15 results on '"Tolentino-Dolores, Maricruz"'
Search Results
2. Prevalence and characteristics of the metabolically healthy obese phenotype in children and adolescents in a Mexican state
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Pizano-Zárate, María Luisa, Horta-Baas, Gabriel, Nuñez-Hernández, Jorge A., Montiel-Jarquín, Álvaro J., Tolentino-Dolores, Maricruz, Hernández-Trejo, María, and Romero-Figueroa, María del Socorro
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- 2020
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Catalog
3. Zinc and selenium indicators and their relation to immunologic and metabolic parameters in male patients with human immunodeficiency virus
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Osuna-Padilla, Ivan Armando, Briceño, Olivia, Aguilar-Vargas, Adriana, Rodríguez-Moguel, Nadia Carolina, Villazon-De la Rosa, Andrea, Pinto-Cardoso, Sandra, Flores-Murrieta, Francisco Javier, Perichart-Perera, Otilia, Tolentino-Dolores, Maricruz, Vargas-Infante, Yetlanezi, and Reyes-Terán, Gustavo more...
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- 2020
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4. Optimizing perinatal wellbeing in pregnancy with obesity: a clinical trial with a multi-component nutrition intervention for prevention of gestational diabetes and infant growth and neurodevelopment impairment.
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Perichart-Perera, Otilia, Reyes-Muñoz, Enrique, Borboa-Olivares, Hector, Rodríguez-Cano, Ameyalli M., Solis Paredes, Juan Mario, Hernández-Hernández, Larissa, Rodríguez-Hernández, Carolina, González-Ludlow, Isabel, Suárez-Rico, Blanca V., Sánchez-Martínez, Maribel, Torres-Herrera, Ursula, Alejandro Canul-Euan, Arturo, Tolentino-Dolores, Maricruz, Espejel-Nuñez, Aurora, and Estrada-Gutierrez, Guadalupe more...
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- 2024
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5. Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy.
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Solis Paredes, Juan Mario, Perichart Perera, Otilia, Montoya Estrada, Araceli, Reyes Muñoz, Enrique, Espino y Sosa, Salvador, Ortega Castillo, Veronica, Medina Bastidas, Diana, Tolentino Dolores, Maricruz, Sanchez Martinez, Maribel, Nava Salazar, Sonia, and Estrada Gutierrez, Guadalupe more...
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WEIGHT gain ,THIRD trimester of pregnancy ,GESTATIONAL diabetes ,PREGNANT women ,RESISTIN - Abstract
Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation. [ABSTRACT FROM AUTHOR] more...
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- 2021
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6. Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial.
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Romero-Maldonado, Silvia, Montoya-Estrada, Araceli, Reyes-Muñoz, Enrique, Guzmán-Grenfell, Alberto Martín, Dorin Torres-Ramos, Yessica, David Sánchez-Mendez, Mario, Tolentino-Dolores, Maricruz, Bernardo Salgado-Valladares, Manuel, Belmont-Gómez, Aurora, Najéra, Nayelli, Ceballos, Guillermo, Arturo Cardona-Pérez, Jorge, Hicks, Juan José, Mancilla-Ramírez, Javier, Torres-Ramos, Yessica Dorin, Sánchez-Mendez, Mario David, Salgado-Valladares, Manuel Bernardo, and Cardona-Pérez, Jorge Arturo more...
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- 2021
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7. Metabolic markers during pregnancy and their association with maternal and newborn weight status.
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Perichart-Perera, Otilia, Muñoz-Manrique, Cinthya, Reyes-López, Angélica, Tolentino-Dolores, Maricruz, Espino y Sosa, Salvador, and Ramírez-González, Maria Cristina
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Background/Aims Obesity during pregnancy increases the risk of adverse clinical outcomes and is associated with low-grade chronic inflammation. We describe maternal metabolic risk and inflammation by maternal weight status, and evaluate the association of metabolic and inflammatory markers with birthweight in a group of pregnant Mexican women. Methods This study derived from a prospective cohort of healthy pregnant women <14 weeks of gestation, receiving prenatal care at National Institute of Perinatology (Mexico, 2009–2013). Metabolic and inflammatory markers were measured in maternal serum in all three pregnancy trimesters (1st: 11.42±1.7; 2nd: 21.06±2.4; 3rd: 32.74±2.3 weeks). Pregestational weight was self-reported, and body mass index (BMI) was calculated. Gestational weight gain was evaluated in the third trimester. Newborn´s weight was measured at birth. We carried out correlations, general mixed linear model and regression analyses, based on pregestational weight (self-reported), body mass index (BMI), gestational weight gain (evaluated in the third trimester) and newborn weight (measured at birth). Results Of the 177 women included in the study (mean age = 26.93±8.49), thirty-eight percent (n = 67) were overweight or had obesity, and 32.8% (n = 58) showed excessive gestational weight gain. We found insulin, lipids (including total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides-TG), leptin and interleukin 1b (IL-1b) all increased significantly (p<0.05) during pregnancy. Pregestational maternal weight status altered longitudinal concentrations of insulin, leptin, adiponectin, TG and C reactive protein. Excessive gestational weight gain was associated with higher maternal insulin in the third trimester (p<0.05). Early pregnancy leptin and TNFα were determinants of birthweight in women with normal weight, but not in overweight or obese women. Conclusions Maternal weight status affected the concentrations of insulin, leptin, adiponectin, triglycerides and C reactive protein throughout pregnancy. The role of early leptin and TNFα in fetal growth need further study given the association was only observed in normal weight women. This study presents data distribution of metabolic and inflammatory markers of normal weight and overweight/obese women that did not develop GDM, preeclampsia nor macrosomia. [ABSTRACT FROM AUTHOR] more...
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- 2017
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8. Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates.
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Hernández-Trejo, María, Montoya-Estrada, Araceli, Torres-Ramos, Yessica, Espejel-Núñez, Aurora, Guzmán-Grenfell, Alberto, Morales-Hernández, Rosa, Tolentino-Dolores, Maricruz, and Laresgoiti-Servitje, Estibalitz more...
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OXIDATIVE stress ,BIOMARKERS ,CYTOKINES ,PREGNANCY complications ,OBESITY in women ,NEWBORN infant health ,FETAL development ,GESTATIONAL diabetes - Abstract
Background: Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabetic/non-diabetic women. Results: Significant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1ß. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1ß in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Conclusions: Oxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth. [ABSTRACT FROM AUTHOR] more...
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- 2017
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9. Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity.
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Solis-Paredes, Mario, Espino y Sosa, Salvador, Estrada-Gutierrez, Guadalupe, Nava-Salazar, Sonia, Ortega-Castillo, Veronica, Rodriguez-Bosch, Mario, Bravo-Flores, Eyerahi, Espejel-Nuñez, Aurora, Tolentino-Dolores, Maricruz, Gaona-Estudillo, Rubí, Martinez-Bautista, Nancy, and Perichart-Perera, Otilia more...
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FETUS ,LIPIDS ,ADIPOKINES ,OBESITY ,METABOLIC disorders ,MOTHER-child relationship - Abstract
Background. Maternal metabolic changes impact fetal metabolism resulting in a higher risk for developing chronic diseases later in life. The aim of this study was to assess the association between maternal and fetal adipokine and lipid profiles, as well as the influence of maternal weight on this association. Methods. Healthy pregnant women at term who delivered by C-section were enrolled. Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. Statistics included descriptives, correlations, and mean differences (SPSS v20.0). Results. Adiponectin and resistin concentrations were higher in fetal blood, while leptin was lower (p<0.05). A significant inverse association between maternal resistin and fetal LDL-cholesterol (LDL-C) (r=-0.327; p=0.022) was observed. A positive correlation was found between maternal and fetal resistin (r=0.358; p=0.013). Women with excessive weight gain had higher leptin levels and their fetuses showed higher LDL-C levels (p<0.05). Conclusions. Maternal resistin showed an inverse association with fetal LDL-C, suggesting that maternal adiposity status may play an active role in the regulation of fetal lipid profile and consequently, in fetal programming. Excessive maternal weight gain during pregnancy may exert an effect over metabolic mediators in both mother and newborn. [ABSTRACT FROM AUTHOR] more...
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- 2016
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10. Secondary Hyperparathyroidism Induced by Plateletpheresis in Donors As a Result of Divalent Cationic Chelation by Citrate.
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Sanchez-Guerrero, Sergio, Zapata-Canto, Nidia, Tolentino-Dolores, Maricruz, Barbosa-Ibarra, Arlette, Volkow-Fernandez, Patricia, Juan, Labardini, Zamora-Sanchez, Lizbeth, Alonso-Lopez, Alma, Rivas-Pichon, Eloisa, Buendia-Gomez, Leticia, Damian-Yañez, Delfina, Ortiz, Claudia Angel, Samano-Samano, Reyna, Morales, Rosa M, and Schnaas, Lourdes more...
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- 2012
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11. Vitamin D Status and Its Determinants in Mexican Pregnant Women from a Rural and an Urban Area: A Comparative Study.
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Chávez-Courtois, Mayra, Godínez-Martínez, Estela, Muñoz-Manrique, Cinthya, Negrete-Martínez, Viviana, González-Leyva, Carla Patricia, Tolentino-Dolores, Maricruz, Suárez-Rico, Blanca, Estrada-Gutierrez, Guadalupe, Perichart-Perera, Otilia, and Suárez-Varela, María M. Morales more...
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- 2021
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12. Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?
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Perichart-Perera, Otilia, González-Leyva, Carla Patricia, González-Ludlow, Isabel, Tolentino-Dolores, Maricruz, Solis-Paredes, Mario, Reyes-Muñoz, Enrique, Borboa-Olivares, Hector, Sánchez-Martínez, Maribel, Parra-Hernández, Sandra, Monterrubio-Flores, Eric, Schnaas y Arrieta, Lourdes, Guzmán-Huerta, Mario, and Estrada-Gutierrez, Guadalupe more...
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Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017–2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0–250, 250–400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (<20 and <30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p < 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72–8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250–400 IU/day were insufficient for achieving an adequate maternal vitamin D status. [ABSTRACT FROM AUTHOR] more...
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- 2020
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13. Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates
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Hernández-Trejo, María, Montoya-Estrada, Araceli, Torres-Ramos, Yessica, Espejel-Núñez, Aurora, Guzmán-Grenfell, Alberto, Morales-Hernández, Rosa, Tolentino-Dolores, Maricruz, and Laresgoiti-Servitje, Estibalitz more...
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Offspring ,Immunology ,Overweight ,Free fatty acids ,medicine.disease_cause ,Fetal Development ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Pregnancy ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Obesity ,Vitamin supplementation ,Nitrites ,Arginase ,Superoxide Dismutase ,business.industry ,Diabetes ,Body Weight ,Infant, Newborn ,Fetal Blood ,medicine.disease ,Malondialdehyde ,Pregnancy Complications ,Oxidative Stress ,030104 developmental biology ,Endocrinology ,chemistry ,Cord blood ,Cytokines ,Female ,Inflammation Mediators ,medicine.symptom ,business ,Biomarkers ,Oxidative stress ,Research Article - Abstract
Background Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabetic/non-diabetic women. Results Significant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1β. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1β in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Conclusions Oxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth. more...
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14. Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function.
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Osuna-Padilla IA, Rodríguez-Moguel NC, Aguilar-Vargas A, Tolentino-Dolores M, Perichart-Perera O, Ahumada-Topete V, Ávila-Ríos S, Soto-Nava M, Diaz-Rivera D, De León-Lara E, Wilson-Verdugo M, and Briceño O more...
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Background and Aim: Deficiency of zinc and selenium is common in persons living with human immunodeficiency virus (PLWHIV) and has been associated with the development of non-AIDS related comorbidities, impaired immune system function and mortality. Micronutrient supplementation on long-term-treated PLWHIV could bring potential clinical and immunological benefits improving their health status and quality of life. The aim of the present study is to analyze the effect of zinc and selenium supplementation on body composition, bone mineral density, CD4+ T-cell counts, metabolic profile and immune system status on clinical stable PLWHIV on long-term antiretroviral therapy (ART)., Methods: This is a randomized pilot clinical trial in which we recruited 60 PLWHIV on ART who were assigned to the intervention groups: zinc (30 mg of zinc gluconate), selenium (200 μg of selenium yeast), zinc + selenium (same doses and presentations) or to a control group (without nutritional supplementation) who received supplementation during 6 months. Primary outcome was defined as changes in body composition (weight, muscle and fat mass and bone mineral density) and secondary outcomes as changes in biochemical and immunological parameters (CD4+ T-cell count, cholesterol, glucose, triglycerides and seric zinc and selenium seric concentrations) before and after supplementation. Peripheral blood mononuclear cells (PBMCs) of one individual of each intervention group were analyzed for single cell transcriptomics before and after supplementation., Results: BMI ( p = 0.03), fat mass ( p = 0.03), and trunk fat ( p = 0.01) decreased after 6 months of selenium supplementation. No changes were observed for cholesterol, glucose or triglycerides after supplementation ( p > 0.05 in all cases). CD4+ T cells percentage increased after 6 months of selenium supplementation ( p = 0.03). On the transcriptome analysis, zinc and selenium supplementation induced changes on de expression of genes associated with the function of naive and memory CD8+ T-cells ( p < 0.05 in all cases)., Conclusion: Zinc and selenium supplementation could represent a complementary intervention that may improve the health status and immune response of treated PLWHIV., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Osuna-Padilla, Rodríguez-Moguel, Aguilar-Vargas, Tolentino-Dolores, Perichart-Perera, Ahumada-Topete, Ávila-Ríos, Soto-Nava, Diaz-Rivera, De León-Lara, Wilson-Verdugo and Briceño.) more...
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- 2024
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15. Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy.
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Vásquez-Procopio J, Espejel-Nuñez A, Torres-Torres J, Martinez-Portilla RJ, Espino Y Sosa S, Mateu-Rogell P, Ortega-Castillo V, Tolentino-Dolores M, Perichart-Perera O, Franco-Gallardo JO, Carranco-Martínez JA, Prieto-Rodríguez S, Guzmán-Huerta M, Missirlis F, and Estrada-Gutierrez G more...
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Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers - suggestive of underlying pathophysiological interactions-occur during SARS-CoV-2 infection in pregnancy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Vásquez-Procopio, Espejel-Nuñez, Torres-Torres, Martinez-Portilla, Espino Y. Sosa, Mateu-Rogell, Ortega-Castillo, Tolentino-Dolores, Perichart-Perera, Franco-Gallardo, Carranco-Martínez, Prieto-Rodríguez, Guzmán-Huerta, Missirlis and Estrada-Gutierrez.) more...
- Published
- 2022
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