1. Low-dose venetoclax combined with azacitidine for blastic plasmacytoid dendritic cell neoplasm: a case report and literature review.
- Author
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Wang, Qiuyan, Zhao, Yajing, Zang, Xiao, Zhou, Guizhi, Liu, Yongxia, Feng, Qi, Li, Xin, Wang, Wen, Dong, Xiaoyuan, Liu, Xinguang, Peng, Jun, and Liu, Chuanfang
- Subjects
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LITERATURE reviews , *DENDRITIC cells , *VENETOCLAX , *HEMATOPOIETIC stem cell transplantation , *AZACITIDINE - Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that is highly aggressive with a poor prognosis. There is no standard treatment for BPDCN. Although conventional chemotherapies are usually sensitive in the initial therapy, relapse and drug resistance are inevitable within a short duration. Targeted therapies have enlightened new prospects for the treatment of BPDCN, especially for those in a frail state and intolerable to standard chemotherapies or hematopoietic stem cell transplantation. Here, we report an 82-year-old man diagnosed with cutaneous-limited BPDCN. Considering the old age and limited involvement of the tumor, we reduced the dosage of venetoclax. His skin lesions subsided significantly after 1 cycle of azacytidine (100 mg d1-7) combined with reduced doses of venetoclax (200 mg d1-14). The reduction in the dose of venetoclax avoided severe myelosuppression while achieving satisfactory outcomes. The patient received 2 cycles of therapy with no skin lesions re-occurred for 7 months before relapsing. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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