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Introduction: Haemophilia is one of the most common haemorrhagic diseases from the group of coagulopathies and results from a deficiency of factors responsible for the first phase of coagulation. Aim: This informative paperwork aims to highlight the principles of oral surgical treatment of patients with haemophilia. Material and methods: The available literature was analysed to indicate the basic characteristics of haemophilia (clinical manifestation, possibilities of treatment and prophylaxis of the disease) with special reference to specificity and principles of dental oral surgical treatment of patients with haemophilia. Conclusion: The treatment of patients with haemophilia is considered one of the riskiest in everyday dental practice. Despite this, dental interventions can be successfully and safely performed. However, the dentist must be acquainted with the nature of the disease, its symptoms and the severity of the clinical picture. Furthermore, the dentist needs to know what kind of therapy the patient receives for the treatment of haemophilia, whether the patient has been diagnosed with inhibitors to the coagulation factor, and whether the patient has concomitant diseases with special reference to possible infectious diseases. Along with that, the key to a successful and safe intervention lies in a well-planned preoperative, perioperative and postoperative treatment of patients with haemophilia.

Introduction: The periodontal diseases lead to the morphological and functional disintegration of the tooth-supporting apparatus, and a basic concept of surgical periodontal therapy is the elimination of periodontal pockets with the bone remodelling and creating the physiological architecture at a more apical level, thereby achieving better conditions for dental plaque control. The progenitor cell population in the periodontal ligament is served for the reconstruction of lost epithelial attachment. Guided Tissue Regeneration (GTR) is a procedure that allows for the repair of a periodontal defect by cells capable of creating new connective tissue attachment and alveolar bone, and the aim is a minimization of postoperative gingival recession. The objectives of GTR are the creation of a new epithelial attachment, an increase in the bone level, and the minimization of postoperative gingival recession. Aim: Presentation of modern approaches, materials, prognostic factors as well as complications of periodontal therapy that are focused on attachment regeneration and complete reconstruction of periodontal tissue. Conclusion: The difference in terms of outcomes of regenerative periodontal therapy relates to the degree of patient's cooperation with the therapist, the level of oral hygiene, the selection of an appropriate bone defect, as well as the methods of surgery. The high level of dental plaque control, elimination of pathogenic microflora and intensive antimicrobial periodontal therapy improve the outcome of periodontal regenerative therapy.

Introduction: Cancer is causing death in countries with more or less economic development, and it is expected that the burden will grow worldwide, especially in countries with less developed populations, where about 82% of the global population lives. The aim of this study was to present and estimate trends in incidence, mortality rate and MIR of malignant neoplasm of otherand ill-defined sites of lip, oral cavity and pharynx cancer in Central Serbia from 1999 to 2020. Material and methods: The registry-based study was conducted using the data from the publically accessible Yearbooks of the Institute of Public Health of Serbia: Incidence and Mortality in Central Serbia, from 1999 to 2020. Joinpoint regression was used to determine the trend and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals. Results: A total number of 558 cases (436men and 122women) of other and ill-defined lip, oral cavity and pharynx cancer sites registered in Central Serbia from 1999 to 2020. The crude rate (CR) and age-standardized rate (ASR-W) of incidence in males increased (p

Introduction: Caries risk assessment is the essential step in the modern clinical approach to caries management. It is a basic prerequisite for the development of preventive measures and strategies for the primary prevention of caries. Its reliability is conditioned by the knowledge of relevant caries risk factors - indicators and predictors of caries. Aim: After reviewing the available literature, the paperwork aimed to analyse the importance of salivary levels of cationic antimicrobial peptides as indicators and predictors of caries in children, i.e., their possible role in caries risk assessment in children. Material and methods: The analysis included original articles in English which studied the association of salivary levels of cationic antimicrobial peptides with caries in children. Three databases were selected: PubMed, Scopus, and Web of Science, and the search was performed using the following keywords: saliva cationic peptides /antimicrobial peptides /AMP/ defensins/ cathelicidin/histatin/statherin/adrenomedullin/azurocidin AND dental caries AND children/children age. Conclusion: Cationic antimicrobial peptides could be important caries risk indicators in children. Unfortunately, there is currently no reliable evidence of their caries predictive value. Well-designed cross-sectional and long-term longitudinal studies are still required to clarify the significance of salivary cationic antimicrobial peptides as reliable caries risk indicators and caries predictors in children. At the same time, this would define their significance as caries risk biomarkers and their potential application in caries risk assessment in children.

Introduction: Under the concept of regenerative periodontal therapy, there are two approaches: the first is the passive regeneration conceptthat includes bone substituents and guided periodontal regeneration by using of biomembranes and the second concept of active regeneration that impliesthe use of growth factors. The aim of the passive regeneration, by using of bone matrix (bone substituens) has been stabilization and bone defects management, preventing epithelial tissue growth, as well as saving space for the new tissue regeneration. This concept implies the use of autogenous transplantats, xenografts, allografts, as well as alloplastic materials. The carriers for active tissue regeneration, growth factors -GF are biological mediators that regulate cellular processes and that is crucial for the tissue regeneration. Aim:Presentation ofmodern approaches to periodontal therapy thatare focused on the attachment regeneration and complete reconstruction of periodontal tissue. Conclusion: In the future, periodontal regenerative therapy with periodontalligament progenitor cells should encourage repopulation of the areas that have been affected by periodontal disease.

Introduction: The aim of this study was to present the therapeutic procedure and the outcome of replantation of the avulsed permanent central maxillary incisor, found at the site of high contamination, after an extraoral period of 15 hours and dry transport. Case report: By clinical examination it was determined that the root reached the full length, with parallel edges, which corresponded to the age of the girl-8.5 years. After carefully removing the necrotic periodontal ligament from the root of the tooth, extraoral endodontic treatment was performed. The pulp was removed, the multi-sessional intracanal medicament fillings were avoided and the definitive obturation of the root canal was performed. The tooth was returned to the alveolar socket and immobilized with a wire-composite splint. After replantation, the condition of the tooth was monitored. Replacement resorption and dentoalveolar ankylosis occurred after nine months, and then cervical inflammatory resorption led to tooth loss after three and a half years. Conclusion: The achieved result can be considered as a success because during this time the replanted tooth met the developmental, functional and aesthetic requirements, which is especially important in the period of intensive growth and development of the child.

Introduction: Permanent tooth avulsions (traumatic extraction; total luxation) are one ofthe most severe permanent tooth injuries and can occur as single injuries or associated with other dental injuries or injuries to the face and jaws region. They are defined as the luxation of teeth from the alveoli with complete rupture of periodontal fibres, or with one part attached to the rootcementum and the other to the alveolar bone, thus compromising the dental pulp, root cementum,and alveolar bone. The high prevalence and numerous negative consequences on the stomatognathic systems they have suggest permanent tooth avulsions should be regarded as an important public health problem. The aim: is to point out the therapeutic possibilities of permanent tooth avulsion that can ensure their longer survival in the oral cavity. Conclusion: The treatment strategy for avulsed permanent teeth is always based on limiting root canal infection and periradicular inflammation, shifting the balance from unfavourable (replacement resorption) to favourable (periodontal) healing. The success of therapy and periodontal healing depend on the duration and conditions of extraoral tooth preservation, the degree of damage to the periodontal ligament, and the condition of the pulp.

Introduction: The oral health of children with special needs is most often impaired, with a high prevalence of caries and its complications. Due to the impossibility of establishing an adequate child-dentist contact and a large number of carious teeth, dental treatment under general anesthesia is often indicated in this population of children. Aim: To perform a comprehensive analysis of the dental treatment of children with special needs under general anesthesia at the Clinic of Dental Medicine in Niš over a period of ten years. Material and methods: A retrospective study analyzed the dental documentation of children with special needs in whom dental treatment was performed under general anesthesia at the Clinic of Dental Medicine in Niš in the period from January 1, 2010 to December 31, 2019. Results: 286 children with special needs (14.7%) out of a total number of 1943 admitted at the Department for Preventive and Pediatric Dentistry of the Clinic of Dental Medicne in Niš during the analyzed period, originally from Nišava, Jablanica, Pčinja, Toplica, Rasina, and other administrative districts of Serbia, were treated under general anesthesia. In the second half of the ten-year follow-up period, almost twice as many children were treated regarding the first five years. The records show that 1754 teeth were restored, 28 endodontically treated, and 1417 extracted. Conclusion: A high percentage of children with special needs treated under general anesthesia and a constant increase in the number of such children in Southeastern Serbia suggest the need for close cooperation between dentists of health care centers in Southeastern Serbia and dentists at the Clinic of Dental Medicine in Niš, a tertiary dental health care center towards which patients of this part of Serbia gravitate.

Background: Imperfect smile and face profile is one of the main reasons why patients turn to orthodontists. Aim was to investigate if there is a difference in perception of smile and profile esthetics between the examined groups. Subjects and method: In conducted research, smiles of 21 persons (8 male and 13 female), 18 to 30 years old were evaluated by 15 orthodontists, 15 students of dentistry and 15 laypeople. They were to rate esthetics of every smile from 1 to 9 and choose just one main reason that impairs aesthetics. Orthodontists and laypeople should also evaluate male and female normal, bimaxillary prognathic and bimaxillary retrognathic profiles from 1 to 3. The most beautiful profile should be marked with number 3. Results: Although there was no statistically significant difference in the evaluation of smile esthetics among groups, laypeople gave the lowest evaluation. Apart from irregular position of certain teeth, all investigated groups emphasized different factors that impair smile esthetics. Orthodontists and laypeople marked bimaxillary prognathic male and female profile as less beautiful than the others. Conclusion: Because of the differences in perception of the smile aesthetics between orthodontists and laypeople, it is necessary to create a new diagnostic plan of treatment protocols that includes studies investigating laypeople perception of smile and facial esthetics.

Introduction: Primary caries prevention from the earliest childhood has multiple significance. Its efficacy is largely conditioned by the knowledge of the caries risk profile of the subpopulation at risk, as an important prerequisite for developing effective strategies and measures for disease prevention and control. Aim: To assess the caries risk profile of preschool children in the City of Niš using a reduced computer Cariogram ® model. Material and methods: To realize the set objectives, a cross-sectional study was conducted, which included preschool children, aged 36-48 months, with permanent residence in the City of Niš since birth. The collection of data was done by interviewing mothers, and by the clinical examination of subjects. The caries risk profile of the subjects was performed using a reduced Cariogram ® model. Results: The study included 276 subjects of preschool age, mean age 41.28 ± 4.40 months. The highest percentage of subjects has a moderate caries risk, with an average of 50% chance of avoiding a new carious lesion in the future. In the assessed caries risk profile of children, the most vulnerable sectors are "susceptibility" (18%) and "bacteria" (14%), related to the use of fluoride by children of this age and their oral hygiene. The highest percentage of subjects belongs to the moderate caries risk group. Conclusion: According to the conducted study, insufficient exposure of teeth to fluoride and inadequate oral hygiene may be considered significant caries risk factors in preschool children, which should be considered when choosing measures and strategies for disease prevention and control. Also, it is necessary to reconsider the time of diagnostic examinations to reduce the prevalence of caries and its negative consequences at this age to a minimum.

Introduction: Cancer treatment, in terms of chemotherapy and radiotherapy has evolved significantly from its beginning. Both therapies, especially used in combination, had the potential to cause side effects, that potentially decrease in quality of life and lead to increased mortality rate in patients with cancer. The aim of the study: The effects of radiotherapy and chemotherapy were described. The oral complications which consequently occurred could be classified into following categories: mucositis, oral dryness, fungal, viral and bacterial infections, disgeusia, disfagio, profuse bleeding, osteonecrosis and muscle trismus. Conclusion: Because of the wide range of preventive and curative measures, it is necessary to create a special team for caring of patients before, during and after radiotherapy and chemotherapy. In such case, dentist, oral medicine specialists should be an active member of oncology team.

Background: Lip cancer is the most frequent oral cancer. The aim of this study was to present and estimate trends in the incidence and mortality of lip cancer in Central Serbia during a 16-year period, from 1999 to 2014. Material and methods: This registry-based study was carried out based on the data extracted from publicly available Yearbooks of the Institute of Public Health of Serbia - Incidence and Mortality in Central Serbia, from 1999 to 2014. The trend and the annual percentage change (APC) of the incidence and mortality rate with the corresponding 95% confidence intervals were calculated by performing join point regression analyses. Results: A total number of 1,922 cases (1,402 in men and 520 in women) of lip cancer were registered in Central Serbia from 1999 to 2014. The crude rate (CR) and age-standardized rate (ASR-W) of the incidence in males decreased (p=0.001, p

Introduction. The data on the health-condition of the first permanent molars among children in our region is scarce. Therefore, the need for more thorough analysis of the state of health of these teeth in the children from our region imposes itself, along with the need to determine the most critical period in which a significant increase in caries prevalence of these teeth takes place. Aim. The aim of the research was to perform a comparative analysis of the prevalence, average rate and structure of decay, missed and filled first permanent molars in the children of the younger school age in relation to those of the older school age. Material and methods. The research included 1.119 examinees, aged from 7 to 14 years. Examinees were divided into two groups according to their age: examinees of the younger school age and older school age. Dental check-up of the students was performed by means of a dental probe and mirror and the health condition of the examined teeth was registered by means of Klein-Palmer's DMF system. Results. The research determined high values of the examined parameters of the first permanent molars caries prevalence which increases with the age of the examinees. In the examinees of the age of 8, 9, and 10, statistically more significant values of the examined teeth caries prevalence parameters were registered, in relation to the examinees of seven years of age. In the examinees of the older school age, statistically significantly higher values were registered only for TCI and ACI and only in the examinees aged 14 in relation to the examinees aged 11. With the age, the percent of decay is decreases, while the percent of filled and extracted first permanent molars increases. Conclusion. Results show that the period between 7 and 10 years of age is the most critical and the most important period for the implementation of preventive-prophylactic measures aimed to preserve the health of the first permanent molars.