing Asian/Pacific Islander American Librarianship.
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Wenli Gao, Pun, Ray, Pelayo-Lozada, Lessa Kanani'opua, and Ruan, Lian
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- *
GRANTS (Money) , *LIBRARY associations , *LIBRARY science - Abstract
In August 2021, the Chinese American Librarians Association (CALA), in partnership with the Asian/Pacific American Librarians Association (APALA), received $100,000 in funding from the Institute of Museum and Library Services (IMLS) Laura Bush 21st Century Librarian Program National Forum Grant in the Lifelong Learning project category for Path to Leadership: National Forum to Advance Asian/Pacific Islander American (APIA) Librarianship. Funding from the grant resulted in an online national forum, webinars, and a reunion program. This paper details the planning and implementation of this project. It also includes project evaluation and a proposed curriculum outline to fully develop an APIA leadership program. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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24. IFLA WLIC 2022: CALA Members Participation and Engagement.
- Author
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Huang, Michael Bailou, Haiyun Cao, Guoying Liu, Ruan, Lian, Jingjing Wu, Hong Yao, Ning Zou, and Shali Zhang
- Subjects
- *
STUDENT engagement , *STUDENT participation - Published
- 2022
25. Career Choices and Advancement: Chinese American Librarians in the 21st Century.
- Author
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Ruan, Lian and Xiong, Jian Anna
- Subjects
LIBRARIANS ,CHINESE Americans ,COMMUNITIES ,INFORMATION science ,INFORMATION technology ,LIBRARY science research - Abstract
There is an increasing need to understand Chinese American librarians as one of the largest ethnic librarian groups in American library communities and a renewed interest to demonstrate a critical role they play in the Library and Information Science profession. This paper documents some strategies Chinese American librarians have adopted to meet the challenges and barriers they face. It is hoped that this study will encourage Chinese American librarians to develop methods for analyzing their careers so as to reach higher career goals. [ABSTRACT FROM AUTHOR]
- Published
- 2008
26. Chinese American Librarians in the 21st Century: Profile Update.
- Author
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Ruan, Lian and Xiong, Jian Anna
- Subjects
LIBRARIANS ,COMMUNITIES ,INFORMATION science ,INFORMATION technology - Abstract
There is an increasing need to understand the role of Chinese American librarians as one of the largest ethnic librarian groups in American library communities and a renewed interest to demonstrate and prove a critical role they play in the Library and Information Science profession. With first-hand insights, this study reports the current status of Chinese American librarians. It helps develop our knowledge about the Chinese American librarians in the 21st Century. A sequel study in a separate paper reports the findings of career development of Chinese American librarians and documents strategies they adapted to meet challenges and barriers facing them. [ABSTRACT FROM AUTHOR]
- Published
- 2008
27. Research progress on the role and mechanism of DNA damage repair in germ cell development.
- Author
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Wang Y, Su M, Chen Y, Huang X, Ruan L, Lv Q, and Li L
- Subjects
- Reproduction, Germ Cells, Cell Differentiation, DNA Repair, DNA Damage
- Abstract
In the complex and dynamic processes of replication, transcription, and translation of DNA molecules, a large number of replication errors or damage can occur which lead to obstacles in the development process of germ cells and result in a decreased reproductive rate. DNA damage repair has attracted widespread attention due to its important role in the maintenance and regulation of germ cells. This study reports on a systematic review of the role and mechanism of DNA damage repair in germline development. First, the causes, detection methods, and repair methods of DNA damage, and the mechanism of DNA damage repair are summarized. Second, a summary of the causes of abnormal DNA damage repair in germ cells is introduced along with common examples, and the relevant effects of germ cell damage. Third, we introduce the application of drugs related to DNA damage repair in the treatment of reproductive diseases and related surgical treatment of abnormal DNA damage, and summarize various applications of DNA damage repair in germ cells. Finally, a summary and discussion is given of the current deficiencies in DNA damage repair during germ cell development and future research development. The purpose of this paper is to provide researchers engaged in relevant fields with a further systematic understanding of the relevant applications of DNA damage repair in germ cells and to gain inspiration from it to provide new research ideas for related fields., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Wang, Su, Chen, Huang, Ruan, Lv and Li.)
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- 2023
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28. Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure.
- Author
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Li HM, Ye ZH, Zhang J, Gao X, Chen YM, Yao X, Gu JX, Zhan L, Ji Y, Xu JL, Zeng YH, Yang F, Xiao L, Sheng GG, Xin W, Long Q, Zhu QJ, Shi ZH, Ruan LG, Yang JY, Li CC, Wu HB, Chen SD, and Luo XL
- Subjects
- Adult, Cell Proliferation drug effects, China, Female, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic mortality, Hepatitis B, Chronic physiopathology, Humans, Kidney physiopathology, Liver physiopathology, Liver virology, Liver Failure diagnosis, Liver Failure mortality, Liver Failure physiopathology, Liver Failure virology, Liver Function Tests, Male, Middle Aged, Time Factors, Treatment Outcome, Drugs, Chinese Herbal therapeutic use, Hepatitis B, Chronic complications, Kidney drug effects, Liver drug effects, Liver Failure drug therapy, Liver Regeneration drug effects, Stem Cell Niche drug effects, Stem Cells drug effects
- Abstract
Aim: To study the clinical efficacy of traditional Chinese medicine (TCM) intervention "tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment" ("TTK") for treating liver failure due to chronic hepatitis B., Methods: We designed the study as a randomized controlled clinical trial. Registration number of Chinese Clinical Trial Registry is ChiCTR-TRC-12002961. A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study. Participants were randomly assigned to the following three groups: (1) a modern medicine control group (MMC group, 36 patients); (2) a "tonifying qi and detoxification" ("TQD") group (72 patients); and (3) a "tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment" ("TTK") group (36 patients). Patients in the MMC group received general internal medicine treatment; patients in the "TQD" group were given a TCM formula "tonifying qi and detoxification" and general internal medicine treatment; patients in the "TTK" group were given a TCM formula of "TTK" and general internal medicine treatment. All participants were treated for 8 wk and then followed at 48 wk following their final treatment. The primary efficacy end point was the patient fatality rate in each group. Measurements of various virological and biochemical indicators served as secondary endpoints. The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups., Results: At the 48-wk post-treatment time point, the patient fatality rates in the MMC, "TQD", and "TTK" groups were 51.61%, 35.38%, and 16.67%, respectively, and the differences between groups were statistically significant (P < 0.05). However, there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups (P > 0.05). Patients in the "TTK" group had significantly higher levels of serum total bilirubin compared to MMC subjects (339.40 μmol/L ± 270.09 μmol/L vs 176.13 μmol/L ± 185.70 μmol/L, P = 0.014). Serum albumin levels were significantly increased in both the "TQD" group and "TTK" group as compared with the MMC group (31.30 g/L ± 4.77 g/L, 30.72 g/L ± 2.89 g/L vs 28.57 g/L ± 4.56 g/L, P < 0.05). There were no significant differences in levels of alanine transaminase among the three groups (P > 0.05). Safety data showed that there was one case of stomachache in the "TQD" group and one case of gastrointestinal side effect in the "TTK" group., Conclusion: Treatment with "TTK" improved the survival rates of patients with liver failure due to chronic hepatitis B. Additionally, liver tissue was regenerated and liver function was restored.
- Published
- 2014
- Full Text
- View/download PDF
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