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29 results on '"Trinchillo, Assunta"'

3. Oromandibular dystonia: from onset to spread a multicenter italian study

Author

Trinchillo, Assunta, Esposito, Marcello, Terranova, Carmen, Rizzo, Vincenzo, Fabbrini, Giovanni, Ferrazzano, Gina, Belvisi, Daniele, Erro, Roberto, Barone, Paolo, Bono, Francesco, Di Biasio, Francesca, Bentivoglio, Anna Rita, Lettieri, Christian, Altavista, Maria Concetta, Scaglione, Cesa Lorella Maria, Albanese, Alberto, Mascia, Marcello Mario, Muroni, Antonella, Pisani, Antonio, Berardelli, Alfredo, and Defazio, Giovanni

Published
2024
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4. Does thyroid diseases contribute to the natural history of idiopathic adult-onset dystonia? Data from the Italian Dystonia Registry

Author

Idrissi, Sarah, Velucci, Vittorio, Esposito, Marcello, Trinchillo, Assunta, Habestwallner, Francesco, Belvisi, Daniele, Fabbrini, Giovanni, Ferrazzano, Gina, Rizzo, Vincenzo, Terranova, Carmen, Girlanda, Paolo, Pellicciari, Roberta, Avanzino, Laura, Di Biasio, Francesca, Marchese, Roberta, Bono, Francesco, Idone, Giovanni, Laterza, Vincenzo, Lettieri, Christian, Rinaldo, Sara, Eleopra, Roberto, Castagna, Anna, Altavista, Maria Concetta, Moschella, Vincenzo, Erro, Roberto, Barone, Paolo, Barbero, Pierangelo, Ceravolo, Roberto, Mazzucchi, Sonia, Mascia, Marcello Mario, Ercoli, Tommaso, Muroni, Antonella, Zibetti, Maurizio, Lopiano, Leonardo, Scaglione, Cesa Lorella Maria, Bentivoglio, Anna Rita, Petracca, Martina, Magistrelli, Luca, Cotelli, Maria Sofia, Cossu, Giovanni, Squintani, Giovanna Maddalena, De Santis, Tiziana, Schirinzi, Tommaso, Misceo, Salvatore, Pisani, Antonio, Berardelli, Alfredo, and Defazio, Giovanni

Published
2024
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11. Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Author

Zaccone, Claudio, Cerne, Denise, Idone, Giovanni, Ferrazzano, Gina, Rinaldo, Sara, Humaidan, Kais, Devigili, Grazia, Polidori, Luigi, Mazzucchi, Sonia, Ramella, Marina, Ledda, Claudia, Petracca, Martina, Oppo, Valentina, Contaldi, Elena, Turla, Marinella, Gigante, Angelo Fabio, Valentino, Francesca, Cassano, Daniela, Modugno, Nicola, Tambasco, Nicola, Aguggia, Marco, Romano, Marcello, Marinelli, Lucio, Mascia, Marcello Mario, Belvisi, Daniele, Esposito, Marcello, Pellicciari, Roberta, Trinchillo, Assunta, Terranova, Carmen, Bertino, Salvatore, Avanzino, Laura, Di Biasio, Francesca, Bono, Francesco, Laterza, Vincenzo, Lettieri, Christian, Eleopra, Roberto, Fabbrini, Giovanni, Barbero, Pierangelo, Bertolasi, Laura, Altavista, Maria Concetta, Erro, Roberto, Ceravolo, Roberto, Castagna, Anna, Zibetti, Maurizio, Bentivoglio, Anna Rita, Cossu, Giovanni, Magistrelli, Luca, Scaglione, Cesa, Albanese, Alberto, Cotelli, Maria Sofia, Misceo, Salvatore, Pisani, Antonio, Schirinzi, Tommaso, Maderna, Luca, Squintani, Giovanna, Berardelli, Alfredo, and Defazio, Giovanni

Published
2023
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12. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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18. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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19. Does sex influence the natural history of idiopathic adult-onset dystonia?

Author

Velucci, Vittorio, Idrissi, Sarah, Pellicciari, Roberta, Esposito, Marcello, Trinchillo, Assunta, Belvisi, Daniele, Fabbrini, Giovanni, Ferrazzano, Gina, Terranova, Carmen, Girlanda, Paolo, Majorana, Giovanni, Rizzo, Vincenzo, Bono, Francesco, Idone, Giovanni, Laterza, Vincenzo, Avanzino, Laura, Di Biasio, Francesca, Marchese, Roberta, Castagna, Anna, and Ramella, Marina

Subjects
FOCAL dystonia, HEPATOLENTICULAR degeneration, PATIENT selection, SLEEP interruptions, SEX reversal, NECK pain, PREMATURE menopause
Published
2024
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20. A case of hemichorea associated with nonketotic hyperglycaemia: A new magnetic resonance spectroscopy (MRS) finding and possible future implications.

Author

Trinchillo, Assunta, Barchetti, Flavio, De Joanna, Gabriella, Esposito, Marcello, Piccirillo, Giovanni, and Miniello, Stefania

Subjects
*NUCLEAR magnetic resonance spectroscopy, *SUDDEN onset of disease, *HYPERGLYCEMIA, *LITERATURE reviews, *DIABETES complications, *MOVEMENT disorders
Abstract

Background: Diabetic Striatopathy (DS) is a rare complication of a poor‐controlled Diabetes Mellitus consisting of sudden onset of movement disorders. To date, there is still poor knowledge about the pathogenesis. Case: We describe a 79 year old men affected by sudden onset hemichoreic movements whose cause was a non‐ketotic hyperglycaemia diagnosed despite the normal blood glucose levels thanks to brain CT and magnetic resonance imaging. Then, we introduce a new magnetic resonance spectroscopy (MRS) finding never described until today which allowed us to produce a new pathogenetic theory of a phenomenon still without definitive explanations. Literature Review: We performed a review of DS cases using the Medline database and we extracted main data regarding imaging findings. Conclusions: Thanks to our MRS we show new imaging findings never described until today, with a new pathogenetic explanation, since all the causative hypotheses produced during the past years have never found evidence. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Clinimetrics of the Italian version of the Montreal Cognitive Assessment (MoCA) in adult-onset idiopathic focal dystonia.

Author

D'Iorio, Alfonsina, Aiello, Edoardo Nicolò, Trinchillo, Assunta, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, Poletti, Barbara, Esposito, Marcello, and Santangelo, Gabriella

Subjects
MONTREAL Cognitive Assessment, FOCAL dystonia, FACTOR structure, MEMORY testing, TEST validity
Abstract

This study aimed at assessing the clinimetrics of the Montreal Cognitive Assessment (MoCA) in an Italian cohort of patients with adult-onset idiopathic focal dystonia (AOIFD). N = 86 AOIFD patients and N = 92 healthy controls (HCs) were administered the MoCA. Patients further underwent the Trail-Making Test (TMT) and Babcock Memory Test (BMT), being also screened via the Beck Depression Inventory-II (BDI-II) and the Dimensional Apathy Scale (DAS). Factorial structure and internal consistency were assessed. Construct validity was tested against TMT, BMT, BDI-II and DAS scores, whilst diagnostics against the co-occurrence of a defective performance on at least one TMT measure and on the BMT. Case–control discrimination was examined. The association between MoCA scores and motor-functional measures was explored. The MoCA was underpinned by a mono-component structure and acceptably reliable at an internal level. It converged towards TMT and BMT scores, as well as with the DAS, whilst diverging from the BDI-II. Its adjusted scores accurately detected cognitive impairment (AUC =.86) at a cut-off of < 17.212. The MoCA discriminated patients from HCs (p <.001). Finally, it was unrelated to disease duration and severity, as well as to motor phenotypes. The Italian MoCA is a valid, diagnostically sound and feasible cognitive screener in AOIFD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Phenotypic Variability in Acquired and Idiopathic Dystonia.

Author

Defazio, Giovanni, Gigante, Angelo Fabio, Erro, Roberto, Belvisi, Daniele, Esposito, Marcello, Trinchillo, Assunta, De Joanna, Gabriella, Ceravolo, Roberto, Mazzucchi, Sonia, Unti, Elisa, Barone, Paolo, Scannapieco, Sara, Cotelli, Maria Sofia, Turla, Marinella, Bianchi, Marta, Bertolasi, Laura, Pisani, Antonio, Valentino, Francesca, Altavista, Maria Concetta, and Moschella, Vincenzo

Subjects
PHENOTYPIC plasticity, NECK pain, DYSTONIA, AGE of onset
Abstract

Background: To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias. Objectives: To compare demographic data and clinical features in patients with adult‐onset acquired and idiopathic dystonias. Methods: Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult‐onset dystonia. Study population included 116 patients with adult‐onset acquired dystonia and 651 patients with isolated adult‐onset idiopathic dystonia. Results: Comparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor. Conclusions: The clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Concomitant diagnosis of multiple sclerosis and human immunodeficiency virus (HIV) infection: case report and the review of literature

Author

Assunta Trinchillo, Antonio Luca Spiezia, Antonio Carotenuto, Enrico Tedeschi, Giuseppe Servillo, Carmine Iacovazzo, Francesco Borrelli, Giovanni Di Filippo, Vincenzo Brescia Morra, Roberta Lanzillo, Trinchillo, Assunta, Spiezia, Antonio Luca, Carotenuto, Antonio, Tedeschi, Enrico, Servillo, Giuseppe, Iacovazzi, Carmine, Borrelli, Francesco, Di Filippo, Giovanni, Morra, Vincenzo Brescia, and Lanzillo, Roberta

Subjects
Psychiatry and Mental health, Natalizumab, HIV, Multiple sclerosi, Neurology (clinical), Dermatology, General Medicine
Abstract

Background: To date, few cases of multiple sclerosis (MS) patients with concomitant Human Immunodeficiency Virus (HIV) infection have been described. However, none of the previously described cases has been treated with Natalizumab, probably due to the increasing risk of progressive multifocal leukoencephalopathy (PML). Case: We report the case of a patient concomitantly diagnosed for HIV infection and MS treated with combined antiretroviral therapy (cART) and Natalizumab for 19 months, without clinical or radiological MS activity. Conclusions: Our case might suggest considering Natalizumab in patients with concomitant HIV infection, especially for those with significant disease activity requiring a high efficacy disease modifying treatment.

Published
2023

27. Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Author

Mascia, Marcello Mario, Belvisi, Daniele, Esposito, Marcello, Pellicciari, Roberta, Trinchillo, Assunta, Terranova, Carmen, Bertino, Salvatore, Avanzino, Laura, Di Biasio, Francesca, Bono, Francesco, Laterza, Vincenzo, Lettieri, Christian, Eleopra, Roberto, Fabbrini, Giovanni, Barbero, Pierangelo, Bertolasi, Laura, Altavista, Maria Concetta, Erro, Roberto, Ceravolo, Roberto, and Castagna, Anna

Subjects
*CEREBROVASCULAR disease, *NECK pain, *DYSTONIA, *LOGISTIC regression analysis, *STROKE, *DISEASE duration
Abstract

Although acquired dystonia may develop following ischaemic/haemorrhagic stroke, the relationship between cerebrovascular disease and idiopathic dystonia has been poorly investigated. This cross sectional study aimed at evaluating the impact of cerebrovascular risk factors on the clinical expression of idiopathic adult onset dystonia (IAOD), with reference to dystonia localization and dystonia-associated features. Data were obtained from the Italian Dystonia Registry. Patients with IAOD were stratified into two groups according to the presence of diabetes mellitus and/or arterial hypertension and/or dyslipidemia and/or heart disease. The two groups were compared for demographic features, dystonia phenotype, and dystonia-associated features (sensory trick, tremor, eye symptoms in blepharospasm, and neck pain in cervical dystonia). A total of 1108 patients participated into the study. Patients who reported one cerebrovascular factor or more (n = 555) had higher age and longer disease duration than patients who did not. On multivariable logistic regression analysis, blepharospasm was the only localization, and sensory trick was the only dystonia-associated feature that was significantly associated with cerebrovascular risk factors. Linear regression analysis showed that the strength of the association between cerebrovascular factors and blepharospasm/sensory trick increased with increasing the number of cerebrovascular factors per patient. Results of the present study showed that cerebrovascular risk factors may be associated with specific features of IAOD that is development of blepharospasm and sensory trick. Further studies are needed to better understand the meaning and the mechanisms underlying this association. • We assessed the impact of vascular risk factors (VRFs) on idiopathic dystonia. • VRFs may be associated with specific phenotypes of idiopathic dystonia. • This may suggest that VRFs-related lesions changes impact on idiopathic dystonia. [ABSTRACT FROM AUTHOR]

Published
2023
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28. The C-Terminal Cross-linked Telopeptide of Type I Collagen (CTX-I) as a Potential Cardiomyopathy Biomarker in Friedreich Ataxia Patients

Author

Chiara Pane, Assunta Trinchillo, Andrea Salzano, Angela Marsili, Giorgia Puorro, Antonio Cittadini, Francesco Saccà, Cinzia Valeria Russo, Pane, Chiara, Trinchillo, Assunta, Salzano, Andrea, Marsili, Angela, Puorro, Giorgia, Cittadini, Antonio, Sacca, Francesco, and Russo, Cinzia Valeria

Subjects
Neurology, Friedreich ataxia, Cardiomyopathy, C-Terminal cross-linked telopeptide of type I collagen, Neurology (clinical), Serum biomarker, TT3
Abstract

Friedreich's ataxia (FRDA) is the most common inherited recessive ataxia. Cardiomyopathy (CM) with myocardial hypertrophy is the predominant cause of death. The presence of CM is variable and the risk factors for cardiac involvement are not entirely clear. Markers of collagen degradation, such as C-terminal cross-linked telopeptide of type I collagen (CTX-I), seem to be associated with unfavorable cardiovascular outcomes. The aim of our study was to measure serum CTX-I as a marker of cardiac fibrosis in FRDA patients. We measured serum CTX value in twenty-five FRDA patients (mean age, 31.3 ± 14.7 years) and nineteen healthy controls (mean age, 34.0 ± 13.5 years). Patients underwent echocardiography and SARA scale evaluation. CTX values were significantly higher in the patients than in the control group (31.82 ± 2.27 vs 16.44 ± 1.6 μg/L; p = 0.006). CTX-I was inversely correlated with age (R = - 0,535; n = 44; p

Published
2022

29. Pharmacotherapy to prevent the onset of depression following traumatic brain injury.

Author

Fornaro M, Trinchillo A, Saccà F, Iasevoli F, Nolano M, and de Bartolomeis A

Subjects
Cognition, Humans, Prospective Studies, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic drug therapy, Depression drug therapy, Depression etiology, Depression prevention & control
Abstract

Introduction: Depressive symptoms may follow traumatic brain injury (TBI), affecting cognition, apathy, and overall general functioning. Pharmacotherapy to prevent the onset of depression following TBI is, therefore, crucial., Areas Covered: The present report critically appraises current pharmacotherapy to prevent the onset of depression following TBI as well as novel potential pharmacological avenues on the matter. Both efficacy and safety issues are considered, emphasizing an evidence-based approach whenever feasible. The authors further provide the reader with their expert opinion and future perspectives on the subject., Expert Opinion: Despite its clinical burden and relatively frequent occurrence, the prophylaxis of post-TBI depression warrants further research. The current clinical guidelines of depression do not account for people with a primary diagnosis of TBI. Prospective cohort studies supported by proof-of-concept trials are nonetheless urged toward more effective, patient-tailored pharmacotherapy to prevent the onset of depression and treatment-resistance phenomena following TBI.

Published
2022
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