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15. Japan College of Rheumatology guidance for the use of methotrexate in patients with rheumatoid arthritis: Secondary publication.

Author

Kameda, Hideto, Yamaoka, Kunihiro, Yamanishi, Yuji, Tada, Masahiro, Koike, Ryuji, Nakajima, Ayako, Fusama, Mie, and Fujii, Takao

Subjects
RHEUMATOID arthritis, COUNSELING in higher education, METHOTREXATE, ERYTHROCYTES, JAPANESE people
Abstract

Methotrexate (MTX), the anchor drug in the current treatment strategy for rheumatoid arthritis (RA), was first approved for the treatment of RA in Japan in 1999 at a recommended dose of 6–8 mg/week. The approved maximum dose of MTX has been 16 mg/week since February 2011 when MTX was approved as a first-line drug in the treatment of RA. Recent evidence of MTX-polyglutamate concentration in the red blood cells of Japanese patients with RA justifies the current daily use of MTX in Japan. Additionally, after a nationwide clinical trial, a subcutaneous MTX injection formula (7.5–15 mg/week) was approved for RA treatment in September 2022. Therefore, in March 2023, a subcommittee of the Japan College of Rheumatology updated the guidance (formerly 'guidelines') for the use of MTX in Japanese patients with RA. This article, an abridged English translation summarizing the 2023 update of the Japan College of Rheumatology guidance for the use of MTX and management of patients with RA, will be helpful to both Japanese and global rheumatology communities. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The bioimpedance phase angle may be associated with frailty in rheumatoid arthritis patients: Results from a prospective, cohort study.

Author

Matsumoto, Yoshinari, Tada, Masahiro, Yamada, Yutaro, Mandai, Koji, Hidaka, Noriaki, and Koike, Tatsuya

Subjects
*RHEUMATOID arthritis, *FRAILTY, *COHORT analysis, *ANGLES
Abstract

Objectives: This study investigated whether the phase angle (PhA) on bioelectrical impedance analysis is related to frailty in rheumatoid arthritis (RA) patients. Methods: Data from a prospective cohort study of RA patients were analysed. The PhA was assessed by the bioelectrical impedance analysis method, and frailty was assessed by the Kihon Check List (KCL) annually. The cut-off value of the PhA for frailty was calculated by receiveroperating characteristic analysis. The relationships between the PhA and frailty were evaluated by logistic regression analysis. The relationships between the change in PhA and frailty status and the KCL score were evaluated by analysis of covariance and multiple regression analysis. Results: A total of 170 patients (81.2% female, 66.2 ±13.1 years) were included in the analysis. A PhA of less than the cut-off for frailty was significantly associated with frailty (odds ratio: 4.75, 95% confidence interval: 1.86, 12.17). The change in the PhA was significantly associated with the change in the KCL score (β=-0.15). In robust patients, there was a significant difference in the rate of change of the PhA between the group that became pre-frail in the next year and the group that remained robust. Conclusions: The PhA may be associated with frailty in RA patients. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Multi-Perspective Indexing of Diverse Spatial Characteristics of an Outdoor Field toward Redesigning of Real-World Learning

Author

Okada, Masaya and Tada, Masahiro

Abstract

Real-world learning is important because it encourages learners to obtain knowledge through various experiences. To design effective real-world learning, it is necessary to analyze the diverse learning activities that occur in real-world learning and to develop effective strategies for learning support. By inventing the technologies of multimodal sensing and knowledge externalization, we propose a method to capture the time-series occurrence of real-world learning and to analyze the spatial characteristics of a learning field that draws out diverse intellectual interactions. Our method generates multi-perspective indexes of the structure of a real-world learning field from the viewpoint of the occurrence probability of important learning behavior and knowledge acquisition. Our data analysis by this method extracted the regions where abundant discovery knowledge was not found and learners did not succeed in acquiring knowledge. Our method is useful for redesigning on-site and off-site activities in real-world learning, and for formatively improving the learning environment of real-world learning.

Published
2014

30. Growth and salt accumulation capacity of the common ice plant in the tsunami-affected soil.

Author

Agarie, Sakae, Tada, Masahiro, Kimura, Masako, Suzuki, Hitoshi, Morokuma, Masahiro, Toyota, Masanori, and Nakamura, Ichiro

Subjects
SOIL salinity, PLANT-soil relationships, SOIL permeability, HALOPHYTES, SOIL moisture, PLANT collecting
Abstract

Halophytes are salt-tolerant plant that grows naturally in saline areas where almost all conventional crops die due to NaCl toxicity. The common ice plant, Mesembryanthemum crystallinum L., an annual halophyte native to South Africa, tolerates high salinity levels and accumulates NaCl in a shoot at a high level. To check the availability of the ice plant for desalinization of soils, we cultured the ice plant in soils collected from 16 sites located along coastal regions in the prefectures of Miyagi and Iwate, where were attacked by the tsunami disaster in the wake of the 2011 earthquake off the Pacific coast of Tohoku on 11 March 2011. In the soils obtained from some tsunami affected areas, the growth was better than that in the non-contaminated soil. The factors associated with growth inhibition were suggested to be water ratio (an index of water content) and soil water permeability. The ice plant's estimated biological yield ranged from 0.33 to 14.6 kg m−2, equivalent to 2.3 to 101.7 t ha−1. The sum of Na+ and Cl− was about 9.5 g in the shoot (31.8% on a dry weight basis), and the estimated total amount of these ions removed from salinized soil was 2.38 t ha−1. These results indicated that the common ice plant could be used as a crop under salinity and a tool for ameliorating NaCl from salinized soils. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Aging Brains Degrade Driving Safety Performances of the Healthy Elderly.

Author

Park, Kaechang, Renge, Kazumi, Nakagawa, Yoshinori, Yamashita, Fumio, Tada, Masahiro, and Kumagai, Yasuhiko

Subjects
TRAFFIC safety, OLDER people, MAGNETIC resonance imaging, CEREBRAL atrophy, AGING, BRAIN, SAFETY, TASK performance, REGRESSION analysis, T-test (Statistics), AUTOMOBILE driving, DESCRIPTIVE statistics, RESEARCH funding, LOGISTIC regression analysis, OLD age
Abstract

The relationship between aging brains and driving safety performances (DSPs) of elderly drivers was studied. A total of 90 dementia-free participants (63 men and 27 women, mean age 75.31 ± 4.795 years) were recruited and their DSPs were analyzed on actual vehicles running through a closed-circuit course. DSPs were comprehensively evaluated on the basis of driving instructors' scores (DIS). Signaling and visual research behaviors, part of DSPs, were measured to supplement the DIS evaluation by driving recorders (DR) and wearable wireless sensors (WS), respectively. Aging brains were evaluated via magnetic resonance imaging (MRI) findings and experimentally assigned to two grades (high vs. low) of brain atrophy (BA) and leukoaraiosis (LA). Regression analyses on DIS and DR data, and logistic analysis on WS scores showed significant correlations of aging brains with degradation of DSPs. The participant group with more advanced BAs and LAs showed lower DIS, DR data, and WS scores representing degraded DSP regardless of age. These results suggest that MRI examinations from both volumetric and pathological perspectives of brains have the potential to help identify elderly drivers with dangerous driving behaviors. Brain healthcare, lifestyle improvements and medical treatments to suppress BA and LA, may contribute to preventing DSP degradation of elderly drivers with aging brains. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Abstracts of selected papers presented at the 33rd Annual Meeting of the Japanese Society of Gastroenterology

Author

Hasuo, Tomonobu, Hosoi, Tohzo, Nagano, M., Motizuki, F., Arima, Miwako, Kouzu, Teruo, Murata, Yoko, Ide, Hiroko, Shiozaki, Hitoshi, Kobayashi, Kenji, Kawano, Tatsuyuki, Endo, Mitsuo, Koyama, Shohei, Tsujii, Hirohiko, Kondo, Fukuo, Ebara, Masaaki, Nakashima, Osamu, Kojiro, Masamichi, Takayama, Tadatoshi, Makuuchi, Masatoshi, Kurokawa, Fumie, Okita, Kiwamu, Itoh, Yoshinobu, Akamatsu, Kouichi, Tanaka, Sachiko, Kitamura, Tsugio, Ikeda, Kenji, Kumada, Hiromitsu, Majima, Yasuo, Tanikawa, Kyuichi, Imaoka, Shingi, Sasaki, Yo, Ohkura, Yasuo, Nakamura, Kyoichi, Hirakawa, Masahiko, Fuchigami, Tadahiko, Tsuda, Sumio, Matsui, Toshiyuki, Tsuruta, Osamu, Arima, Nobuyuki, Ohishi, Takashi, Egawa, Naoto, Sawada, Toshio, Muto, Tetsuichiro, Sata, Michio, Tanikawa, Kyuichi, Takase, Shujiro, Tsutsumi, Mikihiro, Uchikoshi, Toshiyuki, Maeyama, Shiro, Unoura, M., Kaneko, S., Kiyosawa, Kendo, Tanaka, Eiji, Nishiguchi, Shuhei, Kuroki, Tetsuo, Hosoda, Ito, Yoshimi, Yasuda, Kiyomi, Tashima, Koichi, Ohta, Yasuyuki, Okazaki, Yukinori, Miyoshi, Yasuhiko, Yoshino, Junji, Nakazawa, Saburo, Ashida, Kiyoshi, Sakaguchi, Masahiro, Ohara, Shuichi, Asaki, Shigeru, Ise, Hideo, Matsuno, Seiki, Higashide, Shun-ichi, Inoue, Kazutomo, Matsumoto, Teiji, Tsunoda, Tsukasa, Moriizumi, S., Shimosegawa, T., Sawabu, Norio, Satomura, Yoshitake, Noda, Aiji, Ibuki, Eri, Atsumi, M., Kashima, K., Omagari, Kazuhiro, Toyonaga, Atsushi, Takasaki, Yoshihisa, Muranaga, Tomoko, Tada, Masahiro, Murakami, Atsushi, Kihira, Ken, Yosida, Yukio, Kimura, Ken, Miyazaki, Yasuhiro, Hirao, Masanori, Inoue, Kazuhiko, Hidaka, Tohru, Inoue, Osami, Yatsuhashi, Hiroshi, Kaminishi, Michio, Shimoyama, Shouji, Takahashi, Michiko, Yamada, Gotaro, Takano, Susumu, Omata, Masao, Ito, Nobuyasu, Tameda, Yukihiko, Kondo, T., Sainokami, S., Arase, Yasuji, Kumada, Hiromitsu, Seki, Takeshi, Kiyosawa, Kendo, Yasunaga, Mitsuru, Sanuki, Kazutosi, Tomiya, Tomoaki, Fujiwara, Kenji, Tada, Kouji, Akamatsu, Kouichi, Ohtake, Yoshio, Hirasawa, Hiroyuki, Suzuki, Kazuyuki, Sato, Shunichi, Takahashi, Hiroaki, Mizumoto, Ryuji, Aoike, Akira, Watanabe, Kazuhiko, Yamaguti, Osahumi, Kuwayama, Hajime, Asakura, Hitoshi, Narisawa, Rintaro, Kumashiro, Ryukichi, Sata, Michio, Kubota, Yoshitsugu, Inoue, Kyoichi, Shibata, Tokimune, Hayakawa, Tetsuo, and Hattori, Takanori

Published
1993
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