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3. Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Elfgen, Constanze, Leo, Cornelia, Kubik-Huch, Rahel A., Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J., Mann, Ritse M, Bago-Horvath, Zsuzsanna, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean-Christophe, Körner, Meike, Decker, Thomas, Lax, Sigurd F., Daniaux, Martin, Bjelic-Radisic, Vesna, Kacerovsky-Strobl, Stephanie, Condorelli, Rosaria, Gnant, Michael, and Varga, Zsuzsanna

Published
2023
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5. Revisiting surgical margins for invasive breast cancer patients treated with breast conservation therapy - Evidence for adopting a 1 mm negative width

Author

Rakha, Emad A., Quinn, Cecily, Masannat, Yazan A., Lee, AndrewH. S., Tan, Puay Hoon, Karakatsanis, Andreas, Matrai, Zoltan Tamas, Al Shaibani, Salman Husain M., Gehani, Salahddin A., Shaaban, Abeer, Khout, Hazem, Chagla, Leena, Cserni, Gábor, Varga, Zsuzsanna, Yong, Wong Fuh, Meattini, Icro, Kulka, Janina, Yang, Wentao, Tse, Gary M., Pinder, Sarah E., Fox, Stephen, and Dixon, J Michael

Published
2024
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8. EUSOMA quality indicators for non-metastatic breast cancer: An update

Author

Rubio, Isabel T., Marotti, Lorenza, Biganzoli, Laura, Aristei, Cynthia, Athanasiou, Alexandra, Campbell, Christine, Cardoso, Fatima, Cardoso, Maria Joao, Coles, Charlotte E., Eicher, Manuela, Harbeck, Nadia, Karakatsanis, Andreas, Offersen, Birgitte V., Pijnappel, Ruud, Ponti, Antonio, Regitnig, Peter, Santini, Donatella, Sardanelli, Francesco, Spanic, Tanja, Varga, Zsuzsanna, Vrancken Peeters, Marie Jeanne T.F.D., Wengström, Yvonne, Wyld, Lynda, and Curigliano, Giuseppe

Published
2024
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10. European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO

Author

Rubio, Isabel T., Wyld, Lynda, Marotti, Lorenza, Athanasiou, Alexandra, Regitnig, Peter, Catanuto, Giuseppe, Schoones, Jan W., Zambon, Marzia, Camps, Julia, Santini, Donatella, Dietz, Jill, Sardanelli, Francesco, Varga, Zsuzsanna, Smidt, Marjolein, Sharma, Nisha, Shaaban, Abeer M., and Gilbert, Fiona

Published
2024
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11. Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases

Author

Perakakis, Nikolaos, Harb, Hani, Hale, Benjamin G, Varga, Zsuzsanna, Steenblock, Charlotte, Kanczkowski, Waldemar, Alexaki, Vasileia Ismini, Ludwig, Barbara, Mirtschink, Peter, Solimena, Michele, Toepfner, Nicole, Zeissig, Sebastian, Gado, Manuel, Abela, Irene Alma, Beuschlein, Felix, Spinas, Giatgen A, Cavelti-Weder, Claudia, Gerber, Philipp A, Huber, Michael, Trkola, Alexandra, Puhan, Milo A, Wong, Wendy Wei-Lynn, Linkermann, Andreas, Mohan, Viswanathan, Lehnert, Hendrik, Nawroth, Peter, Chavakis, Triantafyllos, Mingrone, Geltrude, Wolfrum, Christian, Zinkernagel, Annelies S, and Bornstein, Stefan R

Published
2023
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14. Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

Author

De Schepper, Maxim, Vincent-Salomon, Anne, Christgen, Matthias, Van Baelen, Karen, Richard, François, Tsuda, Hitoshi, Kurozumi, Sasagu, Brito, Maria Jose, Cserni, Gabor, Schnitt, Stuart, Larsimont, Denis, Kulka, Janina, Fernandez, Pedro Luis, Rodríguez-Martínez, Paula, Olivar, Ana Aula, Melendez, Cristina, Van Bockstal, Mieke, Kovacs, Aniko, Varga, Zsuzsanna, Wesseling, Jelle, Bhargava, Rohit, Boström, Pia, Franchet, Camille, Zambuko, Blessing, Matute, Gustavo, Mueller, Sophie, Berghian, Anca, Rakha, Emad, van Diest, Paul J., Oesterreich, Steffi, Derksen, Patrick W. B., Floris, Giuseppe, and Desmedt, Christine

Published
2022
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19. Sexual dimorphism in COVID-19: potential clinical and public health implications

Author

Bechmann, Nicole, Barthel, Andreas, Schedl, Andreas, Herzig, Stephan, Varga, Zsuzsanna, Gebhard, Catherine, Mayr, Manuel, Hantel, Constanze, Beuschlein, Felix, Wolfrum, Christian, Perakakis, Nikolaos, Poston, Lucilla, Andoniadou, Cynthia L, Siow, Richard, Gainetdinov, Raul R, Dotan, Arad, Shoenfeld, Yehuda, Mingrone, Geltrude, and Bornstein, Stefan R

Published
2022
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20. Writing for the Family Audience

Author

Varga Zsuzsanna

Subjects
hungarian domestic magazines, családi kör, gartenlaube, e.marlitt, women’s employment, periodical culture in the 19th century, History of Central Europe, DAW1001-1051, Language and Literature
Abstract

Családi Kör (1860–1880) was the leading Hungarian domestic magazine of the mid-19th period, which, under the editorship of the first Hungarian woman of letters Emília Kánya, played a major role in introducing the domestic readership to contemporary European literature and in discussing the struggle of women’s employment opportunities before a wider public. Critical studies have also suggested that it was edited and published under the influence of the German Gartenlaube (1853–1944), the journal credited with embedding the journal of domestic magazine in the broader regime of 19th century print culture. Based on a close reading of the two magazines’ coverage in its European cultural historical context, this chapter offers an account of the possible connections and affinities between the two periodicals, and argues that the Hungarian magazine was significantly more daring in its politics and more systematic in its pursuit of introducing the local audience to European literary trends and works.

Published
2021
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33. Higher parental education was associated with good cognitive outcomes in infants with hypoxic‐ischaemic encephalopathy.

Author

Varga, Zsuzsanna, Andorka, Csilla, Pataki, Margit, Meder, Unoke, Szakmar, Eniko, Szabo, Attila J., Szabo, Miklos, and Jermendy, Agnes

Subjects
*BRAIN injuries, *MAGNETIC resonance imaging, *BRAIN diseases, *HIGHER education, *INFANTS, *CRYING
Abstract

Aim: Predicting neurodevelopmental outcomes in hypoxic‐ischaemic encephalopathy (HIE) remains imprecise, despite advanced imaging and neurophysiological tests. We explored the predictive value of socio‐economic status (SES). Methods: The cohort comprised 93 infants (59% male) with HIE, who had received therapeutic hypothermia. Patients underwent magnetic resonance imaging, and brain injuries were quantified using the Barkovich scoring system. Family SES was self‐reported using a questionnaire. Adverse outcomes were defined as mild to severely delayed development with a score of ≤85 in any domain at 2 years of age, based on the Bayley Scales of Infant Development, Second Edition. Data are presented as odds ratios (OR) with 95% confidence intervals (95% CI). Results: Multiple regression modelling revealed that higher parental education was strongly associated with good cognitive development, when adjusted for gestational age, serum lactate and brain injuries (OR 2.20, 95% CI 1.16–4.36). The effect size of parental education (β = 0.786) was higher than one score for any brain injury using the Barkovich scoring system (β = −0.356). The literacy environment had a significant effect on cognitive development in the 21 infants who had brain injuries (OR 40, 95% CI 3.70–1352). Conclusion: Parental education and the literacy environment influenced cognitive outcomes in patients with HIE. [ABSTRACT FROM AUTHOR]

Published
2024
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34. ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features.

Author

Forster‐Sack, Miriam, Zoche, Martin, Pestalozzi, Bernhard, Witzel, Isabell, Schwarz, Esther Irene, Herzig, Joel Julien, Fansa, Hisham, Tausch, Christoph, Ross, Jeff, Moch, Holger, and Varga, Zsuzsanna

Subjects
BREAST, CYCLIN-dependent kinases, LOBULAR carcinoma, FLUORESCENCE in situ hybridization, GENE amplification, HORMONE receptors
Abstract

Most invasive lobular breast carcinomas (ILBCs) are luminal‐type carcinomas with an HER2‐negative phenotype (ERBB2 or HER2 un‐amplified) and CDH1 mutations. Rare variants include ERBB2‐amplified subtypes associated with an unfavorable prognosis and less response to anti‐HER2 targeted therapies. We analyzed the clinicopathological and molecular features of ERBB2‐amplified ILBC and compared these characteristics with ERBB2‐unamplified ILBC. A total of 253 patients with ILBC were analyzed. Paraffin‐embedded formalin‐fixed tumor samples from 250 of these patients were added to a tissue microarray. Protein expression of prognostic, stem cell and breast‐specific markers was tested by immunohistochemistry (IHC). Hybrid capture‐based comprehensive genomic profiling (CGP) was performed for 10 ILBCs that were either fluorescent in situ hybridization (FISH) or IHC positive for HER2 amplification/overexpression and 10 ILBCs that were either FISH or IHC negative. Results were compared with a CGP database of 44,293 invasive breast carcinomas. The CGP definition of ERBB2 amplification was five copies or greater. A total of 17 of 255 ILBC (5%) were ERBB2 amplified. ERBB2‐amplified ILBC had higher tumor stage (p < 0.0001), more frequent positive nodal status (p = 0.00022), more distant metastases (p = 0.012), and higher histological grade (p < 0.0001), and were more often hormone receptor negative (p < 0.001) and more often SOX10 positive (p = 0.005). ERBB2 short variant sequence mutations were more often detected in ERBB2‐unamplified tumors (6/10, p = 0.027), whereas CDH1 mutations/copy loss were frequently present in both subgroups (9/10 and 7/10, respectively). Amplification of pathogenic genes were more common in HER2‐positive ILBC (p = 0.0009). CDK12 gene amplification (≥6 copies) was detected in 7 of 10 ERBB2‐amplified ILBC (p = 0.018). There were no CDK12 gene amplifications reported in 44,293 invasive breast carcinomas in the FMI Insights CGP database. ERBB2‐amplified ILBC is a distinct molecular subgroup with frequent coamplification of CDK12, whereas ERBB2 sequence mutations occur only in ERBB2‐unamplified ILBC. CDK12/ERBB2 co‐amplification may explain the poor prognosis and therapy resistance of ERBB2‐amplified ILBC. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Long-Term Follow-Up of High-Risk Breast Lesions at Vacuum-Assisted Biopsy without Subsequent Surgical Resection.

Author

Elfgen, Constanze, Varga, Zsuzsanna, Breitling, Katrin, Pauli, Eliane, Schwegler-Guggemos, Daniela, Kampmann, Gert, Kubik-Huch, Rahel A., Leo, Cornelia, Lepori, Domenico, Sonnenschein, Martin, Tausch, Christoph, and Schrading, Simone

Subjects
BREAST cancer prognosis, BREAST tumor diagnosis, BREAST tumor risk factors, PATIENT aftercare, EVALUATION of medical care, RESEARCH, DISEASE progression, BIOPSY, SCIENTIFIC observation, SPECIALTY hospitals, ULTRASONIC imaging, CANCER invasiveness, AGE distribution, OPERATIVE surgery, VACUUM, RETROSPECTIVE studies, FISHER exact test, HYPERPLASIA, MAGNETIC resonance imaging, NEOPLASTIC cell transformation, CANCER treatment, DUCTAL carcinoma, BREAST cancer, COMPARATIVE studies, T-test (Statistics), SYMPTOMS, DESCRIPTIVE statistics, HISTOLOGICAL techniques, MENOPAUSE, BREAST tumors, PATIENT safety, CARCINOMA in situ, LONGITUDINAL method
Abstract

Introduction: B3-lesions of the breast are a heterogeneous group of neoplasms, associated with a higher risk of breast cancer. Recent studies show a low upgrade rate into malignancy after subsequent open surgical excision (OE) of most B3-lesions when proven by vacuum-assisted biopsy (VAB). However, there is a lack of long-term follow-up data after VAB of high-risk lesions. The primary aim of this study was to demonstrate whether follow-up of B3 lesions is a beneficial and reliable alternative to OE in terms of long-term outcome. The secondary aim was to identify patient and lesion characteristics of B3 lesions for which OE is still necessary. Methods: This retrospective multicenter study was conducted at 8 Swiss breast centers between 2010 and 2019. A total of 278 women (mean age: 53.5 ± 10.7 years) with 286 B3-lesions who had observation only and who had at least 24 months of follow-up were included. Any event during follow-up (ductal carcinoma in situ [DCIS], invasive cancer, new B3-lesion) was systematically recorded. Data from women who had an event during follow-up were compared with those who did not. The results for the different B3 lesions were analyzed using the t test and Fisher's exact test. A p value of <0.05 was considered statistically significant. Results: The median follow-up interval was 59 months (range: 24–143 months) with 52% (148/286) having a follow-up of more than 5 years. During follow-up, in 42 women, 44 suspicious lesions occurred, with 36.4% (16/44) being invasive cancer and 6.8% (3/44) being DCIS. Thus, 6.6% (19/286) of all women developed malignancy during follow-up after a median follow-up interval of 6.5 years (range: 31–119 months). The initial histology of the B3 lesion influenced the subsequent occurrence of a malignant lesion during follow-up (p < 0.038). The highest malignancy-developing rate was observed in atypical ductal hyperplasia (ADH) (24%, 19/79), while all other B3-lesions had malignant findings ipsi- and contralateral between 0% and 6%. The results were not influenced by the VAB method (Mx-, US-, magnetic resonance imaging-guided), the radiological characteristics of the lesion, or the age or menopausal status of the patient (p > 0.12). Conclusion: With a low risk of <6% of developing malignancy, VAB followed by long-term follow-up is a safe alternative to OE for most B3-lesions. A higher malignancy rate only occurred in ADH (24%). Based on our results, radiological follow-up should be bilateral, preferable using the technique of initial diagnosis. As we observed a late peak (6–7 years) of breast malignancies after B3-lesions, follow-up should be continued for a longer period (>10 years). Knowledge of these long-term outcome results will be helpful in making treatment decisions and determining the optimal radiological follow-up interval. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Large and Small Cerebral Vessel Involvement in Severe COVID-19: Detailed Clinical Workup of a Case Series

Author

Keller, Emanuela, Brandi, Giovanna, Winklhofer, Sebastian, Imbach, Lukas L., Kirschenbaum, Daniel, Frontzek, Karl, Steiger, Peter, Dietler, Sabeth, Haeberlin, Marcellina, Willms, Jan, Porta, Francesca, Waeckerlin, Adrian, Huber, Michael, Abela, Irene A., Lutterotti, Andreas, Stippich, Christoph, Globas, Christoph, Varga, Zsuzsanna, and Jelcic, Ilijas

Published
2020
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41. Prospective Evaluation of Residual Breast Tissue After Skin- or Nipple-Sparing Mastectomy: Results of the SKINI-Trial

Author

Papassotiropoulos, Bärbel, Güth, Uwe, Chiesa, Federica, Rageth, Christoph, Amann, Esther, Baege, Astrid, Elfgen, Constanze, Varga, Zsuzsanna, Moskovszky, Linda, Endhardt, Katharina, Masser, Regina, Tinguely, Marianne, Farhadi, Jian, Lardi, Alessia, Dammann, Florian, Diebold, Joachim, Li, Qiyu, Dubsky, Peter, and Tausch, Christoph

Published
2019
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42. Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J., O’Flynn, Elizabeth A. M., Pinker, Katja, Kubik-Huch, Rahel A., Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A., Fallenberg, Eva Maria, Foschini, Maria P., Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, and Varga, Zsuzsanna

Published
2019
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43. Single-neuron representation of learned complex sounds in the auditory cortex

Author

Wang, Meng, Liao, Xiang, Li, Ruijie, Liang, Shanshan, Ding, Ran, Li, Jingcheng, Zhang, Jianxiong, He, Wenjing, Liu, Ke, Pan, Junxia, Zhao, Zhikai, Li, Tong, Zhang, Kuan, Li, Xingyi, Lyu, Jing, Zhou, Zhenqiao, Varga, Zsuzsanna, Mi, Yuanyuan, Zhou, Yi, Yan, Junan, Zeng, Shaoqun, Liu, Jian K., Konnerth, Arthur, Nelken, Israel, Jia, Hongbo, and Chen, Xiaowei

Published
2020
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46. Corrigendum to “European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO” [Eur J Surg Oncol 50 (1) (January 2024) 107292]

Author

Rubio, Isabel T., Wyld, Lynda, Marotti, Lorenza, Athanasiou, Alexandra, Regitnig, Peter, Catanuto, Giuseppe, Schoones, Jan W., Zambon, Marzia, Camps, Julia, Santini, Donatella, Dietz, Jill, Sardanelli, Francesco, Varga, Zsuzsanna, Smidt, Marjolein, Sharma, Nisha, Shaaban, Abeer M., and Gilbert, Fiona

Published
2024
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49. Spinsters and authors : women's roles in Margaret Oliphant's writing

Author

Varga, Zsuzsanna

Subjects
820.9008
Abstract

Using recent critical developments in feminist social history and literary historiography, as well as the recently increasing interest in Victorian journalism, this thesis re-examines Margaret Oliphant’s position on women’s roles from a sociological and historical perspective. The question of Oliphant’s position on women’s roles has been raised before, yet literary historians, inspired by the presuppositions of second-wave feminism and second-wave literary history, have restricted the debate to the question whether she was a ‘bad’ feminist or a ‘good’ one, and have ignored Oliphant’s representation of female authorship. This thesis attempts to redress the balance by providing a close reading of Oliphant’s journalism in a historical context. The examination of Oliphant’s journalism, a largely neglected area, along with selections from her extensive output of fiction, has allowed the identification of two fundamental roles for women which she represents as natural to the 19th century woman: the domestic woman and the woman writer. While the former appears to be a less than radical point, it explains Oliphant’s ostensibly conservative views on the nascent women’s rights movement. Moreover, in the second part of her long writing career, Oliphant explored alternative domestic structures that enable female authority and domestic existence. Oliphant’s examination of the position of the female author partly replicates this pattern by suggesting the naturalness of female authorship to the domestic women, and this allows her to start to develop an early theory of female writing and literary history, analysing the ways in which the female author can exercise authority in the marketplace. While the Oliphant represents both of these positions as natural to the domestic woman, she also investigates those social structures that allow the proper exercise of female authority. At the same time the thesis attempts to describe Oliphant’s ideas on the ideal humane community as well as her ground-breaking work in literary history and the definition of alternative versions of domestic authority and female authority.

Published
2004

50. Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas

Author

Pareja, Fresia, Geyer, Felipe C., Brown, David N., Sebastião, Ana P. Martins, Gularte-Mérida, Rodrigo, Li, Anqi, Edelweiss, Marcia, Da Cruz Paula, Arnaud, Selenica, Pier, Wen, Hannah Y., Jungbluth, Achim A., Varga, Zsuzsanna, Palazzo, Juan, Rubin, Brian P., Ellis, Ian O., Brogi, Edi, Rakha, Emad A., Weigelt, Britta, and Reis-Filho, Jorge S.

Published
2019
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