483 results on '"Shoamanesh, Ashkan"'
Search Results
2. Predictors and Prognostic Impact of Hematoma Expansion in Infratentorial Cerebral Hemorrhage
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Pezzini, Debora, Nawabi, Jawed, Schlunk, Frieder, Li, Qi, Mazzacane, Federico, Busto, Giorgio, Scola, Elisa, Arba, Francesco, Brancaleoni, Laura, Giacomozzi, Sebastiano, Simonetti, Luigi, Laudisi, Michele, Cavallini, Anna, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Zini, Andrea, Casetta, Ilaria, Fainardi, Enrico, Morotti, Andrea, and Padovani, Alessandro
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- 2024
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3. Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE
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Chen, Chih-Hao, Shoamanesh, Ashkan, Colorado, Pablo, Saad, Feryal, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Xu, Lizhen, Heenan, Laura, Masjuan, Jaime, Christensen, Hanne, Connolly, Stuart J., Khatri, Pooja, Mundl, Hardi, Hart, Robert G., and Smith, Eric E.
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- 2024
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4. Derivation of the Falls Decision Rule to exclude intracranial bleeding without head CT in older adults who have fallen
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de Wit, Kerstin, Mercuri, Mathew, Clayton, Natasha, Mercier, Eric, Morris, Judy, Jeanmonod, Rebecca, Eagles, Debra, Varner, Catherine, Barbic, David, Buchanan, Ian M., Ali, Mariyam, Kagoma, Yoan K., Shoamanesh, Ashkan, Engels, Paul, Sharma, Sunjay, Worster, Andrew, McLeod, Shelley, Emond, Marcel, Stiell, Ian, Papaioannou, Alexandra, and Parpia, Sameer
- Subjects
Anticoagulants (Medicine) ,Head injuries ,CT imaging ,Health ,McMaster University - Abstract
Background: Ground-level falls are common among older adults and are the most frequent cause of traumatic intracranial bleeding. The aim of this study was to derive a clinical decision rule that safely excludes clinically important intracranial bleeding in older adults who present to the emergency department after a fall, without the need for a computed tomography (CT) scan of the head. Methods: This prospective cohort study in 11 emergency departments in Canada and the United States enrolled patients aged 65 years or older who presented after falling from standing on level ground, off a chair or toilet seat, or out of bed. We collected data on 17 potential predictor variables. The primary outcome was the diagnosis of clinically important intracranial bleeding within 42 days of the index emergency department visit. An independent adjudication committee, blinded to baseline data, determined the primary outcome. We derived a clinical decision rule using logistic regression. Results: The cohort included 4308 participants, with a median age of 83 years; 2770 (64%) were female, 1119 (26%) took anticoagulant medication and 1567 (36%) took antiplatelet medication. Of the participants, 139 (3.2%) received a diagnosis of clinically important intracranial bleeding. We developed a decision rule indicating that no head CT is required if there is no history of head injury on falling; no amnesia of the fall; no new abnormality on neurologic examination; and the Clinical Frailty Scale score is less than 5. Rule sensitivity was 98.6% (95% confidence interval [CI] 94.9%-99.6%), specificity was 20.3% (95% CI 19.1%-21.5%) and negative predictive value was 99.8% (95% CI 99.2%-99.9%). Interpretation: We derived a Falls Decision Rule, which requires external validation, followed by clinical impact assessment. Trial registration: ClinicalTrials. gov, no. NCT03745755., As populations age, emergency departments are managing a growing number of older adults who fall. (1-3) Falling on level ground is the most common cause of traumatic intracranial bleeding. (4-6) [...]
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- 2023
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5. Secondary stroke prevention in people with atrial fibrillation: treatments and trials
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Seiffge, David J, Cancelloni, Virginia, Räber, Lorenz, Paciaroni, Maurizio, Metzner, Andreas, Kirchhof, Paulus, Fischer, Urs, Werring, David J, Shoamanesh, Ashkan, and Caso, Valeria
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- 2024
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6. Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes
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Smith, Eric E., Shoamanesh, Ashkan, Xu, Lizhen, Heenan, Laura, Saad, Feryal, Colorado, Pablo, Chen, Chih-Hao, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Masjuan, Jaime, Hirano, Teruyuki, Milanov, Ivan, Campbell, Bruce C.V., Mas, Jean-Louis, Connolly, Stuart J., Mundl, Hardi, Hart, Robert G., Bailey, P., Campbell, B.C.V., Kleinig, T., Cordato, D., Choi, P., Garcia-Esperon, C., Chew, A., Cloud, G., Stanislaus, V., Krause, M., Priglinger, M., Grimley, R., Ghia, D., Sahathevan, R., Brown, H., Kwan, C., Devlin, M., Greisenegger, S., Bonelli-Nauer, S., Rath, J., Langer, A., Marko, M., Ferrari, J., Bernegger, A., Baumgartinger, M., Vigl, M., Krebs, S., Lang, W., Knoflach, M., Dejakum, B., Kiechl, S., Töll, T., Domig, L., Mutzenbach, J.S., Ganser, B., Hecker, C., Rösler, C., Bubel, N., Pikija, S., Zellner, T., Leitner, U., Berger, O., Surböck, B., Beirer, S., Staykov, D., Schrammel, D., Halilovic, A., Frattner, M., Barmherzigen, D., Lampl, C., Höfer, C., Nagl, S., Bocksrucker, C., Lemmens, R., Demeestere, J., Desfontaines, P., Ciobanu, C., De Pauw, A., Terwecoren, A., Hasenbroekx, M.C., Clement, F., De Klippel, N., Soors, P., Hermans, S., De Raedt, S., Vandervorst, F., Seynaeve, L., Fockaert, N., Smet, S., Rutgers, M., Del Gaudio, N., Paindeville, P., Staikov, I., Simeonova, A., Stoyanova, I., Cholakova, M., Mihnev, N., Petrova, T., Koralova, A., Dimov, D., Kuzev, Y., Danovska, M., Marinova, D., Marinova-Trifonova, D., Ovcharova, E., Mladenovski, I., Yanakieva, M., Stoev, P., Dimitrova, M., Todorova-Georgieva, S., Haralanov, L., Milkov, B., Solakov, D., Petkova, N., Ignatova-Valkova, V., Karabinov, V., Marinova, V., Miteva, Y., Andonova, V., Kasabova, D., Kostadinova, E., Shopova-Vrabcheva, Y., Gatev, D., Semova, D., Halil, E., Kaprelyan, A., Ivanov, B., Panov, G., Grudkova, M., Syuleyman, N., Kalpachki, R., Alexiev, F., Ivanova, I., Kancheva, K., Sakelarova, T., Maslarov, D., Drenska, D., Georgiev, V., Petrova, K., Petrova, N., Ivanova, I., Milanov, I., Semerdjieva, N., Zhelyazkov, P., Spasova-Markova, S., Dong, X., Wang, D., Wang, S., Huang, W., Zhao, H., Wang, C., Jie, L., Xinyang, Y., Ping, Z., Dong, Q., Wang, Y., Fuling, Y., Yue, W., Liu, R., Yang, Y., Stetkarova, I., Mikulenka, P., Vasko, P., Peisker, T., Bar, M., Roubec, M., Mikulik, R., Cabukova, M., Vinklarek, J., Kovar, M., Pansky, M., Mencl, P., Skoda, O., Carek, M., Pernicka, M., Skodova, M., Geier, P., Cepkova, J., Drlik, J., Prax, T., Herzig, R., Krajickova, D., Vitkova, E., Haluskova, S., Vaclavik, D., Martinkova, J., Blejcharova, K., Tkacova, M., Pavlik, O., Nevšímalová, M., Rosol, J., Nevsimalova, M., Hruby, R., Iversen, H., Andersen, A.V., Rahimi, D., Christensen, H., Grundtvig, J., Hjort, N., Andersen, G., Sandal, B., Stilund, M., Modrau, B., Strade, A., Porobic, M., Andersen, S.D., Kruuse, C., Ölmestig, J., Kolmos, M., Parvez, A., Christensen, T., Stokholm, J., Jensen, H.B., Putaala, J., Strbian, D., Sibolt, G., Tiainen, M., Martinez-Majander, N., Curtze, S., Raty, S., Kraemer, Y., Roine, R., Aivo, J., Ruuskanen, J., Ylikotila, P., Roine, S., Hallikainen, M., Jakala, P., Kurl, S., Julkunen, V., Sibon, I., Olindo, S., Richard, S., Larrue, V., Gollion, C., Catala, H., Henon, H., Lucie, D.S., Nelly, D., Mas, J.L., Calvet, D., Malbranque, A., Mazé, B., Barbieux-Ghitu, C., Pitie Salpetriere, G.H., Rosso, C., Samson, Y., Vannier, S., Moulin, T., Bonnet, L., Reiner, P., Buffon, F., Denier, C., Amri, K., Legris, N., Chassin, O., Selli, N., Mariana, S., Berrouschot, J., Stoll, A., Klunk, D., Keilitz, J., Neustadt, M., Zerrenner, S., Veltkamp, R., Hajjar, K., Heeger, A., Winezki, E., Apel, L., Pompsch, M., Mueller, P., Rappard, P., Auer, R., Ringleb, P.A., Berberich, A., Heyse, M., Mundiyanapurath, S., Reiff, T., Poli, S., Gomez-Exposito, A., Mengel, A., Tünnerhoff, J., Adeyemi, K., Poli, K., Kusch, V., Pelz, J., Michalski, D., Wartenberg, K., Althaus, K., Tavares, F., Mueller, S., Soda, H., Rascher, A., Hiermann, E., Weinhardt, R., Weissenborn, K., Leotescu, A., Grosse, G., Worthmann, H., Ernst, J., Gabriel, M., Schuppner, R., Schäfer, J.H., Charisse, D., Gruber, K., Kurka, N., Reitz, S.C., Pfeilschifter, W., Lee, J.I., Gliem, M., Moll, M., Steiner, T., Segura, L., Szegedi, N., Barandi, D., Uhrinakova, L., Czencz, M., Pasztor, M., Gyuker, N., Bartha, N.E., May, Z., Simony, Z., Szasz, G., Kakuk, I., Pető, N., Panczel, G.F., Olah, A., Racz, O., Balla, T., Horvath, B., Tuba, K., Czinderi, V., Klivenyi, P., Annus, A., Hertelendy, P., Szapary, L., Bosnyak, E., Kalmar, P., Karadi, Z., Cziba, L., Olah, L., Berki, A., Hudak, L., Kozák, M., Babel, S., Nemeth, L., Molnár, B., Simon, Z., Roveri, L., Cerri, F., Giacalone, G., Zini, A., Mauro, G., Asioli, G.M., Forlivesi, S., Arnone, G., Caso, V., Fiaccadori, A., Maria Fontana Francesca, E., Allegra, G., Mosconi, M.G., Longoni, M., Terlizzi, R., Paolucci, M., Tassi, R., Franci, B., Lucani, B., Domenichelli, C., Paoletti, D., Acampa, M., Zedde, M.L., Pezzella, F.R., Mangiardi, M., Galizia, P., Anticoli, S., Scalise, S., Lattanzi, S., Norata, D., Cannuccia, M., Cavallini, A., Federica, F., Denaro, M.F., Tosi, P., Sonoda, K., Kawajiri, M., Kusano, Y., Haraguchi, K., Kawano, H., Terasaki, T., Kaneko, C., Murase, S., Kumagai, M., Murai, N., Miyazaki, Y., Mori, T., Hatano, T., Kawanishi, M., Ochiai, J., Ishihara, S., Uehara, T., Yasaka, M., Nakagawa, H., Makino, M., Yonehara, T., Fukushima, Y., Hirotsune, N., Sakai, N., Yamasaki, M., Coutinho, J., Wouters, A., den Hertog, H., Zwartbol, R., Beumer, D., Kerklaan, J., Hilkens, P., Schreuder, T., Propper, D., Slowik, A., Wlodarczyk, E., Wrona, P., Pulyk, R., Lasek-Bal, A., Kosarz-Lanczek, K., Puz, P., Bilik, M., Magielska, A., Zamiela – Żółciak, A., Ochocinska, L., Bahdasaryan, S., Stępień, A., Dębiec, A., Joanna, K., Pawel, M., Jacek, S., Daniel, P., Marta, S., Rejdak, K., Wojczal, J., Luchowski, P., Fryze, W., Wisniewska, A., Krzyzanowska, M., Skowron, P., Wolosz, A., Galan, A., Grzymala, K., Krajewska, M., Nowak, R., Kłos, M., Cruz, V., Castro, P., Ferro, J., Canhão, P., Gouveia, R., Inácio, N., Rodrigues, M., Rachão, A., Ionel, C., Pereira, L., Viana-Baptista, M., Machado, C., Fernandes, C., Sargento, J., Inácio, N., Timchenko, L., Mironova, J., Zhadan, O., Torgashova, A., Bazhenova, O., Barashenkova, M., Kireeva, M., Romadina, N., Stepanova, I., Lenskaya, L., Lukinykh, L., Vorontsova, T., Agafina, A., Fedorova, A., Yashina, A., Alasheev, A., Smolkin, A., Prazdnichkova, E., Lutskovich, O., Gonysheva, Y., Mordvintseva, E., Nechaev, A., Martynova, E., Fedoraeva, N., Vishnyakova, T., Popov, D., Merzliakova, A., Margarita, K., Rechkalova, L., Ilyina, A., Kurenkova, N., Barbarash, O., Bazdyrev, E., Zvereva, T., Hromova, A., Morkvenas, A., Postnikova, E., Kovalenko, G., Taran, I., Pavlov, L., Ott, M., Chernitsova, N., Vodopyanova, N., Drozdova, E., Korebo, E., Lobanova, M., Lazareva, N., Snegova, N., Nikolaeva, O., Kolesnikov, Y., Kosheleva, Y., Krastev, G., Tomasova, K., Danis, M., Mako, M., Jankovicova, Z., Stevkova, Z., Kovacik, M., Kubikova, T., Jarosova, A., Serdahely, V., Cilingova, I., Pribulova, I., Sedlak, J., Slebodova, K., Paldaufova, M., Risnovsky, R., Berndtova, B., Urbanova, I., Junas, R., Karapetian, S., Gurcik, L., Vantrobova, A., Verbovsky, F., Vanacka, K., Ferenc, M., Galik, P., Bucakova, S., Ferencova, M., Kubalova, P., Boksanska, Z., Zacharova, E., Mahundi, E., Judita, H., Bachnak, M., Turcani, P., Kvasnicova Kamenska, A., Jurik, M., Vestenicka, V., Kycina, M., Sagatova, E., Dvorak, M., Hlubekova, A., Kucera, C., Gernath, L., Ferenc, M., Frimmelova, P., Slebodnikova, J., Aksteinerova, N., Horny, V., Gregova, Z., Segura, T., Romero, C., Ayo, O., Masjuan Vallejo, J., Cruz, A., . De felipe, A, Matute, M.C., Garcia, S., Tembl Ferrairo, J., Vielba, I., Morales Caba, L., Molina, C., Garcia-Tornel García-Camba, Á., Requena Ruiz, M., Noelia, R., Rodriguez-Yañez, M., Rodriguez Castro, E., Lopez, I., Santamaria, M., Arias, S., Purroy García, F., Vázquez Justes, D., Mauri Capdevila, G., Vicente Pascual, M., Martí Fabregas, J., Camps Renom, P., Rodríguez Campello, A., Giralt, E., Krupinski, J., Molina, J., Trillo Senin, C. Ramos Martin, S., De La Fuente Sanz, E., Moniche, F., Manuel, M.R., Pardo, B., Martínez, I., Hernández Pérez, M., Arenillas Lara, J.F., De Lera, M., Egido, J.A., Gomez Escalonilla, C., Guillan, M., Martinez, J., Lindgren, A., Andsberg, G., Wictor, L., Leonidou, M., Stenman, M., Dalberg, N., Laska, A.C., Grünfeldt, A., Lundström, A., Nadzjafov, E., Rooth, E., Dalenbring, I., Sandén, P., Johansson, E., Thomas, G., De Marchis, G.M., Zietz, A.V., Rudin, S., Dittrich, T.D., Lilian, K., Kägi, G., Vehoff, J., Arnold, M., Scutelnic, A., Clénin, L., Beyeler, M., Madlaine, M., Maamari, B., Siepen, B., Vynckier, J., Tarnutzer, A., Bertschi, D., Luciani, M., Cereda, C., Maulucci, F., Bianco, G., Shairin, S., Pihan, H.A., Salmen, S., Quinn, T., McAlpine, C., Wright, F., Kalladka, D., Taylor, E., Sohaa, J., Brown, Z., Dawson, J., Cameron, A., Muir, S., Dima, S., Khan, U., Zhang, L., Warburton, E., Chatterjee, K., Nallasivan, A., Curran, D., Haider, S., Ghani, U., Kenton, A., Dallol, B., Mirza, M., Menezes, B., Davies, R., Robinson, T.G., Manning, L., Sztriha, L., Phinney, T., Sethi, P., Altafullah, I., Sharaf, A., Ostrander, M., Renati, S., Burgin, W.S., Olds, K., Delio, P., Malek, A., Dissin, J., Khatri, P., Flaherty, M., Demel, S., and Dofitas, S.
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- 2024
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7. Relationship between prior statin therapy and radiological features and clinical outcomes of intracerebral hemorrhage
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Lee, Kun He, Carvalho, Filipa, Lioutas, Vasileios-Arsenios, Heistand, Elizabeth, Das, Alvin S., Marchina, Sarah, Shoamanesh, Ashkan, Katsanos, Aristeidis H., Shehadah, Amjad, Incontri, Diego, and Selim, Magdy
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- 2023
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8. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials
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Klug, Didier, Casolla, Barbara, Puy, Laurent, Coffee, Morgane, Kuchcinski, Grégory, Labreuche, Julien, van Nieuwenhuizen, Koen M., Algra, Ale, van Gelder, Isabelle C., Kappelle, L. Jaap, Rinkel, Gabriel J.E., Schutgens, Roger E.G., Khatri, Pooja, Conwit, Robin, Falcone, Guido, Elm, Jordan, Anderson, Craig S., Song, Lili, Pandian, Jeyaraj, Hart, Robert G., Sharma, Mukul, Aref, Hany, Tarhuni, Wadea, Fabregas, Joan Marti, Diener, Hans-Christoph, Endres, Matthias, Lemmens, Robin, Kwon, Sun U., Lee, Byung-Chul, Ameriso, Sebastian, Milling, Truman J., Kasner, Scott E., Mikulik, Robert, Xavier, Denis, Beer, Ronny, Toni, Danilo, Eckstein, Jens, Seiffge, David, Ferro, Jose M., Tsivgoulis, Georgios, Sharma, Sanjib K., Wei-Liou, Chia, Hohnloser, Stefan H., Katsanos, Aristeidis, Bosch, Jackie, Healey, Jeff, Eikelboom, John, Khaw, Alexander, Gladstone, David, Pikula, Aleksandra, Coutts, Shelagh, Smith, Eric E., Butcher, Ken, Field, Thalia, Gioia, Laura, Stapf, Christian, Halse, Omid, Ringleb, Peter, Enzinger, Christian, Sibon, Igor, Montaner, Joan, Caso, Valeria, Heuschmann, Peter, Lip, Gregory Y.H., Haefeli, Walter, Debette, Stefanie, Dennis, Martin S., Wyller, Torgeir Bruun, Rønning, Ole M., Eilertsen, Helle, Ihle-Hansen, Hege, Sandset, Else Charlotte, Pennlert, Johanna, Glader, Eva-Lotta, Kruuse, Christina, Wester, Per, Carlsson, Maria, Forfang, Elisabeth, Al-Shahi Salman, Rustam, Stephen, Jacqueline, Tierney, Jayne F, Lewis, Steff C, Newby, David E, Parry-Jones, Adrian R, White, Philip M, Connolly, Stuart J, Benavente, Oscar R, Dowlatshahi, Dar, Cordonnier, Charlotte, Viscoli, Catherine M, Sheth, Kevin N, Kamel, Hooman, Veltkamp, Roland, Larsen, Kristin T, Hofmeijer, Jeannette, Kerkhoff, Henk, Schreuder, Floris H B M, Shoamanesh, Ashkan, Klijn, Catharina J M, and van der Worp, H Bart
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- 2023
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9. Is There Still a Role for Dual Antiplatelet Therapy in the Secondary Prevention of Lacunar Stroke?
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Shoamanesh, Ashkan
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- 2023
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10. World-wide variations in tests of cognition and activities of daily living in participants of six international randomized controlled trials
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Katsanos, Aristeidis H., Lee, Shun Fu, Cukierman-Yaffe, Tali, Sherlock, Laura, Muniz-Terrera, Graciela, Canavan, Michele, Joundi, Raed, Sharma, Mukul, Shoamanesh, Ashkan, Derix, Andrea, Gerstein, Hertzel C., Yusuf, Salim, O'Donnell, Martin J., Bosch, Jackie, and Whiteley, William N.
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- 2023
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11. Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors
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Milling, Truman J., Jr, Middeldorp, Saskia, Xu, Lizhen, Koch, Bruce, Demchuk, Andrew, Eikelboom, John W., Verhamme, Peter, Cohen, Alexander T., Beyer-Westendorf, Jan, Michael Gibson, C., Lopez-Sendon, Jose, Crowther, Mark, Shoamanesh, Ashkan, Coppens, Michiel, Schmidt, Jeannot, Albaladejo, Pierre, Connolly, Stuart J., Anand, R., Bastani, A., Clark, C., Concha, M., Cornell, J., Dombrowski, K., Fermann, G., Fulmer, J., Goldstein, J., Kereiakes, D., Milling, T., Pallin, D., Patel, N., Refaai, M., Rehman, M., Schmaier, A., Schwarz, E., Shillinglaw, W., Spohn, M., Takata, T., Venkat, A., Welker, J., Welsby, I., Wilson, J., Van Keer, L., Verschuren, F., Blostein, M., Eikelboom, J., Althaus, K., Berrouschot, J., Braun, G., Doeppner, T., Dziewas, R., Genth-Zotz, S., Greinacher, P., Hamann, F., Hanses, F., Heide, W., Kallmuenzer, B., Kermer, P., Poli, S., Royl, G., Schellong, S., Schnupp, S., Schwarze, J., Spies, C., Thomalla, G., von Mering, M., Weissenborn, K., Wollenweber, F., Gumbinger, C., Jaschinski, U., Maschke, M., Mochmann, H-C., Pfeilschifter, W., Pohlmann, C., Zahn, R., Bouzat, P., Schmidt, J., Vallejo, C., Floccard, B., Coppens, M., van Wissen, S., Arellano-Rodrigo, E., Valles, E., Alikhan, R., Breen, K., Hall, R., Crowther, M., Albaladejo, P., Cohen, A., Demchuk, A.M., Schmidt, J., Wyse, D.G., Garcia, D.A., Prins, M., Nakamya, J., Büller, H.R., Mahaffey, K. W., Alexander, J. H., Cairns, J.A., Hart, R.G., Joyner, C.D., Raskob, G.E., Schulman, S., Veltkamp, R., Meeks, B., Zotova, E., Ahmad, S., Pinto, T., Baker, K., Dykstra, A., Holadyk-Gris, I., Malvaso, A., and Demchuk, A.M.
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- 2023
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12. Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial
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Shoamanesh, Ashkan, Mundl, Hardi, Smith, Eric E, Masjuan, Jaime, Milanov, Ivan, Hirano, Teruyuki, Agafina, Alina, Campbell, Bruce, Caso, Valeria, Mas, Jean-Louis, Dong, Qiang, Turcani, Peter, Christensen, Hanne, Ferro, Jose M, Veltkamp, Roland, Mikulik, Robert, De Marchis, Gian Marco, Robinson, Thompson, Lemmens, Robin, Stepien, Adam, Greisenegger, Stefan, Roine, Risto, Csiba, Laszlo, Khatri, Pooja, Coutinho, Jonathan, Lindgren, Arne G, Demchuk, Andrew M, Colorado, Pablo, Kirsch, Bodo, Neumann, Christoph, Heenan, Laura, Xu, Lizhen, Connolly, Stuart J, and Hart, Robert G
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- 2022
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13. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial
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Srivastava, Abhilekh, Aljammaz, Ahmed M, Akindotun, Akintomide Femi, Jin, Albert Y, Fraser, Alexander, Khaw, Alexander V, Lemnaru, Alexandru, Southwell, Alisia, Ramji, Alnar, Alvarado-Bolaños, Alonso, Mouminah, Amr, Lahlouh, Amro B, Yu, Amy Y, Alrohimi, Anas, Lavoie, Andre, Rogge, Andrea, Micieli, Andrew, Nguyen, Andrew Linh, Callaghan-Brown, Angelique, Florendo-Cumbermack, Anita, Wadhwa, Ankur, Beaudoin, Ann-Marie, Cayley, Anne, Liddy, Anne Marie, Trivedi, Anurag, Katsanos, Aristeidis H, Shuaib, Ashfaq, Butt, Asif Javed, Bereznyakova, Olena, Beauchamp, Beth, Mahlitz, Breane, Graham, Brett R, Dewar, Brian, Buck, Brian H, Durafourt, Bryce A, Holtby, Caitlin, Jackson-Tarlton, Caitlin S, Bockus, Caitlyn, Stephenson, Caroline, Galloway, Camille, Odier, Céline, Deacon, Charles, Zerna, Charlotte, Vekhande, Chetan C, Bocti, Christian, Stapf, Christian, Hawkes, Christine, Stables, Christine Anne, Bogiatzi, Chrysi, Rodriguez, Claudia, Candale-Radu, Claudia, Murphy, Colleen, Casserly, Courtney Sarah, Fok, Daniel, Boasquevisque, Danielle de Sa, Wile, Daryl, Volders, David, Sahlas, Demetrios J, Shand, Elaine, Cora, Elena Adela, Battista, Eliane Di, Stewart, Eileen, Junk, Emily, Harrison, Emma L, Frenette, Eric, Teleg, Ericka, Abdellah, Eslam, Ghrooda, Esseddeeg, Akthar, Farhana, Evoy, François, Klein, Gary M, Maclean, Genoveva, Jickling, Glen C, Hawthorne, Glenda, Boyd, Gordon, Walker, Gregory, Saposnik, Gustavo, Lau, H Lee, Badr, Hanan E, Toma, Hassanain, Kalashyan, Hayrapet, Marion-Moffet, Hugo, Grant, Ian, Fatakdawala, Idris, Beaulieu-Boire, Isabelle, Williams, Janice, Brar, Jaskiran, Rivest, Jean, Wang, Jeffrey Z, Dawe, Jessica, Stang, Jillian, Day, Joanne, Miller, Jodi, Gorman, Johnathon, Hopyan, Julia Jasmine, Lee, Julian, Kromm, Julie, Foster, Kaitlyn, Ratnayake, Kanchana, Perera, Kanjana S, Murray, Karina Villaluna, Ryckborst, Karla, Lin, Katie, Sage, Kayla, Sivakuma, Keithan, MacDonald, Kelly A, Ng, Kelvin Kuan, Merchant, Ketki, Khan, Khurshid, Ghavami, Kimia, Johnston, Kyra, Mai, Lauren M, White, Leah, Barratt, Lee, Longpre, Linda, Crellin, Lisa, Peeling, Lissa, Piquette, Lori, Lomax, Lysa Boissé, Sadeghi, Mahsa, Kamra, Maneesha, Lavoie-April, Manuel, Moores, Margaret, Bullrich, Maria Bres, McClelland, Marie, Salluzzi, Marina, Wilcox, Mark, Boulos, Mark I, Marko, Martha, Boyko, Matthew, Lantagne-Hurtubise, Maude, AlHamid, May Adel, Shawawrah, Mays, Kelly, Michael E, Thorne, Michael W D, Shamy, Michel, Bussiere, Miguel, Dominc Tse, Ming Yin, Benguzzi, Mowad, Sharma, Mukul, Horton, Myles, Newcommon, Nancy, Simon, Nandy-Shelwine, Parks, Natalie E, Sultan, Nazeem, Markovic, Nevena, Daneault, Nicole, Ishaque, Noman, Fairall, Paige, Kostyrko, Pawel B, Stys, Peter K, Teal, Philip, Couillard, Philippe, King-Azote, Princess, Collier, Quentin, Epp, Rachel, Nair, Radhika, Joundi, Raed A, Jassal, Rajive, Schneider, Raphael, Hosseini, Reza, Bouchard, Rosalie, Whelan, Ruth, Cooley, S Regan, Sujanthan, Sajeevan, Mansoor, Salman, Yip, Samuel, Wasyliw, Sanchea, Taylor, Sean W., Friedman, Sebastian, Mann, Sharan, Maley, Sharleen Weese, Chiasson, Sherry, Hu, Sherry Xueying, Althubait, Shorog, Himed, Shuhira, Chen, Shuo, Bal, Simerpreet S, Page, Stacey A, Beck, Stacey D, Woodroffe, Stephanie, Reiter, Stephanie D, Gaal, Stephen van, Peters, Steven Ray, Darvesh, Sultan, Save, Supriya, Alcock, Susan, Piercey, Susannah, Adam, Suzie, Gosselin, Sylvie, Fitzpatrick, Tess, Perron, Thomas-Louis, Stewart, Tim, Benstead, Timothy J, Naidoo, Vishaya, Wahab, Wasan Abd, Oczkowski, Wiesław, Kingston, William, Leduc, William, To, William T H, Yu, Yeyao Joe, Liu, Zhongyu A, Aljundi, Ziad Ezzat, Menon, Bijoy K, Singh, Nishita, Deschaintre, Yan, Almekhlafi, Mohammed A, Coutts, Shelagh B, Thirunavukkarasu, Sibi, Khosravani, Houman, Appireddy, Ramana, Moreau, Francois, Gubitz, Gord, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Medvedev, George, Mandzia, Jennifer, Pikula, Aleksandra, Shankar, Jai, Williams, Heather, Field, Thalia S, Manosalva, Alejandro, Siddiqui, Muzaffar, Zafar, Atif, Imoukhuede, Oje, Hunter, Gary, Demchuk, Andrew M, Mishra, Sachin, Gioia, Laura C, Jalini, Shirin, Cayer, Caroline, Phillips, Stephen, Elamin, Elsadig, Shoamanesh, Ashkan, Subramaniam, Suresh, Kate, Mahesh, Jacquin, Gregory, Camden, Marie-Christine, Benali, Faysal, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Stotts, Grant, Hill, Michael D, Gladstone, David J, Poppe, Alexandre, Sehgal, Arshia, Zhang, Qiao, Lethebe, Brendan Cord, Doram, Craig, Ademola, Ayoola, Kenney, Carol, Sajobi, Tolulope T, and Swartz, Richard H
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- 2022
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14. Intensive Blood Pressure Lowering and DWI Lesions in Intracerebral Hemorrhage: Exploratory Analysis of the ATACH-2 Randomized Trial
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Shoamanesh, Ashkan, Cassarly, Christy, Morotti, Andrea, Romero, Javier M., Oliveira-Filho, Jamary, Schlunk, Frieder, Jessel, Michael, Butcher, Kenneth, Gioia, Laura, Ayres, Alison, Vashkevich, Anastasia, Schwab, Kristin, Afzal, Mohammad Rauf, Martin, Renee H., Qureshi, Adnan I., Greenberg, Steven M., Rosand, Jonathan, and Goldstein, Joshua N.
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- 2022
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15. Emergency physician gender and head computed tomography orders for older adults who have fallen.
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Kraft, Rhys, Mercuri, Mathew, Clayton, Natasha, Worster, Andrew, Mercier, Eric, Emond, Marcel, Varner, Catherine, McLeod, Shelley L., Eagles, Debra, Stiell, Ian, Barbic, David, Morris, Judy, Jeanmonod, Rebecca, Kagoma, Yoan K., Shoamanesh, Ashkan, Engels, Paul T., Sharma, Sunjay, Papaioannou, Alexandra, Parpia, Sameer, and Buchanan, Ian
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CRANIAL radiography ,ACCIDENTAL falls in old age ,PATIENTS ,SECONDARY analysis ,RESEARCH funding ,SEX distribution ,COMPUTED tomography ,LOGISTIC regression analysis ,EMERGENCY medical services ,DECISION making in clinical medicine ,DESCRIPTIVE statistics ,ODDS ratio ,PHYSICIANS ,DATA analysis software ,CONFIDENCE intervals - Abstract
Objective: Physicians vary in their computed tomography (CT) scan usage. It remains unclear how physician gender relates to clinical practice or patient outcomes. The aim of this study was to assess the association between physician gender and decision to order head CT scans for older emergency patients who had fallen. Methods: This was a secondary analysis of a prospective observational cohort study conducted in 11 hospital emergency departments (EDs) in Canada and the United States. The primary study enrolled patients who were 65 years and older who presented to the ED after a fall. The analysis evaluated treating physician gender adjusted for multiple clinical variables. Primary analysis used a hierarchical logistic regression model to evaluate the association between treating physician gender and the patient receiving a head CT scan. Secondary analysis reported the adjusted odds ratio (OR) for diagnosing intracranial bleeding by physician gender. Results: There were 3663 patients and 256 physicians included in the primary analysis. In the adjusted analysis, women physicians were no more likely to order a head CT than men (OR 1.26, 95% confidence interval 0.98–1.61). In the secondary analysis of 2294 patients who received a head CT, physician gender was not associated with finding a clinically important intracranial bleed. Conclusions: There was no significant association between physician gender and ordering head CT scans for older emergency patients who had fallen. For patients where CT scans were ordered, there was no significant relationship between physician gender and the diagnosis of clinically important intracranial bleeding. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient-Level Meta-Analysis From COMBINE AF.
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Johnson, Linda S., Benz, Alexander P., Shoamanesh, Ashkan, Eikelboom, John W., Ezekowitz, Michael, Giugliano, Robert P., Wallentin, Lars, Ruff, Christian T., Lopes, Renato D., Jolly, Sanjit, Whitlock, Richard, Granger, Christopher B., Connolly, Stuart, and Healey, Jeffrey S.
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- 2024
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17. Predictors of severe intracerebral hemorrhage expansion.
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Morotti, Andrea, Li, Qi, Nawabi, Jawed, Busto, Giorgio, Mazzacane, Federico, Cavallini, Anna, Shoamanesh, Ashkan, Morassi, Mauro, Schlunk, Frieder, Piccolo, Laura, Urbinati, Giacomo, Pezzini, Debora, Paciaroni, Maurizio, Fainardi, Enrico, Casetta, Ilaria, Padovani, Alessandro, and Zini, Andrea
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- 2024
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18. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis
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Katsanos, Aristeidis H., Lioutas, Vasileios-Arsenios, Charidimou, Andreas, Catanese, Luciana, Ng, Kelvin Kuan Huei, Perera, Kanjana, de Sa Boasquevisque, Danielle, Falcone, Guido J., Sheth, Kevin N., Romero, Jose Rafael, Tsivgoulis, Georgios, Smith, Eric E., Sharma, Mukul, Selim, Magdy H., and Shoamanesh, Ashkan
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- 2021
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19. Stroke and Thromboprophylaxis in the Era of COVID-19
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Ma, Alice, Kase, Carlos S., Shoamanesh, Ashkan, Abdalkader, Mohamad, Pikula, Aleksandra, Sathya, Anvitha, Catanese, Luciana, Ellis, Alun T., and Nguyen, Thanh N.
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- 2021
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20. Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE.
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Chih-Hao Chen, Shoamanesh, Ashkan, Colorado, Pablo, Saad, Feryal, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Lizhen Xu, Heenan, Laura, Masjuan, Jaime, Christensen, Hanne, Connolly, Stuart J., Khatri, Pooja, Mundl, Hardi, Hart, Robert G., and Smith, Eric E.
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- 2024
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21. Andexanet alfa versus non-specific treatments for intracerebral hemorrhage in patients taking factor Xa inhibitors — Individual patient data analysis of ANNEXA-4 and TICH-NOAC.
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Siepen, Bernhard M, Polymeris, Alexandros, Shoamanesh, Ashkan, Connolly, Stuart, Steiner, Thorsten, Poli, Sven, Lemmens, Robin, Goeldlin, Martina B, Müller, Madlaine, Branca, Mattia, Rauch, Janis, Meinel, Thomas, Kaesmacher, Johannes, Z'Graggen, Werner, Arnold, Marcel, Fischer, Urs, Peters, Nils, Engelter, Stefan T, Lyrer, Philippe, and Seiffge, David
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CEREBRAL hemorrhage ,VENOUS thrombosis ,DATA analysis ,MYOCARDIAL infarction ,ISCHEMIC stroke - Abstract
Background: Data comparing the specific reversal agent andexanet alfa with non-specific treatments in patients with non-traumatic intracerebral hemorrhage (ICH) associated with factor-Xa inhibitor (FXaI) use are scarce. Aim: The study aimed to determine the association between the use of andexanet alfa compared with non-specific treatments with the rate of hematoma expansion and thromboembolic complications in patients with FXaI-associated ICH. Methods: We performed an individual patient data analysis combining two independent, prospective studies: ANNEXA-4 (180 patients receiving andexanet alfa, NCT02329327) and TICH-NOAC (63 patients receiving tranexamic acid or placebo ± prothrombin complex concentrate, NCT02866838). The primary efficacy outcome was hematoma expansion on follow-up imaging. The primary safety outcome was any thromboembolic complication (ischemic stroke, myocardial infarction, pulmonary embolism, or deep vein thrombosis) at 30 days. We used binary logistic regression models adjusted for baseline hematoma volume, age, calibrated anti-Xa activity, times from last intake of FXaI, and symptom onset to treatment, respectively. Results: Among 243 participants included, the median age was 80 (IQR 75–84) years, baseline hematoma volume was 9.1 (IQR 3.4–21) mL and anti-Xa activity 118 (IQR 78–222) ng/mL. Times from last FXaI intake and symptom onset to treatment were 11 (IQR 7–16) and 4.7 (IQR 3.0–7.6) h, respectively. Overall, 50 patients (22%) experienced hematoma expansion (ANNEXA-4: n=24 (14%); TICH-NOAC: n=26 (41%)). After adjusting for pre-specified confounders (baseline hematoma volume, age, calibrated anti-Xa activity, times from last intake of FXaI, and symptom onset to treatment, respectively), treatment with andexanet alfa was independently associated with decreased odds for hematoma expansion (aOR 0.33, 95% CI 0.13–0.80, p = 0.015). Overall, 26 patients (11%) had any thromboembolic complication within 30 days (ANNEXA-4: n=20 (11%); TICH-NOAC: n=6 (10%)). There was no association between any thromboembolic complication and treatment with andexanet alfa (aOR 0.70, 95% CI 0.16–3.12, p = 0.641). Conclusion: The use of andexanet alfa compared to any other non-specific treatment strategy was associated with decreased odds for hematoma expansion, without increased odds for thromboembolic complications. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Cerebral microbleeds and asundexian in non-cardioembolic ischemic stroke: Secondary analyses of the PACIFIC-STROKE randomized trial.
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Balali, Pargol, Hart, Robert G, Smith, Eric E, Saad, Feryal, Colorado, Pablo, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Xu, Lizhen, Heenan, Laura, Connolly, Stuart J, Mundl, Hardi, and Shoamanesh, Ashkan
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ISCHEMIC stroke ,CEREBRAL small vessel diseases ,TRANSIENT ischemic attack ,INTRACRANIAL hemorrhage ,STROKE - Abstract
Background and aims: Cerebral microbleeds are magnetic imaging resonance (MRI) markers of hemorrhage-prone cerebral small vessel disease that predict future risk of ischemic stroke and intracranial hemorrhage (ICrH). There exist concerns about the net benefit of antithrombotic therapy in patients with microbleeds. We aimed to investigate the effects of an oral factor-XIa inhibitor (asundexian), that is hypothesized to inhibit thrombosis without compromising hemostasis, on the development of new microbleeds over time and interactions between microbleeds and asundexian treatment on clinical outcomes. We additionally assessed associations between baseline microbleeds and the risks of clinical and neuroimaging outcomes in patients with non-cardioembolic ischemic stroke. Methods: This is a secondary analysis of the PACIFIC-STROKE, international, multi-center Phase 2b double-blind, randomized clinical trial. PACIFIC-STROKE enrolled patients aged ⩾ 45 years with mild-to-moderate non-cardioembolic ischemic stroke who presented within 48 h of symptom onset for whom antiplatelet therapy was intended. Microbleeds were centrally adjudicated, and participants with an interpretable T2*-weighted sequence at their baseline MRI were included in this analysis. Patients were randomized to asundexian (10/20/50 mg daily) versus placebo plus standard antiplatelet treatment. Regression models were used to estimate the effects of (1) all pooled asundexian doses and (2) asundexian 50 mg daily on new microbleed formation on 26-week MRIs. Cox proportional hazards or regression models were additionally used to estimate interactions between treatment assignment and microbleeds for ischemic stroke/transient ischemic attack (TIA) (primary outcome), and ICrH, all-cause mortality, hemorrhagic transformation (HT), and new microbleeds (secondary outcomes). Results: Of 1746 participants (mean age, 67.0 ± 10.0; 34% female) with baseline MRIs, 604 (35%) had microbleeds. During a median follow-up of 10.6 months, 7.0% (n = 122) had ischemic stroke/TIA, 0.5% (n = 8) ICrH, and 2.1% (n = 37) died. New microbleeds developed in 10.3% (n = 155) of participants with adequate follow-up MRIs and HT in 31.4% (n = 345). In the total sample of patients with adequate baseline and 26-week follow-up MRIs (n = 1507), new microbleeds occurred in 10.2% of patients assigned to any asundexian dose and 10.5% of patients assigned to placebo (OR, 0.96; 95% CI, 0.66–1.41). There were no interactions between microbleeds and treatment assignment for any of the outcomes (p for interaction > 0.05). The rates of new microbleeds, HT, and ICrH were numerically less in patients with microbleeds assigned to asundexian relative to placebo. The presence of microbleeds was associated with a higher risk of HT (aOR, 1.6; 95% CI, 1.2–2.1) and new microbleeds (aOR, 4.4; 95% CI, 3.0–6.3). Conclusion: Factor XIa inhibition with asundexian appears safe in patients with non-cardioembolic ischemic stroke and hemorrhage-prone cerebral small vessel disease marked by microbleeds on MRI. These preliminary findings will be confirmed in the ongoing OCEANIC-STROKE randomized trial. Trial Registration: ClinicalTrials.gov Identifier: NCT04304508. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding.
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Horn, MacKenzie, Banerjee, Ankur, Kasickova, Linda, Volny, Ondrej, Choi, Hyun Seok, Letteri, Federica, Ohara, Tomoyuki, Tanaka, Koji, Connolly, Stuart, Ladenvall, Per, Crowther, Mark, Beyer‐Westendorf, Jan, Shoamanesh, Ashkan, Demchuk, Andrew M., and Al Sultan, Abdulaziz S.
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- 2024
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24. Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children
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Rabi, Doreen M., McBrien, Kerry A., Sapir-Pichhadze, Ruth, Nakhla, Meranda, Ahmed, Sofia B., Dumanski, Sandra M., Butalia, Sonia, Leung, Alexander A., Harris, Kevin C., Cloutier, Lyne, Zarnke, Kelly B., Ruzicka, Marcel, Hiremath, Swapnil, Feldman, Ross D., Tobe, Sheldon W., Campbell, Tavis S., Bacon, Simon L., Nerenberg, Kara A., Dresser, George K., Fournier, Anne, Burgess, Ellen, Lindsay, Patrice, Rabkin, Simon W., Prebtani, Ally P.H., Grover, Steven, Honos, George, Alfonsi, Jeffrey E., Arcand, JoAnne, Audibert, François, Benoit, Geneviève, Bittman, Jesse, Bolli, Peter, Côté, Anne-Marie, Dionne, Janis, Don-Wauchope, Andrew, Edwards, Cedric, Firoz, Tabassum, Gabor, Jonathan Y., Gilbert, Richard E., Grégoire, Jean C., Gryn, Steven E., Gupta, Milan, Hannah-Shmouni, Fady, Hegele, Robert A., Herman, Robert J., Hill, Michael D., Howlett, Jonathan G., Hundemer, Gregory L., Jones, Charlotte, Kaczorowski, Janusz, Khan, Nadia A., Kuyper, Laura M., Lamarre-Cliche, Maxime, Lavoie, Kim L., Leiter, Lawrence A., Lewanczuk, Richard, Logan, Alexander G., Magee, Laura A., Mangat, Birinder K., McFarlane, Philip A., McLean, Donna, Michaud, Andre, Milot, Alain, Moe, Gordon W., Penner, S. Brian, Pipe, Andrew, Poppe, Alexandre Y., Rey, Evelyne, Roerecke, Michael, Schiffrin, Ernesto L., Selby, Peter, Sharma, Mike, Shoamanesh, Ashkan, Sivapalan, Praveena, Townsend, Raymond R., Tran, Karen, Trudeau, Luc, Tsuyuki, Ross T., Vallée, Michel, Woo, Vincent, Bell, Alan D., and Daskalopoulou, Stella S.
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- 2020
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25. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
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Magid-Bernstein, Jessica R, Li, Yunke, Cho, Sung-Min, Piran, Pirouz J., Roh, David J., Gupta, Ajay, Shoamanesh, Ashkan, Merkler, Alexander, Zhang, Cenai, Avadhani, Radhika, Montano, Nataly, Iadecola, Constantino, Falcone, Guido, Sheth, Kevin, Qureshi, Adnan, Rosand, Jonathan, Goldstein, Joshua, Awad, Issam, Hanley, Daniel, Kamel, Hooman, Ziai, Wendy C., and Murthy, Santosh B.
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- 2021
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26. Prevalence of Clinical and Neuroimaging Markers in Cerebral Amyloid Angiopathy: A Systematic Review and Meta-Analysis
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Malhotra, Konark, Theodorou, Aikaterini, Katsanos, Aristeidis H., Zompola, Christina, Shoamanesh, Ashkan, Boviatsis, Efstathios, Paraskevas, George P., Spilioti, Martha, Cordonnier, Charlotte, Werring, David J., Alexandrov, Andrei V., and Tsivgoulis, Georgios
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- 2022
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27. Predictors of Recurrent Ischemic Stroke in Patients with Embolic Strokes of Undetermined Source and Effects of Rivaroxaban Versus Aspirin According to Risk Status: The NAVIGATE ESUS Trial
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Hart, Robert G., Veltkamp, Roland C., Sheridan, Patrick, Sharma, Mukul, Kasner, Scott E., Bangdiwala, Shrikant I., Ntaios, George, Shoamanesh, Ashkan, Ameriso, Sebastian F., Toni, Danilo, Czlonkowska, Anna, Lindgren, Arne, Hankey, Graeme J., Perera, Kanjana. S., Shuaib, Ashfaq, Coutts, Shelagh B., Gagliardi, Rubens J., Berkowitz, Scott D., Mundl, Hardi, Peters, Gary, and Connolly, Stuart J.
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- 2019
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28. Blood Pressure After Endovascular Thrombectomy and Outcomes in Patients With Acute Ischemic Stroke: An Individual Patient Data Meta-analysis
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Katsanos, Aristeidis H., Malhotra, Konark, Ahmed, Niaz, Seitidis, Georgios, Mistry, Eva A., Mavridis, Dimitris, Kim, Joon-Tae, Veroniki, Areti Angeliki, Maier, Ilko, Matusevicius, Marius, Khatri, Pooja, Anadani, Mohammad, Goyal, Nitin, Arthur, Adam S., Sarraj, Amrou, Yaghi, Shadi, Shoamanesh, Ashkan, Catanese, Luciana, Kantzanou, Maria, Psaltopoulou, Theodora, Rentzos, Alexandros, Psychogios, Marios, Van Adel, Brian, Spiotta, Alejandro M., Sandset, Else Charlotte, de Havenon, Adam, Alexandrov, Andrei V., Petersen, Nils H., and Tsivgoulis, Georgios
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- 2022
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29. Patterns of Stroke Transfers and Identification of Predictors for Thrombectomy
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Catanese, Luciana, Gupta, Raghav, Griessenauer, Christoph J., Moore, Justin M., Adeeb, Nimer, Enriquez-Marulanda, Alejandro, Alturki, Abdulrahman Y., Ascanio, Luis C., Lioutas, Vasileios, Shoamanesh, Ashkan, Cohen, Wendy, Kumar, Sandeep, Selim, Magdy, Thomas, Ajith J., and Ogilvy, Christopher S.
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- 2019
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30. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
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Abdelhamid, N, Abdul Rahman, D, Abdul-Saheb, M, Abreu, P, Abroskina, M, Abu Ahmad, F, Accassat, S, Acciaresi, M, Adami, A, Ahmad, N, Ahmed, F, Alberto Hawkes, M, Alemseged, F, Ali, A, Altavilla, R, Alwis, L, Amarenco, P, Amaro, S, Amaya Sanchez, LE, Amelia Pinto, A, Ameriso, SF, Amin, H, Amino, T, Amjad, AK, Anagnostou, E, Andersen, G, Anderson, C, Anderson, DC, Andrea Falco, M, Andres Mackinnon, F, Andreu, D, Androulakis, M, Angel Gamero, M, Angel Saredo, G, Angeles Diaz, R, Angels Font, M, Anticoli, S, Arauz, A, Arauz Gongora, AA, Araya, P, Arenillas Lara, JF, Arias Rivas, S, Arnold, M, Augustin, S, Avelar, W, Azevedo, E, Babikian, V, Bacellar, A, Badalyan, K, Bae, HJ, Baez Martinez, EM, Bagelmann, H, Bailey, P, Bak, Z, Baker, M, Balazs, A, Baldaranov, D, Balogun, I, Balueva, T, Bankuti, Z, Bar, M, Baranowska, A, Bardutzky, J, Barker Trejo, S, Barlinn, J, Baronnet, F, Barroso, C, Barteys, M, Bartolottiova, T, Barulin, A, Bas, M, Bashir, S, Basile, V, Bathe-Peters, R, Bathula, R, Batista, C, Batur Caglayan, H, Baumgartner, P, Bazan, R, Bazhenova, O, Beaudry, M, Beer, J, Behnam, Y, Beilei, C, Beinlich, A, Bejot, Y, Belkin, A, Benavente, OR, Benjamin, A, Berardi, V, Bereczki, D, Berkowitz, SD, Berlingieri, J, Berrios, W, Berrouschot, J, Bhandari, M, Bhargavah, M, Bicker, H, Bicsak, T, Bilik, M, Bindila, D, Birchenall, J, Birnbaum, L, Black, T, Blacker, D, Blacquiere, D, Blanc-Labarre, C, Blank, C, Blazejewska-Hyzorek, B, Bloch, S, Bodiguel, E, Bogdanov, E, Boos, L, Borcsik, L, Bornstein, N, Bouly, S, Braga, G, Bragado, I, Bravi, MC, Brokalaki, C, Brola, W, Brouns, R, Bruce, D, Brzoska-Mizgalska, J, Buck, B, Buksinska-Lisik, M, Burke, J, Burn, M, Bustamante, G, Cabrejo, L, Cai, K, Cajaraville, S, Calejo, M, Calvet, D, Campillo, J, Campos Costa, E, Camps, P, Can Alaydin, H, Candeloro, E, Canepa, C, Cantu Brito, CG, Cappellari, M, Carcel, C, Cardona Portela, P, Cardoso, F, Carek, M, Carletti, M, Carlos Portilla, J, Caruso, P, Casado-Naranjo, I, Castellini, P, 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- 2018
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31. Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke.
- Author
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Katsanos, Aristeidis H., Joundi, Raed A., Palaiodimou, Lina, Ahmed, Niaz, Kim, Joon-Tae, Goyal, Nitin, Maier, Ilko L., de Havenon, Adam, Anadani, Mohammad, Matusevicius, Marius, Mistry, Eva A., Khatri, Pooja, Arthur, Adam S., Sarraj, Amrou, Yaghi, Shadi, Shoamanesh, Ashkan, Catanese, Luciana, Psychogios, Marios-Nikos, Tsioufis, Konstantinos, and Malhotra, Konark
- Abstract
BACKGROUND: Data on systolic blood pressure (SBP) trajectories in the first 24 hours after endovascular thrombectomy (EVT) in acute ischemic stroke are limited. We sought to identify these trajectories and their relationship to outcomes. METHODS: We combined individual-level data from 5 studies of patients with acute ischemic stroke who underwent EVT and had individual blood pressure values after the end of the procedure. We used group-based trajectory analysis to identify the number and shape of SBP trajectories post-EVT. We used mixed effects regression models to identify associations between trajectory groups and outcomes adjusting for potential confounders and reported the respective adjusted odds ratios (aORs) and common odds ratios. RESULTS: There were 2640 total patients with acute ischemic stroke included in the analysis. The most parsimonious model identified 4 distinct SBP trajectories, that is, general directional patterns after repeated SBP measurements: high, moderate-high, moderate, and low. Patients in the higher blood pressure trajectory groups were older, had a higher prevalence of vascular risk factors, presented with more severe stroke syndromes, and were less likely to achieve successful recanalization after the EVT. In the adjusted analyses, only patients in the high-SBP trajectory were found to have significantly higher odds of early neurological deterioration (aOR, 1.84 [95% CI, 1.20–2.82]), intracranial hemorrhage (aOR, 1.84 [95% CI, 1.31–2.59]), mortality (aOR, 1.75 [95% CI, 1.21–2.53), death or disability (aOR, 1.63 [95% CI, 1.15–2.31]), and worse functional outcomes (adjusted common odds ratio,1.92 [95% CI, 1.47–2.50]). CONCLUSIONS: Patients follow distinct SBP trajectories in the first 24 hours after an EVT. Persistently elevated SBP after the procedure is associated with unfavorable short-term and long-term outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis.
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Palaiodimou, Lina, Joundi, Raed A, Katsanos, Aristeidis H, Ahmed, Niaz, Kim, Joon-Tae, Goyal, Nitin, Maier, Ilko L, de Havenon, Adam, Anadani, Mohammad, Matusevicius, Marius, Mistry, Eva A, Khatri, Pooja, Arthur, Adam S, Sarraj, Amrou, Yaghi, Shadi, Shoamanesh, Ashkan, Catanese, Luciana, Psychogios, Marios-Nikos, Malhotra, Konark, and Spiotta, Alejandro M
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- 2024
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33. Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities
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de Havenon, Adam, Sheth, Kevin N., Madsen, Tracy E., Johnston, Karen C., Turan, Tanya N., Toyoda, Kazunori, Elm, Jordan J., Wardlaw, Joanna M., Johnston, S. Claiborne, Williams, Olajide A., Shoamanesh, Ashkan, and Lansberg, Maarten G.
- Published
- 2021
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34. Tandem Occlusions: A Tale of Two Treatments
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Catanese, Luciana, Shoamanesh, Ashkan, and Poppe, Alexandre Y.
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- 2021
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35. Colchicine for the prevention of vascular events after non-cardioembolic stroke
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Katsanos, Aristeidis H and Shoamanesh, Ashkan
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- 2024
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36. Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial
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Kasner, Scott E., Lavados, Pablo, Sharma, Mukul, Wang, Yongjun, Wang, Yilong, Dávalos, Antoni, Shamalov, Nikolay, Cunha, Luis, Lindgren, Arne, Mikulik, Robert, Arauz, Antonio, Lang, Wilfried, Czlonkowska, Anna, Eckstein, Jens, Gagliardi, Rubens, Amarenco, Pierre, Ameriso, Sebastián F., Tatlisumak, Turgut, Veltkamp, Roland, Hankey, Graeme J., Toni, Danilo S., Bereczki, Daniel, Uchiyama, Shinichiro, Ntaios, George, Yoon, Byung-Woo, Brouns, Raf, DeVries Basson, M.M., Endres, Matthias, Muir, Keith, Bornstein, Natan, Ozturk, Serefnur, O'Donnell, Martin, Mundl, Hardi, Pater, Calin, Weitz, Jeffrey, Peacock, W. Frank, Swaminathan, Balakumar, Kirsch, Bodo, Berkowitz, Scott D., Peters, Gary, Pare, Guillaume, Themeles, Ellison, Shoamanesh, Ashkan, Connolly, Stuart J., and Hart, Robert G.
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- 2018
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37. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
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Nerenberg, Kara A., Zarnke, Kelly B., Leung, Alexander A., Dasgupta, Kaberi, Butalia, Sonia, McBrien, Kerry, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Padwal, Raj S., Tran, Karen C., Grover, Steven, Rabkin, Simon W., Moe, Gordon W., Howlett, Jonathan G., Lindsay, Patrice, Hill, Michael D., Sharma, Mike, Field, Thalia, Wein, Theodore H., Shoamanesh, Ashkan, Dresser, George K., Hamet, Pavel, Herman, Robert J., Burgess, Ellen, Gryn, Steven E., Grégoire, Jean C., Lewanczuk, Richard, Poirier, Luc, Campbell, Tavis S., Feldman, Ross D., Lavoie, Kim L., Tsuyuki, Ross T., Honos, George, Prebtani, Ally P.H., Kline, Gregory, Schiffrin, Ernesto L., Don-Wauchope, Andrew, Tobe, Sheldon W., Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Woo, Vincent, Hegele, Robert A., Selby, Peter, Pipe, Andrew, McFarlane, Philip A., Oh, Paul, Gupta, Milan, Bacon, Simon L., Kaczorowski, Janusz, Trudeau, Luc, Campbell, Norman R.C., Hiremath, Swapnil, Roerecke, Michael, Arcand, Joanne, Ruzicka, Marcel, Prasad, G.V. Ramesh, Vallée, Michel, Edwards, Cedric, Sivapalan, Praveena, Penner, S. Brian, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Dionne, Janis, Magee, Laura A., Logan, Alexander G., Côté, Anne-Marie, Rey, Evelyne, Firoz, Tabassum, Kuyper, Laura M., Gabor, Jonathan Y., Townsend, Raymond R., Rabi, Doreen M., and Daskalopoulou, Stella S.
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- 2018
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38. Oral factor Xa inhibitors and risk of subdural hematoma: COMPASS trial results and meta-analysis
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Catanese, Luciana, Eikelboom, John W., Bosch, Jackie, Shestakovska, Olga, Ng, Kelvin, Nayar, Sumiti, Perera, Kanjana S., Shoamanesh, Ashkan, Sharma, Mukul, and Hart, Robert G.
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- 2020
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39. Recommendations for Clinical Trials in ICH: The Second Hemorrhagic Stroke Academia Industry Roundtable
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Selim, Magdy, Hanley, Daniel, Steiner, Thorsten, Christensen, Hanne Krarup, Lafuente, Jesus, Rodriguez, David, Selim, Magdy, Keep, Richard, Steiner, Thorsten, Anderson, Craig, Hanley, Daniel, Keep, Richard, Parry-Jones, Adrian, Nilsson, Michael, Sunnerhagen, Katharina Stibrant, Novick, Elizabeth, Aronowski, Jaroslaw, Lawson, Brooke, Chaudhary, Neeraj, Zhou-Ping, Tang, Steiner, Thorsten, Christensen, Hanne Krarup, Zuccarello, Mario, Woo, Daniel, Shoamanesh, Ashkan, Qureshi, Adnan I., Cordonnier, Charlotte, Anderson, Craig, Klijn, Karin, Salman, Rustam Al-Shahi, Sprigg, Nikola, Gregson, Barbara, Mendelow, David, Gaudin, Christophe, Pandey, Aditya, Ziai, Wendy, Alcázar-Romero, Pedro Pablo, Montaner, Joan, Marti-Fabregas, Joan, Nilsson, Sara, Schenk, Bettina, Riess, Hanno, You, Chao, Gaist, David, and Broderick, Joseph
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- 2020
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40. Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention
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Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Caso, Valeria, Toso, Elisabetta, Angelini, Filippo, Canavero, Isabella, Micieli, Giuseppe, Antonenko, Kateryna, Rocco, Alessandro, Diomedi, Marina, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Giannopoulos, Sotirios, Ageno, Walter, Pegoraro, Samuela, Putaala, Jukka, Strbian, Daniel, Sallinen, Hanne, Mac Grory, Brian C., Furie, Karen L., Stretz, Christoph, Reznik, Michael E., Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Franco, Laura, Zepponi, Giorgia, Romoli, Michele, Zini, Andrea, Brancaleoni, Laura, Riva, Letizia, Silvestrelli, Giorgio, Ciccone, Alfonso, Zedde, Maria Luisa, Giorli, Elisa, Kosmidou, Maria, Ntais, Evangelos, Palaiodimou, Lina, Halvatsiotis, Panagiotis, Tassinari, Tiziana, Saia, Valentina, Ornello, Raffaele, Sacco, Simona, Bandini, Fabio, Mancuso, Michelangelo, Orlandi, Giovanni, Ferrari, Elena, Pezzini, Alessandro, Poli, Loris, Cappellari, Manuel, Forlivesi, Stefano, Rigatelli, Alberto, Yaghi, Shadi, Scher, Erica, Frontera, Jennifer A., Masotti, Luca, Grifoni, Elisa, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Marcheselli, Simona, Gasparro, Antonio, Terruso, Valeria, Arnao, Valentina, Aridon, Paolo, Abdul-Rahim, Azmil H., Dawson, Jesse, Saggese, Carlo Emanuele, Palmerini, Francesco, Doronin, Boris, Volodina, Vera, Toni, Danilo, Risitano, Angela, Schirinzi, Erika, Del Sette, Massimo, Lochner, Piergiorgio, Monaco, Serena, Mannino, Marina, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Lotti, Enrico Maria, Padroni, Marina, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Ntaios, George, Sagris, Dimitrios, Baldi, Antonio, D’Amore, Cataldo, Mumoli, Nicola, Porta, Cesare, Denti, Licia, Chiti, Alberto, Corea, Francesco, Acciarresi, Monica, Flomin, Yuriy, Popovic, Nemanja, and Tsivgoulis, Georgios
- Published
- 2021
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41. Combatting Secondary Injury From Intracerebral Hemorrhage With Supplemental Antioxidant Therapy
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Shoamanesh, Ashkan and Katsanos, Aristeidis H.
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- 2021
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42. Intravenous Thrombolysis With Tenecteplase in Patients With Large Vessel Occlusions: Systematic Review and Meta-Analysis
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Katsanos, Aristeidis H., Safouris, Apostolos, Sarraj, Amrou, Magoufis, Georgios, Leker, Ronen R., Khatri, Pooja, Cordonnier, Charlotte, Leys, Didier, Shoamanesh, Ashkan, Ahmed, Niaz, Alexandrov, Andrei V., and Tsivgoulis, Georgios
- Published
- 2021
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43. Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study
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Romero, José R., Beiser, Alexa, Himali, Jayandra J., Shoamanesh, Ashkan, DeCarli, Charles, and Seshadri, Sudha
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- 2017
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44. Intensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage.
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Li, Qi, Morotti, Andrea, Warren, Andrew, Qureshi, Adnan I, Dowlatshahi, Dar, Falcone, Guido, Sheth, Kevin N., Shoamanesh, Ashkan, Murthy, Santosh B., Viswanathan, Anand, and Goldstein, Joshua N.
- Subjects
BLOOD pressure ,INTRACEREBRAL hematoma ,CEREBRAL hemorrhage ,HEMATOMA ,HEMORRHAGE ,COMPUTED tomography - Abstract
Objective: Patients with spontaneous intracerebral hemorrhage (ICH) at the highest risk of hematoma growth are those with the most potential to benefit from anti‐expansion treatment. Large clinical trials have not definitively shown a clear benefit of blood pressure (BP) reduction. We aim to determine whether intensive blood pressure reduction could benefit patients with fast bleeding ICH. Methods: An exploratory analysis of data from the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH‐2) randomized controlled trial was performed. In order to capture not just early bleeding (even if a small amount), but the rate of bleeding (ml/hour), we restricted the study to "Fast bleeding ICH," defined as an ICH volume/onset to computed tomography (CT) time >5 ml/hr. Hematoma growth, as defined as an increase of hematoma volume > 33% between baseline and 24 hours. Results: A total of 940 patients were included (mean age = 62.1 years, 61.5% men), of whom 214 (22.8%) experienced hematoma expansion. Of these, 567 (60.3%) met the definition of "fast bleeding" with baseline ICH volume/time to presentation of at least 5 ml/hr. Intensive BP reduction was associated with a significantly lower rate of hematoma growth in fast bleeding patients (20.6% vs 31.0%, p = 0.005). In a subgroup of 266 (46.9%) fast‐bleeding patients who received treatment within 2 hours after symptom onset, intensive BP lowering was associated with improved functional independence (odds ratio [OR] = 1.98, 95% confidence interval [CI] = 1.06–3.69, p = 0.031). Interpretation: Our results suggest that early use of intensive BP reduction may reduce hematoma growth and improve outcome in fast bleeding patients. ANN NEUROL 2024;95:129–136 [ABSTRACT FROM AUTHOR]
- Published
- 2024
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45. Transcranial Doppler ultrasound to evaluate the risk of hyperperfusion after endovascular stroke thrombectomy.
- Author
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Katsanos, Aristeidis H., Srivastava, Abhilekh, Sahlas, Demetrios J., Perera, Kanjana, Ng, Kelvin K. H., Joundi, Raed A., Van Adel, Brian, Larrazabal, Ramiro, Ratnayake, Kanchana, Tsivgoulis, Georgios, Benavente, Oscar, Hart, Robert, Sharma, Mukul, Shoamanesh, Ashkan, and Catanese, Luciana
- Subjects
TRANSCRANIAL Doppler ultrasonography ,ENDOVASCULAR surgery ,HYPERPERFUSION ,ISCHEMIC stroke ,FLOW velocity ,CEREBRAL arteries ,BLOOD pressure - Abstract
Background and Purpose: Hemorrhagic transformation (HT) has been reported in up to 50% of acute ischemic stroke (AIS) patients with a large vessel occlusion (LVO) treated with endovascular thrombectomy (EVT). HT may be driven by postrecanalization hyperperfusion injury and is independently associated with worse functional outcomes. Strategies to identify patients at risk for HT may assist in developing preventive therapies. Methods: We prospectively included adult AIS patients with an anterior circulation LVO achieving successful recanalization after EVT. Consenting participants received transcranial Doppler ultrasound (TCD) within 18 hours of procedure completion. We compared flow velocities according to the presence of HT on the computed tomography scan performed within the first 24±12 hours from the end of EVT. We also evaluated the association of flow velocities with systemic blood pressure (BP) readings at the time of insonation. Results: A total of 48 patients consented to participate in the study. Six (12%) were excluded due to the absence of temporal windows. HT was detected in 20 participants (48%). Those with HT had higher peak systolic velocities on the middle cerebral arteries compared to those without HT for both the symptomatic (107±42 vs. 82±25 cm/second, p =.024) and asymptomatic (97±21 vs. 81±25 cm/second, p =.040) sides. No correlation of flow velocities on either the symptomatic or asymptomatic side and BP measurements at the time of insonation was detected. Conclusion: TCD can identify patients at risk of HT following successful EVT. TCD could serve as an inexpensive ancillary test to guide participant selection for clinical trials targeting postprocedural reperfusion injury. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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46. High-Sensitivity Cardiac Troponin T for Risk Stratification in Patients With Embolic Stroke of Undetermined Source
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Scheitz, Jan F., Pare, Guillaume, Pearce, Lesly A., Mundl, Hardi, Peacock, W. Frank, Czlonkowska, Anna, Sharma, Mukul, Nolte, Christian H., Shoamanesh, Ashkan, Berkowitz, Scott D., Krahn, Thomas, and Endres, Matthias
- Published
- 2020
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47. Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial
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Mikulík, Robert, Eckstein, Jens, Pearce, Lesly A., Mundl, Hardi, Rudilosso, Salvatore, Olavarría, Veroníca V., Shoamanesh, Ashkan, Chamorro, Ángel, Martí-Fàbregas, Joan, Veltkamp, Roland, Öztürk, Şerefnur, Tatlisumak, Turgut, Peacock, W. Frank, Berkowitz, Scott D., Connolly, Stuart J., and Hart, Robert G.
- Published
- 2020
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48. Atrial Cardiopathy and Nonstenosing Large Artery Plaque in Patients With Embolic Stroke of Undetermined Source
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Kamel, Hooman, Pearce, Lesly A., Ntaios, George, Gladstone, David J., Perera, Kanjana, Roine, Risto O., Meseguer, Elena, Shoamanesh, Ashkan, Berkowitz, Scott D., Mundl, Hardi, Sharma, Mukul, Connolly, Stuart J., Hart, Robert G., and Healey, Jeff S.
- Published
- 2020
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49. Racial/ethnic disparities in the risk of intracerebral hemorrhage recurrence
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Leasure, Audrey C., King, Zachary A., Torres-Lopez, Victor, Murthy, Santosh B., Kamel, Hooman, Shoamanesh, Ashkan, Al-Shahi Salman, Rustam, Rosand, Jonathan, Ziai, Wendy C., Hanley, Daniel F., Woo, Daniel, Matouk, Charles C., Sansing, Lauren H., Falcone, Guido J., and Sheth, Kevin N.
- Published
- 2020
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50. Education in Stroke Medicine: A Canadian Perspective
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Poppe, Alexandre Y., Casaubon, Leanne K., Gubitz, Gord, and Shoamanesh, Ashkan
- Published
- 2019
- Full Text
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