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This study assessed the effectiveness of training leaders in behaviors that satisfy meeting attendees' psychological needs for autonomy, competence, and relatedness. Three managers who regularly lead meetings with their workgroups participated in the study. The study used a research design of multiple baselines across groups and began with baselines ranging over three to five meetings. Group leaders then received a session of behavioral skills training with a role-play component, followed by post-training assessment over three to five meetings. The final assessment occurred one month later. Leaders reported the number of recommended leader behaviors they used prior to training and at subsequent meetings. Group members anonymously completed ratings of: (1) the extent of their psychological need satisfaction; (2) their satisfaction with each meeting; and (3) how productive each meeting was. Meeting leaders showed significantly more use of the recommended behaviors after training than before training. Member ratings indicated a significant increase in need satisfaction, satisfaction with meetings, and meeting productivity after the training of their leader. Significant positive effects remained at a one-month follow-up. The findings show that training leaders in needs-focused behaviors to use in running meetings can be used to satisfy attendee-needs and to improve meeting satisfaction and productivity.

This research examined the effects of meeting leader behavior on organizational meetings. Two studies investigated whether leader behavior that satisfies the psychological needs of meeting attendees, leads to higher levels of meeting productivity and satisfaction. Study 1 used correlational methods, with regression-based mediation analysis, to assess whether satisfaction of attendee needs mediated the association between leader behavior and attendee ratings of actual meetings in a sample of 110 employees. Study 2 involved an analogue experiment with 158 employees to test the effects of leader behavior on ratings of hypothetical meeting scenarios. The studies provide correlational and experimental evidence for the positive impact of needs-focused behaviors, offering organizational leaders practical solutions for improving meetings.

Abstract Triple-negative breast cancer (TNBC) remains the most lethal breast cancer subtype with poor response rates to the current chemotherapies and a lack of additional effective treatment options. We have identified deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) as a critical gatekeeper that protects tumour DNA from the genotoxic misincorporation of uracil during treatment with standard chemotherapeutic agents commonly used in the FEC regimen. dUTPase catalyses the hydrolytic dephosphorylation of deoxyuridine triphosphate (dUTP) to deoxyuridine monophosphate (dUMP), providing dUMP for thymidylate synthase as part of the thymidylate biosynthesis pathway and maintaining low intracellular dUTP concentrations. This is crucial as DNA polymerase cannot distinguish between dUTP and deoxythymidylate triphosphate (dTTP), leading to dUTP misincorporation into DNA. Targeting dUTPase and inducing uracil misincorporation during the repair of DNA damage induced by fluoropyrimidines or anthracyclines represents an effective strategy to induce cell lethality. dUTPase inhibition significantly sensitised TNBC cell lines to fluoropyrimidines and anthracyclines through imbalanced nucleotide pools and increased DNA damage leading to decreased proliferation and increased cell death. These results suggest that repair of treatment-mediated DNA damage requires dUTPase to prevent uracil misincorporation and that inhibition of dUTPase is a promising strategy to enhance the efficacy of TNBC chemotherapy.

Multimedia learning is widely used in life science education where the use of pictures and text can bring complex structures and processes to life. However the impact on academic performance and deeper understanding is not well documented. We therefore carried out a systematic review to evaluate the effectiveness of multimedia resources in tertiary level life science education. Comprehensive literature searches were conducted; studies were selected based on stringent pre-set criteria, and data were extracted for meta-analysis. In total, 17 studies were used in the meta-analyses with a total population of 2,290 students. The results show that, when used as a substitute for laboratory practicals, multimedia improved student learning gains assessed with an end-of-year examination, (mean difference 7.06, plus or minus 4.61). Although it did not improve short-term learning gains in this scenario, multimedia improved learning gains in 10 of the 16 sub-group comparisons made across all the studies. Overall, multimedia learning was more effective than many traditional educational methods although the numbers of studies included in the analysis were ultimately considered to be small due to many exclusions from the studies included in the analysis. Therefore, more good quality trials are required to evaluate a broader range of scenarios relevant to modern practices. Studies would benefit from being rigorous in design with good quality reporting of all aspects of methodology and study results. (Contains 3 figures and 3 tables.)

Examines the impact that new information technology has had on the rhetoric, theory, and practice of trans-national educational collaboration within Europe. Highlights include the role of electronic learning in the European Union; models for describing online courses within open and distance learning (ODL); and three examples of ODL projects. (Author/LRW)

Describes examples of two computer technologies that have the potential to enhance and contribute to developmental learning: the adoption of computer-mediated communication systems in a part-time master's degree program at Lancaster University (United Kingdom) and a computer-based learning environment for personal growth that uses interactive video. (20 references) (LRW)

Glucose derangement is commonly observed among adults admitted to hospital with acute stroke. This paper presents the findings from a descriptive cohort study that investigated the glucose monitoring practices of nurses caring for adults admitted to hospital with stroke or transient ischaemic attack. We found that a history of diabetes mellitus was strongly associated with initiation of glucose monitoring and higher frequency of that monitoring. Glucose monitoring was continued for a significantly longer duration of days for adults with a history of diabetes mellitus, when compared to the remainder of the cohort. As glucose monitoring was not routine practice for adults with no history of diabetes mellitus, the detection and treatment of hyperglycaemia and hypoglycaemia events could be delayed. There was a significant positive association between the admission hospital that is most likely to offer stroke unit care and the opportunity for glucose monitoring. We concluded that adults with acute stroke, irrespective of their diabetes mellitus status prior to admission to hospital, are vulnerable to both hyperglycaemic and hypoglycaemic events. This study suggests that the full potential of nurses in the monitoring of glucose among hospitalised adults with stroke has yet to be realised.

Introduction The role of the DSN is described as advanced, multifaceted and flexible. It has been clearly established in the UK and plays a vital role in diabetes care. However, [...]

This article examines the phenomenon of dynamic capabilities in international new ventures (INVs) from emerging markets. While this research stream is gaining traction, the literature is fragmented as to how INVs from emerging markets develop dynamic capabilities to overcome resource constraints and legitimacy issues. The authors highlight the importance of a comprehensive international entrepreneurial culture (IEC) to better understand how these INVs develop dynamic capabilities and foster international performance. This study draws on organisational learning and the knowledge-based view (KBV) to examine the role of IEC in shaping dynamic capabilities and international performance under various levels of market turbulence. To conduct our analyses, this study uses a sample of INVs from India – a key emerging market. The results indicate that IEC shapes dynamic capabilities and both support superior international performance. The findings also confirm the utility of IEC towards dynamic capabilities and international performance when operating in turbulent markets. [ABSTRACT FROM AUTHOR]