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2. Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.

3. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

4. Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

7. Structural characterization of nonactive site, TrkA-selective kinase inhibitors

9. A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

10. Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.

13. Identification of potent inhibitors of the sortilin-progranulin interaction

14. Platensimycin is a selective FabF inhibitor with potent antibiotic properties

15. Structural analysis of autoinhibition in the Ras activator Son of sevenless

16. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

17. The discovery and synthesis of potent zwitterionic inhibitors of renin

20. Discoveryof 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide(MK-8033): A Specific c-Met/Ron Dual Kinase Inhibitor withPreferential Affinity for the Activated State of c-Met.

22. Expression, purification and crystallization of human prolylcarboxypeptidase.

23. Structural definition and substrate specificity of theS28 protease family: the crystal structure of humanprolylcarboxypeptidase.

24. Surface-entropy reduction approaches to manipulate crystal forms of β-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae.

25. Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

26. Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of Sevenless

29. Identification of an allosteric binding site for RORγt inhibition.

31. Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.

32. Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer.

33. Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met.

34. Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.

35. Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.

36. Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels.

37. A non-canonical mechanism of GPCR activation.

38. Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.

39. Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

40. Structural basis for selectivity and diversity in angiotensin II receptors.

41. Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.

42. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

43. Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

44. Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

45. Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

46. Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae.

47. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

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