302 results on '"Shears, Stephen B."'
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2. Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
3. Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10
4. IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight
5. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop
6. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line
7. InsP₇ is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
8. Control of XPR1-dependent cellular phosphate efflux by InsP₈ is an exemplar for functionally-exclusive inositol pyrophosphate signaling
9. A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase
10. Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors
11. Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs.
12. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress
13. KO of 5-InsP₇ kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype
14. Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
15. The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family
16. PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus
17. Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling.
18. A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging
19. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery
20. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut
21. Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues.
22. Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP 7.
23. Dephosphorylation of 2,3-Bisphosphoglycerate by MIPP Expands the Regulatory Capacity of the Rapoport-Luebering Glycolytic Shunt
24. Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7† †Electronic supplementary information (ESI) available: Data deposition: atomic coordinates and structure factors have been deposited in the Protein Data Bank (PDB ID code 6N5C). See DOI: 10.1039/c9md00163h
25. The Effects of Mastoparan on the Carrot Cell Plasma Membrane Polyphosphoinositide Phospholipase C
26. Changes in Phosphatidylinositol Metabolism in Response to Hyperosmotic Stress in Daucus carota L. Cells Grown in Suspension Culture
27. Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs.
28. Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
29. The Nucleolus Exhibits an Osmotically Regulated Gatekeeping Activity That Controls the Spatial Dynamics and Functions of Nucleolin
30. Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”
31. Telomere Maintenance by Intracellular Signals: New Kid on the Block?
32. Inhibition by inositoltetrakisphosphates of calcium- and volume-activated Cl– currents in macrovascular endothelial cells
33. The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase
34. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization
35. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
36. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.
37. Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode.
38. Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae
39. Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling.
40. Flavored e-liquids increase cytoplasmic Ca2+ levels in airway epithelia.
41. Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7.
42. Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress.
43. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure–Activity Analysis.
44. Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.
45. Synthetic Inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
46. Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs
47. Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate.
48. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
49. Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.
50. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.
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