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Type 2 Diabetes Mellitus (T2DM) is influenced by the action of both hereditary and environmental factors. These factors are comprehended in the disease interaction with β cells and insulin sensitivity to the receptors.The main cause of T2DM development is ageing, obesity, and oxidative stress. The dysfunction of the β cells of the pancreas leads to insulin insensitivity in the liver, muscle and fat metabolism. These occur due to the result of oxidative stress. Lipid peroxidation is a key initiating factor in the development of oxidative stress, which results in T2DM and its related micro-and macro-vascular problems. These are initially compensated for the generation of excess insulin synthesis, thus ensuring normal glucose tolerance. When these compensatory processes are disrupted, the majority of persons develop T2DM. Although the gene is the primary cause of T2DM, the environment also plays an important role in the disease's progression. Particularly, a sedentary lifestyle characterised by excessive food consumption and physical inactivity is a known risk factor for obesity and type 2 diabetes. This review has briefly discussed the significance of numerous causal factors, and genomic and biochemical pathways which are responsible for increasing the production of oxidative stress, a crucial component for the etiology and development of T2DM. The conclusion drawn was that the analysis of oxidative stress markers may be one of the potential methods for the diagnosis and prognosis of T2DM. Furthermore, this review will be helpful to establish the broaden conceptual framework for future studies on oxidative stress with relation to etiology of type 2 diabetes and therapeutic development. [ABSTRACT FROM AUTHOR]

Introduction: Diabetic foot syndrome is one of the common and most devastating preventable complications of diabetes mellitus (DM). It is associated with morbidity and premature mortality due to long-term complications affecting foot. The American Diabetes Association recommends that people with diabetes should have a comprehensive foot examination once per year. Most of the foot problems can be prevented with careful foot care. It may take effort and time to build up good foot care habits, but self-care is essential. Aim: The main aim of the study is to analyze the knowledge, attitude, and practice of foot care in patients with DM in central rural India. Methodology: This study was conducted at a rural educational hospital in central part of India over 200 patients who have Type 1 and Type 2 diabetes. They were evaluated for their knowledge about foot care and footwear practices. A structured and validated questionnaire was administered to cases. Results: Around 82.9% of the patients were aware of the disease and 23.2% were aware of the complications of the DM. In 63% of the patients, foot care examination and education regarding foot complications were not suggested by their treating physicians. Annual examination of feet by the physician and self-examination were not known facts to the diabetic population. Conclusion: It is necessary to firstly develop awareness of diabetes mellitus and the related complications, one amongst which is foot care. Certain educational strategies should be established for both the consultant physician and also the common man to create awareness for effective foot care. [ABSTRACT FROM AUTHOR]