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1,284 results on '"Skinner, R"'

13. Acute nasal injury

Author

Razavi, A, Farboud, A, Skinner, R, and Saw, K

Published
2014

14. RNA-sequencing revealed apple pomace ameliorates expression of genes in the hypothalamus associated with neurodegeneration in female rats fed a Western diet during adolescence to adulthood.

Author

Alawadi, Ayad A., Benedito, Vagner A., Skinner, R. Chris, Warren, Derek C., Showman, Casey, and Tou, Janet C.

Subjects
WESTERN diet, GENE expression, NON-alcoholic fatty liver disease, HYPOTHALAMUS, RNA sequencing, ANIMAL feeds, NEUROTRANSMITTERS
Abstract

Apple pomace, a waste byproduct of apple processing, is rich in nutrients (e.g. polyphenols and soluble fiber) with the potential to be neuroprotective. The aim of this study was to employ RNA-sequencing (RNASeq) technology to investigate diet-gene interactions in the hypothalamus of rats after feeding a Western diet calorically substituted with apple pomace. Adolescent (age 21–29 days) female Sprague–Dawley rats were randomly assigned (n = 8 rats/group) to consume either a purified standard diet, Western (WE) diet, or Western diet calorically substituted with 10% apple pomace (WE/AP) for 8 weeks. RNA-seq was performed (n = 5 rats/group) to determine global differentially expressed genes in the hypothalamus. RNA-seq results comparing rats fed WE to WE/AP revealed 15 differentially expressed genes in the hypothalamus. Caloric substitution of WE diet with 10% apple pomace downregulated (q < 0.06) five genes implicated in brain aging and neurodegenerative disorders: synuclein alpha, phospholipase D family member 5, NADH dehydrogenase Fe-S protein 6, choline O-acetyltransferase, and frizzled class receptor 6. Altered gene expression of these five genes suggests that apple pomace ameliorated synthesis of the neurotransmitter, acetylcholine, in rats fed a WE diet. Apple pomace, a rich source of antioxidant polyphenols and soluble fiber, has been shown to reverse nonalcoholic fatty liver disease (NAFLD). Diet-induced NAFLD decreases hepatic de novo synthesis of choline, a precursor to acetylcholine. Based on preclinical evidence, apple pomace has the potential to be a sustainable functional food for maintaining brain function and for reducing the risk of neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2023
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17. OPTIMIZATION OF A CLINICALLY VALIDATED CART FLOW ASSAY FOR COMMERCIAL ANTI-CD19 CART T-CELL THERAPY AND UNIVERSAL ASSAYS FOR DETECTION OF NOVEL CAR-T CONSTRUCTS

Author

Denlinger, N., Doseck, N., Pearson, R., Bradbury, H., Williams, J., Brown, D., Skinner, R., Stauffer, E., Dorado, J., Romanoff, N., Elsberry, D., Nelson, S., Howitz, M., Mead, T., Fenske, B., Nichols, S., Daneault, B., Chan, W., Alinari, L., Krull, A., Vasu, S., Lozanski, G., de Lima, M., and O'Donnell, L.

Published
2024
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18. Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: Prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children's cancer...

Author

Miller, PDE, Patel, SR, Skinner, R, Dignan, F, Richter, A, Jeffery, K, Khan, A, Heath, PT, Clark, A, Orchard, K, Snowden, JA, de Silva, TI, Patel, S R, Heath, P T, Snowden, J A, and de Silva, T I

Abstract

Haematopoietic stem cell transplant (HSCT) recipients have deficiencies in their adaptive immunity against vaccine preventable diseases. National and International guidance recommends that HSCT recipients are considered 'never vaccinated' and offered a comprehensive course of revaccination. This position statement aims to draw upon the current evidence base and existing guidelines, and align this with national vaccine availability and licensing considerations in order to recommend a pragmatic and standardised re-vaccination schedule for adult and paediatric HSCT recipients in the UK. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 3 Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, RL, Font-Gonzalez, A, van Dulmen-Den Broeder, E, Quinn, GP, Ginsberg, JP, Loeffen, EAH, Hudson, MM, Burns, KC, van Santen, HM, Berger, C, Diesch, T, Dirksen, U, Giwercman, A, Gracia, C, Hunter, SE, Kelvin, JF, Klosky, JL, Laven, Joop, Lockart, BA, Neggers, S.J.C.M.M., Peate, M, Phillips, B, Reed, DR, Tinner, EME, Byrne, J, Veening, M, van de Berg, M, Verhaak, CM, Anazodo, A, Rodriguez-Wallberg, K, Van den Heuvel - Eibrink, Marry, Asogwa, OA, Brownsdon, A, Wallace, WH, Green, DM, Skinner, R, Haupt, R, Kenney, LB, Levine, J, Wetering, MD, Tissing, WJE, Paul, NW, Kremer, LCM (Leontien), Inthorn, J, Obstetrics & Gynecology, Internal Medicine, and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Published
2021

33. Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 2 Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, RL, Font-Gonzalez, A, Green, DM, Loeffen, EAH, Jacqueline, MMH, Loonen, J, Yu, RC, Ginsberg, JP, Mitchell, RT, Byrne, J, Skinner, R, Anazodo, A, Constine, LS, Vries, Anja, Jahnukainen, K, Lorenzo, A, Meissner, A, Nahata, L, Smit, Marij, Tournaye, H, Haupt, R, Van den Heuvel - Eibrink, Marry, Santen, HMV, Pelt, A, Dirksen, U, Hartogh, JD, Broeder, EVD, Wallace, WH, Levine, J, Tissing, WJE, Kremer, LCM (Leontien), Kenney, LB, Wetering, MD, Erasmus MC other, Urology, and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Published
2021

36. Wiley Series in Survey Methodology

Author

R. L. Chambers, C. J. Skinner, R. L. Chambers, C. J. Skinner and R. L. Chambers, C. J. Skinner, R. L. Chambers, C. J. Skinner

Published
2003

45. Root distribution of temperate forage species subjected to water and nitrogen stress

Author

Skinner, R. Howard and Comas, Louise H.

Subjects
Roots (Botany) -- Research, Roots (Botany) -- Environmental aspects, Forage -- Research, Forage -- Environmental aspects, Forage plants -- Research, Forage plants -- Environmental aspects, Plant growth inhibiting substances -- Research, Soils -- Nitrogen content, Soils -- Research, Soils -- Environmental aspects, Agricultural industry, Business
Abstract

Root allocation and distribution patterns can influence forage yield during periods of moisture or nitrogen stress, as deep-rooted species access water and nutrients found deeper in the soil profile. In a greenhouse study, we examined rooting characteristics to a depth of 50 cm for 21 cool-season forage species (9 grasses, 6 legumes, and 6 forbs) exposed to drought and low N conditions. The goal of this research was to compare root distribution under uniform growing conditions for common grass, legume and non-leguminous forb species found in humid-temperate pastures of the northeast United States. Nitrogen or water stressed grasses generally had greater root biomass and a greater proportion of roots in the 30 to 40 cm soil layer than did stressed legumes or forbs. Low N significantly reduced root weight, but to a lesser extent than the decrease in shoot weight, resulting in an increase in root/shoot ratio. Drought stress reduced shoot weight but had no effect on root weight, also resulting in a greater root/shoot ratio. Drought stress also increased the proportion of deep roots compared with controls, whereas, N stress did not. Comparisons with previously published field studies suggested that information from container-grown plants could provide insights into field results, and also suggested that inherent species differences in root distribution could explain some, but not all, rooting patterns observed in multi-species forage mixtures. doi: 10.2135/cropsci2009.08.0461

Published
2010

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