33 results on '"Tong, Dandan"'
Search Results
2. Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier
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Liu, Xin, Li, Yue, Chen, Chunjing, Dong, Jiyang, Zhou, Jie, Tong, Dandan, Wang, Lei, Gao, Xiang, and Kang, Xinmei
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- 2023
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3. Incorporating STEAM activities into creativity training in higher education
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Gu, Xiaojing, Tong, Dandan, Shi, Peiqi, Zou, Yuchen, Yuan, Han, Chen, Chen, and Zhao, Guoqing
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- 2023
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4. Bullying Victimization and Malevolent Creativity in Rural Adolescents: The Longitudinal Mediational Role of Hostile Attribution.
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Tong, Dandan, Shi, Yanan, Gu, Xiaojing, and Lu, Peng
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BULLYING & psychology , *SCALE analysis (Psychology) , *CYBERBULLYING , *T-test (Statistics) , *RESEARCH funding , *SCHOOLS , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *CHI-squared test , *CRIME victims , *AGGRESSION (Psychology) , *TEENAGERS' conduct of life , *LONGITUDINAL method , *RURAL population , *ADOLESCENCE - Abstract
Extensive research has documented bully victimization as a pivotal risk factor contributing to aggressive behaviors among adolescents. Particularly, the negative outcome of increased aggressive behaviors may be exacerbated when the aggressive actions are novel and difficult to detect. The present study aims to explore the complex relationships between cyberbullying and school bullying victimization and malevolent creativity and the potential mediating role of hostile attribution using two-wave longitudinal data. The present study analyzed data from 262 rural adolescents. The results revealed that cyberbullying victimization significantly predicted malevolent creativity, whereas school bullying victimization did not. Hostile attribution served as a mediator in the relationship between cyberbullying victimization and malevolent creativity in the longitudinal models. These findings provide significant implications for mitigating the negative influence of bullying victimization on the emergence of malevolent creativity in rural adolescents. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Does forgiveness alleviate depression after being phubbed for emerging adults? The mediating role of self-esteem
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Xie, Xiaochun, Tang, Xiangyun, Rapp, Hannah, Tong, Dandan, and Wang, Pengcheng
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- 2020
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6. Critical thinking and regional gray matter volume interact to predict representation connection in scientific problem solving
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Tong, Dandan, Lu, Peng, Li, Weiwei, Yang, Wenjing, Yang, Yang, Yang, Dong, Qiu, Jiang, and Zhang, Qinglin
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- 2019
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7. Habitual suppression relates to difficulty in regulating emotion with cognitive reappraisal
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Che, Xianwei, Luo, Xi, Tong, Dandan, Fitzgibbon, Bernadette M., and Yang, Juan
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- 2015
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8. An illustrated heuristic prototype facilitates scientific inventive problem solving: A functional magnetic resonance imaging study
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Tong, Dandan, Li, Wenfu, Tang, Chaoying, Yang, Wenjing, Tian, Yan, Zhang, Lei, Zhang, Meng, Qiu, Jiang, Liu, Yijun, and Zhang, Qinglin
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- 2015
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9. How can we gain insight in scientific innovation? Prototype heuristic is one key
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Ming, Dan, Tong, Dandan, Yang, Wenjing, Qiu, Jiang, and Zhang, Qinglin
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- 2014
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10. The Impact of Emotional Intelligence on Domain-Specific Creativity: The Mediating Role of Resilience and the Moderating Effects of Gratitude.
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Tong, Dandan, Kang, Hanxiao, Li, Minghui, Yang, Junyi, Lu, Peng, and Xie, Xiaochun
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EMOTIONAL intelligence , *CREATIVE thinking , *CREATIVE ability , *DIVERGENT thinking , *GRATITUDE - Abstract
Creativity incorporates both domain-general and domain-specific ideas. While previous studies have explored the impact of emotional intelligence (EI) on creativity in both domains, a consensus has not been reached, and the mechanism is currently unclear. In the present study, we examined which aspect of creativity EI was most strongly associated with in a group of undergraduates. Moreover, we explored the moderated mediation effect between EI and domain-specific creativity. In Study 1, 532 undergraduates completed questionnaires measuring EI, convergent and divergent creative thinking, and creative achievement. The results revealed that the most reliable positive correlations were between EI and domain-specific creativity. In Study 2, 926 undergraduates completed measurements of EI, resilience, gratitude, and creative achievement. The results revealed that resilience mediates the relationship between EI and creative achievement. Furthermore, gratitude moderated the indirect effect of EI on creative achievement through resilience. The indirect effect of EI on creative achievement was stronger for high-gratitude individuals than for low-gratitude individuals. This orientation and other results are discussed. Overall, our findings add further nuance to the relationship between EI and creativity in different domains. This study serves as a basis for other contributions aligned with these concepts. [ABSTRACT FROM AUTHOR]
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- 2022
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11. RBMS3 is a tumor suppressor gene that acts as a favorable prognostic marker in lung squamous cell carcinoma
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Liang, Ya-nan, Liu, Yu, Meng, Qingwei, Li, Xiaobo, Wang, Fan, Yao, Guodong, Wang, Letian, Fu, Songbin, and Tong, Dandan
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- 2015
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12. E2F1 Affects the Therapeutic Response to Neoadjuvant Therapy in Breast Cancer.
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Ye, Xinxing, Zhou, Jie, Tong, Dandan, Wang, Dandan, Wang, Hui, Guo, Jixue, and Kang, Xinmei
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NEOADJUVANT chemotherapy ,CANCER treatment ,BREAST cancer ,TREATMENT effectiveness ,CANCER chemotherapy ,BREAST - Abstract
This study is aimed at screening genes for predicting the sensitivity response and favorable outcome of neoadjuvant therapy in breast cancer. We downloaded neoadjuvant therapy genetic data of breast cancer and separated it into the pathological complete response (pCR) group and the non-pCR group. Differential expression analysis was performed to select the differentially expressed genes (DEGs). After that, we investigated the enriched biological processes and pathways of DEGs. Then, core up/down protein-protein interaction (PPI) network was, respectively, constructed to identify the hub genes. A transcription factor-target gene regulation network was built to screen core transcription factors (TFs). We found one upregulated DEG (KLHDC7B) and four downregulated DEGs (TFF1, LOC440335, SLC39A6, and MLPH) overlapped in three datasets. All DEGs were mainly enriched in pathways related to DNA biosynthesis, cell cycle, immune response, metabolism, and angiogenesis. The hub genes were KRT18, IL7R, HIST1H1A, and E2F1. The core TFs were HOXA9, SPDEF, FOXA1, E2F1, and PGR. RT-qPCR suggested that E2F1 was overexpressed in MCF-7, but HOXA9 was low-expressed. Western blot suggested that the MAPK signal pathway was inhibited in MCF-7/ADR. That is to say, some genes and core TFs can predict the sensitivity response of neoadjuvant therapy in breast cancer. And E2F1 may be involved in the process of drug resistance by regulating the MAPK signaling pathway. These might be useful as sensitive genes for the efficacy evaluation of neoadjuvant chemotherapy in breast cancer. [ABSTRACT FROM AUTHOR]
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- 2022
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13. A meta-analysis of neuroimaging studies on divergent thinking using activation likelihood estimation
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Wu, Xin, Yang, Wenjing, Tong, Dandan, Sun, Jiangzhou, Chen, Qunlin, Wei, Dongtao, Zhang, Qinglin, Zhang, Meng, and Qiu, Jiang
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- 2015
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14. DJ-1 may contribute to metastasis of non-small cell lung cancer
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Bai, Jing, Guo, Changlong, Sun, Wenjing, Li, Ming, Meng, Xiangning, Yu, Yang, Jin, Yan, Tong, Dandan, Geng, Jingshu, Huang, Qi, Qi, Jiping, and Fu, Songbin
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- 2012
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15. Differential Expression of PAI-RBP1, C1orf142, and COTL1 in Non–Small Cell Lung Cancer Cell Lines With Different Tumor Metastatic Potential
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Sun, Wenjing, Guo, Changlong, Meng, Xiangning, Yu, Yang, Jin, Yan, Tong, Dandan, Geng, Jingshu, Huang, Qi, Qi, Jiping, Liu, An, Guan, Rongwei, Xu, Lidan, Sun, Donglin, Ji, Wei, Liu, Peng, Liu, Fangli, Sun, Haiming, Ji, Guohua, Fu, Songbin, and Bai, Jing
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- 2012
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16. Will the patient's double eyelid shape be like that of the surgeon performing the procedure? A study of surgeons' aesthetics in East Asian Blepharoplasty.
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Wang, Hayson Chenyu, Ting, Wenyun, Tong, Dandan, Dong, Ruijia, Long, Xiao, Huang, Jiuzuo, Cao, Hairu, Tianyu Sun, Elliot, Yu, Nanze, Wang, Xiaojun, and Zhao, Ru
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BLEPHAROPLASTY ,EYELIDS ,STRUCTURAL equation modeling ,SURGEONS ,AESTHETICS - Abstract
Background: No reports of the potential areas of surgeons' aesthetics in blepharoplasty. Aims: To explore the association between the surgeons' own double eyelid morphology and their aesthetics and surgical outcome. Methods: An investigation of 1605 patients was carried collecting the data of double eyelid shape, based on which to propose a preliminary double eyelid classification for analyzing the aesthetics of surgeons. Ten double eyelid surgical cases were randomly collected from each surgeon according to the inclusion criteria, whose double eyelid shape, ideal shape, the selection tendency of surgical approach, most cared factor during surgery, and design concept of eyelid shape were collected. Structural equation modeling (SEM) was performed to assess the association between participants' double eyelid shape, aesthetics, and blepharoplasty outcome. Results: Fifty‐three double eyelid surgeons were enrolled for study, whose double eyelids shapes mostly were obviously fan‐shaped (37.74%) and low‐parallel eyelid (26.42%), and the ideal shapes were obviously fan‐shaped (41.51%) and high‐parallel eyelid (24.53%). 54.72% of the subjects preferred to use the full‐incisional method. 45.28% cared for long‐term outcome most. Regarding blepharoplasty outcome style, 49.06% of the subjects preferred obviously fan‐shaped type and 24.53% for high‐parallel type. SEM showed that aesthetics rank increased by 0.692 points for surgeons' shape (P <.001), and surgical outcome rank increased by 0.861 points for aesthetics (P <.001). However, their eyelid shape had no direct contribution to surgical outcome (P =.96). Conclusions: The findings indicated that surgeons' double eyelid shape positively affected their aesthetics, which affected their surgical outcomes further, but their double eyelid shape failed to affect the surgical outcomes directly. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor.
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Liu, Yu, Liang, Yanan, Li, Ming, Liu, Duanyang, Tang, Jing, Yang, Weiwei, Tong, Dandan, and Jin, Xiaoming
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THYROID cancer diagnosis ,EPIDERMAL growth factor receptors ,HOMOLOGY (Biology) ,PROTEIN expression ,IMMUNOHISTOCHEMISTRY - Abstract
Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain‑containing 1 (EHD1) is associated with EGFR‑mediated endocytotic recycling in multiple tumor types. The objective of the present study was to determine the protein expression levels and clinical significance of EHD1, EGFR, caveolin‑1 (CAV‑1) and RAB11 family interacting protein 3 (RAB11FIP3) in PTC. PTC specimens were analyzed for EHD1, EGFR, CAV‑1 and RAB11FIP3 expression via immunohistochemistry and western blotting. The associations between protein expression and clinicopathological features were assessed. EHD1, EGFR, CAV‑1 and RAB11FIP3 expression levels were increased in human PTC. Additionally, the expression level of EHD1 protein was significantly associated with tumor size, lymph node metastasis and EGFR expression (P<0.05). CAV‑1 was associated with tumor size and EGFR expression (P<0.05). EGFR was only associated with lymph node metastasis (P=0.027) and RAB11FIP3 was not associated with any clinicopathological characteristics. The correlations between EHD1 and EGFR (r=0.564, P<0.05), CAV‑1 (r=0.865, P<0.01) and RAB11FIP3 (r=0.504, P<0.05) were statistically significant. Overall, EHD1, CAV‑1 and RAB11FIP3, which are key proteins in endocytotic recycling, promote PTC tumorigenesis through the regulation of the transport of EGFR. [ABSTRACT FROM AUTHOR]
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- 2018
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18. Combined caveolin‑1 and epidermal growth factor receptor expression as a prognostic marker for breast cancer.
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Liang, Ya-Nan, Liu, Yu, Wang, Letian, Yao, Guodong, Li, Xiaobo, MENg, Xiangning, Wang, Fan, Li, Ming, Tong, Dandan, and GENg, Jingshu
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BREAST cancer prognosis ,EPIDERMAL growth factor receptors ,CAVEOLINS ,IMMUNOHISTOCHEMISTRY ,PROPORTIONAL hazards models - Abstract
Previous studies have indicated that caveolin‑1 (Cav‑1) is able to bind the signal transduction factor epidermal growth factor receptor (EGFR) to regulate its tyrosine kinase activity. The aim of the present study was to evaluate the clinical significance of Cav‑1 gene expression in association with the expression of EGFR in patients with breast cancer. Primary breast cancer samples from 306 patients were analyzed for Cav‑1 and EGFR expression using immunohistochemistry, and clinical significance was assessed using multivariate Cox regression analysis, Kaplan‑Meier estimator curves and the log‑rank test. Stromal Cav‑1 was downregulated in 38.56% (118/306) of tumor tissues, whereas cytoplasmic EGFR and Cav‑1 were overexpressed in 53.92% (165/306) and 44.12% (135/306) of breast cancer tissues, respectively. EGFR expression was positively associated with cytoplasmic Cav‑1 and not associated with stromal Cav‑1 expression in breast cancer samples; however, low expression of stromal Cav‑1 was negatively associated with cytoplasmic Cav‑1 expression in total tumor tissues, and analogous results were identified in the chemotherapy group. Multivariate Cox's proportional hazards model analysis revealed that, for patients in the estrogen receptor (ER)(+) group, the expression of stromal Cav‑1 alone was a significant prognostic marker of breast cancer. However, in the chemotherapy, human epidermal growth factor receptor 2 (HER‑2)(‑), HER‑2(+) and ER(‑) groups, the use of combined markers was more effective prognostic marker. Stromal Cav‑1 has a tumor suppressor function, and the combined marker stromal Cav‑1/EGFR expression was identified as an improved prognostic marker in the diagnosis of breast cancer. Parenchymal expression of Cav‑1 is able to promote EGFR signaling in breast cancer, potentially being required for EGFR‑mediated initiation of mitosis. [ABSTRACT FROM AUTHOR]
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- 2018
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19. NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
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Wang, Yuhui, Wu, Nan, Sun, Donglin, Sun, Haiming, Tong, Dandan, Liu, Duo, Pang, Bo, Li, Su, Wei, Jia, Dai, Jialin, Liu, Yang, Bai, Jing, Geng, Jingshu, Fu, Songbin, and Jin, Yan
- Abstract
Nucleotide binding protein-like, NUBPL, is an assembly factor for human mitochondrial complex I, which is the biggest member of the mitochondrial respiratory chain. However, the relationship between NUBPL and carcinoma progression remains unknown. In this study, NUBPL was characterized for its role in colorectal cancer ( CRC) and the underlying molecular mechanisms. Data ( n = 197) from the Oncomine database revealed that mRNA levels of NUBPL were remarkably overexpressed in CRC tissues compared with normal tissues. In addition, immunohistochemical analysis of 75 pairs of CRC and non-tumor tissues showed that the expression level of NUBPL was significantly higher in CRC tissues, and its expression level was positively associated with lymph node metastasis ( P = 0.028) and advanced staging (P = 0.030). Expression of NUBPL in metastatic lymph nodes of CRC patients was also detected by immunohistochemical staining and high expression levels of NUBPL were observed. Overexpression of NUBPL significantly promoted the migration and invasion ability of CRC cell lines SW480 and SW620, whereas knockdown of NUBPL lead to an opposite effect. Our further study found that NUBPL could induce epithelial-mesenchymal transition ( EMT), characterized by downregulation of epithelial markers (E-cadherin) and upregulation of mesenchymal markers (N-cadherin and vimentin). Moreover, NUBPL was able to activate ERK, which is believed to promote EMT and tumor metastasis. Inhibition of ERK suppressed the NUBPL-induced changes in EMT and cell motility. These data showed that NUBPL plays a vital role in CRC migration and invasion by inducing EMT and activating ERK. It might be a novel therapeutic target for CRC. [ABSTRACT FROM AUTHOR]
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- 2017
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20. The oriental armyworm genome yields insights into the long-distance migration of noctuid moths.
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Tong, Dandan, Zhang, Lei, Wu, Ningning, Xie, Dianjie, Fang, Gangqi, Coates, Brad S., Sappington, Thomas W., Liu, Yueqiu, Cheng, Yunxia, Xia, Jixing, Jiang, Xingfu, and Zhan, Shuai
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The oriental armyworm, Mythimna separata , is known for its long-distance seasonal migration and environment-dependent phase polymorphisms. Here, we present a chromosome-level genome reference and integrate multi-omics, functional genetics, and behavioral assays to explore the genetic bases of the hallmark traits of M. separata migration. Gene family comparisons show expansion of gustatory receptor genes in this cereal crop pest. Functional investigation of magnetoreception-related genes and associated flight behaviors suggest that M. separata may use the geomagnetic field to guide orientation in its nocturnal flight. Comparative transcriptome characterizes a suite of genes that may confer the observed plasticity between phases, including genes involved in protein processing, hormone regulation, and dopamine metabolism. We further report molecular signatures that underlie the dynamic regulation of a migratory syndrome coordinating reproduction and flight. Our study yields insights into environment-dependent developmental plasticity in moths and advances our understanding of long-distance migration in nocturnal insect pests. [Display omitted] • Chromosome-level genome and gene editing system are presented for Mythimna separata • Silencing of magnetoreception-related genes disrupts the orientation of nocturnal flight • Conditional flight attenuates reproduction-flight trade-off via hormone regulation • Transcriptome profiles characterize genes underlying the phase differentiation Mythimna separata is a night-flying migrant that displays characteristic migratory syndrome. Tong et al. present its chromosome-level genome along with an efficient gene editing system. Their integrative study characterizes molecular signatures underlying the biology of nocturnal migration in terms of flight orientation, developmental plasticity, and trade-offs between flight and reproduction. [ABSTRACT FROM AUTHOR]
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- 2022
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21. Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition.
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Wu, Nan, Wei, Jia, Wang, Yuhui, Yan, Jinyan, Qin, Ying, Tong, Dandan, Pang, Bo, Sun, Donglin, Sun, Haiming, Yu, Yang, Sun, Wenjing, Meng, Xiangning, Zhang, Chunyu, Bai, Jing, Chen, Feng, Geng, Jingshu, Lee, Ki-Young, Fu, Songbin, and Jin, Yan
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RIBOSOMES ,OVARIAN cancer ,EPITHELIAL cells ,MESENCHYMAL stem cells ,CELL transformation - Abstract
Double minute chromosomes (DMs) have important implications for cancer progression because oncogenes frequently amplified on them. We previously detected a functionally undefined gene amplified on DMs, Ribosomal L22-like1 (RPL22L1). The relationship between RPL22L1 and cancer progression is unknown. Here, RPL22L1 was characterized for its role in ovarian cancer (OC) metastasis and its underlying mechanism was examined. DNA copy number and mRNA expression of RPL22L1 in OC cells was analyzed using data obtained from The Cancer Genome Atlas and the Gene Expression Omnibus database. An immunohistochemical analysis of clinical OC specimens was performed and the relationships between expression level and clinicopathological factors were evaluated. Additionally, in vivo and in vitro assays were performed to understand the role of RPL22L1 in OC. RPL22L1 expression was higher in OC specimens than in normal tissues, and its expression level was highly positively correlated with invasion and lymph node metastasis (P < 0.05). RPL22L1 over-expression significantly enhanced intraperitoneal xenograft tumor development in nude mice and promoted invasion and migration in vitro. Additionally, RPL22L1 knockdown remarkably inhibited UACC-1598 cells invasion and migration. Further, RPL22L1 over-expression up-regulated the mesenchymal markers vimentin, fibronectin, and α-SMA, reduced expression of the epithelial markers E-cadherin, α-catenin, and β-catenin. RPL22L1 inhibition reduced expression of vimentin and N-cadherin. These results suggest that RPL22L1 induces epithelial-to-mesenchymal transition (EMT). Our data showed that the DMs amplified gene RPL22L1 is critical in maintaining the aggressive phenotype of OC and in triggering cell metastasis by inducing EMT. It could be employed as a novel prognostic marker and/or effective therapeutic target for OC. [ABSTRACT FROM AUTHOR]
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- 2015
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22. Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry.
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Tong, Dandan, Yang, Wenjing, Zhang, Qinglin, Li, Wenfu, Wei, Dongtao, Che, Xianwei, Zhang, Meng, Hitchman, Glenn, Qiu, Jiang, Liu, Yijun, and Cao, Guikang
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- *
WHITE matter (Nerve tissue) , *GRAY matter (Nerve tissue) , *AMBIGUITY tolerance , *VOXEL-based morphometry , *INDIVIDUAL differences , *PREFRONTAL cortex - Abstract
The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors. [ABSTRACT FROM AUTHOR]
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- 2015
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23. Working memory and creativity: A bibliometric analysis using VOSviewer.
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Lu, Peng, Zhang, Ruolin, and Tong, Dandan
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BIBLIOMETRICS , *CONTROL (Psychology) , *COGNITIVE ability , *SHORT-term memory , *CREATIVE ability , *WEB databases - Abstract
To provide researchers with a systematic reference on initial contact with working memory and creativity, we elucidated an essential bibliometric analysis of publications based on the Web of Science database. Results were as follows: (a) Related research started in 2003 and entered a period of rapid development since 2013, with more than 20 articles published annually; (b) Roger E. Beaty and Benedek Mathias had the most publications, while Ryuta Kawashima, Hikaru Takeuchi, and Yasuyuki Taki had the most extensive cooperation with others; (c) only 9 out of 527 organizations had formed locally finite cooperative networks; and (d) eight major research popular topics were identified: creativity, cognition, memory, working memory, performance, fMRI, cognitive control, and brain. Enhancing the study of the neural mechanisms of working memory and creativity through fMRI or functional connectivity is of great significance so that we can understand how brain regions interact not only with brain regions that are directly connected structurally but also with those that are not structurally connected. [ABSTRACT FROM AUTHOR]
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- 2023
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24. Reduced ING4 Expression Is Associated with the Malignancy of Human Bladder.
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Wang, Yongquan, Wang, Tianying, Han, Yelu, Wu, Heng, Zhao, Wenran, Tong, Dandan, Wei, Lanlan, Zhong, Zhaohua, an, Ruihua, and Wang, Yan
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BLADDER cancer treatment ,CANCER chemotherapy ,GENE expression ,TUMOR suppressor genes ,WESTERN immunoblotting ,IMMUNOHISTOCHEMISTRY ,CELL migration - Abstract
Introduction: Inhibitor of growth 4 (ING4) is a tumor suppressor. However the role of ING4 in human bladder malignancy is unknown. In this study, ING4 expression in human bladder cancer and its potential effects were studied. Materials and Methods: ING4 expression in 47 human bladder cancer tissues and paired adjacent normal tissues was detected by Western blotting, quantitative reverse transcription-polymerase chain reaction, and immunohistochemistry. The migration and cell cycle progression of SV-HUC-1 and T24 cells with aberrant ING4 expression were examined. Results: ING4 protein and mRNA were significantly decreased in bladder cancer tissues. ING4 protein level was significantly lower in the group of patients over 50 years of age. ING4 knockdown caused more rapid cell migration and increased the population of SV-HUC-1 and T24 cells in the G2-M phase. Conclusion: Our data suggest a close connection between aberrant ING4 expression and the carcinogenesis of human bladder cells. ING4 may be a potential target for bladder cancer chemotherapy. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2015
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25. Creative Thinking and Executive Functions: Associations and Training Effects in Adolescents.
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Zhao, Xin, Zhang, WenYan, Tong, Dandan, and Maes, Joseph H. R.
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Previous research on the association between executive functions and creativity has revealed mixed results. Here, we examined which of three components of executive functioning, working memory (WM) updating, inhibition, and shifting ability, is most strongly associated with which aspect of creative thinking in a group of young adolescents. Moreover, we assessed the effects of specifically training that function on various measures of creative thinking. In Study 1, 73 13- to 15-year-old adolescents performed tasks measuring information processing speed, WM maintenance, WM updating, inhibition, shifting ability, and convergent and divergent creative thinking. In Study 2, 68 12- to 14-year-old adolescents were randomly assigned to an adaptive WM updating training or active control condition. Before and after training, all children were assessed using a WM updating transfer task and tests of convergent and divergent thinking. Study 1 identified WM updating as most reliable correlate of most of the creative thinking outcome measures. Study 2 revealed training-induced beneficial effects on the WM transfer task and on most of the creative outcome measures. These results, together with the outcome of previous studies, are promising in suggesting the potential of cognitive training programs that specifically target WM updating to enhance aspects of creative thinking. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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26. Expression of RUNX3 Gene, Methylation Status and Clinicopathological Significance in Breast Cancer and Breast Cancer Cell Lines.
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Jiang, Ying, Tong, Dandan, Lou, Ge, Zhang, Ying, and Geng, Jingshu
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- 2008
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27. Probiotics as antifungal agents: Experimental confirmation and future prospects.
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Kosgey, Janet Cheruiyot, Jia, Lina, Fang, Yong, Yang, Jianxun, Gao, Lei, Wang, Jielin, Nyamao, Rose, Cheteu, Martin, Tong, Dandan, Wekesa, Vitalis, Vasilyeva, Natalia, and Zhang, Fengmin
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ANTIFUNGAL agents , *PROBIOTICS , *MYCOSES , *PROSPECTING - Abstract
Fungal burden throughout the world is very high and it keeps escalating due to increasing numbers of immunocompromised individuals. In contrast, the drugs used in management of fungal infections are so few some with high toxicity. Furthermore, highly resistant fungal pathogens are emerging for example Candida auris , Candida glabrata , Candida gullemondii and Aspergillus species among others. Thus now, more than ever, there is a need for combined efforts and an all round search for possible solutions to curb these problems. Therefore, the role of probiotics in management of fungal infections is indispensable. In fact, the antimicrobial activity of probiotics has been screened with promising results against microbial pathogens. Although, recent reports indicated that probiotics may also contribute to protect against fungal infections, the research done in checking antifungal activity of probiotics has used varied technology. This calls for harmonization of the methods used to screen and confirm the antimicrobial activity of probiotics and other candidate microorganisms. We therefore sought to address issues of disparity in probiotic research and their outcomes. Thus this paper is in order as it comprehensively reviews' publications, provides a summary of the methods and future prospects of probiotics as antifungal agents. • Fungal pathogens are increasingly becoming a challenge in the medical field. • Eminent challenges are resistance, association with cancer and few antifungals. • Probiotics is a promising field for the challenges faced in fungal management. • The methods used to screen probiotics need harmonization. • In vitro , in vivo and randomized clinical trials warrant conclusive results. [ABSTRACT FROM AUTHOR]
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- 2019
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28. Regional gray matter volume mediates the relationship between neuroticism and depressed emotion.
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Yang J, Huangfu X, Tong D, and He A
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The underlying psychological mechanism of the effect of neuroticism on depressed emotion has been widely studied. However, the neural mechanism of this relationship remains unclear. Therefore, the present study aimed to apply voxel-based morphometry (VBM) to explore the neural mechanism of the relationship between depressed emotion and neuroticism in healthy and young participants through longitudinal tracking research. The behavioral results showed that neuroticism was positively related to depressed emotion at T1 and T2 (6 months later). The VBM analysis revealed that neuroticism positively associated with the gray matter volume (GMV) in the dorsal medial prefrontal cortex (dmPFC). Mediation analysis was conducted to investigate the neural basis of the association between depressed emotion and neuroticism. The mediation result revealed that GMV of the dmPFC partially mediates the relationship between neuroticism and depressed emotion at T1 but not T2. Together, these findings suggest that the gray matter volume of dmPFC could may affect the relationship between depressed emotion and neuroticism., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Yang, Huangfu, Tong and He.)
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- 2022
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29. Current status of cancer starvation therapy.
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Li J, Tong D, and Lin J
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- Amino Acids, Glycine therapeutic use, Humans, Integrins therapeutic use, Serine therapeutic use, Angiogenesis Inhibitors pharmacology, Angiogenesis Inhibitors therapeutic use, Neoplasms drug therapy
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Conventional therapies for malignant tumors have limitations and disadvantages. In recent years, the cancer starvation therapy has emerged which intends to deprive cancer cells of nutritional supply. There are several approaches to"starve" cancer cells: to intervene tumor angiogenesis by targeted inhibition of angiogenic factors or their receptors and integrins; to block the blood supply of cancer cells by embolizing or compressing blood vessels; to intervene metabolic process of cancer cells by inhibition of the signal pathways of mitochondrial serine-glycine-one earbon metabolism, glycolysis and amino acid metabolism; cancer starvation therapy can be employed with oxidation therapy, chemotherapy, sonodynamic therapy, anti-autophagy therapy or other therapies to achieve synergistic effects. This article reviews the research progress of cancer starvation therapy in recent years and discusses the existing problems.
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- 2022
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30. TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways.
- Author
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Wang Y, Wu N, Pang B, Tong D, Sun D, Sun H, Zhang C, Sun W, Meng X, Bai J, Chen F, Geng J, Fu S, and Jin Y
- Subjects
- Adult, Aged, Cell Adhesion, Cell Line, Tumor, Cell Movement, Cell Proliferation, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Ectopic Gene Expression, Female, Gene Amplification, Gene Expression, Humans, Intracellular Signaling Peptides and Proteins genetics, Male, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Protein Serine-Threonine Kinases genetics, Protein Serine-Threonine Kinases metabolism, Colorectal Neoplasms metabolism, Focal Adhesion Kinase 1 metabolism, Intracellular Signaling Peptides and Proteins metabolism, MAP Kinase Signaling System, Matrix Metalloproteinase 2 metabolism, Protein Serine-Threonine Kinases antagonists & inhibitors, src-Family Kinases metabolism
- Abstract
Colorectal cancer (CRC) is the third most common cancer in the world and distant metastasis is the leading cause of death among CRC patients. However, the underlying mechanisms of distant metastasis remain largely unknown. Amplification of 8q24 is a common chromosomal abnormality in CRC. In the present study, a putative oncogene at 8q24, TRIB1, was characterized for its role in CRC metastasis and underlying molecular mechanisms. Higher expression of TRIB1 protein was detected in 58/83 (69.9%) of CRC tissues, compared with adjacent non-tumor tissues. Moreover, the expression of TRIB1 was significantly associated with distant metastasis (P=0.043) and advanced staging (P=0.008) in CRC tissues. TRIB1 overexpression was also correlated with poor prognosis in CRC patients as analyzed in PrognoScan database. In addition, elevated expression of TRIB1 promoted CRC cell motility and adhesive ability, while silencing of TRIB1 reduced those effects. Further study revealed that TRIB1-mediated migration and invasion of CRC cells required up-regulation of MMP-2 through the activation of FAK/Src and ERK pathway. Collectively, the results suggest that TRIB1 promotes CRC cell motility by activation MMP-2 via the FAK/Src and ERK pathways. It may provide a potential diagnostic and therapeutic target for CRC.
- Published
- 2017
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31. Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling.
- Author
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Tong D, Liang YN, Stepanova AA, Liu Y, Li X, Wang L, Zhang F, and Vasilyeva NV
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Female, Humans, Middle Aged, Paraffin Embedding, Adaptor Proteins, Signal Transducing metabolism, Breast Neoplasms metabolism, Carrier Proteins metabolism, ErbB Receptors metabolism, Vesicular Transport Proteins metabolism
- Abstract
Recent research indicates that the C-terminal Eps15 homology domain 1 is associated with epithelial growth factor receptor-mediated endocytosis recycling in non-small-cell lung cancer. The aim of this study was to determine the clinical significance of Eps15 homology domain 1 gene expression in relation to phosphorylation of epithelial growth factor receptor expression in patients with breast cancer. Primary breast cancer samples from 306 patients were analyzed for Eps15 homology domain 1, RAB11FIP3, and phosphorylation of epithelial growth factor receptor expression via immunohistochemistry. The clinical significance was assessed via a multivariate Cox regression analysis, Kaplan-Meier curves, and the log-rank test. Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor were upregulated in 60.46% (185/306) and 53.92% (165/306) of tumor tissues, respectively, as assessed by immunohistochemistry. The statistical correlation analysis indicated that Eps15 homology domain 1 overexpression was positively correlated with the increases in phosphorylation of epithelial growth factor receptor ( r = 0.242, p < 0.001) and RAB11FIP3 ( r = 0.165, p = 0.005) expression. The multivariate Cox proportional hazard model analysis demonstrated that the expression of Eps15 homology domain 1 alone is a significant prognostic marker of breast cancer for the overall survival in the total, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. However, the use of combined expression of Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor markers is more effective for the disease-free survival in the overall population, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. Moreover, the combined markers are also significant prognostic markers of breast cancer in the human epidermal growth factor receptor 2 (+), estrogen receptor (+), and estrogen receptor (-) groups. Eps15 homology domain 1 has a tumor suppressor function, and the combined marker of Eps15 homology domain 1/phosphorylation of epithelial growth factor receptor expression was identified as a better prognostic marker in breast cancer diagnosis. Furthermore, RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor.
- Published
- 2017
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32. miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer.
- Author
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Yan M, Li X, Tong D, Han C, Zhao R, He Y, and Jin X
- Subjects
- Animals, Cadherins biosynthesis, Cell Line, Tumor, Cell Proliferation genetics, Epithelial-Mesenchymal Transition genetics, Female, GTPase-Activating Proteins, Genes, Tumor Suppressor, Humans, MCF-7 Cells, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness pathology, Neoplasm Recurrence, Local genetics, Snail Family Transcription Factors biosynthesis, Vimentin biosynthesis, Carrier Proteins metabolism, Cell Movement genetics, MicroRNAs genetics, Triple Negative Breast Neoplasms genetics, Triple Negative Breast Neoplasms pathology
- Abstract
MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis.
- Published
- 2016
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33. S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells.
- Author
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Tong D, Qu H, Meng X, Jiang Y, Liu D, Ye S, Chen H, Jin Y, Fu S, and Geng J
- Subjects
- Apoptosis, Carcinoma, Hepatocellular drug therapy, Carcinoma, Hepatocellular pathology, Cell Line, Tumor, Cell Proliferation drug effects, Cysteine pharmacology, Drug Synergism, Gene Expression Regulation, Neoplastic drug effects, Hep G2 Cells, Humans, Liver Neoplasms drug therapy, Liver Neoplasms pathology, Transforming Growth Factor beta metabolism, Carcinoma, Hepatocellular metabolism, Cysteine analogs & derivatives, Liver Neoplasms metabolism, Protein Kinase Inhibitors pharmacology, Signal Transduction drug effects
- Abstract
S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, can induce the apoptosis of many types of cancer cells through the MAPK signaling pathway. The TGF-β signaling pathway also plays a pivotal role in the process of oncogenesis, and has a certain crosstalk with the MAPK pathway. In the present study, hepatocellular carcinoma cell line HepG2 with an intact TGF-β signal and colon cancer cell line SW620 with an imperfect TGF-β signal were selected to ascertain whether SAMC induces the apoptosis of cancer cells by TGF-β signaling. In both cell lines treated with MAPK inhibitors and SAMC, an increased apoptosis rate was observed by electron microscopy, TUNEL and flow cytometric assays. Immunohistochemistry and western blot assays showed that SAMC induced the apoptosis of cancer cells by activating TGF-β1, TβRII, p-smad2/3, smad4 and smad7 signals, and promoting Bim expression while decreasing Bcl-2 expression and finally activating the mitochondrial apoptosis pathway proteins caspase-3 and caspase-9 in the HepG2 cell line. In contrast, in the SW620 cell line, the apoptosis induced by SAMC only affected TGF-β1 and smad7 signals, and promoted the expression of Bax and Bad and finally activated the mitochondrial apoptosis pathway protein caspase-9. When we compare the apoptosis rate in both cell lines, a significantly lower apoptosis rate was noted in the SW620 cell line than the rate noted in the HepG2 cell line. In summary, SAMC induces the apoptosis of cancer cells by activating the TGF-β signaling pathway, after MAPK signaling is inhibited.
- Published
- 2014
- Full Text
- View/download PDF
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