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3. Response to 'Comment on 'Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution''

Author

Boogaard, Hanna, Atkinson, Richard W., Brook, Jeffrey R., Chang, Howard H., Hoek, Gerard, Hoffmann, Barbara, Sagiv, Sharon K., Samoli, Evangelia, Smargiassi, Audrey, Szpiro, Adam A., Vienneau, Danielle, Weuve, Jennifer, Lurmann, Frederick W., and Forastiere, Francesco

Abstract

We appreciate the emphasis on the flexibility of the OHAT approach, including a narrative assessment. We respectfully disagree that we incorrectly portrayed the OHAT approach, and we clarify below with [...]

Published
2024
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4. Temporal variations in the short-term effects of ambient air pollution on cardiovascular and respiratory mortality: a pooled analysis of 380 urban areas over a 22-year period

Author

Kan, Haidong, Osorio, Samuel, Orru, Hans, Indermitte, Ene, Maasikmets, Marek, Ryti, Niilo, Pascal, Mathilde, Katsouyanni, Klea, Analitis, Antonis, Entezari, Alireza, Mayvaneh, Fatemeh, Kim, Yoonhee, Alahmad, Barrak, Hurtado Diaz, Magali, Félix Arellano, Eunice Elizabeth, Rao, Shilpa, Diz-Lois Palomares, Alfonso, Scovronick, Noah, Acquaotta, Fiorella, Kim, Ho, Lee, Whanhee, Íñiguez, Carmen, Forsberg, Bertil, Ragettli, Martina S, Guo, Yue Leon, Pan, Shih-Chun, Li, Shanshan, Zanobetti, Antonella, Schwarz, Maximilian, Peters, Annette, Stafoggia, Massimo, de'Donato, Francesca, Sera, Francesco, Bell, Michelle L, Guo, Yuming, Honda, Yasushi, Huber, Veronika, Jaakkola, Jouni J K, Urban, Aleš, Vicedo-Cabrera, Ana Maria, Masselot, Pierre, Lavigne, Eric, Achilleos, Souzana, Kyselý, Jan, Samoli, Evangelia, Hashizume, Masahiro, Fook Sheng Ng, Chris, das Neves Pereira da Silva, Susana, Madureira, Joana, Garland, Rebecca M, Tobias, Aurelio, Armstrong, Ben, Schwartz, Joel, Gasparrini, Antonio, Schneider, Alexandra, and Breitner, Susanne

Published
2024
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5. Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, So, Rina, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Zhang, Jiawei, Zitt, Emanuel, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2023
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6. Long-term exposure to ambient air pollution and risk of lung cancer – A comparative analysis of incidence and mortality in four administrative cohorts in the ELAPSE study

Author

Chen, Jie, Atkinson, Richard W., Andersen, Zorana Jovanovic, Oftedal, Bente, Stafoggia, Massimo, Lim, Youn-Hee, Bekkevold, Terese, Krog, Norun Hjertager, Renzi, Matteo, Zhang, Jiawei, Bauwelinck, Mariska, Janssen, Nicole, Strak, Maciek, Forastiere, Francesco, de Hoogh, Kees, Rodopoulou, Sophia, Katsouyanni, Klea, Raaschou-Nielsen, Ole, Samoli, Evangelia, Brunekreef, Bert, Hoek, Gerard, and Vienneau, Danielle

Published
2024
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9. Long-term exposure to air pollution and chronic kidney disease-associated mortality–Results from the pooled cohort of the European multicentre ELAPSE-study

Author

Kadelbach, Pauline, Weinmayr, Gudrun, Chen, Jie, Jaensch, Andrea, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Ljungman, Petter, Magnusson, Patrik K.E., Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, Severi, Gianluca, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Peters, Annette, Wolf, Kathrin, Raaschou-Nielsen, Ole, Brunekreef, Bert, Hoek, Gerard, Zitt, Emanuel, and Nagel, Gabriele

Published
2024
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10. Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland

Author

Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard

Published
2023
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11. Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project

Author

Weinmayr, Gudrun, Chen, Jie, Jaensch, Andrea, Skodda, Lea, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K.E., Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, Severi, Gianluca, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, Thurston, George, Hoek, Gerard, Raaschou-Nielsen, Ole, and Nagel, Gabriele

Published
2024
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12. Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement

Author

Domingo, Nina G.G., Fiore, Arlene M., Lamarque, Jean-Francois, Kinney, Patrick L., Jiang, Leiwen, Gasparrini, Antonio, Breitner, Susanne, Lavigne, Eric, Madureira, Joana, Masselot, Pierre, Silva, Susana das Neves Pereira da, Sheng Ng, Chris Fook, Kyselý, Jan, Guo, Yuming, Tong, Shilu, Kan, Haidong, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Pascal, Mathilde, Katsouyanni, Klea, Samoli, Evangelia, Scortichini, Matteo, Stafoggia, Massimo, Hashizume, Masahiro, Alahmad, Barrak, Diaz, Magali Hurtado, De la Cruz Valencia, César, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue Leon, Pan, Shih-Chun, Colistro, Valentina, Bell, Michelle, Zanobetti, Antonella, Schwartz, Joel, Schneider, Alexandra, Vicedo-Cabrera, Ana M., and Chen, Kai

Published
2024
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13. Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort

Author

Taj, Tahir, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Besson, Caroline, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2024
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14. Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Forastiere, Francesco, Brynedal, Boel, Hertel, Ole, Hoffmann, Barbara, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, So, Rina, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2023
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15. Joint effect of heat and air pollution on mortality in 620 cities of 36 countries

Author

Stafoggia, Massimo, Michelozzi, Paola, Schneider, Alexandra, Armstrong, Ben, Scortichini, Matteo, Rai, Masna, Achilleos, Souzana, Alahmad, Barrak, Analitis, Antonis, Åström, Christofer, Bell, Michelle L., Calleja, Neville, Krage Carlsen, Hanne, Carrasco, Gabriel, Paul Cauchi, John, DSZS Coelho, Micheline, Correa, Patricia M., Diaz, Magali H., Entezari, Alireza, Forsberg, Bertil, Garland, Rebecca M., Leon Guo, Yue, Guo, Yuming, Hashizume, Masahiro, Holobaca, Iulian H., Íñiguez, Carmen, Jaakkola, Jouni J.K., Kan, Haidong, Katsouyanni, Klea, Kim, Ho, Kyselý, Jan, Lavigne, Eric, Lee, Whanhee, Li, Shanshan, Maasikmets, Marek, Madureira, Joana, Mayvaneh, Fatemeh, Fook Sheng Ng, Chris, Nunes, Baltazar, Orru, Hans, V Ortega, Nicolás, Osorio, Samuel, Palomares, Alfonso D.L., Pan, Shih-Chun, Pascal, Mathilde, Ragettli, Martina S, Rao, Shilpa, Raz, Raanan, Roye, Dominic, Ryti, Niilo, HN Saldiva, Paulo, Samoli, Evangelia, Schwartz, Joel, Scovronick, Noah, Sera, Francesco, Tobias, Aurelio, Tong, Shilu, DLC Valencia, César, Maria Vicedo-Cabrera, Ana, Urban, Aleš, Gasparrini, Antonio, Breitner, Susanne, and de' Donato, Francesca K.

Published
2023
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16. Long-Term Exposure to Low-Level P[M.sub.2.5] and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe

Author

Chen, Jie, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Wu, Xiao, Yuchi, Weiran, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A.H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Lim, Youn-Hee, Oftedal, Bente, Strak, Maciej, Vienneau, Danielle, Zhang, Jiawei, Burnett, Richard T., Hoek, Gerard, Dominici, Francesca, Brauer, Michael, and Brunekreef, Bert

Subjects
Mortality -- Statistics -- Environmental aspects -- Health aspects -- Europe -- Canada -- United States, Air pollution -- Statistics -- Health aspects, Particles -- Statistics -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter [less than or equal to]2.5 [micro]m (P[M.sub.2.5]) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on P[M.sub.2.5] effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived P[M.sub.2.5] exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-[micro]g/[m.sup.3] increase in P[M.sub.2.5] were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed P[M.sub.2.5] levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. https://doi.org/10.1289/EHP12141, Introduction Ambient particulate matter (PM) pollution has been identified as a leading risk factor for global disease burden. (1) Evaluating the risks attributable to PM with aerodynamic diameter [less than [...]

Published
2023
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17. Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution

Author

Boogaard, Hanna, Atkinson, Richard W., Brook, Jeffrey R., Chang, Howard H., Hoek, Gerard, Hoffmann, Barbara, Sagiv, Sharon K., Samoli, Evangelia, Smargiassi, Audrey, Szpiro, Adam A., Vienneau, Danielle, Weuve, Jennifer, Lurmann, Frederick W., and Forastiere, Francesco

Subjects
United States. Environmental Protection Agency, Oncology, Experimental, Environmental health, Cancer -- Prevention -- Research, Air pollution, Educational evaluation, Environmental issues, Health, United Nations. International Labour Organization
Abstract

Background: There is a long tradition in environmental health of using frameworks for evidence synthesis, such as those of the U.S. Environmental Protection Agency for its Integrated Science Assessments and the International Agency for Research on Cancer Monographs. The framework, Grading of Recommendations Assessment, Development, and Evaluation (GRADE), was developed for evidence synthesis in clinical medicine. The U.S. Office of Health Assessment and Translation (OHAT) elaborated an approach for evidence synthesis in environmental health building on GRADE. Methods: We applied a modified OHAT approach and a broader 'narrative' assessment to assess the level of confidence in a large systematic review on traffic-related air pollution and health outcomes. Discussion: We discuss several challenges with the OHAT approach and its implementation and suggest improvements for synthesizing evidence from observational studies in environmental health. We consider the determination of confidence using a formal rating scheme of up- and downgrading of certain factors, the treatment of every factor as equally important, and the lower initial confidence rating of observational studies to be fundamental issues in the OHAT approach. We argue that some observational studies can offer high-confidence evidence in environmental health. We note that heterogeneity in magnitude of effect estimates should generally not weaken the confidence in the evidence, and consistency of associations across study designs, populations, and exposure assessment methods may strengthen confidence in the evidence. We mention that publication bias should be explored beyond statistical methods and is likely limited when large and collaborative studies comprise most of the evidence and when accrued over several decades. We propose to identify possible key biases, their most likely direction, and their potential impacts on the results. We think that the OHAT approach and other GRADE-type frameworks require substantial modification to align better with features of environmental health questions and the studies that address them. We emphasize that a broader, 'narrative' evidence assessment based on the systematic review may complement a formal GRADE-type evaluation. https://doi.org/10.1289/EHP11532, Introduction Evidence synthesis is widely used to summarize findings of health effects studies of environmental exposures. Such syntheses are typically part of systematic reviews of observational epidemiologic study findings and [...]

Published
2023
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18. Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe

Author

de Bont, Jeroen, Pickford, Regina, Åström, Christofer, Coloma, Fabian, Dimakopoulou, Konstantina, de Hoogh, Kees, Ibi, Dorina, Katsouyanni, Klea, Melén, Erik, Nobile, Federica, Pershagen, Göran, Persson, Åsa, Samoli, Evangelia, Stafoggia, Massimo, Tonne, Cathryn, Vlaanderen, Jelle, Wolf, Kathrin, Vermeulen, Roel, Peters, Annette, and Ljungman, Petter

Published
2023
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20. Comparison of traditional Cox regression and causal modeling to investigate the association between long-term air pollution exposure and natural-cause mortality within European cohorts

Author

Wolf, Kathrin, Rodopoulou, Sophia, Chen, Jie, Andersen, Zorana J., Atkinson, Richard W., Bauwelinck, Mariska, Janssen, Nicole A.H., Kristoffersen, Doris Tove, Lim, Youn-Hee, Oftedal, Bente, Strak, Maciek, Vienneau, Danielle, Zhang, Jiawei, Brunekreef, Bert, Hoek, Gerard, Stafoggia, Massimo, and Samoli, Evangelia

Published
2023
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21. Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study

Author

So, Rina, Chen, Jie, Stafoggia, Massimo, de Hoogh, Kees, Katsouyanni, Klea, Vienneau, Danielle, Samoli, Evangelia, Rodopoulou, Sophia, Loft, Steffen, Lim, Youn-Hee, Westendorp, Rudi G.J., Amini, Heresh, Cole-Hunter, Thomas, Bergmann, Marie, Shahri, Seyed Mahmood Taghavi, Zhang, Jiawei, Maric, Matija, Mortensen, Laust H., Bauwelinck, Mariska, Klompmaker, Jochem O., Atkinson, Richard W., Janssen, Nicole A.H., Oftedal, Bente, Renzi, Matteo, Forastiere, Francesco, Strak, Maciek, Brunekreef, Bert, Hoek, Gerard, and Andersen, Zorana J.

Published
2023
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22. Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries

Author

Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne

Published
2023
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23. Excess mortality attributed to heat and cold: a health impact assessment study in 854 cities in Europe

Author

Achilleos, Souzana, Kyselý, Jan, Indermitte, Ene, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Katsouyanni, Klea, Analitis, Antonis, Goodman, Patrick, Zeka, Ariana, Michelozzi, Paola, Houthuijs, Danny, Ameling, Caroline, Rao, Shilpa, das Neves Pereira da Silva, Susana, Madureira, Joana, Holobaca, Iulian-Horia, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Surname, First name, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Monteiro, Ana, Rai, Masna, Zhang, Siqi, Aunan, Kristin, Masselot, Pierre, Mistry, Malcolm, Vanoli, Jacopo, Schneider, Rochelle, Iungman, Tamara, Garcia-Leon, David, Ciscar, Juan-Carlos, Feyen, Luc, Orru, Hans, Urban, Aleš, Breitner, Susanne, Huber, Veronika, Schneider, Alexandra, Samoli, Evangelia, Stafoggia, Massimo, de’Donato, Francesca, Armstrong, Ben, Nieuwenhuijsen, Mark, Vicedo-Cabrera, Ana Maria, and Gasparrini, Antonio

Published
2023
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24. Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study

Author

Cole-Hunter, Thomas, Zhang, Jiawei, So, Rina, Samoli, Evangelia, Liu, Shuo, Chen, Jie, Strak, Maciej, Wolf, Kathrin, Weinmayr, Gudrun, Rodopolou, Sophia, Remfry, Elizabeth, de Hoogh, Kees, Bellander, Tom, Brandt, Jørgen, Concin, Hans, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hoffmann, Barbara, Hvidtfeldt, Ulla A., Jöckel, Karl-Heinz, Mortensen, Laust H., Ketzel, Matthias, Yacamán Méndez, Diego, Leander, Karin, Ljungman, Petter, Faure, Elodie, Lee, Pei-Chen, Elbaz, Alexis, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, Vermeulen, Roel C.H., Schramm, Sara, Stafoggia, Massimo, Katsouyanni, Klea, Brunekreef, Bert, Hoek, Gerard, Lim, Youn-Hee, and Andersen, Zorana J.

Published
2023
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25. Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

Author

Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Taj, Tahir, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Verschuren, W. M. Monique, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, van der Schouw, Yvonne T., Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Raaschou-Nielsen, Ole, and Hoek, Gerard

Published
2022
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26. Long-Term Exposure to Particulate Matter and Mortality: An Update of the WHO Global Air Quality Guidelines Systematic Review and Meta-Analysis.

Author

Orellano, Pablo, Kasdagli, Maria-Iosifina, Pérez Velasco, Román, and Samoli, Evangelia

Subjects
POLLUTION risk assessment, HEALTH risk assessment, AIR pollution, AIR quality, PARTICULATE matter
Abstract

Objectives: For the development of the 2021 global air quality guidelines, the World Health Organization (WHO) commissioned a series of systematic reviews and metaanalyses to assess the association between exposure to air pollution and all-cause and cause-specific mortality. One of these reviews, which we aim to update, focused on the effects of long-term exposure to PM2.5 and PM10 on all-cause and causespecific mortality. Methods: The protocol for this study was registered in PROSPERO (CRD42023425327). We searched the PubMed and Embase databases for studies published between September 2018 and May 2023. Study-specific effects were pooled using randomeffects models. Results: We included 106 studies in the meta-analysis, 46 studies from the previous review and 60 from this update. All exposure-outcome pairs analysed showed positive and significant associations, except for PM10 and cerebrovascular mortality. The certainty of the evidence was rated as high for the majority of exposure-outcome pairs. Conclusion: We included a large number of new cohorts, and provided new concentration-response functions that will inform WHO advice on the use of this information for air pollution health risk assessments. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project

Author

Stafoggia, Massimo, Oftedal, Bente, Chen, Jie, Rodopoulou, Sophia, Renzi, Matteo, Atkinson, Richard W, Bauwelinck, Mariska, Klompmaker, Jochem O, Mehta, Amar, Vienneau, Danielle, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, de Hoogh, Kees, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla A, Jöckel, Karl-Heinz, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Kristoffersen, Doris Tove, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter L S, Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Rizzuto, Debora, Schramm, Sara, Schwarze, Per E, Severi, Gianluca, Sigsgaard, Torben, Strak, Maciek, van der Schouw, Yvonne T, Verschuren, Monique, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Samoli, Evangelia, Forastiere, Francesco, Brunekreef, Bert, Hoek, Gerard, and Janssen, Nicole A H

Published
2022
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29. Mortality risk attributable to wildfire-related PM2·5 pollution: a global time series study in 749 locations

Author

Chen, Gongbo, Guo, Yuming, Yue, Xu, Tong, Shilu, Gasparrini, Antonio, Bell, Michelle L, Armstrong, Ben, Schwartz, Joel, Jaakkola, Jouni J K, Zanobetti, Antonella, Lavigne, Eric, Nascimento Saldiva, Paulo Hilario, Kan, Haidong, Royé, Dominic, Milojevic, Ai, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Samoli, Evangelia, Mayvaneh, Fatemeh, Sera, Francesco, Carrasco-Escobar, Gabriel, Lei, Yadong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Teixeira, João Paulo, Madureira, Joana, Katsouyanni, Klea, Hurtado-Díaz, Magali, Maasikmets, Marek, Ragettli, Martina S, Hashizume, Masahiro, Stafoggia, Massimo, Pascal, Mathilde, Scortichini, Matteo, de Sousa Zanotti Stagliorio Coêlho, Micheline, Valdés Ortega, Nicolás, Ryti, Niilo R I, Scovronick, Noah, Matus, Patricia, Goodman, Patrick, Garland, Rebecca M, Abrutzky, Rosana, Garcia, Samuel Osorio, Rao, Shilpa, Fratianni, Simona, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Ye, Tingting, Yu, Wenhua, Abramson, Michael J, Samet, Jonathan M, and Li, Shanshan

Published
2021
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30. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project

Author

Wolf, Kathrin, Hoffmann, Barbara, Andersen, Zorana J, Atkinson, Richard W, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, de Faire, Ulf, de Hoogh, Kees, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hvidtfeldt, Ulla Arthur, Janssen, Nicole A H, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O, Lager, Anton, Liu, Shuo, MacDonald, Conor J, Magnusson, Patrik K E, Mehta, Amar J, Nagel, Gabriele, Oftedal, Bente, Pedersen, Nancy L, Pershagen, Göran, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, van der Schouw, Yvonne T, Schramm, Sara, Schwarze, Per, Sigsgaard, Torben, Sørensen, Mette, Stafoggia, Massimo, Strak, Maciek, Tjønneland, Anne, Verschuren, W M Monique, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, Peters, Annette, and Ljungman, Petter L S

Published
2021
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31. Short term association between ozone and mortality : global two stage time series study in 406 locations in 20 countries

Author

Vicedo-Cabrera, Ana M, Sera, Francesco, Liu, Cong, Armstrong, Ben, Milojevic, Ai, Guo, Yuming, Tong, Shilu, Lavigne, Eric, Kyselý, Jan, Urban, Aleš, Orru, Hans, Indermitte, Ene, Pascal, Mathilde, Huber, Veronika, Schneider, Alexandra, Katsouyanni, Klea, Samoli, Evangelia, Stafoggia, Massimo, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Ng, Chris Fook Sheng, Hurtado-Diaz, Magali, Cruz, Julio, Silva, Susana, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S, Röösli, Martin, Guo, Yue-Liang Leon, Chen, Bing-Yu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L, Kan, Haidong, and Gasparrini1, Antonio

Published
2020

33. External exposome and all-cause mortality in European cohorts: the EXPANSE project.

Author

Nobile, Federica, Dimakopoulou, Konstantina, Åström, Christofer, Coloma, Fabián, Dadvand, Payam, de Bont, Jeroen, de Hoogh, Kees, Ibi, Dorina, Katsouyanni, Klea, Ljungman, Petter, Melén, Erik, Nieuwenhuijsen, Mark, Pickford, Regina, Sommar, Johan Nilsson, Tonne, Cathryn, Vermeulen, Roel C. H., Vienneau, Danielle, Vlaanderen, Jelle J., Wolf, Kathrin, and Samoli, Evangelia

Subjects
ENVIRONMENTAL exposure, AIR pollution, ATMOSPHERIC temperature, BUILT environment, HEALTH planning
Abstract

Background: Many studies reported associations between long-term exposure to environmental factors and mortality; however, little is known on the combined effects of these factors and health. We aimed to evaluate the association between external exposome and all-cause mortality in large administrative and traditional adult cohorts in Europe. Methods: Data from six administrative cohorts (Catalonia, Greece, Rome, Sweden, Switzerland and the Netherlands, totaling 27,913,545 subjects) and three traditional adult cohorts (CEANS-Sweden, EPIC-NL-the Netherlands, KORA-Germany, totaling 57,653 participants) were included. Multiple exposures were assigned at the residential addresses, and were divided into three a priori defined domains: (1) air pollution [fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and warm-season Ozone (warm-O3)]; (2) land/built environment (Normalized Difference Vegetation Index--NDVI, impervious surfaces, and distance to water); (3) air temperature (cold- and warm-season mean and standard deviation). Each domain was synthesized through Principal Component Analysis (PCA), with the aim of explaining at least 80% of its variability. Cox proportional-hazards regression models were applied and the total risk of the external exposome was estimated through the Cumulative Risk Index (CRI). The estimates were adjusted for individual- and area-level covariates. Results: More than 205 million person-years at risk and more than 3.2 million deaths were analyzed. In single-component models, IQR increases of the first principal component of the air pollution domain were associated with higher mortality [HRs ranging from 1.011 (95% CI: 1.005-1.018) for the Rome cohort to 1.076 (1.071-1.081) for the Swedish cohort]. In contrast, lower levels of the first principal component of the land/built environment domain, pointing to reduced vegetation and higher percentage of impervious surfaces, were associated with higher risks. Finally, the CRI of external exposome increased mortality for almost all cohorts. The associations found in the traditional adult cohorts were generally consistent with the results from the administrative ones, albeit without reaching statistical significance. Discussion: Various components of the external exposome, analyzed individually or in combination, were associated with increased mortality across European cohorts. This sets the stage for future research on the connections between various exposure patterns and human health, aiding in the planning of healthier cities. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Differential Mortality Risks Associated With PM2.5 Components: A Multi-Country, Multi-City Study

Author

Masselot, Pierre, Sera, Francesco, Schneider, Rochelle, Kan, Haidong, Lavigne, Éric, Stafoggia, Massimo, Tobias, Aurelio, Chen, Hong, Burnett, Richard T., Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Chen, Bing-Yu, Guo, Yue-Liang Leon, Ragettli, Martina S., Vicedo-Cabrera, Ana Maria, Åström, Christofer, Forsberg, Bertil, Íñiguez, Carmen, Garland, Rebecca M., Scovronick, Noah, Madureira, Joana, Nunes, Baltazar, De la Cruz Valencia, César, Hurtado Diaz, Magali, Honda, Yasushi, Hashizume, Masahiro, Ng, Chris Fook Cheng, Samoli, Evangelia, Katsouyanni, Klea, Schneider, Alexandra, Breitner, Susanne, Ryti, Niilo R.I., Jaakkola, Jouni J.K., Maasikmets, Marek, Orru, Hans, Guo, Yuming, Valdés Ortega, Nicolás, Matus Correa, Patricia, Tong, Shilu, and Gasparrini, Antonio

Published
2022
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41. Association Between Short-term Exposure to Ultrafine Particles and Mortality in Eight European Urban Areas

Author

UF&HEALTH Study Group, Stafoggia, Massimo, Schneider, Alexandra, Cyrys, Josef, Samoli, Evangelia, Andersen, Zorana Jovanovic, Bedada, Getahun Bero, Bellander, Tom, Cattani, Giorgio, Eleftheriadis, Konstantinos, Faustini, Annunziata, Hoffmann, Barbara, Jacquemin, Bénédicte, Katsouyanni, Klea, Massling, Andreas, Pekkanen, Juha, Perez, Noemi, Peters, Annette, Quass, Ulrich, Yli-Tuomi, Tarja, and Forastiere, Francesco

Published
2017

45. Sociodemographic Disparities in Adults with Kidney Failure: A Meta-Analysis.

Author

Bellos, Ioannis, Marinaki, Smaragdi, Samoli, Evangelia, Boletis, Ioannis N., and Benetou, Vassiliki

Subjects
KIDNEY failure, ADULTS, CENTRAL venous catheters, PERITONEAL dialysis, KIDNEY transplantation, ETHNICITY, CHILD patients
Abstract

This meta-analysis aims to assess current evidence regarding sociodemographic disparities among adults with kidney failure. Medline, Scopus, Web of Science, CENTRAL, and Google Scholar were systematically searched from inception to 20 February 2022. Overall, 165 cohort studies were included. Compared to White patients, dialysis survival was significantly better among Black (hazard ratio—HR: 0.68; 95% CI: 0.61–0.75), Asian (HR: 0.67; 95% CI: 0.61–0.72) and Hispanic patients (HR: 0.80; 95% CI: 0.73–0.88). Black individuals were associated with lower rates of successful arteriovenous fistula use, peritoneal dialysis and kidney transplantation, as well as with worse graft survival. Overall survival was significantly better in females after kidney transplantation compared to males (HR: 0.87; 95% CI: 0.84–0.90). Female sex was linked to higher rates of central venous catheter use and a lower probability of kidney transplantation. Indices of low SES were associated with higher mortality risk (HR: 1.22, 95% CI: 1.14–1.31), reduced rates of dialysis with an arteriovenous fistula, peritoneal dialysis and kidney transplantation, as well as higher graft failure risk. In conclusion, Black, Asian and Hispanic patients present better survival in dialysis, while Black, female and socially deprived patients demonstrate lower rates of successful arteriovenous fistula use and limited access to kidney transplantation. PROSPERO registration: CRD42022300839. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Long-Term Exposure to Low-Level PM2.5 and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe.

Author

Jie Chen, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Xiao Wu, Weiran Yuchi, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A. H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Youn-Hee Lim, and Oftedal, Bente

Subjects
MORTALITY risk factors, PARTICULATE matter, AERODYNAMICS, RELATIVE medical risk, CONFIDENCE intervals, NOSOLOGY, META-analysis, RISK assessment, SOCIAL classes, DESCRIPTIVE statistics, DATA analysis software, ENVIRONMENTAL exposure, LONGITUDINAL method, PROPORTIONAL hazards models, MEDICARE, POISSON distribution
Abstract

BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on PM2.5 effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived PM2.5 exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-μg/m³ increase in PM2.5 were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed PM2.5 levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. [ABSTRACT FROM AUTHOR]

Published
2023
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