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The purpose of this paper is to introduce the class of split regular BiHom-Poisson color algebras, which can be considered as the natural extension of split regular BiHom-Poisson algebras and of split regular Poisson color algebras. Using the property of connections of roots for this kind of algebras, we prove that such a split regular BiHom-Poisson color algebra LL is of the form L=⊕[α]∈Λ/∼I[α]L={\oplus }_{\left[\alpha ]\in \Lambda \text{/} \sim }{I}_{\left[\alpha ]} with I[α]{I}_{\left[\alpha ]} a well described (graded) ideal of LL, satisfying [I[α],I[β]]+I[α]I[β]=0\left[{I}_{\left[\alpha ]},{I}_{\left[\beta ]}]+{I}_{\left[\alpha ]}{I}_{\left[\beta ]}=0 if [α]≠[β]\left[\alpha ]\ne \left[\beta ]. In particular, a necessary and sufficient condition for the simplicity of this algebra is determined, and it is shown that LL is the direct sum of the family of its simple (graded) ideals.

The modern high topography of the eastern Tibetan Plateau is drained by several of the largest rivers on Earth, and exerts a prominent influence on the Asian monsoon pattern. However, when the high terrain was formed remains highly debated. Here, we present detrital zircon U‐Pb ages that indicate a south‐flowing drainage system with distal headwaters passed through the Ninglang Basin at ca. 45 Ma. We advocate for early–middle Eocene surface uplift in the Gonjo Basin and areas to the west creating a southeast tilted topography across eastern Tibet. The termination of sedimentation at ca. 40 Ma implies that the river system had deviated from the Ninglang Basin, which we interpret as a result of rise of the Yalong‐Yulong thrust belt. Combined with other lines of evidence from previous studies, we support the establishment of moderate‐high elevation topography of eastern Tibet by late Eocene time. Plain Language Summary: The eastern Tibetan Plateau has been a hotspot for studying the interactions between tectonic uplift, monsoon evolution, Asian biodiversity, and topographic development during continental collision. However, the timing of high‐elevation topography formation in eastern Tibet is a matter of debate, with age estimates ranging from middle Eocene to late Miocene. This directly leads to contradictory understanding of uplift processes and plateau growth mechanisms. Sedimentary basins are excellent recorders of past drainage pattern and tectonic process, while many Cenozoic basins in eastern Tibet have been understudied. Here we focus on the Ninglang Basin and carry out comprehensive research including stratigraphy, sedimentology, chronology, and provenance analysis. We indicate that the Ninglang Basin was mainly supplied by a south‐flowing exterior drainage system during the middle Eocene, implying the existence of a regional, low‐gradient landscape beveling to the southeast at that time. The extinction of this drainage system in late Eocene time likely means the initiation of the Yalong‐Yulong thrust belt, a major boundary fault system in eastern Tibet. Our study thus support that the topography of eastern Tibet has been elevated in the late Eocene. Key Points: A large‐scale, south‐flowing fluvial system drained through the Ninglang Basin during the middle EoceneThe demise of the Ninglang Basin in the late Eocene resulted from the uplift of the Yalong‐Yulong thrust beltThe elevated terrain of eastern Tibet was initially formed in the late Eocene [ABSTRACT FROM AUTHOR]

The uplift and deformation styles of the Tibetan Plateau have been long debated on stepwise growth and crustal channel flow. Here, we offer new insight into this issue by constraining the pulsed exhumation history of the Yalong thrust belt in eastern Tibet, using apatite and zircon (U–Th)/He data from three ∼1 km vertical transects. The results revealed two rapid cooling pulses in the Late Oligocene (∼24 Ma, 50°C/m.y.) and the Middle Miocene (17–14 Ma, 35 °C/m.y.), respectively, which we ascribe to the staged‐thrusting faulting of this belt. These thrust faulting events indicated upward and eastward growth of the Tibetan Plateau, further suggested that the high topographic relief across the Yalong thrust belt mainly formed (at least) since the Late Oligocene. The available documents from paleoaltimetry, basin sediment accumulation, and thermochronometers and our new results reveal a regional‐scale stepwise propagation pattern of tectonic deformation during the Middle–Late Cenozoic in eastern Tibet. Plain Language Summary: The role of faulting in crust thickening has been one of the main controversies in the formation and evolution of the Tibetan Plateau. The Yalong thrust belt in eastern Tibet is a major Cenozoic structure with a 1.8–2.4 km topographic step, and its deformation processes are closely associated with the Cenozoic eastward plateau growth. In this study, we report 79 apatite and 78 zircon (U–Th)/He (AHe and ZHe) ages of 26 granitoid samples from three ∼1 km vertical transects. We suggest that the Yalong thrust belt underwent two rapid cooling (exhumation) pulses in the Late Oligocene (∼24 Ma, 50°C/m.y.) and the Middle Miocene (17–14 Ma, 35°C/m.y.), respectively. These pulses of exhumation and uplift along the Yalong thrust belt contributed to the development of the current morphology across eastern Tibet. Integrating previous findings and those reported in our study allow us to propose a regional‐scale stepwise propagation pattern of tectonic deformation during the Middle–Late Cenozoic in eastern Tibet. We suggest that the dynamic development of the deformation pattern may have been driven by the northward indentation of the Eastern Himalayan Syntaxis and the consequent lower crustal flow into southeastern Tibet. Key Points: The Yalong thrust belt underwent two rapid cooling pulses in the Late Oligocene (∼24 Ma) and Middle Miocene (17–14 Ma)The topographic relief across the Yalong thrust belt is mainly the result of pulsed thrusting at least since 24 MaA regional‐scale stepwise propagation pattern was proposed for the Middle–Late Cenozoic tectonic deformation in eastern Tibet [ABSTRACT FROM AUTHOR]

The drainage evolution in eastern Tibet during the India‐Eurasia collision has attracted considerable attention because of its critical link to topographic development and plateau growth, but the discussion still persists. In the present study, new and published detrital zircon U‐Pb ages are integrated from Pliocene‐Early Pleistocene Xigeda Formation (XGD) and modern river sands to decipher the paleo‐drainage evolution in eastern Tibet. The results confirm the eastward flow of the Jinsha River before the Pliocene, but the drainage patterns of its major tributaries (Dadu, Yalong, and Anning) in the Pliocene, differ from the modern ones. In conjunction with the previously documented fluvial incision in eastern Tibet, we interpreted that the excavation of the Paleo‐Xigeda lake in Early Pleistocene time initiated and accentuated incision of the Jinsha River and its major tributaries. This led to drainage reorganization and the modern river pattern establishment in eastern Tibet. Plain Language Summary: The developmental history of the Jinsha River and its major tributaries (Dadu, Yalong, and Anning) in eastern Tibet are considered to be closely associated with the topographic evolution during the Cenozoic plateau growth. However, the formation timing and mechanism of the current configuration of these large rivers remains debated. Here, we used detrital zircon U‐Pb age as "provenance tracer" to identify source signatures of the Pliocene‐Early Pleistocene Xigeda Formation, a sequence of lacustrine deposits sporadically distributed along the Middle Jinsha River and its large tributaries. Our provenance results demonstrate that current east‐flowing Jinsha River has been established before Pliocene time, while the present‐day pattern of its major tributaries, including the Yalong, Dadu, and Aning rivers, was achieved in the late Early Pleistocene. Combined with previous thermochronological and provenance studies, we infer that the spillover of dammed lake initiated the fluvial incision that led to drainage reorganization and, consequently, the formation of the modern river system. This study not only challenge existing models of Plio‐Pleistocene drainage pattern of eastern Tibet that flowed southward to the South China Sea, but also illustrates how river reorganization alone can dramatically influence landscape development even in the absence of significant tectonic and climatic forces. Key Points: The Jinsha River has flowed eastward before Pliocene timeThe present pattern of the Dadu, Yalong, and Anning Rivers achieved in the Early PleistoceneThe spillover of the Paleo‐Xigeda lake during the Early Pleistocene triggered incision of the Jinsha River and its major tributaries [ABSTRACT FROM AUTHOR]

The Dadu River in the eastern Tibetan Plateau has the potential to record transient variations of tectonic uplift since the Late Cenozoic. In this study, we extracted bedrock channels of the Dadu River drainage basin from the 30 m ASTER digital elevation model. The longitudinal river profiles were then analyzed, and three generations of knickpoints were recognized via the slope area method. By solving the analytical solution of the linear transient stream power incision model, we determined a Late Cenozoic history of regional tectonic uplift. The results reveal slow pre–middle Miocene uplift rates (<0.1 mm/a) and then increased gradually to 0.33 ± 0.03 mm/a since 12–15 Ma until present. This increase of uplift rate from bedrock channel inversion is consistent with the regional findings of low‐temperature themochronology, emphasizing the potential and significance to utilize channel profiles to infer the tectonic uplift history. Plain Language Summary: Recently, numerous thermochronology studies have provided constraints on the timing of rapid denudation along the eastern Tibetan Plateau. However, the rates of denudation/uplift determined by thermochronological profiles are often given as an average since a certain time duration. Thus, it is difficult to quantify the history of the tectonic uplift and whether uplift has been uniform or varied through time. We used the linear simulation method and inverted the longitudinal river profiles to decipher the Late Cenozoic uplift history of the eastern Tibetan Plateau. The results reveal that before the middle Miocene, the uplift rate was slow (<0.1 mm/a), and it increased gradually to 0.33 ± 0.03 mm/a since 12–15 Ma until present. Key Points: Linear inversion of the longitudinal river profiles for Tibetan Plateau uplift historyIncrease of the uplift rate since 12-15 Ma, consistent with regional resultsNew evidence of the late Miocene tectonic uplift in eastern Tibet [ABSTRACT FROM AUTHOR]

[Display omitted] • Comprehensive immunity and ferroptosis in serous ovarian cancer prognosis has not been reported. • We constructed a prognostic prediction model with immunity- and ferroptosis-related genes (CXCL11, CX3CR1, FH, and DNAJB6) for SOC patients. Our results showed that risk score according to this model was an independent prognostic factor. • Patients with high risk score indicated an immunosuppression in the tumor microenvironment predicting poor prognosis. Serous ovarian cancer (SOC) is the most common type of ovarian cancer (OC), with bad outcomes. To improve the prognosis of SOC patients, a novel risk signature was developed by combining immunity- and ferroptosis-related genes. By means of comparing SOC tissues with normal tissues, we screened the differential expression of immunity-related genes (DE-IRGs) and ferroptosis-related genes(DE-FRGs) with the standards of |log 2 fold change| > 1 and false discovery rate (FDR) < 0.05. After obtaining the meaningful differentially expressed genes from immune and ferroptosis (DEGs), we established a prognostic risk signature by utilizing Cox regression analyses in TCGA training set, which was validated in TCGA testing set and GSE26712 dataset. Besides, the differential expression of immune-related markers, immunophenoscore (IPS), TIDE score,T cell dysfunction score and T cell exclusion score were also analyzed. We further verified the expression of target genes in ovarian tumor cells lines by QRT-PCR. A risk signature constructed by totally four immunity- and ferroptosis-related DEGs (CXCL11, CX3CR1, FH, and DNAJB6) was developed, which distinguished the SOC patients as high-risk and low-risk groups. Patients in the high-risk group showed a lower overall survival (OS) than those in the low-risk group. Furthermore, the risk score was independent when analyzed with clinical augments, which was significantly associated with 13 KEGG signaling pathways. The gene signature showed favorable predictive performance according to Receiver operating characteristic (ROC) curves. Notably, the expression of immune-related markers or IPS indicated a negative connection with the risk score. SOC patients had a lower score of TIDE and T cell dysfunction than Whom had a higher score. Nonetheless, there were no significant differences in T cell exclusion scores between the two groups.Compared with normal ovarian cell line IOSE-80,QRT-PCR experiments exhibited that CXCL11, CX3CR1 and FH were up-regulated in ovarian tumor cells lines(SK-OV-3,COC1,A2780),while DNAJB6 was down-regulated. Four-biomarker signature formed by immunity- and ferroptosis-related genes may be clinically used as risk stratifcation tool in serous ovarian cancer,which can help further clinical decision-making regarding prognostic prediction,individualized treatment and follow-up scheduling. [ABSTRACT FROM AUTHOR]

Introduction: The tumor immune environment and immune-related genes are instrumental in the development, progression, and prognosis of bladder cancer (BLCA). This study sought to pinpoint key immune-related genes influencing BLCA prognosis and decipher their mechanisms of action., Methods and Results: We analyzed differentially expressed genes (DEGs) between high- and low- tumor mutational burden (TMB) groups. Subsequently, we constructed a reliable prognostic model based on immune-related gene pairs (IRGPs) and analyzed DEGs between high- and low-risk groups. A total of 22 shared DEGs were identified across differential TMB and IRGPs-derived risk groups in BLCA patients. Through univariate Cox and multivariate Cox analyses, we highlighted five genes - FLRT2, NTRK2, CYTL1, ZNF683, PRSS41 - significantly correlated with BLCA patient prognosis. Notably, the FLRT2 gene emerged as an independent prognostic factor for BLCA, impacting patient prognosis via modulation of macrophage infiltration in immune microenvironment. Further investigation spotlighted methylation sites - cg25120290, cg02305242, and cg01832662 - as key regulators of FLRT2 expression., Discussion: These findings identified pivotal prognostic genes in BLCA and illuminated the intricate mechanisms dictating patient prognosis. This study not only presents a novel prognostic marker but also carves out potential avenues for immunotherapy and targeted therapeutic strategies in BLCA. By demystifying the profound impact of immune-related genes and the tumor immune environment, this study augments the comprehension and prognostic management of bladder cancer., Competing Interests: Authors JZ and QC were employed by the company Thorgene Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Tao, Yu, Cong, Li, Zhu, Ding, Chen and Cai.)

Understanding the key factors in the tumor microenvironment (TME) that affect the prognosis of gliomas is crucial. In this study, we sought to uncover the prognostic significance of immune cells and immune-related genes in the TME of gliomas. We incorporated data of 970 glioma patient samples from the Chinese Glioma Genome Atlas (CGGA) database as the training set, and an additional set of 666 samples from The Cancer Genome Atlas (TCGA) database served as the validation set. From our analysis, we identified 21 immune-related differentially expressed genes (DEGs) in the TME, which holds implications for glioma prognosis. Based on these genes, we constructed a prognostic risk model on the 21 genes. The prognostic risk model demonstrated robust performance with an area under the curve (AUC) value of 0.848. Notably, the risk score derived from the model emerged as an independent prognostic factor of gliomas, with high risk scores indicative of an unfavorable prognosis. Furthermore, we observed that high infiltration levels of certain immune cells, namely, activated dendritic cells, M0 macrophages, M2 macrophages, and regulatory T cells (Tregs), correlated with an unfavorable glioma prognosis. In conclusion, our findings suggested that the TME of gliomas harbored a distinct immune-associated signature, comprising 21 immune-related genes and specific immune cells. These elements significantly influence the prognosis and present potential as novel indicators in the clinical assessment of glioma patient outcomes., Competing Interests: Authors JZ and QC were employed by ThorGene Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Tao, Zhu, Yu, Cong, Li, Cai and Chen.)

Catechol-O-methyltransferase (COMT) plays a central role in DNA repair and estrogen-induced carcinogenesis. Many recent epidemiologic studies have investigated the association between the COMT Val158Met polymorphism and cancer risk, but the results are inconclusive. In this study, we performed a meta-analysis to investigate the association between cancer susceptibility and COMT Val158Met in different genetic models. Overall, no significant associations were found between COMT Val158Met polymorphism and cancer risk (homozygote model: odds ratio [OR] =1.05, 95% confidence interval [CI] = [0.98, 1.13]; heterozygote model: OR =1.01, 95% CI = [0.98, 1.04]; dominant model: OR =1.02, 95% CI [0.97, 1.06], and recessive model: OR =1.03, 95% CI [0.97, 1.09]). In the subgroup analysis of cancer type, COMT Val158Met was significantly associated with increased risks of bladder cancer in recessive model, and esophageal cancer in homozygote model, heterozygote model, and dominant model. Subgroup analyses based on ethnicities, COMT Val158Met was significantly associated with increased risk of cancer in homozygote and recessive model among Asians. In addition, homozygote, recessive, and dominant models were significantly associated with increased cancer risk in the subgroup of allele-specific polymerase chain reaction genotyping. Significant associations were not observed when data were stratified by the source of the controls. In summary, this meta-analysis suggested that COMT Val158Met polymorphism might not be a risk factor for overall cancer risk, but it might be involved in cancer development at least in some ethnic groups (Asian) or some specific cancer types (bladder and esophageal cell cancer). Further evaluations of more preclinical and epidemiological studies are required.