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1. Retraction for Woo et al., 'False-Positive Results in a Recombinant Severe Acute Respiratory Syndrome-Associated Coronavirus (SARS-CoV) Nucleocapsid Enzyme-Linked Immunosorbent Assay Due to HCoV-OC43 and HCoV-229E Rectified by Western Blotting with Recombinant SARS-CoV Spike Polypeptide'

Author

Patrick C. Y. Woo, Susanna K. P. Lau, Beatrice H. L. Wong, Kwok-Hung Chan, Wai-Ting Hui, Grace S. W. Kwan, J. S. Malik Peiris, Robert B. Couch, and Kwok-Yung Yuen

Subjects
Microbiology (medical), Membrane Glycoproteins, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Cross Reactions, Nucleocapsid Proteins, Antibodies, Viral, Severe Acute Respiratory Syndrome, Recombinant Proteins, Retraction, Severe acute respiratory syndrome-related coronavirus, Viral Envelope Proteins, Spike Glycoprotein, Coronavirus, Coronavirus Nucleocapsid Proteins, Humans, False Positive Reactions, Peptides
Abstract

Using paired serum samples obtained from patients with illness associated with increases in anti-human coronavirus OC43 (HCoV-OC43) or anti-HCoV-229E antibodies, we examined the possibility of false-positive results detected in a recombinant severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein immunoglobulin G enzyme-linked immunosorbent assay (ELISA). Three of the 21 and 1 of the 7 convalescent-phase serum samples from persons with increases in antibodies against HCoV-OC43 and HCoV-229E, respectively, tested positive by the recombinant SARS-CoV nucleocapsid protein-based ELISA. None of these samples were found to contain a specific antibody in the recombinant SARS-CoV spike polypeptide-based Western blot assay.

Published
2022

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