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This brief presents a comprehensive analysis of the output-dependent modulation (ODM) in a current-steering digital-to-analog converter (CS-DAC) based on the differential-quad switching (DQS) structure. A mathematical model is proposed to accurately describe ODM, which is categorized into two types: output transition errors and boundary effect errors. A novel approach of adding isolation devices is introduced and reinterpreted to mitigate the effect of ODM. The simulation results indicate that the inclusion of isolation devices efficiently suppresses the odd harmonics at mid-to-high frequency by a value that is 13 dB lower than before. Experimental validation is conducted on a 16-bit 250 MS/s CS-DAC fabricated in a 180 nm process. [ABSTRACT FROM AUTHOR]

Both surface motion and hole stress concentration have always been concerned in engineering design. In this paper, a theoretical approach is used to study the scattering problem of circular cavities under a non-symmetrical V-shaped canyon. The wave displacement function is obtained by solving the Helmholtz equation that meets the zero-stress boundary conditions by adopting the method of separation of variables and the symmetric method. Based on the complex function method, multi-polar coordinate method and region-matching technique, algebraic equations are established at relevant conditions, which include auxiliary and free boundary conditions. Then, according to sample statistics, a least-square method is used instead of the Fourier expansion method to solve the undetermined coefficients of the algebraic equations by discrete boundary. Numerical results show that the theoretical method is verified valid by the finite element method and the reduced model, and the displacement of the free surface and the stress of the circular cavity are related to the shape of the canyon, the position of the circular cavity, the direction of the incident wave and the frequency content of the excitation. [ABSTRACT FROM AUTHOR]

Toll plazas on expressways often experience congestion owing to the imbalance between traffic demand and supply. To address this issue, this paper designs a proactive traffic control method to relieve congestion at toll plazas based on the model predictive control (MPC) that integrates the dynamic lane configuration, that is, the numbers of electronic toll collection (ETC) and manual toll collection (MTC) lanes, and the variable speed limit (VSL). The proposed method first forecasts short‐term traffic demand in toll plazas based on the long short‐term memory neural network. Then the cell transmission model (CTM) is applied to predict the traffic evolutions in the toll plaza area. At last, the MPC‐based control framework is used to optimize the numbers of ETC and MTC lanes and the variable speed limit to minimize the total vehicle travel time in a rolling horizon. Micro‐simulation tests are carried out in VISSIM to verify the effectiveness of the proposed control method. The simulation results show that the proposed control method can significantly improve the traffic performances at the toll plazas. The findings in this study can lead to field implementation of proactive control at toll plazas. [ABSTRACT FROM AUTHOR]

Park green spaces (PGSs) are an important component of urban natural carbon sinks, while their spatial morphological patterns can affect the carbon sequestration capacity themselves. This study selected six typical urban parks in the central district of Shanghai and analyzed the correlation between spatial morphological indices and CO2 concentration distribution of the PGSs based on ENVI-met and BRT models. It further explored the interaction mechanisms in the carbon cycling process of urban PGSs under the influence of different spatial morphology. The results shows that urban PGSs play the role of carbon sink in diurnal period, and the difference of CO2 concentration distribution in green space is the largest at 11 a.m. The green biomass (Gb) and arboreal area ratio (Ar) are the most important indices affecting the distribution of carbon concentration. The two indices describing spatial patterns, namely, Cohesion (Co) and canopy density (CanopyD) also significantly impact CO2 concentration. These indices have a positive impact on carbon sinks. The parkway area ratio (Pr) is a disturbing index that also has an obvious negative impact on the distribution of CO2 concentration. The moderate herbs area ratio (Hr) and open land area ratio (Or) are conducive to regulating the microclimate environment and enhancing carbon sink capacity. There is an interactive relationship between spatial indices and microclimate environment indices, as well as physical and physiological indices in the carbon sink process of green areas. The study suggested that in green space management aiming at carbon reduction, combined with the influence threshold of Gb on carbon reduction and paying attention to the importance of green amount on carbon sequestration, the vegetation density and allocation ratio should be rationally distributed to form a park green space landscape with efficient carbon fixation. [ABSTRACT FROM AUTHOR]

Plant cell surface-localized receptor-like kinases (RLKs) recognize invading pathogens and transduce the immune signals inside host cells, subsequently triggering immune responses to fight off pathogen invasion. Nonetheless, our understanding of the role of RLKs in wheat resistance to the biotrophic fungus Puccinia striiformis f. sp. tritici (Pst) remains limited. During the differentially expressed genes in Pst infected wheat leaves, a Leucine-repeat receptor-like kinase (LRR-RLK) gene TaBIR1 was significantly upregulated in the incompatible wheat-Pst interaction. qRT-PCR verified that TaBIR1 is induced at the early infection stage of Pst. The transient expression of TaBIR1-GFP protein in N. bentamiana cells and wheat mesophyll protoplasts revealed its plasma membrane location. The knockdown of TaBIR1 expression by VIGS (virus induced gene silencing) declined wheat resistance to stripe rust, resulting in reduced reactive oxygen species (ROS) production, callose deposition, and transcripts of pathogenesis-related genes TaPR1 and TaPR2, along with increased Pst infection area. Ectopic overexpression of TaBIR1 in N. benthamiana triggered constitutive immune responses with significant cell death, callose accumulation, and ROS production. Moreover, TaBIR1 triggered immunity is dependent on NbBAK1, the silencing of which significantly attenuated the defense response triggered by TaBIR1. TaBIR1 interacted with the NbBAK1 homologues in wheat, co-receptor TaSERK2 and TaSERK5, the transient expression of which could restore the impaired defense due to NbBAK1 silencing. Taken together, TaBIR1 is a cell surface RLK that contributes to wheat stripe rust resistance, probably as a positive regulator of plant immunity in a BAK1-dependent manner. [ABSTRACT FROM AUTHOR]

Helicobacter pylori (HP) infection is closely associated with the development of chronic gastritis, peptic ulcer, and gastric cancer. However, the resistance rate of H. pylori strains to antibiotics such as clarithromycin, metronidazole, and levofloxacin has increased significantly, resulting in a significant decrease in the eradication efficacy of commonly used regimens. Tetracycline has received the attention of domestic and foreign scholars because of its low resistance. The purpose of this review is to provide an update on the tetracycline-containing bismuth quadruple eradication therapy for H. pylori infection and review the efficacy and safety of the regimens, hoping to provide guidance for clinical practice. [ABSTRACT FROM AUTHOR]

Background. With respect to effect of surgery on the therapy of patients with metastatic gastrointestinal stromal tumors (mGISTs), still no consensus has been reached. This research designed to investigate the effect of surgical treatment on prognosis in patients with mGISTs. Methods. The population-based study consisted of 6282 GIST patients diagnosed between 2001 and 2016, from the Surveillance, Epidemiology, and End Results (SEER) database registry. The Kaplan-Meier method and Cox model were employed for the exploration of the effect of surgery on overall survival (OS) and GIST-specific survival (GSS). Results. In total, 6282 patients were diagnosed with GISTs, including 1238 (19.7%) mGIST patients and 5044 (80.3%) non-mGIST patients. Compared with the patients with non-mGISTs, metastatic patients assumed relatively lower proportion of surgical management (756 [61.1%] vs. 4666 [92.5%], P < 0.001). Based on unadjusted analysis, mGIST patients with operative management presented higher five years OS together with GSS in comparison with those without operative management (OS: 58.3% vs. 33.1%, P < 0.001 ; GSS: 61.6% vs. 36.7%, P < 0.001). Multivariable analysis found that no surgery was correlated to more than 2-fold increased death risk (OS, adjusted HR = 2.27, 95% CI: 1.90-2.71; GSS, adjusted HR = 2.42, 95% CI: 2.00-2.93). Conclusion. Metastatic GIST patients could potentially benefit from operative management with improved GSS and OS. [ABSTRACT FROM AUTHOR]

With the upgrading of logistics demand and the innovation of modern information technology, the smart logistics platform integrates advanced concepts, technologies, and management methods, maximizes the integration of logistics resources and circulation channels, and effectively improves the efficiency of logistics transactions, but its energy consumption problem is particularly prominent. The study of intelligent measurement and monitoring of carbon emissions in smart logistics is of great value to reduce energy consumption, reduce carbon emissions in buildings, and improve the environment. In this paper, by comparing and analyzing the accounting standards of carbon emissions and their calculation methods, the carbon emission factor method is selected as the method to study the carbon emissions of the smart logistics process in this paper. The working principle of each key storage technology in the smart logistics process is analyzed to find out the equipment factors affecting the carbon emission of each storage technology in the smart logistics process, and the carbon emission calculation model of each key storage technology is established separately by using the carbon emission factor method. Meanwhile, according to the development history of energy consumption assessment, the assessment process of different stages from logistics storage energy consumption assessment to smart logistics energy consumption assessment is analyzed, and based on this, a carbon emission energy consumption assessment framework based on 5G shared smart logistics is constructed. This paper applies the supply chain idea to define the smart logistics supply chain, constructs a conceptual model of the smart logistics supply chain considering carbon emissions, and at the same time combines the characteristics of the smart logistics supply chain to analyze the correlation between the carbon emissions of the smart logistics supply chain and the related social, environmental, and economic systems. [ABSTRACT FROM AUTHOR]

A heterogeneous electro-Fenton system with fluffy clump steel wire (FCSW) was described for the degradation of p-nitrophenol (p-NP) in water. The influences of the initial pH, initial concentration of FCSW, applied current density on the p-NP, and total organic carbon (TOC) removal percentages were investigated. Compared with the homogeneous electro-Fenton process, the presence of the FCSW catalyst significantly improved the degradation efficiency, the p-NP removal percentages could reach 94.31% after 60 min under the appropriate operating conditions that initial pH value of 3.0, initial FCSW concentration of 3.0 g/L, current density of 3.0 mA/cm2, and the TOC removal percentages could reach 78.96% after 180 min. Aromatic intermediates and carboxylic acids had been identified by chromatographic techniques, and a plausible reaction pathway for p-NP mineralization by heterogeneous electro-Fenton process with FCSW was proposed. The catalytic reusability of FCSW was ultimately evaluated for the repeated use, and the degradation ratio of p-NP could be maintained steadily at 89–96% during 10 cycles, as well as the minimal variations of its structure and composition. [ABSTRACT FROM AUTHOR]

This study investigated the potential effect of vacuum annealing on the microstructure and hot salt corrosion behavior of CoNiCrAlY/YSZ/LaMgAl11O19 (LMA) double-ceramic coatings. A hot-salt corrosion test revealed that sprayed coatings exhibited an unsatisfactory anti-corrosion performance, and the LMA layer underwent severe fracture and corrosion degradation. Vacuum annealing induced a prominent recrystallization of the amorphous phase in LMA layer, triggering severe volume shrinkage and microcrack initiation. The recrystallization and volume shrinkage of the LMA layer were aggravated by an increase in the annealing temperature. The annealed coating with a higher fraction of the LaMA phase showed superior resistance to hot-salt corrosion. However, the salt mixture diffused simultaneously along the microcracks and eventually eroded into the YSZ layer. These results confirmed that vacuum annealing significantly enhanced the hot-salt corrosion resistance of the LMA layer. However, it deteriorated the barrier effect of the salt mixture through microcrack formation. [ABSTRACT FROM AUTHOR]

Autophagy-related 8 (ATG8) protein has been reported to be involved in plant’s innate immune response, but it is not clear whether such genes play a similar role in cereal crops against obligate biotrophic fungal pathogens. Here, we reported an ATG8 gene from wheat (Triticum aestivum), designated TaATG8j. This gene has three copies located in chromosomes 2AS, 2BS, and 2DS. The transcriptions of all three copies were upregulated in plants of the wheat cultivar Suwon 11, inoculated with an avirulent race (CYR23) of Puccinia striiformis f. sp. tritici (Pst), the causal fungal pathogen of stripe rust. The transient expression of TaATG8j in Nicotiana benthamiana showed that TaATG8j proteins were distributed throughout the cytoplasm, but mainly in the nucleus and plasma membrane. The overexpression of TaATG8j in N. benthamiana slightly delayed the cell death caused by the mouse apoptotic protein BAX (BCL2-associated X protein). However, the expression of TaATG8j in yeast (Schizosaccharomyces pombe) induced cell death. The virus-induced gene silencing of all TaATG8j copies rendered Suwon 11 susceptible to the avirulent Pst race CYR23, accompanied by an increased fungal biomass and a decreased necrotic area per infection site. These results indicate that TaATG8j contributes to wheat resistance against stripe rust fungus by regulating cell death, providing information for the understanding of the mechanisms of wheat resistance to the stripe rust pathogen. [ABSTRACT FROM AUTHOR]

Background: Post-traumatic stress symptoms (PTSS) are frequently observed in those who have experienced trauma events like the COVID-19 outbreak. The cognitive model of PTSS highlights the relationship between PTSS and negative interpretation bias., Objective: The present study aimed to modify interpretation bias and to improve PTSS as well as PTSS-related fear., Methods: 59 participants with high PTSS levels were recruited and randomly allocated to either the interpretation modification programme (IMP) intervention group or the interpretation control condition (ICC) control group. PTSS, negative interpretation bias, fear of COVID-19, and depression and anxiety symptoms were assessed before and after training., Findings: Intention-to-treat analyses showed that compared with ICC, participants receiving IMP generated fewer negative interpretations for ambiguous scenarios, and the group-by-time interaction effect was significant. IMP also illustrated a more significant change in fear after training compared with ICC. Although no effects of training conditions were found on PTSS, the interaction of training conditions with fear reduction could predict PTSS improvement., Conclusions: IMP could improve negative interpretations and fear related to COVID-19 and might help to ameliorate PTSS., Clinical Implications: The role of PTSS-related emotion should be considered when exploring the effectiveness of IMP. IMP is a flexible approach that can be tailored to the specific characteristics of the traumatic event, which makes it suitable for a broader range of traumatised individuals., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. Published by BMJ.)

As one of the most common mesenchymal malignancies in the digestive system, gastrointestinal stromal tumors (GISTs) occur throughout the alimentary tract with diversified oncological characteristics. With the advent of the tyrosine kinase inhibitor era, the treatment regimens of patients with GISTs have been revolutionized and GISTs have become the paradigm of multidisciplinary therapy. However, surgery resection remains recognized as the potentially curative management for the radical resection and provided with favorable oncological outcomes. The existing available surgery algorithms in clinical practice primarily incorporate open procedure, and endoscopic and laparoscopic surgery together with combined operation techniques. The performance of various surgery methods often refers to the consideration of risk evaluation of recurrence and metastases; the degree of disease progression; size, location, and growth pattern of tumor; general conditions of selected patients; and indications and safety profile of various techniques. In the present review, we summarize the fundamental principle of surgery of GISTs based on risk assessment as well as tumor size, location, and degree of progress with an emphasis on the indications, strengths, and limitations of current surgery techniques., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Yue, Sun, Wang and Hu.)

Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10-15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have a different pathogenesis, clinical characteristics, and treatment response compared to tumors with receptor tyrosine kinase protein (KIT) mutations (60-70%). Many clinical studies have investigated the use of tyrosine kinase inhibitors mainly in patients with KIT mutations; however, there is a lack of attention to the PDGFRA-mutated molecular subtype. The main effective inhibitors of PDGFRA are ripretinib, avapritinib, and crenolanib, and their mechanisms and efficacy in GIST (as confirmed in clinical trials) are described in this review. Some multi-targeted tyrosine kinase inhibitors with inhibitory effects on this molecular subtype are also introduced and summarized in this paper. This review focuses on PDGFRA-mutated GISTs, introduces their clinical characteristics, downstream molecular signaling pathways, and existing resistance mechanisms. We focus on the most recent literature that describes the development of PDGFRA inhibitors and their use in clinical trials, as well as the potential benefits from different combination therapy strategies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sun, Yue, Xu and Hu.)