21 results on '"Saez, Angela"'
Search Results
2. Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
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De Silva, Nilushi S., Siewiera, Johan, Alkhoury, Chantal, Nader, Guilherme P. F., Nadalin, Francesca, de Azevedo, Kevin, Couty, Mickaël, Izquierdo, Helena M., Bhargava, Anvita, Conrad, Cécile, Maurin, Mathieu, Antoniadou, Konstantina, Fouillade, Charles, Londono-Vallejo, Arturo, Behrendt, Rayk, Bertotti, Karine, Serdjebi, Cindy, Lanthiez, François, Gallwitz, Lisa, Saftig, Paul, Herrero-Fernández, Beatriz, Saez, Angela, González-Granado, José María, van Niel, Guillaume, Boissonnas, Alexandre, Piel, Matthieu, and Manel, Nicolas
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- 2023
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3. Role of cis-zeatin in root responses to phosphate starvation
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Silva-Navas, Javier, Conesa, Carlos M., Saez, Angela, Navarro-Neila, Sara, Garcia-Mina, Jose M., Zamarreño, Angel M., Baigorri, Roberto, Swarup, Ranjan, and del Pozo, Juan C.
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- 2019
4. CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease.
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Gomez-Bris, Raquel, Saez, Angela, Herrero-Fernandez, Beatriz, Rius, Cristina, Sanchez-Martinez, Hector, and Gonzalez-Granado, Jose M.
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INFLAMMATORY bowel diseases , *B cells , *CROHN'S disease , *PATHOLOGICAL physiology , *REGULATORY T cells , *CD4 antigen - Abstract
Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or ulcerative colitis (UC). IBD is characterized by exacerbated innate and adaptive immunity in the gut in association with microbiota dysbiosis and the disruption of the intestinal barrier, resulting in increased bacterial exposure. In response to signals from microorganisms and damaged tissue, innate immune cells produce inflammatory cytokines and factors that stimulate T and B cells of the adaptive immune system, and a prominent characteristic of IBD patients is the accumulation of inflammatory T-cells and their proinflammatory-associated cytokines in intestinal tissue. Upon antigen recognition and activation, CD4 T-cells differentiate towards a range of distinct phenotypes: T helper(h)1, Th2, Th9, Th17, Th22, T follicular helper (Tfh), and several types of T-regulatory cells (Treg). T-cells are generated according to and adapt to microenvironmental conditions and participate in a complex network of interactions among other immune cells that modulate the further progression of IBD. This review examines the role of the CD4 T-cells most relevant to IBD, highlighting how these cells adapt to the environment and interact with other cell populations to promote or inhibit the development of IBD. [ABSTRACT FROM AUTHOR]
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- 2023
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5. HAB1-SWI3B Interaction Reveals a Link between Abscisic Acid Signaling and Putative SWI/SNF Chromatin-Remodeling Complexes in Arabidopsis
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Saez, Angela, Rodrigues, Americo, Santiago, Julia, Rubio, Silvia, and Rodriguez, Pedro L.
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- 2008
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6. Enhancement of Abscisic Acid Sensitivity and Reduction of Water Consumption in Arabidopsis by Combined Inactivation of the Protein Phosphatases Type 2C ABI1 and HAB1
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Saez, Angela, Robert, Nadia, Maktabi, Mohammad H., Schroeder, Julian I., Serrano, Ramón, and Rodriguez, Pedro L.
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- 2006
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7. Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.
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Saez, Angela, Herrero-Fernandez, Beatriz, Gomez-Bris, Raquel, Sánchez-Martinez, Hector, and Gonzalez-Granado, Jose M.
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INFLAMMATORY bowel diseases , *PHAGOCYTOSIS , *CROHN'S disease , *INNATE lymphoid cells , *PATHOLOGICAL physiology , *KILLER cells - Abstract
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause. Intestinal innate immunity is enacted by neutrophils, monocytes, macrophages, and dendritic cells (DCs), and innate lymphoid cells and NK cells, characterized by their capacity to produce a rapid and nonspecific reaction as a first-line response. Innate immune cells (IIC) defend against pathogens and excessive entry of intestinal microorganisms, while preserving immune tolerance to resident intestinal microbiota. Changes to this equilibrium are linked to intestinal inflammation in the gut and IBD. IICs mediate host defense responses, inflammation, and tissue healing by producing cytokines and chemokines, activating the complement cascade and phagocytosis, or presenting antigens to activate the adaptive immune response. IICs exert important functions that promote or ameliorate the cellular and molecular mechanisms that underlie and sustain IBD. A comprehensive understanding of the mechanisms underlying these clinical manifestations will be important for developing therapies targeting the innate immune system in IBD patients. This review examines the complex roles of and interactions among IICs, and their interactions with other immune and non-immune cells in homeostasis and pathological conditions. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Triple loss of function of protein phosphatases type 2C leads to partial constitutive response to endogenous abscisic acid
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Rubio, Silvia, Rodrigues, Americo, Saez, Angela, Dizon, Marie B., Galle, Alexander, Kim, Tae-Houn, Santiago, Julia, Flexas, Jaume, Schroeder, Julian I., and Rodriguez, Pedro L.
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Phosphatases -- Research ,Abscisic acid -- Research ,Growth (Plants) -- Research ,Biological sciences ,Science and technology - Published
- 2009
9. The short-rooted phenotype of the brevis radix mutant partly reflects root abscisic acid hypersensitivity
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Rodrigues, Americo, Santiago, Julia, Rubio, Silvia, Saez, Angela, Osmont, Karen S., Gadea, Jose, Hardtke, Christian S., and Rodriguez, Pedro L.
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Plant hormones -- Research ,Abscisic acid -- Research ,Arabidopsis thaliana -- Research ,Growth (Plants) -- Research ,Roots (Botany) -- Research ,Roots (Botany) -- Growth ,Roots (Botany) -- Genetic aspects ,Company growth ,Biological sciences ,Science and technology - Published
- 2009
10. Recent Advances in Intermediate Filaments—Volume 1.
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Saez, Angela and Gonzalez-Granado, Jose M.
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CYTOPLASMIC filaments , *CELL migration , *INTERMEDIATE filament proteins , *FIBROBLAST growth factor 2 , *NUCLEAR membranes , *CYTOSKELETAL proteins - Abstract
Two studies addressed the role of vimentin or vimentin-interacting proteins in cancer cells. This keratin disassembly is accompanied by variations in cell stiffness and migration, suggesting that Withaferin-A can be a valuable drug to disturb the keratin cytoskeleton against conditions that present excessive keratin assembly, such as hyperkeratosis [[6]]. Withaferin-A, an established disruptor of vimentin filaments, can also modulate keratin filament assembly in the absence of vimentin, as occurs in epidermal keratinocytes. Vimentin has been involved in modulating the cell architecture, cell dynamics, migration, contraction, and endocytic and intracellular vesicle transport, among other cellular functions. [Extracted from the article]
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- 2022
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11. Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling
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Saez, Angela, Apostolova, Nadezda, Gonzalez-Guzman, Miguel, Gonzalez-Garcia, Mary Paz, Nicolas, Carlos, Lorenzo, Oscar, and Rodriguez, Pedro L.
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- 2004
12. The polyadenylation factor FIP1 is important for plant development and root responses to abiotic stresses.
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Téllez‐Robledo, Barbara, Manzano, Concepcion, Saez, Angela, Navarro‐Neila, Sara, Silva‐Navas, Javier, Lorenzo, Laura, González‐García, Mary‐Paz, Toribio, René, Hunt, Arthur G., Baigorri, Roberto, Casimiro, Ilda, Brady, Siobhan M., Castellano, M. Mar, and Pozo, J. Carlos
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PLANT development ,ROOT development ,PLANT roots ,ABIOTIC stress ,PLANT adaptation - Abstract
Summary: Root development and its response to environmental changes is crucial for whole plant adaptation. These responses include changes in transcript levels. Here, we show that the alternative polyadenylation (APA) of mRNA is important for root development and responses. Mutations in FIP1, a component of polyadenylation machinery, affects plant development, cell division and elongation, and response to different abiotic stresses. Salt treatment increases the amount of poly(A) site usage within the coding region and 5′ untranslated regions (5′‐UTRs), and the lack of FIP1 activity reduces the poly(A) site usage within these non‐canonical sites. Gene ontology analyses of transcripts displaying APA in response to salt show an enrichment in ABA signaling, and in the response to stresses such as salt or cadmium (Cd), among others. Root growth assays show that fip1‐2 is more tolerant to salt but is hypersensitive to ABA or Cd. Our data indicate that FIP1‐mediated alternative polyadenylation is important for plant development and stress responses. Significance Statement: Genome information is transcribed into cells through mRNA transcription. This information can be amplified by post‐transcriptional mechanisms such as alternative splicing or polyadenylation. Genome‐wide analyses of poly(A) usage in response to salt revealed that FIP1‐mediated polyadenylation is needed for plant development and responses to stress. [ABSTRACT FROM AUTHOR]
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- 2019
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13. Functional Impact of Hospitalization on COPD
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Valenza, Marie Carmen, Flores-Barba, Maria José, Valenza-Demet, Gerald, Torres-Sánchez, Irene, Cabrera-Martos, Irene, and Ruiz-Saez, Angela
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- 2014
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14. Quality of Life in Hospitalized Patients for Exacerbation of COPD Included in a Physical Therapy Program
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Torres-Sánchez, Irene, Valenza, Marie Carmen, Valenza-Demet, Gerald, Cabrera-Martos, Irene, Flores-Barba, María José, and Ruíz-Sáez, Angela
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- 2014
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15. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
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Santiago, Julia, Rodrigues, Americo, Saez, Angela, Rubio, Silvia, Antoni, Regina, Dupeux, Florine, Sang-Youl Park, Márquez, José Antonio, Cutler, Sean R., and Rodriguez, Pedro L.
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DROUGHT tolerance ,ABSCISIC acid ,PLANT development ,PHOSPHOPROTEIN phosphatases ,ARABIDOPSIS - Abstract
Abscisic acid (ABA) is a key phytohormone involved in adaption to environmental stress and regulation of plant development. Clade A protein phosphatases type 2C (PP2Cs), such as HAB1, are key negative regulators of ABA signaling in Arabidopsis. To obtain further insight into regulation of HAB1 function by ABA, we have screened for HAB1-interacting partners using a yeast two-hybrid approach. Three proteins were identified, PYL5, PYL6 and PYL8, which belong to a 14-member subfamily of the Bet v1-like superfamily. HAB1–PYL5 interaction was confirmed using BiFC and co-immunoprecipitation assays. PYL5 over-expression led to a globally enhanced response to ABA, in contrast to the opposite phenotype reported for HAB1-over-expressing plants. F
2 plants that over-expressed both HAB1 and PYL5 showed an enhanced response to ABA, indicating that PYL5 antagonizes HAB1 function. PYL5 and other members of its protein family inhibited HAB1, ABI1 and ABI2 phosphatase activity in an ABA-dependent manner. Isothermal titration calorimetry revealed saturable binding of (+)ABA to PYL5, with Kd values of 1.1 μm or 38 nm in the absence or presence of the PP2C catalytic core of HAB1, respectively. Our work indicates that PYL5 is a cytosolic and nuclear ABA receptor that activates ABA signaling through direct inhibition of clade A PP2Cs. Moreover, we show that enhanced resistance to drought can be obtained through PYL5-mediated inhibition of clade A PP2Cs. [ABSTRACT FROM AUTHOR]- Published
- 2009
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16. Corrigendum.
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Silva‐Navas, Javier, Conesa, Carlos M., Saez, Angela, Navarro‐Neila, Sara, Garcia‐Mina, Jose M., Zamarreño, Angel M., Baigorri, Roberto, Swarup, Ranjan, and del Pozo, Juan C.
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STARVATION - Published
- 2021
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17. Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease.
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Saez, Angela, Gomez-Bris, Raquel, Herrero-Fernandez, Beatriz, Mingorance, Claudia, Rius, Cristina, and Gonzalez-Granado, Jose M.
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INFLAMMATORY bowel diseases , *INNATE lymphoid cells , *INTESTINES , *INTESTINAL physiology , *CROHN'S disease , *T helper cells , *HOMEOSTASIS - Abstract
Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis (UC). IBD has been linked to genetic and environmental factors, microbiota dysbiosis, exacerbated innate and adaptive immunity and epithelial intestinal barrier dysfunction. IBD is classically associated with gut accumulation of proinflammatory Th1 and Th17 cells accompanied by insufficient Treg numbers and Tr1 immune suppression. Inflammatory T cells guide innate cells to perpetuate a constant hypersensitivity to microbial antigens, tissue injury and chronic intestinal inflammation. Recent studies of intestinal mucosal homeostasis and IBD suggest involvement of innate lymphoid cells (ILCs). These lymphoid-origin cells are innate counterparts of T cells but lack the antigen receptors expressed on B and T cells. ILCs play important roles in the first line of antimicrobial defense and contribute to organ development, tissue protection and regeneration, and mucosal homeostasis by maintaining the balance between antipathogen immunity and commensal tolerance. Intestinal homeostasis requires strict regulation of the quantity and activity of local ILC subpopulations. Recent studies demonstrated that changes to ILCs during IBD contribute to disease development. A better understanding of ILC behavior in gastrointestinal homeostasis and inflammation will provide valuable insights into new approaches to IBD treatment. This review summarizes recent research into ILCs in intestinal homeostasis and the latest advances in the understanding of the role of ILCs in IBD, with particular emphasis on the interaction between microbiota and ILC populations and functions. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.
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Saez, Angela, Herrero-Fernandez, Beatriz, Gomez-Bris, Raquel, Somovilla-Crespo, Beatriz, Rius, Cristina, and Gonzalez-Granado, Jose M.
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NUCLEAR membranes , *IMMUNE system , *CYTOPLASMIC filaments , *ANTIGEN presentation , *CELL migration , *CELL cycle , *ANTIGEN presenting cells - Abstract
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense fibrous protein meshwork located in the nuclear interior. Lamin A/C proteins regulate nuclear mechanics and structure and control cellular signaling, gene transcription, epigenetic regulation, cell cycle progression, cell differentiation, and cell migration. The immune system is composed of the innate and adaptive branches. Innate immunity is mediated by myeloid cells such as neutrophils, macrophages, and dendritic cells. These cells produce a rapid and nonspecific response through phagocytosis, cytokine production, and complement activation, as well as activating adaptive immunity. Specific adaptive immunity is activated by antigen presentation by antigen presenting cells (APCs) and the cytokine microenvironment, and is mainly mediated by the cellular functions of T cells and the production of antibodies by B cells. Unlike most cell types, immune cells regulate their lamin A/C protein expression relatively rapidly to exert their functions, with expression increasing in macrophages, reducing in neutrophils, and increasing transiently in T cells. In this review, we discuss and summarize studies that have addressed the role played by lamin A/C in the functions of innate and adaptive immune cells in the context of human inflammatory and autoimmune diseases, pathogen infections, and cancer. [ABSTRACT FROM AUTHOR]
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- 2020
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19. Alternative Polyadenylation and Salicylic Acid Modulate Root Responses to Low Nitrogen Availability.
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Conesa, Carlos M., Saez, Angela, Navarro-Neila, Sara, de Lorenzo, Laura, Hunt, Arthur G., Sepúlveda, Edgar B., Baigorri, Roberto, Garcia-Mina, Jose M., Zamarreño, Angel M., Sacristán, Soledad, and del Pozo, Juan C.
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SALICYLIC acid ,PLANT defenses ,ROOT growth ,NITROGEN ,PLANT hormones ,PLANT growth ,STARVATION - Abstract
Nitrogen (N) is probably the most important macronutrient and its scarcity limits plant growth, development and fitness. N starvation response has been largely studied by transcriptomic analyses, but little is known about the role of alternative polyadenylation (APA) in such response. In this work, we show that N starvation modifies poly(A) usage in a large number of transcripts, some of them mediated by FIP1, a component of the polyadenylation machinery. Interestingly, the number of mRNAs isoforms with poly(A) tags located in protein-coding regions or 5′-UTRs significantly increases in response to N starvation. The set of genes affected by APA in response to N deficiency is enriched in N-metabolism, oxidation-reduction processes, response to stresses, and hormone responses, among others. A hormone profile analysis shows that the levels of salicylic acid (SA), a phytohormone that reduces nitrate accumulation and root growth, increase significantly upon N starvation. Meta-analyses of APA-affected and fip1-2-deregulated genes indicate a connection between the nitrogen starvation response and salicylic acid (SA) signaling. Genetic analyses show that SA may be important for preventing the overgrowth of the root system in low N environments. This work provides new insights on how plants interconnect different pathways, such as defense-related hormonal signaling and the regulation of genomic information by APA, to fine-tune the response to low N availability. [ABSTRACT FROM AUTHOR]
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- 2020
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20. An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis
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Marcos Rodriguez, Marco Marconi, Javier Cabrera, Miguel A. Moreno-Risueno, Laura Serrano-Ron, Angela Saez, Tom Beeckman, Philip N. Benfey, Juan Carlos del Pozo, Alfonso Rodríguez-Patón, Krzysztof Wabnik, Inmaculada Gude, Hugues De Gernier, Alvaro Sanchez-Corrionero, Juan Perianez-Rodriguez, Estefano Bustillo-Avendaño, Pablo Perez-Garcia, Guy Wachsman, Ministerio de Economía y Competitividad (España), European Commission, Comunidad de Madrid, Research Foundation - Flanders, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Perianez-Rodriguez, Juan, Rodriguez, Marcos, Marconi, Marco, Bustillo-Avendaño, Estefano, Wachsman, Guy, Sanchez-Corrionero, Alvaro, De Gernier, Hugues, Cabrera, Javier, Perez-Garcia, Pablo, Gude, Inmaculada, Saez, Angela, Serrano-Ron, Laura, Beeckman, Tom, Benfey, Philip N, Rodríguez-Patón, Alfonso, Del Pozo, Juan Carlos, Wabnik, Krzysztof, Moreno-Risueno, Miguel A, Perianez-Rodriguez, Juan [0000-0003-1002-7111], Rodriguez, Marcos [0000-0003-3741-8593], Marconi, Marco [0000-0002-3457-1384], Bustillo-Avendaño, Estefano [0000-0002-1442-8791], Wachsman, Guy [0000-0002-0551-9333], Sanchez-Corrionero, Alvaro [0000-0001-5360-0294], De Gernier, Hugues [0000-0002-7644-3233], Cabrera, Javier [0000-0002-9277-4876], Perez-Garcia, Pablo [0000-0001-8595-8530], Gude, Inmaculada [0000-0002-3122-1688], Saez, Angela [0000-0002-9189-4737], Serrano-Ron, Laura [0000-0001-5180-6547], Beeckman, Tom [0000-0001-8656-2060], Benfey, Philip N [0000-0001-5302-758X], Rodríguez-Patón, Alfonso [0000-0001-7289-2114], Del Pozo, Juan Carlos [0000-0002-4113-457X], Wabnik, Krzysztof [0000-0001-7263-0560], and Moreno-Risueno, Miguel A [0000-0002-9794-1450]
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0106 biological sciences ,Cell division ,Digital storage ,PROTEINS ,Root (chord) ,CELL-DIVISION ,01 natural sciences ,Plants (botany) ,03 medical and health sciences ,DOMAIN-II ,Auxin ,Arabidopsis ,Timing circuits ,LENGTH ,TRAFFICKING ,RNA-SEQ ,Oscillating gene ,Research Articles ,Cell proliferation ,030304 developmental biology ,GENE-EXPRESSION ,chemistry.chemical_classification ,Physics ,0303 health sciences ,Multidisciplinary ,biology ,Oscillation ,Plant Sciences ,fungi ,SciAdv r-articles ,food and beverages ,Biology and Life Sciences ,Regulatory loop ,DEGRADATION ,biology.organism_classification ,OF-FUNCTION MUTATION ,chemistry ,Biophysics ,PATTERNS ,Gene expression ,Entrainment (chronobiology) ,010606 plant biology & botany ,Research Article - Abstract
CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTENT, and auxin) that form a negative regulatory loop circuit in the oscillation zone. Through multilevel computer modeling fitted to experimental data, we explain how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing. Furthermore, gravistimulation experiments based on the model predictions show that external auxin stimuli can lead to entrainment of the root clock. Our work demonstrates the mechanism underlying a robust biological clock and how it can respond to external stimuli., This work was funded by the Ministerio de Economía y Competitividad of Spain (MINECO) and/or the ERDF (BFU2016-80315-P to M.A.M.-R., BIO2017-82209-R to J.C.d.P., and TIN2016-81079-R to A.R.-P.), the Comunidad de Madrid and/or ERDF and ESF (2017-T1/BIO-5654 to K.W. and S2017/BMD-3691 to A.R.-P.), the Howard Hughes Medical Institute and the NIH (R35-GM131725 to P.N.B.), the Fonds Wetenschappelijk Onderzoek (FWO Flanders) (G022516N, G020918N, and G024118N to T.B.), and the “Severo Ochoa Program for Centres of Excellence in R&D” from the Agencia Estatal de Investigacion of Spain [SEV-2016-0672 (2017–2021)] to K.W., P.P.-G., and M.A.M.-R. through CBGP. M.M. was supported by a postdoctoral contract associated to SEV-2016-0672, E.B.-A. by Ayudante de Investigacion contract PEJ-2017-AI/BIO-7360 from the Comunidad de Madrid, A.S.-C. and L.S.-R. by FPI contracts from MINECO (BES-2014-068852 and BES-2017-080155, respectively), J.C. by a Juan de la Cierva contract from MINECO (FJCI-2016-28607), P.P.-G. by a Juan de la Cierva contract from MINECO (FJCI-2015-24905) and Programa Atraccion Talento from Comunidad Madrid (2017-T2/BIO-3453), A.S. by a Torres Quevedo contract from MINECO (PTQ-15-07915), and K.W. by program PGC2018-093387-A-I00 from the Ministerio de Ciencia e Innovacion (MICIU)
- Published
- 2021
21. An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis.
- Author
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Perianez-Rodriguez, Juan, Rodriguez, Marcos, Marconi, Marco, Bustillo-Avendaño, Estefano, Wachsman, Guy, Sanchez-Corrionero, Alvaro, De Gernier, Hugues, Cabrera, Javier, Perez-Garcia, Pablo, Gude, Inmaculada, Saez, Angela, Serrano-Ron, Laura, Beeckman, Tom, Benfey, Philip N., RodrÃguez-PatÃn, Alfonso, del Pozo, Juan Carlos, Wabnik, Krzysztof, and Moreno-Risueno, Miguel A.
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AUXIN , *ARABIDOPSIS , *NUCLEOTIDE sequencing , *BOTANY , *GREEN fluorescent protein , *ROOT development - Abstract
The article presents research report on auxin-regulable oscillatory circuit drives the root clock in Arabidopsis. Topics include how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing; and time course analyses of in-phase gene oscillations in the mutant showed a persistent signal in the oscillation zone (OZ).
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- 2021
- Full Text
- View/download PDF
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