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Your search keyword '"SEIDEL, KRISTY"' showing total 211 results
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211 results on '"SEIDEL, KRISTY"'

3. Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Author

Vitanza, Nicholas A., Johnson, Adam J., Wilson, Ashley L., Brown, Christopher, Yokoyama, Jason K., Künkele, Annette, Chang, Cindy A., Rawlings-Rhea, Stephanie, Huang, Wenjun, Seidel, Kristy, Albert, Catherine M., Pinto, Navin, Gust, Juliane, Finn, Laura S., Ojemann, Jeffrey G., Wright, Jason, Orentas, Rimas J., Baldwin, Michael, Gardner, Rebecca A., Jensen, Michael C., and Park, Julie R.

Published
2021
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15. Nevirapine resistance by timing of HIV type 1 infection infants treated with single-dose nevirapine

Author

Micek, Mark A., Blanco, Ana Judith, Beck, Ingrid A., Dross, Sandra, Matunha, Laurinda, Montoya, Pablo, Seidel, Kristy, Gantt, Soren, Matediane, Eduardo, Jamisse, Lilia, Gloyd, Stephen, and Frenkel, Lisa M.

Subjects
HIV infection in children -- Care and treatment, HIV infection in children -- Research, Nevirapine -- Dosage and administration, Nevirapine -- Research, Drug resistance in microorganisms -- Demographic aspects, Drug resistance in microorganisms -- Research, Health, Health care industry
Published
2010

17. Do antireflux operations decrease the rate of reflux-related hospitalizations in children?

Author

Goldin, Adam B., Sawin, Robert, Seidel, Kristy D., and Flum, David R.

Subjects
Hospital care -- Statistics, Gastroesophageal reflux in children -- Care and treatment
Abstract

ABSTRACT OBJECTIVE. Gastroesophageal reflux disease is extremely common in the pediatric population, and antireflux procedures are performed with increasing frequency. The objective of this study was to determine whether pediatric [...]

Published
2006

22. The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rational

Author

Portman, Michael A., Fearneyhough, Collette, Karl, Tom R., Tong, Elizabeth, Seidel, Kristy, Mott, Antonio, Cohen, Gordon, Tacy, Theresa, Lewin, Mark, Permut, Lester, Schlater, Mary, and Azakie, Anthony

Subjects
Pediatric cardiology -- Research, Triiodothyronine -- Dosage and administration, Triiodothyronine -- Observations, Cardiopulmonary bypass -- Patient outcomes, Health
Published
2004

37. Perceptions of risk for infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Author

Gilleland Marchak, Jordan, Seidel, Kristy D., Mertens, Ann C., Ritenour, Chad W.M., Wasilewski-Masker, Karen, Leisenring, Wendy, Sklar, Charles A., Ford, Jennifer, Krull, Kevin, Stovall, Marilyn, Robison, Leslie L., Armstrong, Gregory T., and Meacham, Lillian R.

Subjects
Adult, Male, Health Knowledge, Attitudes, Practice, Adolescent, Middle Aged, Article, Cohort Studies, Young Adult, Adult Survivors of Child Adverse Events, Cancer Survivors, Patient Education as Topic, Risk Factors, Child, Preschool, Infertility, Neoplasms, Surveys and Questionnaires, Testis, population characteristics, Humans, Perception, Child
Abstract

The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer.A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37.8 years (range, 22.0-58.7 years) and were 28.4 years from their diagnosis (range, 21.4-39.2 years). Multivariable logistic regression evaluated factors associated with perceptions of risk.Overall, 35.9% of the survivors (443 of 1233 survivors) reported perceptions of their risk of infertility that were discordant with their actual risk based on previous cancer treatment exposures. Discordant perceptions were equally common among men exposed to gonadotoxic therapies (36.3%; 311 of 857 men) and those with no history of gonadotoxic exposure (35.1%; 132 of 376 men). Survivors who fathered children (odds ratio [OR], 4.14; 95% confidence interval [95% CI], 2.74-6.24), had no survivor-focused health care (OR, 3.07; 95% CI, 1.57-5.99), were nonwhite (OR, 2.28; 95% CI, 1.10-4.75), and were of lower income were more likely to report no increased risk of infertility after gonadotoxic treatment. Perceptions of increased risk of infertility among men with no history of gonadotoxic treatment were predicted by never having fathered a child (OR, 1.88; 95% CI, 1.17-3.03), recent participation in survivor-focused health care (OR, 2.11; 95% CI, 1.01-4.42), and higher educational achievement.Many male survivors of childhood cancer are unaware of how their cancer treatments could impact their reproductive health, underscoring the need for all patients to receive education regarding their risk of infertility throughout the continuum of cancer care. Cancer 2018;124:2447-55. © 2018 American Cancer Society.

Published
2018

41. Crowdsourcing to Assess Speech Quality Associated With Velopharyngeal Dysfunction.

Author

Paulsgrove, Kaylee, Miller, Erin, Seidel, Kristy, Kinter, Sara, and Tse, Raymond

Subjects
SPEECH perception, VELOPHARYNGEAL insufficiency, CROWDSOURCING
Abstract

Objective: To assess crowdsourced responses in the evaluation of speech outcomes in children with velopharyngeal dysfunction (VPD). Design: Fifty deidentified speech samples were compiled. Multiple pairwise comparisons obtained by crowdsourcing were used to produce a rank order of speech quality. Ratings of overall and specific speech characteristics were also collected. Twelve speech-language pathologists (SLPs) who specialize in VPD were asked to complete the same tasks. Crowds and experts completed each task on 2 separate occasions at least 1 week apart. Setting: On-line crowdsourcing platform. Participants: Crowdsource raters were anonymous and at least 18 years of age, North American English speakers with self-reported normal hearing. Speech-language pathologists were recruited from multiple cleft/craniofacial teams. Interventions: None. Main Outcome Measure(s): Correlation of repeated assessments and comparison of crowd and SLP assessments. Results: We obtained 6331 lay person assessments that met inclusion criteria via crowdsourcing within 8 hours. The crowds provided reproducible Elo rankings of speech quality, ρ(48) =.89; P <.0001, and consistent ratings of intelligibility and acceptability (intraclass correlation coefficient [ICC] =.87 and.92) on repeated assessments. There was a significant correlation of those crowd rankings, ρ (10) =.86; P =.0003, and ratings (ICC =.75 and.79) with those of SLPs. The correlation of more specific speech characteristics by the crowds and SLPs was moderate to weak (ICC < 0.65). Conclusions: Crowdsourcing shows promise as a rapid way to obtain large numbers of speech assessments. Reliability of repeated assessments was acceptable. Large groups of naive raters yield comparable evaluations of overall speech acceptability, intelligibility, and quality, but are not consistent with expert raters for specific speech characteristics such as resonance and nasal air emission. [ABSTRACT FROM AUTHOR]

Published
2021
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50. A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy.

Author

Brooke, Russell J, Im, Cindy, Wilson, Carmen L, Krasin, Matthew J, Liu, Qi, Li, Zhenghong, Sapkota, Yadav, Moon, WonJong, Morton, Lindsay M, Wu, Gang, Wang, Zhaoming, Chen, Wenan, Howell, Rebecca M, Armstrong, Gregory T, Bhatia, Smita, Mostoufi-Moab, Sogol, Seidel, Kristy, Chanock, Stephen J, Zhang, Jinghui, and Green, Daniel M

Subjects
CHILDHOOD cancer, TUMORS in children, CANCER patients, PREMATURE menopause, MENOPAUSE, ANTINEOPLASTIC agents, COMPARATIVE studies, GENETIC polymorphisms, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, OVARIES, OVARIAN diseases, RADIATION injuries, RADIOTHERAPY, RESEARCH, TUMORS, EVALUATION research, CASE-control method, HAPLOTYPES, SEQUENCE analysis, PHYSIOLOGICAL effects of radiation
Abstract

Background: Childhood cancer survivors are at increased risk of therapy-related premature menopause (PM), with a cumulative incidence of 8.0%, but the contribution of genetic factors is unknown.Methods: Genome-wide association analyses were conducted to identify single nucleotide polymorphisms (SNPs) associated with clinically diagnosed PM (menopause < 40 years) among 799 female survivors of childhood cancer participating in the St. Jude Lifetime Cohort Study (SJLIFE). Analyses were adjusted for cyclophosphamide equivalent dose of alkylating agents and ovarian radiotherapy (RT) dose (all P values two-sided). Replication was performed using self-reported PM in 1624 survivors participating in the Childhood Cancer Survivor Study (CCSS).Results: PM was clinically diagnosed in 30 (3.8%) SJLIFE participants. Thirteen SNPs (70 kb region of chromosome 4q32.1) upstream of the Neuropeptide Receptor 2 gene (NPY2R) were associated with PM prevalence (minimum P = 3.3 × 10-7 for rs9999820, all P < 10-5). Being a homozygous carrier of a haplotype formed by four of the 13 SNPs (seen in one in seven in the general population but more than 50% of SJLIFE clinically diagnosed PM) was associated with markedly elevated PM prevalence among survivors exposed to ovarian RT (odds ratio [OR] = 25.89, 95% confidence interval [CI] = 6.18 to 138.31, P = 8.2 × 10-6); this finding was replicated in an independent second cohort of CCSS in spite of its use of self-reported PM (OR = 3.97, 95% CI = 1.67 to 9.41, P = .002). Evidence from bioinformatics data suggests that the haplotype alters the regulation of NPY2R transcription, possibly affecting PM risk through neuroendocrine pathways.Conclusions: The haplotype captures the majority of clinically diagnosed PM cases and, with further validation, may have clinical application in identifying the highest-risk survivors for PM for possible intervention by cryopreservation. [ABSTRACT FROM AUTHOR]

Published
2018
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