1. Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up.
- Author
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Gay-Andrieu F, Marty P, Pialat J, Sournies G, Drier de Laforte T, and Peyron F
- Subjects
- Abortion, Induced, Adult, Amniocentesis, Animals, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, Humans, Polymerase Chain Reaction, Pregnancy, Pregnancy Trimester, First, Toxoplasma genetics, Toxoplasma immunology, Toxoplasma isolation & purification, Toxoplasmosis, Congenital diagnostic imaging, Ultrasonography, Prenatal
- Abstract
Prenatal diagnosis of congenital toxoplasmosis relies on the PCR test on amniotic fluid and ultrasound follow-up of the fetus. We report two cases of toxoplasma infection during the first trimester of gestation with a discrepant diagnosis of fetal infection. PCR performed more than four weeks after the estimated date of contamination was negative. Ultrasound follow-up was normal up to the third trimester when major hydrocephalus was detected, leading to pregnancy termination. In both cases, post-mortem examination revealed a diffuse infection with severe brain lesions. These observations confirm the necessity to continue a monthly ultrasound follow-up, even if amniocentesis is negative, in case of fetal toxoplasma infection in pregnancy., (Copyright 2003 John Wiley & Sons, Ltd.)
- Published
- 2003
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