Search

This study emphasizes the critical role of psychological adaptation in the growth and development of college students, a cornerstone of successful higher education. We identify critical challenges by exploring first-year students’ psychological adjustments to their new academic environments and propose targeted strategies to enhance their integration into university life. Utilizing a questionnaire-based analysis to pinpoint areas of psychological misadjustment, our research offers practical solutions to facilitate smoother transitions for students, thereby improving the overall effectiveness of college education.

The construction of an ideal view is crucial for the personal growth of college students. The way they perceive the dialectical relationship between individuals and society and how they strive to realize the value of life is determined by it. This study focuses on college students as the survey subject and designs a questionnaire around their ideal beliefs. Analyzing the current pattern of ideal belief construction among college students is the goal. The current reality, factors that influence the construction of ideal views, and existing problems are analyzed in detail using statistical data from the questionnaire. It also proposes feasible methods to encourage the creation of ideal views among college students. Optimizing college education content, cultivating a creative spirit, and reforming family education are some of the strategies that are included in these strategies.

Abstract Pregnant women infected with HCV should be given attention due to their special physiological stage and the effect on offspring health. To examine the prevalence of HCV infection among pregnant women in part of China and explore relevant factors during pregnancy, a cross-sectional study was conducted in four maternal and children health care institutions (MCHC) in Guangdong, Hunan and Chongqing. Pregnant women who were delivered, induced or spontaneous abortion were included and relevant information was collected through the Hospital Information System. Results showed that the prevalence of HCV among pregnant women in four MCHCs was 0.11% (95% CI 0.09–0.13%). Age, occupations, regions, syphilis-infection, intrahepatic cholestasis of pregnancy (ICP), and placenta previa were significant factors (all P

Objective: To assess the difference in survival outcomes between stage IIIC and stages IIIA and IIIB in the 2018 FIGO cervical cancer staging system. Methods: The PubMed, EMBASE, MEDLINE and Web of Science were searched for articles published from November 1, 2018 to January 31, 2023. Articles published in English were considered. The included studies compared the survival outcomes of patients with cervical cancer in FIGO 2018 stage IIIC with those in stages IIIA and IIIB. Studies focused on rare histopathological types were excluded. The statistical analyses were performed using Stata 17 software. The endpoints were overall survival (OS) and progression‐free survival (PFS). Results: Ten retrospective cohort studies were eligible, involving 2113 (6.2%), 9812 (28.6%), 44 (0.1%), 10 171 (29.7%), 11 677 (34.1%) and 445 (1.3%) patients in stage IIIA, IIIB, IIIA&B, IIIC, IIIC1, and IIIC2, respectively. In the OS group, stage IIIC/C1 was significantly associated with superior survival compared with stage IIIA (hazard risk [HR] 0.62, 95% confidence interval [CI] 0.41–0.93, P = 0.022; I2 = 92.9%) and stage IIIB(A&B) (HR 0.56, 95% CI 0.44–0.71, P < 0.001; I2 = 94.0%). The FIGO 2018 stage IIIC2 was not associated with an increased mortality risk compared with stage IIIA and stage IIIB(A&B). In the PFS group, the outcome of FIGO 2018 stage IIIC/C1 was similar to stage IIIA (HR 0.66, 95% CI 0.27–1.64, P = 0.371; I2 = 65.6%), but better than stage IIIB(A&B) (HR 0.75, 95% CI 0.68–0.83, P < 0.001; I2 = 0.0%). The FIGO 2018 stage IIIC2 has similar PFS outcomes to stage IIIA and stage IIIB(A&B). Conclusion: Our findings demonstrate that survival outcomes of stage IIIC are no worse than those of stage IIIA and stage IIIB in the 2018 FIGO cervical cancer staging system. In cervical cancer, FIGO 2018 stage IIIC1 has significantly better OS outcomes than stage IIIA and stage IIIB. Synopsis: In the 2018 FIGO cervical cancer staging system, survival outcomes of stage IIIC are no worse than those of stages IIIA and IIIB. [ABSTRACT FROM AUTHOR]

We investigated the psychosocial well-being of children in HIV/AIDS-affected families in rural China from the child's and caregiver's perspectives. Semi-structured interviews were conducted among children living in HIV/AIDS-affected families (n = 16), their caregivers (n = 16) and key community informants (n = 5). Our findings showed that all of the children relied heavily on caregivers and peers to gain psychological support. Children's psychosocial problems included fear, anxiety, grief, and loss of self-esteem and confidence. Stigma towards children existed, including isolation, ignorance and rejection. Our study illustrates that HIV/AIDS has impacted negatively on the psychosocial well-being of children. These findings can be used as preliminary data supporting more researches to profoundly explore the psychosocial impact of HIV/AIDS on children and appropriately indicate the need for interventions.

Vinpocetine injection is often used in clinical treatment of acute cardiovascular and cerebrovascular diseases. However, it was reported that vinpocetine injection caused allergic reactions in clinical use; therefore, its safety needs urgent attention. Until now, research on its sensitization is rarely reported. Here, the components contained in three vinpocetine injections were examined. It was found that besides vinpocetine, the synthetic raw material vincamine, the excipients benzyl alcohol and ethyl p‐toluenesulfonate, and the impurities A, B, C, and D, which are excipients specified in the European Pharmacopoeia, were also present in them. Then the Mas‐related G‐protein‐coupled receptor X2 (MRGPRX2)‐HEK293 cell membrane chromatography was used to investigate the affinity of them with MRGPRX2 and found that vinpocetine, vincamine, and impurities A, B, C, and D bind to MRGPRX2. Afterwards, these compounds were further used to investigate the local sensitization ability in vivo. The results showed that vinpocetine, vincamine, and impurity C could induce swelling of the paw and decrease body temperature in mice, but only impurity C could cause local skin mast cell degranulation and serum histamine release increase. In vitro, the results also indicated that impurity C could increase intracellular [Ca2+] in MRGPRX2‐HEK293 cells, whereas vinpocetine and vincamine did not. Therefore, the impurity C was the potential anaphylactoid component in vinpocetine injection, which may be one of the reasons for the occurrence of allergic reactions in the clinical use of vinpocetine injection. This work provides evidence on the sensitization of impurity C and also contributes to promoting the clinical safety of vinpocetine injection. Vinpocetine injection is used in clinical treatment of acute cardiovascular and was reported that caused allergic reactions in use without any research. Here, the components contained in three vinpocetine injections were examined. In this study, we demonstrate that impurity C in vinpocetine injection can activate MRGPRX2, a novel allergy‐like‐related receptor with potential sensitizing effects, and induce allergic symptom in vivo. The hazard of impurity C requires attention in clinical use of vinpocetine injection. [ABSTRACT FROM AUTHOR]

A central principle of synaptic transmission is that action potential‐induced presynaptic neurotransmitter release occurs exclusively via Ca2+‐dependent secretion (CDS). The discovery and mechanistic investigations of Ca2+‐independent but voltage‐dependent secretion (CiVDS) have demonstrated that the action potential per se is sufficient to trigger neurotransmission in the somata of primary sensory and sympathetic neurons in mammals. One key question remains, however, whether CiVDS contributes to central synaptic transmission. Here, we report, in the central transmission from presynaptic (dorsal root ganglion) to postsynaptic (spinal dorsal horn) neurons in vitro, (i) excitatory postsynaptic currents (EPSCs) are mediated by glutamate transmission through both CiVDS (up to 87%) and CDS; (ii) CiVDS‐mediated EPSCs are independent of extracellular and intracellular Ca2+; (iii) CiVDS is faster than CDS in vesicle recycling with much less short‐term depression; (iv) the fusion machinery of CiVDS includes Cav2.2 (voltage sensor) and SNARE (fusion pore). Together, an essential component of activity‐induced EPSCs is mediated by CiVDS in a central synapse. Synopsis: Axonal action potential triggers synaptic transmission independent of Ca2+ in a mammalian central synapse.In the synapses between dorsal root ganglion and dorsal horn neurons, activity‐induced excitatory postsynaptic currents (EPSCs) are mediated by both Ca2+‐independent but voltage‐dependent secretion (CiVDS) and Ca2+‐dependent secretion (CDS).In contrast to CDS, CiVDS‐mediated EPSC shows faster vesicle recycling and less short‐term depression.CiVDS‐mediated glutamate release depends on Cav2.2 (voltage sensor) and SNARE (fusion pore). [ABSTRACT FROM AUTHOR]

Large dense‐core vesicles (LDCVs) are larger in volume than synaptic vesicles, and are filled with multiple neuropeptides, hormones, and neurotransmitters that participate in various physiological processes. However, little is known about the mechanism determining the size of LDCVs. Here, it is reported that secretogranin II (SgII), a vesicle matrix protein, contributes to LDCV size regulation through its liquid–liquid phase separation in neuroendocrine cells. First, SgII undergoes pH‐dependent polymerization and the polymerized SgII forms phase droplets with Ca2+ in vitro and in vivo. Further, the Ca2+‐induced SgII droplets recruit reconstituted bio‐lipids, mimicking the LDCVs biogenesis. In addition, SgII knockdown leads to significant decrease of the quantal neurotransmitter release by affecting LDCV size, which is differently rescued by SgII truncations with different degrees of phase separation. In conclusion, it is shown that SgII is a unique intravesicular matrix protein undergoing liquid–liquid phase separation, and present novel insights into how SgII determines LDCV size and the quantal neurotransmitter release. [ABSTRACT FROM AUTHOR]

Human resource development and capacity-building during China's rapid scale-up of methadone maintenance treatment services/Developpement des ressources humaines et renforcement des competences lors du developpement rapide et a grande echelle des services de traitement de maintien a la methadone en Chine/Desarrollo de los recursos humanos y creacion de capacidad en relacion con el rapido aumento en China de los servicios de tratamiento de mantenimiento con metadona. Problem China's National Methadone Maintenance Treatment Programme (MMT) has expanded from eight clinics serving approximately 1000 clients to 738 clinics that have served more than 340 000 clients cumulatively in only 8 years. This has created an enormous demand for trained providers. Approach Human resource development and capacity building efforts have been conducted in China's National MMT Programme to create a supply of providers trained in administering MMT for opioid dependence. Local setting From 2004 to 2007, China's National MMT Programme faced several problems: inappropriately low methadone doses, poor compliance, high concurrent drug use and high drop-out rates among clients, and little experience, little training and high turnover rates among providers. Relevant changes Training programmes for individual providers and their trainers were redeveloped and expanded in 2008. Although programme performance metrics show an increase in patients' annual mean duration in treatment (93 days in 2004 versus 238 days in 2011), the increase in their mean daily methadone dose (from 47.2 mg in 2004 to 58.6 mg in 2011) is modest. Lessons learnt Some of the problems that can arise during the development, launch and scale-up of a major national public health effort, such as China's National MMT Programme, cannot be foreseen. Key to the programme's success so far have been the strong commitment on the part of China's government and the optimism and pragmatism of programme managers. Human resources development and capacity-building during scale-up have contributed to improved service quality in MMT treatment clinics and are critical to long-term success. Probleme Le programme national chinois de traitement de maintien a la methadone est passe de 8 hopitaux traitant environ 1 000 patients a 738 cliniques qui ont suivi plus de 340 000 patients au total en seulement 8 ans. Cela a genere une enorme demande en prestataires experimentes. Approche Le developpement des ressources humaines et des efforts de renforcement des competences ont ete menes par le programme national chinois de traitement de maintien a la methadone (TMM) afin de proposer des prestataires formes a la gestion du TMM en termes de dependance aux opiaces. Environnement local De 2004 a 2007, le programme national chinois de TMM s'est heurte a divers problemes: doses de methadone inadequatement faibles, observance mediocre, importante consommation simultanee de drogues et taux d'abandon eleves chez les patients, faible experience et taux de renouvellement eleve des prestataires. Changements significatifs Des programmes de formation pour les prestataires et leurs formateurs ont ete elabores et developpes en 2008. Bien que des mesures de performance du programme montrent une augmentation de la duree moyenne annuelle du traitement des patients (93 jours en 2004 pour 238 jours en 2011), l'augmentation de leur dose quotidienne moyenne de methadone est modeste (de 47,2 mg en 2004 a 58,6 mg en 2011). Lecons tirees Certains problemes qui peuvent survenir lors du developpement, du lancement et de l'application a grande echelle d'un effort national majeur dans le domaine de la sante publique, tel que le programme national chinois du traitement de maintien a la methadone, ne peuvent etre prevus. A ce jour, les cles du succes du programme sont l'engagement marque de la part du gouvernement chinois ainsi que l'optimisme et le pragmatisme des responsables du programme. Le developpement des ressources humaines et le renforcement des competences lors du developpement a grande echelle ont contribue a une amelioration de la qualite du service dans les cliniques de TMM et sont essentiels pour une reussite a long terme. Situacion El Programa Nacional para el Tratamiento de Mantenimiento con Metadona de China ha pasado de tener ocho clinicas que atendian a aproximadamente 1000 clientes a 738 clinicas con un total acumulado de mas de 340 000 clientes atendidos en solo ocho anos, lo que ha creado una demanda enorme de proveedores de servicios cualificados. Enfoque Los esfuerzos para el desarrollo de los recursos humanos y la creacion de capacidad adecuada han llevado al Programa Nacional para el TMM de China a crear un programa para aportar proveedores cualificados capaces de administrar el tratamiento de mantenimiento con metadona (TMM) para la dependencia de opiaceos. Marco regional Desde el ano 2004 hasta el 2007, el Programa Nacional para el TMM chino tuvo que hacer frente a numerosos problemas: dosis inadecuadamente bajas de metadona, cumplimiento deficiente del programa, elevado uso simultaneo de drogas, tasas altas de abandono entre los clientes, falta de experiencia y de formacion, asi como indices elevados de rotacion entre los proveedores de servicios. Cambios importantes En el ano 2008 se volvieron a disenar y se aumentaron los programas de formacion para los proveedores individuales, asi como para sus instructores. Aunque las mediciones del rendimiento del programa muestran un aumento de la duracion media anual del tratamiento de los pacientes (93 dias en 2004 frente a 238 dias en 2011), el aumento de la dosis diaria de metadona (de 47,2 mg en 2004 a 58,6 mg en 2011) resulta moderado. Lecciones aprendidas No es posible prever todos los problemas que pueden surgir durante el desarrollo, el lanzamiento y la expansion de un esfuerzo de tal relevancia en materia de salud publica nacional como es el Programa chino para el Tratamiento de Mantenimiento con Metadona. Las claves para el exito del programa han sido, hasta ahora, el fuerte compromiso por parte del gobierno chino, asi como el optimismo y el pragmatismo de los gestores del programa. El desarrollo de los recursos humanos y la creacion de capacidad durante su proceso de expansion han contribuido a mejorar la calidad del servicio en las clinicas de TMM y son fundamentales para el exito a largo plazo., Introduction The injection of illicit drugs and the epidemic of human immunodeficiency virus (HIV) infection to which it contributes are still public health challenges in China. (1) Methadone maintenance treatment [...]

Cold cities will cause a lot of inconvenience for the elderly to travel and exercise due to their low temperature, snowfall, freezing, and other climatic characteristics. On the basis of theoretical support, this paper firstly analyzes the physical, psychological, and behavioral characteristics of the elderly in cold cities and their impact on the design of small- and medium-sized sports venues from the physical needs of the elderly in cold cities. Secondly, based on architectural theory, combined with the research results of aging sociology, behavioral sociology, sports sociology, and other disciplines, combined with a large number of literature, examples, and practical research data, this paper summarizes the problems faced by middle-aged and elderly people in cold cities, constraints, advantages, and motivations for age-friendly design and problems in construction. [ABSTRACT FROM AUTHOR]

This document is a retraction notice from the journal Cancer Management & Research regarding an article titled "LncRNA EMX2OS Induces Proliferation, Invasion and Sphere Formation of Ovarian Cancer Cells via Regulating the miR-654-3p/AKT3/PD-L1 Axis." The retraction is due to concerns about the duplication of images from other unrelated articles in Figures 2, 3, and 4 of the published article. The authors did not respond to inquiries or provide an explanation for the duplicated images. The retracted article will remain online but will be digitally marked as "Retracted." [Extracted from the article]