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The transformation behaviors of Zn during co-pyrolysis of waste tires and coal were studied in a fixed-bed reaction system. The effects of pyrolysis temperature and the Zn content of coal mixture on the Zn distributions in the pyrolytic products (coke, tar and gas) were investigated in detail. It is found that the relative percentages of Zn in the pyrolytic products are closely related to the contents of S and mineral elements (Ca, Al, Si and Fe) in the coal. The thermodynamic equilibrium simulations conducted using FactSage 8.0 show that S, Al and Si can interact with Zn to inhibit the volatilization of Zn from coke. The reaction sequence with Zn is S > Al > Si, and the thermal stability of products is in the order of ZnS > ZnAl2O4 > Zn2SiO4. These results provide insights into the migration characteristics of Zn during co-pyrolysis of coal and waste tires, which is vital to the prevention and control of Zn emissions to reduce the environmental burden.

Long non-coding (lnc)RNA HAND2 antisense RNA 1 (HAND2-AS1) exhibited tumor suppression activity in different types of cancer. However, its role in cervical squamous cell carcinoma (CSCC), which is frequently diagnosed among females, has not been elucidated. The current study revealed that lncRNA HAND2-AS1 was downregulated, while Rho-associated protein kinase 1 (ROCK1) was upregulated in serum of human papillomavirus (HPV)-positive and -negative patients with CSCC compared with healthy controls. Correlation analysis revealed that the expression levels of lncRNA HAND2-AS1 were negatively correlated with the expression levels of ROCK1 in HPV-positive and -negative patients with CSCC but not in healthy controls. Downregulation of lncRNA HAND2-AS1 distinguished patients with CSCC from healthy controls. Additionally, lncRNA HAND2-AS1 overexpression led to reduced expression levels of ROCK1 in HPV-positive and -negative human CSCC cell lines but not in normal cervical cell lines. ROCK1 overexpression did not significantly affect the expression of lncRNA HAND2-AS1 in all the cell lines investigated. lncRNA HAND2-AS1 overexpression inhibited, while ROCK1 overexpression promoted the proliferation, migration and invasion of HPV-positive and -negative human CSCC cell lines but not normal cervical cell lines. ROCK1 overexpression attenuated the effects of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration and invasion. lncRNA HAND2-AS1 may inhibit cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and -negative CSCC.

Huizhen Zhang,1 Shuangling Jin,1 Aifang Ji,2 Ying Ma,3 Chunyan Zhang,1 Ailan Wang,1 Rui Wang1 1Department of Gynecology, Heping Hospital Affiliated to Changzhi Medical College, Changzi, Shanxi Province, 046000, People’s Republic of China; 2Department of Clinical Laboratory, Heping Hospital Affiliated to Changzhi Medical College, Changzi, Shanxi Province, 046000, People’s Republic of China; 3Department of Obstetrics, Heping Hospital Affiliated to Changzhi Medical College, Changzi, Shanxi Province, 046000, People’s Republic of ChinaCorrespondence: Shuangling JinDepartment of Gynecology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi City, Shanxi Province, 046000, People’s Republic of ChinaEmail nj6077@163.comBackground: SLC16A1-AS1 has been characterized as an oncogenic long non-coding (lncRNA) in breast cancer and bladder cancer, while its role in cervical squamous cell carcinoma (CSCC) is unknown.Methods: CSCC and non-tumor tissue samples were collected from 60 female patients, and qPCR was performed to detect the expression of SLC16A1-AS1, miR-194 and SOCS2. Luciferase reporter assay was performed to detect the interaction between SLC16A1-AS1 and miR-194. Colony formation assay was used to detect cell proliferation.Results: SLC16A1-AS1 was down-regulated in CSCC and correlated with poor survival. Overexpression of SLC16A1-AS1 could inhibit the proliferation of cervical cancer cells. In addition, SLC16A1-AS1 could sponge miR-194 and increase the expression levels of SOCS2, ultimately inhibiting the proliferation of cervical cancer cells.Conclusion: SLC16A1-AS1 was downregulated in CSCC and suppressed cell proliferation in cervical squamous cell carcinoma (CSCC) through the miR-194/SOCS2 axis.Keywords: cervical squamous cell carcinoma, SLC16A1-AS1, miR-194, SOCS2

Novel Mn&ndash, Ce&ndash, Ti&ndash, O composite aerogels with large mesopore size were prepared via a one-pot sol&ndash, gel method by using propylene oxide as a network gel inducer and ethyl acetoacetate as a complexing agent. The effect of calcination temperature (400, 500, 600, and 700 &deg, C) on the NH3&ndash, selective catalytic reduction (SCR) performance of the obtained Mn&ndash, O composite aerogels was investigated. The results show that the Mn&ndash, O catalyst calcined at 600 &deg, C exhibits the highest NH3&ndash, SCR activity and lowest apparent activation energy due to its most abundant Lewis acid sites and best reducibility. The NO conversion of the MCTO-600 catalyst maintains 100% at 200 &deg, C in the presence of 100 ppm SO2, showing the superior resistance to SO2 poisoning as compared with the MnOx&ndash, CeO2&ndash, TiO2 catalysts reported the literature. This should be mainly attributed to its large mesopore sizes with an average pore size of 32 nm and abundant Lewis acid sites. The former fact facilitates the decomposition of NH4HSO4, and the latter fact reduces vapor pressure of NH3. The NH3&ndash, SCR process on the MCTO-600 catalyst follows both the Eley&ndash, Rideal (E&ndash, R) mechanism and the Langmuir&ndash, Hinshelwood (L&ndash, H) mechanism.

Four activated carbons (ACs) activated by different activation methods from different precursors were heat-treated at 600℃ to decrease surface oxygen functional groups and to separate the effect of pore texture from surface chemistry on their sulfur adsorption performance. The ACs and the heat-treated ones were used as adsorbents for thiophene (T), dibenzothiophene (DBT), and 4,6-dimethyl dibenzothiophene (4,6-DMDBT) for model fuels with or without a competing benzene. The correlations of surface functional groups and pore textures to their adsorption capacities for T, DBT and 4,6-DMDBT were investigated. Results indicated that the heat treatment not only decreased surface oxygen content, but also caused a pore texture modification. The adsorption isotherms can be well fitted by the Langmuir–Freundlich single solute isotherm. The sulfur adsorption capacity of ACs after the treatment for T, DBT, and 4,6-DMDBT has a good linear relationship with the pore volume of pores within 0.536–1.090, 0.536–1.179, and 0.679–1.268 nm, respectively. The decreased percentage of surface oxygen of ACs by the heat treatment is correlated linearly with the decreased percentage of the sulfur adsorption capacity for all the thiophenic compounds. Micropore filling via the π–π interaction is the dominant adsorption mechanism of thiophenic compounds for both the untreated and heat-treated ACs. Surface oxides contribute to the thiophenic adsorption by a cooperative interaction of the π–π interaction and the acid–base interaction between the basic sulfur atom and the acidic carbon atoms linked with oxygen in graphene edges. A flat adsorption is the most possible geometry in the adsorption of thiophenic compounds.