107 results on '"Smil, David"'
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2. Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
3. Discovery of Conformationally Constrained ALK2 Inhibitors.
4. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
5. Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
6. Part 1: efficient strategies for the construction of variably substituted bicyclo[5.3.1]undecenones (AB taxane ring systems)
7. Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**.
8. SP-013 - Leveraging an open science approach for PET radiotracer discovery: radiolabelling and preliminary neuroimaging of 11C-labelled activin receptor-like kinase 2 inhibitors
9. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
10. Tethered α-boryl radical cyclizations of haloalkyl boronates
11. Potassium allyl- and crotyltrifluoroborates: Stable and efficient agents for allylation and crotylation
12. Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
13. Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
14. Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
15. Sulfamides as novel histone deacetylase inhibitors
16. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
17. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
18. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
19. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
20. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.
21. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
22. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
23. Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
24. A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor
25. Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
26. Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors.
27. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
28. A stereoselective intramolecular Diels–Alder strategy for the tricyclo[9.3.1.0 3,8]pentadecane core of aromatic C-ring taxanes
29. A stereoselective intramolecular Diels–Alder strategy for the tricyclo[9.3.1.03,8]pentadecane core of aromatic C-ring taxanes
30. The First Boron-Tethered Radical Cyclizations and Intramolecular Homolytic Substitutions at Boron.
31. Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
32. Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
33. A General Carbometalation, Three Component Coupling Strategy for the Synthesis of α,β-Unsaturated γ-Sultines (III) Including Thio-Rofecoxib (IV), a Selective COX-2 Inhibitor.
34. ChemInform Abstract: Diastereoselective Allylation and Crotylation Reactions of Aldehydes with Potassium Allyl- and Crotyltrifluoroborates under Lewis Acid Catalysis.
35. ChemInform Abstract: Tethered α-Boryl Radical Cyclizations of Haloalkyl Boronates.
36. ChemInform Abstract: Potassium Alkenyl- and Aryltrifluoroborates: Stable and Efficient Agents for Rhodium-Catalyzed Addition to Aldehydes and Enones.
37. ChemInform Abstract: The First Boron-Tethered Radical Cyclizations and Intramolecular Homolytic Substitutions at Boron.
38. ChemInform Abstract: Potassium Allyl- and Crotyltrifluoroborates: Stable and Efficient Agents for Allylation and Crotylation.
39. Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
40. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.
41. (R)-β-Lysine-modified Elongation Factor P Functions in Translation Elongation.
42. An Allosteric Inhibitor of Protein Arginine Methyltransferase 3
43. A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues.
44. Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of 11 C-Labeled ALK2 Inhibitors.
45. Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
46. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
47. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
48. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
49. Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
50. Functional interdependence of BRD4 and DOT1L in MLL leukemia.
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