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827 results on '"Schoenfeld, David"'

1. Interview Day Environment May Influence Applicant Selection of Emergency Medicine Residency Programs

Author

Lewis, Jason, Dubosh, Nicole, Rosen, Carlo, Schoenfeld, David, Fisher, Jonathan, and Ullman, Edward

Subjects
residency, match, interview day, Medicine, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

The structure of the interview day affects applicant interactions with faculty and residents, which can influence the applicant’s rank list decision. We aimed to determine if there was a difference in matched residents between those interviewing on a day on which didactics were held and had increased resident and faculty presence (didactic day) versus an interview day with less availability for applicant interactions with residents and faculty (non-didactic day). This was a retrospective study reviewing interview dates of matched residents from 2009-2015. Forty-two (61.8%) matched residents interviewed on a didactic day with increased faculty and resident presence versus 26 (38.2%) on a non-didactic interview day with less availability for applicant interactions (p = 0.04). There is an association between interviewing on a didactic day with increased faculty and resident presence and matching in our program.

Published
2017
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10. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better

Author

Djureinovic, Dijana, Weiss, Sarah A., Krykbaeva, Irina, Qu, Rihao, Vathiotis, Ioannis, Moutafi, Myrto, Zhang, Lin, Perdigoto, Ana L., Wei, Wei, Anderson, Gail, Damsky, William, Hurwitz, Michael, Johnson, Barbara, Schoenfeld, David, Mahajan, Amit, Hsu, Frank, Miller-Jensen, Kathryn, Kluger, Yuval, Sznol, Mario, Kaech, Susan M., Bosenberg, Marcus, Jilaveanu, Lucia B., and Kluger, Harriet M.

Published
2023
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17. Assessing the one‐month mortality impact of civilian‐setting prehospital transfusion: A systematic review and meta‐analysis.

Author

Schoenfeld, David W., Rosen, Carlo L., Harris, Tim, and Thomas, Stephen H.

Subjects
RISK assessment, MEDICAL information storage & retrieval systems, PROBABILITY theory, EMERGENCY medicine, EMERGENCY medical services, HOSPITAL mortality, META-analysis, RELATIVE medical risk, SYSTEMATIC reviews, MEDLINE, BLOOD transfusion, ONLINE information services
Abstract

Background: Based on convincing evidence for outcomes improvement in the military setting, the past decade has seen evaluation of prehospital transfusion (PHT) in the civilian emergency medical services (EMS) setting. Evidence synthesis has been challenging, due to study design variation with respect to both exposure (type of blood product administered) and outcome (endpoint definitions and timing). The goal of the current meta‐analysis was to execute an overarching assessment of all civilian‐arena randomized controlled trial (RCT) evidence focusing on administration of blood products compared to control of no blood products. Method: The review structure followed the Cochrane group's Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA). Using the Transfusion Evidence Library (transfusionevidencelibrary.com), the multidatabase (e.g. PubMed, EMBASE) Harvard On‐Line Library Information System (HOLLIS), and GoogleScholar, we accessed many databases and gray literature sources. RCTs of PHT in the civilian setting with a comparison group receiving no blood products with 1‐month mortality outcomes were identified. Results: In assessing a single patient‐centered endpoint—1‐month mortality—we calculated an overall risk ratio (RR) estimate. Analysis of three RCTs yielded a model with acceptable heterogeneity (I2 = 48%, Q‐test p = 0.13). Pooled estimate revealed civilian PHT results in a statistically nonsignificant (p = 0.38) relative mortality reduction of 13% (RR 0.87, 95% CI 0.63–1.19). Conclusions: Current evidence does not demonstrate 1‐month mortality benefit of civilian‐setting PHT. This should give pause to EMS systems considering adoption of civilian‐setting PHT programs. Further studies should not only focus on which formulations of blood products might improve outcomes but also focus on which patients are most likely to benefit from any form of civilian‐setting PHT. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Application of Genome-Wide Expression Analysis to Human Health and Disease

Author

Cobb, J. Perren, Mindrinos, Michael N., Miller-Graziano, Carol, Calvano, Steve E., Baker, Henry V., Xiao, Wenzhong, Laudanski, Krzysztof, Brownstein, Bernard H., Elson, Constance M., Hayden, Douglas L., Herndon, David N., Lowry, Stephen F., Maier, Ronald V., Schoenfeld, David A., Moldawer, Lyle L., Davis, Ronald W., and Tompkins, Ronald G.

Published
2005

24. Nation-Wide Variation in Presence of Legislation or Protocols for EMS Care of Operational Canines.

Author

Schoenfeld, David W., Thomas, Caroline E., Palmer, Lee, Justice, William, Hwang, Esther, Zimmerman, Kate D., Goodloe, Jeffrey M., Shecter, Jonathan D., and Thomas, Stephen H.

Subjects
UNITED States census, EMERGENCY medical services, FISHER exact test, VETERINARY emergencies, MEDICAL protocols
Abstract

Background & Aims: Deployment of law enforcement operational canines (OpK9s) risks injuries to the animals. This study's aim was to assess the current status of states' OpK9 (veterinary Emergency Medical Services [VEMS]) laws and care protocols within the United States. Methods: Cross-sectional standardized review of state laws/regulations and OpK9 VEMS treatment protocols was undertaken. For each state and for the District of Columbia (DC), the presence of OpK9 legislation and/or care protocols was ascertained. Information was obtained through governmental records and from stakeholders (eg, state EMS medical directors and state veterinary boards). The main endpoints were proportions of states with OpK9 laws and/or treatment protocols. Proportions are reported with 95% confidence intervals (CIs). Fisher's exact test (P <.05) assessed whether presence of an OpK9 law in a given jurisdiction was associated with presence of an OpK9 care protocol, and whether there was geographic variation (based on United States Census Bureau regions) in presence of OpK9 laws or protocols. Results: Of 51 jurisdictions, 20 (39.2%) had OpK9 legislation and 23 (45.1%) had state-wide protocols for EMS treatment of OpK9s. There was no association (P =.991) between presence of legislation and presence of protocols. There was no association (P =.144) between presence of legislation and region: Northeast 66.7% (95% CI, 29.9-92.5%), Midwest 50.0% (95% CI, 21.1-78.9%), South 29.4% (95% CI, 10.3-56.0%), and West 23.1% (95% CI, 5.0-53.8%). There was significant (P =.001) regional variation in presence of state-wide OpK9 treatment protocols: Northeast 100.0% (95% CI, 66.4-100.0%), Midwest 16.7% (95% CI, 2.1-48.4%), South 47.1% (95% CI, 23.0-72.2%), and West 30.8% (95% CI, 9.1-61.4%). Conclusion: There is substantial disparity with regard to presence of OpK9 legal and/or clinical guidance. National collaborative guidelines development is advisable to optimize and standardize care of OpK9s. Additional attention should be paid to educational and training programs to best utilize the limited available training budgets. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Randomized, double-blinded, placebo-controlled trial of allogeneic cord blood T-regulatory cells for treatment of COVID-19 ARDS

Author

Gladstone, Douglas E, D'Alessio, Franco, Howard, Christopher, Lyu, Mi-Ae, Mock, Jason R., Gibbs, Kevin W., Abrams, Darryl, Huang, Meixian, Zeng, Ke, Herlihy, James P., Castillo, Sergio T., Bassett, Roland, Sadeghi, Tara, Parmar, Simrit, Flowers, Christopher R., Mukherjee, Siddhartha, Schoenfeld, David, Thall, Peter F., and Slutsky, Arthur S.

Published
2023
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46. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

Author

Miller, Timothy M, Pestronk, Alan, David, William, Rothstein, Jeffrey, Simpson, Ericka, Appel, Stanley H, Andres, Patricia L, Mahoney, Katy, Allred, Peggy, Alexander, Katie, Ostrow, Lyle W, Schoenfeld, David, Macklin, Eric A, Norris, Daniel A, Manousakis, Georgios, Crisp, Matthew, Smith, Richard, Bennett, C Frank, Bishop, Kathie M, and Cudkowicz, Merit E

Published
2013
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50. A Pragmatic Cluster-Randomized Trial of Provider Education and Community Health Worker Support for Tobacco Cessation.

Author

Evins, A. Eden, Cather, Corinne, Maravic, Melissa Culhane, Reyering, Sally, Pachas, Gladys N., Thorndike, Anne N., Levy, Douglas E., Fung, Vicki, Fischer, Michael A., Schnitzer, Kristina, Pratt, Sarah, Fetters, Michael D., Deeb, Bianca, Potter, Kevin, and Schoenfeld, David A.

Subjects
COMMUNITY health workers, PEOPLE with mental illness, TEMPERANCE, TOBACCO, COMMUNITY mental health services
Abstract

Individuals with serious mental illness have a high prevalence of tobacco use disorder and related early mortality but underutilize smoking cessation medication. The authors determined whether clinician-delivered education to primary care providers regarding safety, efficacy, and importance of cessation medication (provider education [PE]) alone or combined with community health worker (CHW) support would increase tobacco abstinence in this population, compared with usual care. All adult current tobacco smokers receiving psychiatric rehabilitation for serious mental illness through two community agencies in Greater Boston were eligible, regardless of readiness to quit smoking. Primary care clinics were cluster randomized to PE or usual care, with a nested, participant-level randomization to CHW or no CHW in PE-assigned clinics. The primary outcome was blindly assessed, biochemically verified tobacco abstinence at year 2. Overall, 1,010 eligible participants were enrolled. PE was delivered to providers in 53 of 55 assigned clinics; 220 of 336 CHW-assigned participants consented to CHW support. Year 2 abstinence rates were significantly higher among participants assigned to PE+CHW versus usual care (12% vs. 5%; adjusted odds ratio [AOR]=2.40, 95% confidence interval [CI]=1.20–4.79) or PE alone (12% vs. 7%; AOR=1.84, 95% CI=1.04–3.24). No effect of PE alone on abstinence was detected. Compared with participants assigned to usual care, those assigned to PE+CHW had greater odds of varenicline use (OR=2.77, 95% CI=1.61–4.75), which was associated with higher year 2 abstinence (OR=1.97, 95% CI=1.16–3.33). Combined PE and CHW tobacco cessation support increased tobacco abstinence rates among adults with serious mental illness. [ABSTRACT FROM AUTHOR]

Published
2023
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