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Aims: Both hypercapnia and hypocapnia are common in patients with acute heart failure (AHF), but the association between partial pressure of arterial carbon dioxide (PaCO2) and AHF prognosis remains unclear. The objective of this study was to investigate the connection between PaCO2 within 24 h after admission to the intensive care unit (ICU) and mortality during hospitalization and at 1 year in AHF patients. Methods and results: AHF patients were enrolled from the Medical Information Mart for Intensive Care IV database. The patients were divided into three groups by PaCO2 values of <35, 35–45, and >45 mmHg. The primary outcome was to investigate the connection between PaCO2 and in‐hospital mortality and 1 year mortality in AHF patients. The secondary outcome was to assess the prediction value of PaCO2 in predicting in‐hospital mortality and 1 year mortality in AHF patients. A total of 2374 patients were included in this study, including 457 patients in the PaCO2 < 35 mmHg group, 1072 patients in the PaCO2 = 35–45 mmHg group, and 845 patients in the PaCO2 > 45 mmHg group. The in‐hospital mortality was 19.5%, and the 1 year mortality was 23.9% in the PaCO2 < 35 mmHg group. Multivariate logistic regression analysis showed that the PaCO2 < 35 mmHg group was associated with an increased risk of in‐hospital mortality [hazard ratio (HR) 1.398, 95% confidence interval (CI) 1.039–1.882, P = 0.027] and 1 year mortality (HR 1.327, 95% CI 1.020–1.728, P = 0.035) than the PaCO2 = 35–45 mmHg group. The PaCO2 > 45 mmHg group was associated with an increased risk of in‐hospital mortality (HR 1.387, 95% CI 1.050–1.832, P = 0.021); the 1 year mortality showed no significant difference (HR 1.286, 95% CI 0.995–1.662, P = 0.055) compared with the PaCO2 = 35–45 mmHg group. The Kaplan–Meier survival curves showed that the PaCO2 < 35 mmHg group had a significantly lower 1 year survival rate. The area under the receiver operating characteristic curve for predicting in‐hospital mortality was 0.591 (95% CI 0.526–0.656), and the 1 year mortality was 0.566 (95% CI 0.505–0.627) in the PaCO2 < 35 mmHg group. Conclusions: In AHF patients, hypocapnia within 24 h after admission to the ICU was associated with increased in‐hospital mortality and 1 year mortality. However, the increase in 1 year mortality may be influenced by hospitalization mortality. Hypercapnia was associated with increased in‐hospital mortality. [ABSTRACT FROM AUTHOR]

The Sustainable Development Goals, adopted by all United Nations Member States, emphasize sustainable cities and communities, aiming to strengthen development planning and foster positive links between urban and rural areas by 2030. As the newly leading platform for urbanization development, characteristic towns ('Tese Xiaozhen' in Chinese) contribute to the target of sustainable urbanisation, wherein town policies are especially important for leading the sound development of characteristic towns. However, the effect of these characteristic towns policies remains uncertain. Additionally, most related studies have utilized qualitative methodologies in policy evaluation, which may be inadequate to guide actual practice. Thus, in order to accurately acknowledge the effect of characteristic towns policies, a policy evaluation framework is established in this paper, utilising the multiple streams theory, text mining and the Policy Modelling Consistency Index model (PMC-Index model). Then, taking 225 policy documents promulgated in China from 2015 to 2022 as the research objects, policy evaluation indicators were selected by combining the multiple streams theory to improve the PMC-Index model and a text mining method. Thereafter, an empirical analysis was conducted to evaluate the consistency of 10 characteristic towns policies chosen. The results indicate that the mean value of the PMC indexes of the 10 examined policies is 7.13 in the total of 9 points, which means that the general performance of the characteristic town policies is satisfactory, yet the low scores in terms of effectiveness, content, and guarantee. In the end, some recommendations and suggestions are proposed for clarifying administrative attributes, optimizing the integration of urban and rural resources, and adjusting the policy hierarchy to a bottom-up approach. This study not only provides a policy evaluation framework to comprehensively understand the consistency of global urbanization policies but also offers a beneficial reference for promote urban–rural sustainable development. [ABSTRACT FROM AUTHOR]

Effective and economical processes for the advanced treatment of coking wastewater were urgently needed to reduce the persistent organic pollutants of external drainage. In the present work, we investigated the degradation of organic pollutants in coking wastewater through IHC/FO (imping stream hydrodynamic cavitation (IHC) coupled with the Fenton oxidation (FO) process) and IHC alone for their feasibility in the advanced treatment of coking wastewater. To select the optimum parameters, attention was paid to the effects of main operation conditions including inlet fluid pressure, medium temperature, initial pH, reaction time, and initial Fe(II) and initial H2O2 concentrations. The results showed that the effects of conditions that need energy to be maintained (such as initial pH and inlet pressure) on the organic pollutant removal efficiency through IHC/FO were less pronounced than those through IHC alone. Moreover, the application of IHC/FO could remove more organic pollutants from coking wastewater than IHC even at an energy-efficient condition. For example, the highest COD removal efficiency of 12.5% was achieved in the IHC treatment at 0.4 MPa, pH 3, and 60 min for the reaction time. In the case of IHC/FO, the maximum COD removal of 33.2% was obtained at pH 7, 0.1 MPa, 12 mmol/L H2O2, and 3 mmol/L Fe2+ after reacting for 15 min. The ultraviolet and visible spectrophotometry (UV-Vis) absorption spectra and gas chromatography and mass spectrometry (GC–MS) analysis further revealed that the kinds and amounts of pollutants (especially those that had benzenes) remaining in water treated through IHC/FO were much fewer and smaller than in water treated through IHC alone. The better performances of IHC/FO than IHC alone were likely related to the more hydroxyl radicals produced through IHC/FO. Taken together, our findings indicate that IHC/FO has great application potential in the advanced treatment of coking wastewater. [ABSTRACT FROM AUTHOR]

Background: The ratio of fibrinogen to prealbumin (FPR) is associated with the prognosis of many cancers. However, the prognostic significance of FPR in resectable gastric cancer has not been clarified. Methods: A total of 760 patients with resectable gastric cancer participated in this study. The receiver operating characteristic curve (ROC) was used to calculate the optimal cutoff value of each immunonutrition marker. Univariate and multivariate Cox regression analyses were used to confirm the prognostic value of FPR in patients with gastric cancer and to select appropriate variables for the construction of nomogram. Results: Utilizing ROC analysis, we calculated the optimal cutoff value for FPR and stratified 760 patients into high and low FPR groups. Subsequent examination revealed notable distinctions in baseline characteristics between these groups. For instance, Patients with higher FPR tend to be older and have more lymph node metastasis. Statistical analysis through the chi-square test confirmed the significance of these differences (P < 0.05). In addition, the results of the multivariate Cox proportional hazards regression analysis indicate that the factors related to OS were age (P = 0.001), T stage (P < 0.001), N stage (P < 0.001), radical resection (P < 0.001), and FPR (P < 0.024). The nomogram is composed of the above five variables. ROC analysis showed that the area under the curve (AUC) of the nomogram was 0.859 (95% CI: 0.831– 0.887), and the sensitivity and specificity were 77.4% and 82.1%, respectively. Conclusion: FPR is a potential marker in patients with resectable gastric cancer. The nomogram based on FPR shows good predictive ability, which is helpful for clinicians to judge the prognosis of patients and choose targeted treatment strategies. [ABSTRACT FROM AUTHOR]

Virtual power plants (VPPs), serving as an integration and coordination platform for energy sources, have been rapidly developed in recent years. With the rapid expansion of distributed energy sources, disturbance problems within the VPP and cluster are becoming increasingly prominent. In this study, we commence by addressing the internal fluctuations within the VPP through the construction of a source-load uncertainty model. Then, we integrate the Nash bargaining game theory, treating different VPPs as participants in the game. This approach significantly mitigates disturbances within both VPPs and the cluster through the negotiation of power trading strategies. In addition, the coordination between VPPs and their coordination with the distribution network in the network-wide interaction is considered, and an optimization algorithm for distributed electricity trading based on the alternating direction method of multipliers is proposed to solve the model. The results show that the proposed model effectively copes with the internal and external disturbances of the VPP, improves the system's ability to cope with the uncertainty risk, and reduces the operation cost. [ABSTRACT FROM AUTHOR]

Summary: Abscisic acid (ABA) is best known for regulating the responses to abiotic stressors. Thus, applications of ABA signaling pathways are considered promising targets for securing yield under stress. ABA levels rise in response to abiotic stress, mounting physiological and metabolic responses that promote plant survival under unfavorable conditions. ABA elicits its effects by binding to a family of soluble receptors found in monomeric and dimeric states, differing in their affinity to ABA and co‐receptors. However, the in vivo significance of the biochemical differences between these receptors remains unclear.We took a gain‐of‐function approach to study receptor‐specific functionality. First, we introduced activating mutations that enforce active ABA‐bound receptor conformation. We then transformed Arabidopsis ABA‐deficient mutants with the constitutive receptors and monitored suppression of the ABA deficiency phenotype.Our findings suggest that PYL4 and PYL5, monomeric ABA receptors, have differential activity in regulating transpiration and transcription of ABA biosynthesis and stress response genes. Through genetic and metabolic data, we demonstrate that PYR1, but not PYL5, is sufficient to activate the ABA positive feedback mechanism.We propose that ABA signaling – from perception to response – flows differently when triggered by different PYLs, due to tissue and transcription barriers, thus resulting in distinct circuitries. [ABSTRACT FROM AUTHOR]