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10 results on '"Sanchez‐Reus, Ferran"'

1. Detection of azole resistance in Aspergillus fumigatus complex isolates using MALDI-TOF mass spectrometry

Author

Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Zvezdanova, Margarita Estreya, Arroyo, Manuel J., Méndez, Gema, Candela, Ana, Mancera, Luis, Rodríguez, Julio García, and Rodríguez-Sánchez, Belén

Published
2022
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2. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015

Author

Perez-Nadales, Elena, Alastruey-Izquierdo, Ana, Linares-Sicilia, Maria Jose, Soto-Debran, Juan Carlos, Abdala, Edson, Garcia-Rodriguez, Julio, Montejo, Miguel, Munoz, Patricia, Lleti, Miguel Salavert, Rezusta, Antonio, de Pipaon, Maite Ruiz Perez, Yanez, Lucrecia, Merino, Esperanza, Campos-Herrero, Maria Isolina, Costa-Mateo, Jose Maria, Fortun, Jesus, Garcia-Lozano, Tomas, Garcia-Vidal, Carolina, Fernandez-Ruiz, Mario, Sanchez-Reus, Ferran, Castro-Mendez, Carmen, Guerrero-Lozano, Inmaculada, Soler-Palacin, Pere, Aguado, Jose Maria, Martinez-Martinez, Luis, Torre-Cisneros, Julian, and Nucci, Marcio

Subjects
Neutropenia -- Complications and side effects -- Demographic aspects, Mycoses -- Diagnosis -- Risk factors -- Demographic aspects, Fusarium -- Health aspects, Health
Abstract

Invasive fusariosis (IF) is a fungal disease that mostly affects patients with hematologic malignancies or who have received hematopoietic cell transplants. These patients often have prolonged and profound neutropenia, low [...]

Published
2021
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5. Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain

Author

Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Rodríguez-Sánchez, Belén, Martín-Gómez, María Teresa, Ibáñez-Martínez, Elisa, García-Gómez de la Pedrosa, Elia, Tejero-García, Rocío, Labayru-Echeverría, Cristina, and Alastruey-Izquierdo, Ana

Published
2021
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9. In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida : A European Study.

Author

Quindós, Guillermo, Miranda-Cadena, Katherine, San-Millán, Rosario, Borroto-Esoda, Katyna, Cantón, Emilia, Linares-Sicilia, María José, Hamprecht, Axel, Montesinos, Isabel, Tortorano, Anna Maria, Prigitano, Anna, Vidal-García, Matxalen, Marcos-Arias, Cristina, Guridi, Andrea, Sanchez-Reus, Ferran, Machuca-Bárcena, Jesús, Rodríguez-Iglesias, Manuel Antonio, Martín-Mazuelos, Estrella, Castro-Méndez, Carmen, López-Soria, Leyre, and Ruiz-Gaitán, Alba

Subjects
CANDIDEMIA, CANDIDA, CANDIDA tropicalis, INVASIVE candidiasis, CANDIDA albicans, CASPOFUNGIN, SPECIES
Abstract

Background: Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. Objective: The aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolates of Candida. Methods: Ibrexafungerp, caspofungin, fluconazole, and micafungin minimum inhibitory concentrations (MICs) were collected from 12 European laboratories for 434 blood isolates, including 163 Candida albicans , 108 Candida parapsilosis , 60 Candida glabrata , 40 Candida tropicalis , 29 Candida krusei , 20 Candida orthopsilosis , 6 Candida guilliermondii , 2 Candida famata , 2 Candida lusitaniae , and 1 isolate each of Candida bracarensis, Candida catenulata , Candida dubliniensis , and Candida kefyr. MICs were determined by the EUCAST broth microdilution method, and isolates were classified according to recommended clinical breakpoints and epidemiological cutoffs. Additionally, 22 Candida auris from different clinical specimens were evaluated. Results: Ibrexafungerp MICs ranged from 0.016 to ≥8 mg/L. The lowest ibrexafungerp MICs were observed for C. albicans (geometric MIC 0.062 mg/L, MIC range 0.016–0.5 mg/L) and the highest ibrexafungerp MICs were observed for C. tropicalis (geometric MIC 0.517 mg/L, MIC range 0.06–≥8 mg/L). Modal MICs/MIC50s (mg/L) against Candida spp. were 0.125/0.06 for C. albicans , 0.5/0.5 for C. parapsilosis , 0.25/0.25 for C. glabrata , 0.5/0.5 for C. tropicalis , 1/1 for C. krusei , 4/2 for C. orthopsilosis , and 0.5/0.5 for C. auris. Ibrexafungerp showed activity against fluconazole- and echinocandin-resistant isolates. If adopting wild-type upper limits, a non-wild-type phenotype for ibrexafungerp was only observed for 16/434 (3.7%) isolates: 11 (4.6%) C. parapsilosis , 4 (5%) C. glabrata , and 1 (2.5%) C. tropicalis. Conclusion: Ibrexafungerp showed a potent in vitro activity against Candida. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Pseudomonas aeruginosa resistance patterns and clinical outcomes in hospitalized exacerbations of COPD.

Author

Rodrigo‐Troyano, Ana, Suarez‐Cuartin, Guillermo, Peiró, Meritxell, Barril, Silvia, Castillo, Diego, Sanchez‐Reus, Ferran, Plaza, Vicente, Restrepo, Marcos I., Chalmers, James D., and Sibila, Oriol

Subjects
OBSTRUCTIVE lung disease treatment, PSEUDOMONAS aeruginosa infections, OBSTRUCTIVE lung diseases patients, DRUG resistance, SPUTUM examination, THERAPEUTICS
Abstract

Background and objective Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) due to Pseudomonas aeruginosa (PA) are associated with worse outcomes. PA antibiotic resistance is important to determine treatment and may influence clinical outcomes. The aim was to study clinical characteristics and outcomes in patients with AECOPD associated with PA based on their antibiotic resistance. Methods This was a prospective observational study including all patients with AECOPD and positive PA sputum culture admitted in a respiratory ward in a tertiary hospital in Barcelona during 2013-2014. PA was defined as resistant (PA-R) when the antibiogram showed ≥1 resistance. Results Four hundred one patients with AECOPD were evaluated. Of them, 54 (13%) had a positive PA sputum culture. Eighty-two per cent were men, median age was 77 (SD 7) years old and FEV1 was less than 36% (SD 17) of predicted value. PA-R was isolated in 35 patients (66%), and PA-sensitive (PA-S) was isolated in 18 (34%) patients. No differences were found in demographics, lung function and comorbidities among groups. PA-R patients were more likely exposed to prior oral corticosteroids (77% vs 44%, P = 0.03) and antibiotics (77% vs 31%, P = 0.01), respectively. AECOPD patients associated with PA-S were more likely to die at 30 days (odds ratio 13.53, 95% confidence interval: 1.14-69.56, P = 0.03) and 90 days (odds ratio 7.09, 95% confidence interval: 1.33-37.89, P = 0.02), respectively. Conclusion Pseudomonas aeruginosa-resistant affects patients with severe AECOPD and previous use of corticosteroids and antibiotics. The presence of PA-S is associated with higher mortality. These results may suggest increased virulence in PA-S strains causing acute infections. [ABSTRACT FROM AUTHOR]

Published
2016
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