1. The molecular basis of T cell acute lymphoblastic leukemia
- Author
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Vlierberghe, Pieter and Ferrando, Adolfo
- Subjects
Gene mutations -- Health aspects -- Research ,T cells -- Physiological aspects -- Research -- Genetic aspects ,Acute lymphocytic leukemia -- Risk factors -- Genetic aspects -- Research ,Health care industry - Abstract
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL., T cell acute lymphoblastic leukemias (T-ALLs) are aggressive hematologic tumors resulting from the malignant transformation of T cell progenitors. T-ALL accounts for 10%-15% of pediatric and 25% of adult ALL [...]
- Published
- 2012
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