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3. Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial.

Author

Proft, Fabian, Torgutalp, Murat, Muche, Burkhard, Rodriguez, Valeria Rios, Listing, Joachim, Protopopov, Mikhail, Rademacher, Judith, Haibel, Hildrun, Spiller, Laura, Weber, Anne- Katrin, Verba, Maryna, Brandt-Juergens, Jan, Kiltz, Uta, Sieburg, Maren, Jacki, Swen, Sieper, Joachim, and Poddubnyy, Denis

Published
2024
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10. Radiographic Progression in Sacroiliac Joints in Patients With Axial Spondyloarthritis: Results From a Five‐Year International Observational Study.

Author

Poddubnyy, Denis, Sieper, Joachim, Akar, Servet, Muñoz‐Fernández, Santiago, Haibel, Hildrun, Diekhoff, Torsten, Protopopov, Mikhail, Altmaier, Elisabeth, Ganz, Fabiana, and Inman, Robert D.

Subjects
SACROILIAC joint radiography, DISEASE progression, SACROILIAC joint, SCIENTIFIC observation, CONFIDENCE intervals, ANKYLOSIS, SPONDYLOARTHROPATHIES, KAPLAN-Meier estimator, DESCRIPTIVE statistics, RESEARCH funding, ODDS ratio, DATA analysis software, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Objective: To evaluate progression from nonradiographic (nr‐) to radiographic axial spondyloarthritis (r‐axSpA) over 5 years in patients with recently diagnosed (≤1 year) axSpA fulfilling the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. Methods: A prospsective, observational study (Patients with Axial Spondyloarthritis: Multi‐Country Registry of Clinical Characteristics) was conducted in rheumatology practices in 29 countries. Baseline and follow‐up radiographs of sacroiliac joints were centrally evaluated by three readers according to the grading system of the modified New York criteria for patients initially classified as nr‐axSpA. Radiographic progression from nr‐axSpA to r‐axSpA was evaluated by Kaplan‐Meier analysis. Cox proportional regression analyses for progression from nr‐axSpA to r‐axSpA were also conducted. Results: Among 2,165 patients with axSpA, 1,612 (74%) were classified as having r‐axSpA (1,050 [65%]) or nr‐axSpA (562 [35%]) by central reading. Of 246 patients with nr‐axSpA (mean [SD] symptom duration: 4.4 [6.2] years) who had at least one follow‐up sacroiliac joint radiograph, progression from nr‐axSpA to r‐axSpA at any follow‐up visit was observed in 40 patients (16%) over 5 years. Mean time to radiographic progression was 2.4 years (ranging from 0.9 to 5.1 years). Progression to r‐axSpA was associated with male sex (hazard ratio [HR] 3.16 [95% CI 1.22–8.17]), fulfillment of the imaging arm of the ASAS classification criteria (HR 6.64 [1.37–32.25]), and good response to nonsteroidal anti‐inflammatory drugs (HR 4.66 [1.23–17.71]). Conclusion: 16% of patients with nr‐axSpA progressed to r‐axSpA within 5 years. Male sex, fulfillment of the imaging arm of the ASAS criteria, and good response to nonsteroidal anti‐inflammatory drugs were predictors of radiographic progression in patients with recently diagnosed axSpA. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Goodbye to the term 'ankylosing spondylitis', hello 'axial spondyloarthritis': time to embrace the ASAS-defined nomenclature.

Author

van der Heijde, Désirée, Molto, Anna, Ramiro, Sofia, Braun, Jürgen, Dougados, Maxime, van Gaalen, Floris A., Gensler, Lianne S., Inman, Robert D., Landewé, Robert B. M., Marzo-Ortega, Helena, Navarro-Compán, Victoria, Phoka, Andri, Poddubnyy, Denis, Protopopov, Mikhail, Reveille, John, Rudwaleit, Martin, Sampaio-Barros, Percival, Sepriano, Alexandre, Sieper, Joachim, and den Bosch, Filip E. Van

Published
2024
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24. Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force

Author

Smolen, Josef S, Schöls, Monika, Braun, Jürgen, Dougados, Maxime, FitzGerald, Oliver, Gladman, Dafna D, Kavanaugh, Arthur, Landewé, Robert, Mease, Philip, Sieper, Joachim, Stamm, Tanja, Wit, Maarten de, Aletaha, Daniel, Baraliakos, Xenofon, Betteridge, Neil, Bosch, Filip van den, Coates, Laura C, Emery, Paul, Gensler, Lianne S, Gossec, Laure, Helliwell, Philip, Jongkees, Merryn, Kvien, Tore K, Inman, Robert D, McInnes, Iain B, Maccarone, Mara, Machado, Pedro M, Molto, Anna, Ogdie, Alexis, Poddubnyy, Denis, Ritchlin, Christopher, Rudwaleit, Martin, Tanew, Adrian, Thio, Bing, Veale, Douglas, Vlam, Kurt de, and Heijde, Désirée van der

Published
2018
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25. Comparing MRI and conventional radiography for the detection of structural changes indicative of axial spondyloarthritis in the ASAS cohort.

Author

Protopopov, Mikhail, Proft, Fabian, Wichuk, Stephanie, Machado, Pedro M, Lambert, Robert G, Weber, Ulrich, Pedersen, Susanne Juhl, Østergaard, Mikkel, Sieper, Joachim, Rudwaleit, Martin, Baraliakos, Xenofon, Maksymowych, Walter P, and Poddubnyy, Denis

Subjects
MAGNETIC resonance imaging, RADIOGRAPHY, ANKYLOSIS, SPONDYLOARTHROPATHIES, COMPARATIVE studies, LONGITUDINAL method
Abstract

Objectives To compare MRI and conventional radiography of SI joints for detection of structural lesions typical for axial spondyloarthritis (axSpA). Methods Adult patients from the Assessment of SpondyloArthritis international Society (ASAS) cohort with symptoms suggestive of axSpA and both SI joint MRI and radiographs available for central reading were included. Radiographs were evaluated by three readers according to the modified New York (mNY) criteria grading system. The presence of structural damage on radiographs was defined as fulfilment of the radiographic mNY criterion and, additionally, a lower threshold for sacroiliitis of at least grade 2 unilaterally. MRI scans were assessed for the presence of structural changes indicative of axSpA by seven readers. Diagnostic performance [sensitivity, specificity, positive and negative predictive values (PPV and NPV) and positive and negative likelihood ratios (LR+ and LR−)] of MRI and radiographs (vs rheumatologist's diagnosis of axSpA) were calculated. Results Overall, 183 patients were included and 135 (73.7%) were diagnosed with axSpA. Structural lesions indicative of axSpA on MRI had sensitivity 38.5%, specificity 91.7%, PPV 92.9%, NPV 34.6%, LR+ 4.62 and LR− 0.67. Sacroiliitis according to the mNY criteria had sensitivity 54.8%, specificity 70.8%, PPV 84.1%, NPV 35.8%, LR+ 1.88 and LR− 0.64. Radiographic sacroiliitis of at least grade 2 unilaterally had sensitivity 65.2%, specificity 50.0%, PPV 78.6%, NPV 33.8%, LR+ 1.30 and LR− 0.69. Conclusion Structural lesions of the SI joint detected by MRI demonstrated better diagnostic performance and better interreader reliability compared with conventional radiography. [ABSTRACT FROM AUTHOR]

Published
2023
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35. List of contributors

Author

Abell, Thomas, Acosta, Camilo J., Adadey, Samuel Mawuli, Anaya, Juan-Manuel, Annibale, Bruno, Antonini, Simone, Aqeel, Faten, Arepalli, Sruthi, Assassi, Shervin, Babushok, Daria V., Barkin, Jodie A., Bartalena, Luigi, Ben Nasr, Moufida, Berentsen, Sigbjørn, Betterle, Corrado, Birtolo, Maria Francesca, Bisarya, Pooja Nikki, Blüml, Stephan, Bonomi, Marco, Bowlus, Christopher L., Brassard, Alain, Brusch, Anna, Burrone, Marco, Carrillo-Bayona, Jorge Alberto, Casciola-Rosen, Livia, Caturegli, Patrizio, Chang, Christopher, Chatzis, Loukas, Chaves, Juan José, Chen, Dhruti P., Chen, Jingjing, Chen, Saijuan, Cheng, Wenyan, Chhabra, Garvit, Choi, Jamie H., Cianferotti, Luisella, Crowell, Eric, Cuda, Carla M., Davidson, Anne, Deane, Sean, del Carmen Moleon, Maria, Di Dalmazi, Giulia, Dilaghi, Emanuele, Dixon Johns, James, Doost, Mohammad Saffari, Dyke, Jason, D’Addio, Francesca, D’Cruz, David P., Falk, Ronald J., Farina, Antonio, Fattizzo, Bruno, Fernandez-Carbonell, Cristina, Fiorina, Paolo, Flanagan, Eoin P., Franzen, Daniel P., Frederiksen, Henrik, Free, Meghan E., Frejo, Lidia, Fung, Maxwell A., Gaffney, Patrick M., Galindo, Javier Leonardo, Gallo, Daniela, Gately, Ursula, Geetha, Duvuru, Gershwin, M. Eric, Goldbach-Mansky, Raphaela, Goronzy, Jörg J., Goules, Andreas V., Gudjonsson, Johann E., Guilherme, Luiza, Guo, Weinan, Hajj-Ali, Rula A., Hamburger, Nicole, He, Liting, Herrán, María, Hoa, Michael, Honnorat, Jérôme, Hu, Qingjie, Hu, Yue, Husebye, Eystein S., Ippolito, Silvia, James, Eddie A., James, Judith A., Jennette, J. Charles, Jian, Zhe, Jiang, Ying, Kaklamanos, Aimilios, Kalil, Jorge, Kaminski, Henry J., Kammeyer, Ryan, Kaya, Ziya, Kelly, Jennifer A., Khakoo, Nidah Shabbir, Khoury, Samia J., Kolios, Antonios G.A., Königs, Christoph, Kopplin, Laura J., Krupp, Lauren B., Kuker, Russ, Kwapnoski, Zachary, Kyttaris, Vasileios C., La Cava, Antonio, Lahner, Edith, Lania, Andrea G., Lehmann, Helmar C., Levy, Cynthia, Li, Chunying, Li, Kun, Li, Shuli, Li, Xiangqian, Liu, Hui, Liu, Ling, Liu, Yudong, Lleo, Ana, Long, Hai, Lopez-Escamez, Jose A., Lu, Qianjin, Lunati, Maria Elena, Lunn, Michael P.T., Lupi, Isabella, Malattia, Clara, Maletic-Savatic, Mirjana, Marietta, Eric V., Martin, Cole, Martini, Alberto, Mastaglia, Frank, Mathur, Prateek, Mazziotti, Gherardo, McDonald, Benjamin, Mehta, Neesurg S., Mieli-Vergani, Giorgina, Milano, Reza V., Morel, Laurence, Moss, Brandon, Moussa, Kareem, Murray, Joseph A., Naing, LeYu, Needham, Merrilee, Nelson, Andrew J., Nilsson, Jakob, O'Neill, Kimberly A., Ochoa, Jorge R., Öztosun, Gülşen, Pan, Meng, Paramalingam, Shereen, Pathak, Shresh, Pei, Chenchen, Perl, Andras, Perlman, Harris, Persani, Luca, Pillai, Shiv, Piquet, Amanda L., Poddubnyy, Denis, Polo, Fernando, Presotto, Fabio, Rabb, Hamid, Radin, Massimo, Rochat, Pete, Rodolfi, Stefano, Rojas, Manuel, Rosen, Antony, Rossetti, Raffaella, Rubin, David T., Saab, Georges, Sabbadin, Chiara, Salbach, Christian, Schreiber, Karen, Sciascia, Savino, Sheikh, Kazim A., Shen, Yang, Shusko, Alexander R., Sieper, Joachim, Smilek, Dawn Elaine, Smith, Kenneth, Smolen, Josef S., Sorkhabi, Sharareh Yousefpour, Stocker, Abigail, Stone, John H., Stroikova, Vera, Sun, Yonghu, Syrbe, Uta, Tanda, Maria Laura, Taubenslag, Kenneth J., Terziroli Beretta-Piccoli, Benedetta, Tessneer, Kandice L., Thakolwiboon, Smathorn, Tian, Jingru, Tiniakou, Eleni, Titulaer, Maarten J., Tsui, Edmund, Tzioufas, Athanasios G., Vambutas, Andrea, van Steenhoven, Robin W., Varga, John, Vergani, Diego, Villagrán-García, Macarena, Vondenberg, Jaime A., Vora, Paras, Wagner, Catriona A., Wang, Gang, Wang, Jingying, Wang, Min, Wang, Xin, Weinstein, Jessica E., Weyand, Cornelia M., Xin, Yue, Xing, Enze, Yao, Xu, Yu, Cong, Zhang, Furen, Zhang, Jianzhong, Zhang, Xuan, Zhou, Cheng, Zhu, Haiqin, Zhu, Hong, Zinger, Adar, and Zuo, Xiaoxia

Published
2024
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36. A cluster analysis in the worldwide ASAS-PerSpA study

Author

López-Medina, Clementina, Chevret, Sylvie, Molto, Anna, Sieper, Joachim, Duruöz, Tuncay, Kiltz, Uta, Elzorkany, Bassel, Hajjaj-Hassouni, Najia, Burgos-Vargas, Ruben, Maldonado-Cocco, José, Ziade, Nelly, Gavali, Meghna, Navarro-Compan, Victoria, Luo, Shue Fen, Biglia, Alessandro, Tae-Jong, Kim, Kishimoto, Mitsumasa, Pimentel-Santos, Fernando M., Gu, Jieruo, Muntean, Laura, Van Gaalen, Floris A., Geher, Pál, Magrey, Marina, Ibáñez-Vodnizza, Sebastián E., Bautista-Molano, Wilson, Maksymowych, Walter, MacHado, Pedro M., Landewé, Robert, Van Der Heijde, Desirée, Dougados, Maxime, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
musculoskeletal diseases, ankylosing, arthritis, Rheumatology, Immunology, Immunology and Allergy, spondylitis, psoriatic
Abstract

Objective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist € s diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations. publishersversion published

Published
2021

38. Predictive validity of the ASAS classification criteria for axial and peripheral spondyloarthritis after follow-up in the ASAS cohort: a final analysis

Author

Sepriano, Alexandre, Landewé, Robert, van der Heijde, Désirée, Sieper, Joachim, Akkoc, Nurullah, Brandt, Jan, Braun, Jürgen, Collantes-Estevez, Eduardo, Dougados, Maxime, Fitzgerald, Oliver, Huang, Feng, Gu, Jieruo, Kirazli, Yesim, Maksymowych, Walter P, Marzo-Ortega, Helena, Olivieri, Ignazio, Ozgocmen, Salih, Roussou, Euthalia, Scarpato, Salvatore, Sørensen, Inge J, Valle-Oñate, Rafael, Van den Bosch, Filip, van der Horst-Bruinsma, Irene, Weber, Ulrich, Wei, James, and Rudwaleit, Martin

Published
2016
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40. Course of Magnetic Resonance Imaging–Detected Inflammation and Structural Lesions in the Sacroiliac Joints of Patients in the Randomized, Double-Blind, Placebo-Controlled Danish Multicenter Study of Adalimumab in Spondyloarthritis, as Assessed by the Berlin and Spondyloarthritis Research Consortium of Canada Methods

Author

Pedersen, Susanne J., Poddubnyy, Denis, Srensen, Inge J., Loft, Anne-Gitte, Hindrup, Jens S., Thamsborg, Gorm, Asmussen, Karsten, Hendricks, Oliver, Nrregaard, Jesper, Piil, Anne-Dorthe, Mller, Jakob M., Jurik, Anne-Grethe, Balding, Lone, Lambert, Robert G., Sieper, Joachim, and stergaard, Mikkel

Published
2016
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42. Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy: a double-blind, randomised, placebo-controlled phase 3 trial.

Author

van der Heijde, Désirée, Baraliakos, Xenofon, Sieper, Joachim, Deodhar, Atul, Inman, Robert D., Hideto Kameda, Xiaofeng Zeng, Yunxia Sui, Xianwei Bu, Pangan, Aileen L., Wung, Peter, In-Ho Song, Kameda, Hideto, Zeng, Xiaofeng, Sui, Yunxia, Bu, Xianwei, and Song, In-Ho

Abstract

Objectives: To evaluate the efficacy and safety of upadacitinib, a Janus kinase inhibitor, in patients with active ankylosing spondylitis (AS) with an inadequate response (IR) to biological disease-modifying antirheumatic drugs (bDMARDs).Methods: Adults with active AS who met modified New York criteria and had an IR to one or two bDMARDs (tumour necrosis factor or interleukin-17 inhibitors) were randomised 1:1 to oral upadacitinib 15 mg once daily or placebo. The primary endpoint was Assessment of SpondyloArthritis international Society 40 (ASAS40) response at week 14. Sequentially tested secondary endpoints included Ankylosing Spondylitis Disease Activity score, Spondyloarthritis Research Consortium of Canada MRI spine inflammation score, total back pain, nocturnal back pain, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Maastricht Ankylosing Spondylitis Enthesitis Score. Results are reported from the 14-week double-blind treatment period.Results: A total of 420 patients with active AS were randomised (upadacitinib 15 mg, n=211; placebo, n=209). Significantly more patients achieved the primary endpoint of ASAS40 at week 14 with upadacitinib vs placebo (45% vs 18%; p<0.0001). Statistically significant improvements were observed with upadacitinib vs placebo for all multiplicity-controlled secondary endpoints (p<0.0001). Adverse events were reported for 41% of upadacitinib-treated and 37% of placebo-treated patients through week 14. No events of malignancy, major adverse cardiovascular events, venous thromboembolism or deaths were reported with upadacitinib.Conclusion: Upadacitinib 15 mg was significantly more effective than placebo over 14 weeks of treatment in bDMARD-IR patients with active AS. No new safety risks were identified with upadacitinib.Trial Registration Number: NCT04169373. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Defining an optimal referral strategy for patients with a suspicion of axial spondyloarthritis: what is really important? Response to: ‘Evaluating the ASAS recommendations for early referral of axial spondyloarthritis in patients with chronic low back pain; is one parameter present sufficient for primary care practice?’ by van Hoeven et al

Author

Poddubnyy, Denis, van Tubergen, Astrid, Landewé, Robert, Sieper, Joachim, and van der Heijde, Désirée

Published
2015
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