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Earthquake early warning system uses high-speed computer network to transmit earthquake information to population center ahead of the arrival of destructive earthquake waves. This short (10 s of seconds) lead time will allow emergency responses such as turning off gas pipeline valves to be activated to mitigate potential disaster and casualties. However, the excessive false alarm rate of such a system imposes heavy cost in terms of loss of services, undue panics, and diminishing credibility of such a warning system. At the current, the decision algorithm to issue an early warning of the onset of an earthquake is often based on empirically chosen features and heuristically set thresholds and suffers from excessive false alarm rate. In this paper, we experimented with three advanced machine learning algorithms, namely, $K$ -nearest neighbor (KNN), classification tree, and support vector machine (SVM) and compared their performance against a traditional criterion-based method. Using the seismic data collected by an experimental strong motion detection network in Taiwan for these experiments, we observed that the machine learning algorithms exhibit higher detection accuracy with much reduced false alarm rate. [ABSTRACT FROM AUTHOR]

ATP has been shown to mediate stress responses in the brain. The present study examined the ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes. Our results revealed that ATP stimulated HSP60 expression in a dose- and time-dependent manner. The stimulation requires a minimal ATP concentration of 500 microM and high concentration of extracellular ATP (1 mM) stimulated a significant increase of HSP60 expression from 2 to 24 h. In addition, the ATP-stimulated HSP60 expressions were inhibited by inhibitors for protein kinase C (PKC) and phospholipase D (PLD), and by antioxidants, resveratrol, and catalase. Furthermore, ATP stimulated the expression of Cu/Zn superoxide dismutase (SOD). In addition, ATP and P2X7 receptor selective agonist BzATP also decreased mitochondria membrane potential measured by flow cytometry. To further examine the proteins involving in ATP-mediated stress responses, we conducted proteomic analysis. We found that RBA-2 astrocytes possess abundant peroxiredoxin II (Prx II), an antioxidant enzyme. ATP and exogenous H2O2 stimulated Prx II shifting from oxidized form to reduced form. Thus, we concluded that ATP potentiated the expression of HSP60 and Cu/Zn SOD, and decreased mitochondria membrane potential. In addition, RBA-2 astrocytes expressed Prx II that might also serve as a protective mechanism to control the concentration of reactive oxygen species., (Copyright 2005 Wiley-Liss, Inc.)