34 results on '"Wellmann, Robin"'
Search Results
2. Selection index theory for populations under directional and stabilizing selection
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Wellmann, Robin
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- 2023
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3. Economic benefits of herd genotyping and using sexed semen for pure and beef-on-dairy breeding in dairy herds
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Wellmann, Robin, Rolfes, Anke, Rensing, Stefan, and Bennewitz, Jörn
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- 2024
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4. Simulation of dual-purpose chicken breeding programs implementing gene editing
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Chuang, Edward Y. S., Wellmann, Robin, Meijboom, Franck L. B., Tetens, Jens, and Bennewitz, Jörn
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- 2024
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5. Optimum contribution selection for animal breeding and conservation: the R package optiSel
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Wellmann, Robin
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- 2019
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6. Genomic dominance variance analysis of health and milk production traits in German Holstein cattle.
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Schneider, Helen, Heise, Johannes, Tetens, Jens, Thaller, Georg, Wellmann, Robin, and Bennewitz, Jörn
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HOLSTEIN-Friesian cattle ,MILK yield ,HEALTH of cattle ,ANALYSIS of variance ,SOCIAL dominance ,DAIRY cattle ,MILK contamination ,VARIANCES - Abstract
Genomic analyses commonly explore the additive genetic variance of traits. The non‐additive variance, however, is usually small but often significant in dairy cattle. This study aimed at dissecting the genetic variance of eight health traits that recently entered the total merit index in Germany and the somatic cell score (SCS), as well as four milk production traits by analysing additive and dominance variance components. The heritabilities were low for all health traits (between 0.033 for mastitis and 0.099 for SCS), and moderate for the milk production traits (between 0.261 for milk energy yield and 0.351 for milk yield). For all traits, the contribution of dominance variance to the phenotypic variance was low, varying between 0.018 for ovarian cysts and 0.078 for milk yield. Inbreeding depression, inferred from the SNP‐based observed homozygosity, was significant only for the milk production traits. The contribution of dominance variance to the genetic variance was larger for the health traits, ranging from 0.233 for ovarian cysts to 0.551 for mastitis, encouraging further studies that aim at discovering QTLs based on their additive and dominance effects. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Genomic rotational crossbreeding with advanced optimum contribution selection methods applied to simulated German Angler and German Holstein dairy cattle populations.
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Stock, Joana, Esfandyari, Hadi, Wellmann, Robin, Hinrichs, Dirk, and Bennewitz, Jörn
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HOLSTEIN-Friesian cattle ,DAIRY cattle ,CROSSBREEDING ,CATTLE crossbreeding ,CATTLE breeds ,CATTLE breeding ,ENDANGERED species ,FISH populations - Abstract
Many local dairy cattle breeds are facing genetic extinction due to a large proportion of foreign genes, which have been introgressed in the past. In addition, the performance gap to popular high‐yielding breeds is increasing, resulting in a risk of numeric extinction. In the present simulation study, a genomic rotational crossbreeding scheme with the high‐yielding German Holstein breed and the numerically small German Angler breed was analysed with the aim to utilize heterosis effects in the crossbred animals. Simultaneously inbreeding was controlled, and the amount of Holstein introgression observed in the Angler breed was reduced. Different scenarios of implementing OCS methods for Angler individuals were evaluated, which differed in their restrictions regarding kinship, native kinship, as well as the amount of genetic contributions from German Holstein. The results showed that rotational crossbreeding can result in superior crossbred offspring compared to the purebred parental lines, whereby OCS methods can simultaneously restrict the increase in inbreeding and keep the Holstein contributions at their current level. However, reducing the amount of migrant contributions while restricting the increase in the native kinship in Angler turned out to be a costly restriction. The reason was that Angler with low genetic contributions from Holsteins tended to have similar Angler ancestors. Consequently, reducing Holstein contributions would considerably increase the native kinship in Angler if it were not constrained. The constraint on the native kinship made a constraint on the conventional kinship superfluous and caused it to increase at a much lower rate than envisaged. This led to both, a high genetic diversity and a low genetic gain. The high genetic diversity in Angler also resulted in lower and oscillating heterosis effects in the crossbred animals. Thus, the reduction of migrant contribution did not increase heterosis effects in the crossbred offspring, and did not result in superior crossbred offspring in general. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Power and precision of QTL mapping in simulated multiple porcine F2 crosses using whole-genome sequence information
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Schmid, Markus, Wellmann, Robin, and Bennewitz, Jörn
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- 2018
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9. Depth notions for orthogonal regression
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Wellmann, Robin and Müller, Christine H.
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- 2010
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10. Tests for multiple regression based on simplicial depth
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Wellmann, Robin and Müller, Christine H.
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- 2010
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11. Distribution-free tests for polynomial regression based on simplicial depth
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Wellmann, Robin, Harmand, Peter, and Müller, Christine H.
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- 2009
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12. Improving the Accuracy of Multi-Breed Prediction in Admixed Populations by Accounting for the Breed Origin of Haplotype Segments.
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Schmid, Markus, Stock, Joana, Bennewitz, Jörn, and Wellmann, Robin
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LINKAGE disequilibrium ,HAPLOTYPES ,ALLELES ,FORECASTING ,PHENOTYPES - Abstract
Numerically small breeds have often been upgraded with mainstream breeds. This historic introgression predisposes the breeds for joint genomic evaluations with mainstream breeds. The linkage disequilibrium structure differs between breeds. The marker effects of a haplotype segment may, therefore, depend on the breed from which the haplotype segment originates. An appropriate method for genomic evaluation would account for this dependency. This study proposes a method for the computation of genomic breeding values for small admixed breeds that incorporate phenotypic and genomic information from large introgressed breeds by considering the breed origin of alleles (BOA) in the evaluation. The proposed BOA model classifies haplotype segments according to their origins and assumes different but correlated SNP effects for the different origins. The BOA model was compared in a simulation study to conventional within-breed genomic best linear unbiased prediction (GBLUP) and conventional multi-breed GBLUP models. The BOA model outperformed within-breed GBLUP as well as multi-breed GBLUP in most cases. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Bayesian models with dominance effects for genomic evaluation of quantitative traits
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WELLMANN, ROBIN and BENNEWITZ, JÖRN
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- 2012
14. The contribution of dominance to the understanding of quantitative genetic variation
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WELLMANN, ROBIN and BENNEWITZ, JÖRN
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- 2011
15. Optimum contribution selection for conserved populations with historic migration
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Wellmann Robin, Hartwig Sonja, and Bennewitz Jörn
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Animal culture ,SF1-1100 ,Genetics ,QH426-470 - Abstract
Abstract Background In recent decades, local varieties of domesticated animal species have been frequently crossed with economically superior breeds which has resulted in considerable genetic contributions from migrants. Optimum contribution selection by maximizing gene diversity while constraining breeding values of the offspring or vice versa could eventually lead to the extinction of local breeds with historic migration because maximization of gene diversity or breeding values would be achieved by maximization of migrant contributions. Therefore, other objective functions are needed for these breeds. Results Different objective functions and side constraints were compared with respect to their ability to reduce migrant contributions, to increase the genome equivalents originating from native founders, and to conserve gene diversity. Additionally, a new method for monitoring the development of effective size for breeds with incomplete pedigree records was applied. Approaches were compared for Vorderwald cattle, Hinterwald cattle, and Limpurg cattle. Migrant contributions could be substantially decreased for these three breeds, but the potential to increase the native genome equivalents is limited. Conclusions The most promising approach was constraining migrant contributions while maximizing the conditional probability that two alleles randomly chosen from the offspring population are not identical by descent, given that both descend from native founders.
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- 2012
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16. Genetic parameter estimates and targeted association analyses of growth, carcass, and meat quality traits in German Merinoland and Merinoland-cross lambs
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Stratz, Patrick, Schiller, Katja Franziska, Wellmann, Robin, Preuss, Siegfried, Baes, Christine Francoise, and Bennewitz, Jörn
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630 Agriculture ,food and beverages ,590 Animals (Zoology) ,570 Life sciences ,biology - Abstract
In this study, genetic parameters of nine growth, carcass, and meat quality (MQ) traits were estimated, and targeted association studies were conducted using mixed models. Phenotypic information was collected on 1,599 lambs, including both purebred Merinoland (ML) animals and five different F1 crosses. The F1 lambs were produced by mating rams of the meat-type breeds Charollais, Ile de France, German Blackheaded Mutton (Deutsches Schwarzköpfiges Fleischschaf), Suffolk, and Texel with ML ewes. Between four and six sires were used per sire breed. In total, 29 sires and 298 purebred ML sheep were genotyped with the Illumina OvineSNP50 BeadChip. All F1 individuals were genotyped for 289 SNPs located on the chromosomes 1, 2, 3, 18, and 21. These SNPs were used to impute SNPs on five chromosomes of the Illumina Ovine chip in the F1 individuals. Several Bonferroni-corrected significant associations were identified for shoulder width. A number of additional significant associations were found for other traits. Genetic parameters were estimated and single-marker association analyses were performed with breed-specific effects. Moderate heritability estimates were found for average daily gain (0.23), kidney fat weight (0.19), carcass length (0.15), shoulder width (0.33), subcutaneous fat thickness (0.22), and cutlet area (0.36). While heritability for cooking loss was found to be low (0.07), shear force (0.17) and dressing percentage (0.20) showed moderate heritability, and thus might be candidate traits to be included in the selection index in the population. In general, low phenotypic and low or moderate genetic correlations were detected between the traits.
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- 2018
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17. The Gut Microbial Architecture of Efficiency Traits in the Domestic Poultry Model Species Japanese Quail (Coturnix japonica) Assessed by Mixed Linear Models.
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Vollmar, Solveig, Wellmann, Robin, Borda-Molina, Daniel, Rodehutscord, Markus, Camarinha-Silva, Amélia, and Bennewitz, Jörn
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JAPANESE quail , *POULTRY , *GUT microbiome , *MAMMALS , *SPECIES , *RIBOSOMAL RNA - Abstract
It is well known that mammals and avian gut microbiota compositions are shaped by the host genomes and affect quantitative traits. The microbial architecture describes the impact of the microbiota composition on quantitative trait variation and the number and effect distribution of microbiota features. In the present study the gut microbial architecture of feed-related traits phosphorus and calcium utilization, daily gain, feed intake and feed per gain ratio in the domestic poultry model species Japanese quail were assessed by mixed linear models. The ileum microbiota composition was characterized by 16S rRNA amplicon sequencing techniques of growing individuals. The microbiability of the traits was on a similar level as the narrow sense heritability and was highly significant except for calcium utilization. The animal microbial correlation of the traits was substantial. Microbiome-wide association analyses revealed several traits associated and highly significant microbiota features, both on the bacteria genera as well as on the operational taxonomic unit level. Most features were significant for more than one trait, which explained the high microbial correlations. It can be concluded that the traits are polymicrobial determined with some microbiota features with larger effects and many with small effects. The results are important for the development of hologenomic selection schemes for feed-related traits in avian breeding programs that are targeting the host genome and the metagenome simultaneously. [ABSTRACT FROM AUTHOR]
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- 2020
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18. A Review of Genomic Models for the Analysis of Livestock Crossbred Data.
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Stock, Joana, Bennewitz, Jörn, Hinrichs, Dirk, and Wellmann, Robin
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CROSSBREEDING ,POULTRY breeding ,LIVESTOCK ,LINKAGE disequilibrium ,CATTLE crossbreeding ,LIVESTOCK breeding ,FORECASTING - Abstract
Livestock breeding has shifted during the past decade toward genomic selection. For the estimation of breeding values in purebred breeding schemes, genomic best linear unbiased prediction has become the method of choice. Systematic crossbreeding with the aim to utilize heterosis and breed complementary effects is widely used in livestock breeding, especially in pig and poultry breeding. The goal is to improve the performance of the crossbred animals. Due to genotype-by-environment interactions, imperfect linkage disequilibrium, and the existence of dominance and imprinting, purebred and crossbred performances are not perfectly correlated. Hence, more complex genomic models are required for crossbred populations. This study reviews and compares such models. Compared to purebred genomic models, the reviewed models were of much higher complexity due to the inclusion of dominance effects, breed-specific effects, imprinting effects, and the joint evaluation of purebred and crossbred performance data. With the model assessment work conducted until now, it is not possible to come to a clear recommendation as to which existing method is most suitable for a specific breeding program and a specific genetic trait architecture. Since it is expected that a superior method includes all the different genetic effects in a single model, a dominance model with imprinting and breed-specific SNP effects is proposed. Further progress could be made by assuming realistic covariance structures between the genetic effects of the different breeding lines, and by using larger marker panels and mixture distributions for the SNP effects. [ABSTRACT FROM AUTHOR]
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- 2020
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19. Selecting the hologenome to breed for an improved feed efficiency in pigs—A novel selection index.
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Weishaar, Ramona, Wellmann, Robin, Camarinha‐Silva, Amelia, Rodehutscord, Markus, and Bennewitz, Jörn
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ANIMAL breeding , *SWINE , *SWINE breeding , *CONDITIONAL expectations , *ANIMAL feeds , *GASTROINTESTINAL system , *HOMOZYGOSITY - Abstract
Most traits in animal breeding, including feed efficiency traits in pigs, are affected by many genes with small effect and have a moderately high heritability between 0.1 and 0.5, which enables efficient selection. Since the microbiota composition in the gastrointestinal tract is also partly heritable and was shown to have a substantial effect on feed efficiency, the host genes affect the phenotype not only directly by altering metabolic pathways, but also indirectly by changing the microbiota composition. The effect mi of the microbiota composition on the breeding value gi of an animal i is the conditional expectation of its breeding value, given the vector φi with microbiota frequencies, that is mi=Egi|φi. The breeding value gi of an animal can therefore be decomposed into a heritable contribution mi that arises from an altered microbiota composition and a heritable contribution pi that arises from altered metabolic pathways within the animal, so gi=mi+pi. Instead of selecting for breeding value g^i, an index comprising the two components m^i and p^i with appropriate weights, that is Ii=λ1m^i+λ2p^i, can be used. The present study shows how this breeding strategy can be applied in pig genomic selection breeding scheme for two feed efficiency traits and daily gain. [ABSTRACT FROM AUTHOR]
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- 2020
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20. Managing genomes of conserved livestock breeds with historical introgression to decrease genetic overlap with other breeds.
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Wang, Yu, Bennewitz, Jörn, and Wellmann, Robin
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INTROGRESSION (Genetics) ,LIVESTOCK breeds ,BREEDING ,CATTLE genetics ,GENOMES ,SPECIES pools ,SPECIES diversity - Abstract
Recovering the native genetic background of a breed and increasing the founder genome equivalent (FGE) that is contributed by a breed to the gene pool of the species can increase its value for conservation. The suitability of several strategies was compared, whereby a hypothetical multi‐breed population, the core set, was used to approximate the genetic diversity of the species. Twenty‐five generations of management were simulated based on genotypes of German Angler cattle. The scenarios were compared when the kinship reached 0.10. The native contribution (NC) increased in a population with 400 births per generation from 0.317 to 0.706, whereas 1,000 births enabled to reach 0.894. This scenario maximized the NC, constrained the native kinship, and the kinship of the core set so that its genetic diversity could not decrease. It increased the proportions of mainstream breeds because their genes were removed from the target breed. A substantial increase of the FGE was achieved in some other scenarios, which arose from reduced genetic overlap and from increased diversity within the breed. The latter factor is especially important for breeds with high contributions to the core set. [ABSTRACT FROM AUTHOR]
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- 2019
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21. Key Genetic Parameters for Population Management.
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Wellmann, Robin and Bennewitz, Jörn
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PARAMETERS (Statistics) ,SPECIES pools ,CONSUMER preferences ,CONSUMPTION (Economics) ,SUPPLY & demand - Abstract
Population management has the primary task of maximizing the long-term competitiveness of a breed. Breeds compete with each other for being able to supply consumer demands at low costs and also for funds from conservation programs. The competition for consumer preference is won by breeds with high genetic gain for total merit who maintained a sufficiently high genetic diversity, whereas the competition for funds is won by breeds with high conservation value. The conservation value of a breed could be improved by increasing its contribution to the gene pool of the species. This may include the recovery of its original genetic background and the maintenance of a high genetic diversity at native haplotype segments. The primary objective of a breeding program depends on the genetic state of the population and its intended usage. In this paper, we review the key genetic parameters that are relevant for population management, compare the methods for estimating them, derive the formulas for predicting their value at a future time, and clarify their usage in various types of breeding programs that differ in their main objectives. These key parameters are kinships, native kinships, breeding values, Mendelian sampling variances, native contributions, and mutational effects. Population management currently experiences a transition from using pedigree-based estimates to marker-based estimates, which improves the accuracies of these estimates and thereby increases response to selection. In addition, improved measures of the factors that determine the competitiveness of a breed and utilize auxiliary parameters, such as Mendelian sampling variances, mutational effects, and native kinships, enable to improve further upon historic recommendations for genetic population management. [ABSTRACT FROM AUTHOR]
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- 2019
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22. Novel optimum contribution selection methods accounting for conflicting objectives in breeding programs for livestock breeds with historical migration.
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Yu Wang, Bennewitz, Jörn, and Wellmann, Robin
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LIVESTOCK breeding ,ANIMAL migration ,ANIMAL behavior ,ANIMAL genetics ,ALLELES - Abstract
Background: Optimum contribution selection (OCS) is effective for increasing genetic gain, controlling the rate of inbreeding and enables maintenance of genetic diversity. However, this diversity may be caused by high migrant contributions (MC) in the population due to introgression of genetic material from other breeds, which can threaten the conservation of small local populations. Therefore, breeding objectives should not only focus on increasing genetic gains but also on maintaining genetic originality and diversity of native alleles. This study aimed at investigating whether OCS was improved by including MC and modified kinships that account for breed origin of alleles. Three objective functions were considered for minimizing kinship, minimizing MC and maximizing genetic gain in the offspring generation, and we investigated their effects on German Angler and Vorderwald cattle. Results: In most scenarios, the results were similar for Angler and Vorderwald cattle. A significant positive correlation between MC and estimated breeding values of the selection candidates was observed for both breeds, thus traditional OCS would increase MC. Optimization was performed under the condition that the rate of inbreeding did not exceed 1% and at least 30% of the maximum progress was achieved for all other criteria. Although traditional OCS provided the highest breeding values under restriction of classical kinship, the magnitude of MC in the progeny generation was not controlled. When MC were constrained or minimized, the kinship at native alleles increased compared to the reference scenario. Thus, in addition to constraining MC, constraining kinship at native alleles is required to ensure that native genetic diversity is maintained. When kinship at native alleles was constrained, the classical kinship was automatically lowered in most cases and more sires were selected. However, the average breeding value in the next generation was also lower than that obtained with traditional OCS. Conclusions: For local breeds with historical introgressions, current breeding programs should focus on increasing genetic gain and controlling inbreeding, as well as maintaining the genetic originality of the breeds and the diversity of native alleles via the inclusion of MC and kinship at native alleles in the OCS process. [ABSTRACT FROM AUTHOR]
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- 2017
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23. Application of a Bayesian dominance model improves power in quantitative trait genome-wide association analysis.
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Bennewitz, Jörn, Edel, Christian, Fries, Ruedi, Meuwissen, Theo H. E., and Wellmann, Robin
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BAYESIAN analysis ,GENOMICS ,GENETIC markers ,DOMINANCE (Genetics) ,GENE mapping - Abstract
Background: Multi-marker methods, which fit all markers simultaneously, were originally tailored for genomic selection purposes, but have proven to be useful also in association analyses, especially the so-called BayesC Bayesian methods. In a recent study, BayesD extended BayesC towards accounting for dominance effects and improved prediction accuracy and persistence in genomic selection. The current study investigated the power and precision of BayesC and BayesD in genome-wide association studies by means of stochastic simulations and applied these methods to a dairy cattle dataset. Methods: The simulation protocol was designed to mimic the genetic architecture of quantitative traits as realistically as possible. Special emphasis was put on the joint distribution of the additive and dominance effects of causative mutations. Additive marker effects were estimated by BayesC and additive and dominance effects by BayesD. The dependencies between additive and dominance effects were modelled in BayesD by choosing appropriate priors. A sliding-window approach was used. For each window, the R. Fernando window posterior probability of association was calculated and this was used for inference purpose. The power to map segregating causal effects and the mapping precision were assessed for various marker densities up to full sequence information and various window sizes. Results: Power to map a QTL increased with higher marker densities and larger window sizes. This held true for both methods. Method BayesD had improved power compared to BayesC. The increase in power was between -2 and 8% for causative genes that explained more than 2.5% of the genetic variance. In addition, inspection of the estimates of genomic window dominance variance allowed for inference about the magnitude of dominance at significant associations, which remains hidden in BayesC analysis. Mapping precision was not substantially improved by BayesD. Conclusions: BayesD improved power, but precision only slightly. Application of BayesD needs large datasets with genotypes and own performance records as phenotypes. Given the current efforts to establish cow reference populations in dairy cattle genomic selection schemes, such datasets are expected to be soon available, which will enable the application of BayesD for association mapping and genomic prediction purposes. [ABSTRACT FROM AUTHOR]
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- 2017
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24. Within- and across-breed genomic prediction using whole-genome sequence and single nucleotide polymorphism panels.
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Iheshiulor, Oscar O. M., Woolliams, John A., Xijiang Yu, Wellmann, Robin, and Meuwissen, Theo H. E.
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SINGLE nucleotide polymorphisms ,DAIRY cattle ,HERITABILITY ,ALLELES ,GENETIC polymorphisms - Abstract
Background: Currently, genomic prediction in cattle is largely based on panels of about 54k single nucleotide polymorphisms (SNPs). However with the decreasing costs of and current advances in next-generation sequencing technologies, whole-genome sequence (WGS) data on large numbers of individuals is within reach. Availability of such data provides new opportunities for genomic selection, which need to be explored. Methods: This simulation study investigated how much predictive ability is gained by using WGS data under scenarios with QTL (quantitative trait loci) densities ranging from 45 to 132 QTL/Morgan and heritabilities ranging from 0.07 to 0.30, compared to different SNP densities, with emphasis on divergent dairy cattle breeds with small populations. The relative performances of best linear unbiased prediction (SNP-BLUP) and of a variable selection method with a mixture of two normal distributions (MixP) were also evaluated. Genomic predictions were based on within- population, across-population, and multi-breed reference populations. Results: The use of WGS data for within-population predictions resulted in small to large increases in accuracy for low to moderately heritable traits. Depending on heritability of the trait, and on SNP and QTL densities, accuracy increased by up to 31 %. The advantage of WGS data was more pronounced (7 to 92 % increase in accuracy depending on trait heritability, SNP and QTL densities, and time of divergence between populations) with a combined reference population and when using MixP . While MixP outperformed SNP-BLUP at 45 QTL/Morgan, SNP-BLUP was as good as MixP when QTL density increased to 132 QTL/Morgan. Conclusions: Our results show that, genomic predictions in numerically small cattle populations would benefit from a combination of WGS data, a multi-breed reference population, and a variable selection method. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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25. Genetic parameters and signatures of selection in two divergent laying hen lines selected for feather pecking behaviour.
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Grams, Vanessa, Wellmann, Robin, Preuß, Siegfried, Grashorn, Michael A., Kjaer, Jörgen B., Bessei, Werner, and Bennewitz, Jörn
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GENETIC drift ,HENS ,ANIMAL genetics ,CHICKENS ,BIOLOGICAL divergence ,SINGLE nucleotide polymorphisms - Abstract
Background: Feather pecking (FP) in laying hens is a well-known and multi-factorial behaviour with a genetic background. In a selection experiment, two lines were developed for 11 generations for high (HFP) and low (LFP) feather pecking, respectively. Starting with the second generation of selection, there was a constant difference in mean number of FP bouts between both lines. We used the data from this experiment to perform a quantitative genetic analysis and to map selection signatures. Methods: Pedigree and phenotypic data were available for the last six generations of both lines. Univariate quantitative genetic analyses were conducted using mixed linear and generalized mixed linear models assuming a Poisson distribution. Selection signatures were mapped using 33,228 single nucleotide polymorphisms (SNPs) genotyped on 41 HFP and 34 LFP individuals of generation 11. For each SNP, we estimated Wright's fixation index (F
ST ). We tested the null hypothesis that FST is driven purely by genetic drift against the alternative hypothesis that it is driven by genetic drift and selection. Results: The mixed linear model failed to analyze the LFP data because of the large number of 0s in the observation vector. The Poisson model fitted the data well and revealed a small but continuous genetic trend in both lines. Most of the 17 genome-wide significant SNPs were located on chromosomes 3 and 4. Thirteen clusters with at least two significant SNPs within an interval of 3 Mb maximum were identified. Two clusters were mapped on chromosomes 3, 4, 8 and 19. Of the 17 genome-wide significant SNPs, 12 were located within the identified clusters. This indicates a non-random distribution of significant SNPs and points to the presence of selection sweeps. Conclusions: Data on FP should be analysed using generalised linear mixed models assuming a Poisson distribution, especially if the number of FP bouts is small and the distribution is heavily peaked at 0. The FST -based approach was suitable to map selection signatures that need to be confirmed by linkage or association mapping. [ABSTRACT FROM AUTHOR]- Published
- 2015
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26. Genomic selection using low density marker panels with application to a sire line in pigs.
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Wellmann, Robin, Preuß, Siegfried, Tholen, Ernst, Heinkel, Jörg, Wimmers, Klaus, and Bennewitz, Jörn
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GENETIC polymorphisms ,ANIMAL classification ,BREEDING ,SINGLE nucleotide polymorphisms ,DAIRY cattle - Abstract
Background: Genomic selection has become a standard tool in dairy cattle breeding. However, for other animal species, implementation of this technology is hindered by the high cost of genotyping. One way to reduce the routine costs is to genotype selection candidates with an SNP (single nucleotide polymorphism) panel of reduced density. This strategy is investigated in the present paper. Methods are proposed for the approximation of SNP positions, for selection of SNPs to be included in the low-density panel, for genotype imputation, and for the estimation of the accuracy of genomic breeding values. The imputation method was developed for a situation in which selection candidates are genotyped with an SNP panel of reduced density but have high-density genotyped sires. The dams of selection candidates are not genotyped. The methods were applied to a sire line pig population with 895 German Piétrain boars genotyped with the PorcineSNP60 BeadChip. Results: Genotype imputation error rates were 0.133 for a 384 marker panel, 0.079 for a 768 marker panel, and 0.022 for a 3000 marker panel. Error rates for markers with approximated positions were slightly larger. Availability of high-density genotypes for close relatives of the selection candidates reduced the imputation error rate. The estimated decrease in the accuracy of genomic breeding values due to imputation errors was 3% for the 384 marker panel and negligible for larger panels, provided that at least one parent of the selection candidates was genotyped at high-density. Genomic breeding values predicted from deregressed breeding values with low reliabilities were more strongly correlated with the estimated BLUP breeding values than with the true breeding values. This was not the case when a shortened pedigree was used to predict BLUP breeding values, in which the parents of the individuals genotyped at high-density were considered unknown. Conclusions: Genomic selection with imputation from very low- to high-density marker panels is a promising strategy for the implementation of genomic selection at acceptable costs. A panel size of 384 markers can be recommended for selection candidates of a pig breeding program if at least one parent is genotyped at high-density, but this appears to be the lower bound. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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27. Genomewide Mapping of Selection Signatures and Genes for Extreme Feather Pecking in Two Divergently Selected Laying Hen Lines.
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Iffland, Hanna, Wellmann, Robin, Schmid, Markus, Preuß, Siegfried, Tetens, Jens, Bessei, Werner, and Bennewitz, Jörn
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HENS , *NEGATIVE binomial distribution , *FEATHERS , *SKIN injuries , *HELPING behavior - Abstract
Simple Summary: Feather pecking is a behavior frequently occurring in commercial layer flocks. It often leads to skin injuries and cannibalism. Besides economic losses, severe animal welfare problems cannot be ignored. Previous research has shown that the trait is heritable. Thus breeding against feather pecking is possible, but phenotyping in a commercial environment is economically unfeasible at the moment because of the lack of proper techniques. Therefore, understanding the genetic background of the trait is mandatory to establish a genomic breeding program. This would require genotypic information of the hens, which is feasible under practical conditions. In the present study, we used different methods to identify regions in the genome that influence feather pecking and extreme feather pecking. We found one trait associated with the genomic region. The use of genotypic information from this region in terms of selection against the undesired behavior may help to improve animal welfare in layer flocks. Feather pecking (FP) is a longstanding serious problem in commercial flocks of laying hens. It is a highly polygenic trait and the genetic background is still not completely understood. In order to find genomic regions influencing FP, selection signatures between laying hen lines divergently selected for high and low feather pecking were mapped using the intra-population iHS and the inter-population FST approach. In addition, the existence of an extreme subgroup of FP hens (EFP) across both selected lines has been demonstrated by fitting a mixture of negative binomial distributions to the data and calculating the posterior probability of belonging to the extreme subgroup (pEFP) for each hen. A genomewide association study (GWAS) was performed for the traits pEFP and FP delivered (FPD) with a subsequent post GWAS analysis. Mapping of selection signatures revealed no clear regions under selection. GWAS revealed a region on Chromosome 1, where the existence of a QTL influencing FP is likely. The candidate genes found in this region are a part of the GABAergic system, which has already been linked to FP in previous studies. Despite the polygenic nature of FP, selection on these candidate genes may reduce FP. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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28. Host Genome Influence on Gut Microbial Composition and Microbial Prediction of Complex Traits in Pigs.
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Camarinha-Silva, Amelia, Maushammer, Maria, Wellmann, Robin, Vital, Marius, Preuss, Siegfried, and Bennewitz, Jörn
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GENOMES , *SWINE , *GENETICS , *MICROBIOLOGY , *PHENOTYPES , *ALLELES , *CHROMOSOMES - Abstract
The aim of the present study was to analyze the interplay between gastrointestinal tract (GIT) microbiota, host genetics, and complex traits in pigs using extended quantitative-genetic methods. The study design consisted of 207 pigs that were housed and slaughtered under standardized conditions, and phenotyped for daily gain, feed intake, and feed conversion rate. The pigs were genotyped with a standard 60 K SNP chip. The GIT microbiota composition was analyzed by 16S rRNA gene amplicon sequencing technology. Eight from 49 investigated bacteria genera showed a significant narrow sense host heritability, ranging from 0.32 to 0.57. Microbial mixed linear models were applied to estimate the microbiota variance for each complex trait. The fraction of phenotypic variance explained by the microbial variance was 0.28, 0.21, and 0.16 for daily gain, feed conversion, and feed intake, respectively. The SNP data and the microbiota composition were used to predict the complex traits using genomic best linear unbiased prediction (G-BLUP) and microbial best linear unbiased prediction (M-BLUP) methods, respectively. The prediction accuracies of G-BLUP were 0.35, 0.23, and 0.20 for daily gain, feed conversion, and feed intake, respectively. The corresponding prediction accuracies of M-BLUP were 0.41, 0.33, and 0.33. Thus, in addition to SNP data, microbiota abundances are an informative source of complex trait predictions. Since the pig is a well-suited animal for modeling the human digestive tract, M-BLUP, in addition to G-BLUP, might be beneficial for predicting human predispositions to some diseases, and, consequently, for preventative and personalized medicine. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
29. Long-Term Impact of Optimum Contribution Selection Strategies on Local Livestock Breeds with Historical Introgression Using the Example of German Angler Cattle.
- Author
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Yu Wang, Segelke, Dierck, Emmerling, Reiner, Bennewitz, Jörn, and Wellmann, Robin
- Subjects
- *
CATTLE crossbreeding , *INTROGRESSION (Genetics) , *ANGELN cattle - Abstract
The long-term performance of different selection strategies was evaluated via simulation using the example of a local cattle breed, German Angler cattle. Different optimum contribution selection (OCS) approaches to maximize genetic gain were compared to a reference scenario without selection and truncation selection. The kinships and migrant contribution (MC) were estimated from genomic data. Truncation selection achieved the highest genetic gain but decreased diversity considerably at native alleles. It also caused the highest increase in MCs. Traditional OCS, which only constrains kinship, achieved almost the same genetic gain but also caused a small increase of MC and remarkably reduced the diversity of native alleles. When MC was required not to increase and the increase of kinship at native alleles was restricted, the MC levels and the diversity at native alleles were well managed, and the genetic gain was only slightly reduced. However, genetic progress was substantially lower in the scenario that aimed to recover the original genetic background. Truncation selection and traditional OCS selection both reduce the genetic originality of breeds with historical introgression. The inclusion of MC and kinship at native alleles as additional constraints in OCS showed great potential for conservation. Recovery of the original genetic background is possible but requires many generations of selection and reduces the genetic progress in performance traits. Hence, constraining MCs at their current values can be recommended to avoid further reduction of genetic originality. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
30. Genetic parameter estimates and targeted association analyses of growth, carcass, and meat quality traits in German Merinoland and Merinoland-cross lambs.
- Author
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Stratz P, Schiller KF, Wellmann R, Preuss S, Baes C, and Bennewitz J
- Subjects
- Animals, Body Weight genetics, Crosses, Genetic, Female, Genotype, Male, Phenotype, Sheep genetics, Sheep growth & development, Body Composition genetics, Meat standards
- Abstract
In this study, genetic parameters of nine growth, carcass, and meat quality (MQ) traits were estimated, and targeted association studies were conducted using mixed models. Phenotypic information was collected on 1,599 lambs, including both purebred Merinoland (ML) animals and five different F1 crosses. The F1 lambs were produced by mating rams of the meat-type breeds Charollais, Ile de France, German Blackheaded Mutton (Deutsches Schwarzköpfiges Fleischschaf), Suffolk, and Texel with ML ewes. Between four and six sires were used per sire breed. In total, 29 sires and 298 purebred ML sheep were genotyped with the Illumina OvineSNP50 BeadChip. All F1 individuals were genotyped for 289 SNPs located on the chromosomes 1, 2, 3, 18, and 21. These SNPs were used to impute SNPs on five chromosomes of the Illumina Ovine chip in the F1 individuals. Several Bonferroni-corrected significant associations were identified for shoulder width. A number of additional significant associations were found for other traits. Genetic parameters were estimated and single-marker association analyses were performed with breed-specific effects. Moderate heritability estimates were found for average daily gain (0.23), kidney fat weight (0.19), carcass length (0.15), shoulder width (0.33), subcutaneous fat thickness (0.22), and cutlet area (0.36). While heritability for cooking loss was found to be low (0.07), shear force (0.17) and dressing percentage (0.20) showed moderate heritability, and thus might be candidate traits to be included in the selection index in the population. In general, low phenotypic and low or moderate genetic correlations were detected between the traits.
- Published
- 2018
- Full Text
- View/download PDF
31. Long-Term Impact of Optimum Contribution Selection Strategies on Local Livestock Breeds with Historical Introgression Using the Example of German Angler Cattle.
- Author
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Wang Y, Segelke D, Emmerling R, Bennewitz J, and Wellmann R
- Subjects
- Alleles, Animals, Cattle, Phenotype, Breeding, Genetic Variation, Livestock genetics, Selection, Genetic
- Abstract
The long-term performance of different selection strategies was evaluated via simulation using the example of a local cattle breed, German Angler cattle. Different optimum contribution selection (OCS) approaches to maximize genetic gain were compared to a reference scenario without selection and truncation selection. The kinships and migrant contribution (MC) were estimated from genomic data. Truncation selection achieved the highest genetic gain but decreased diversity considerably at native alleles. It also caused the highest increase in MCs. Traditional OCS, which only constrains kinship, achieved almost the same genetic gain but also caused a small increase of MC and remarkably reduced the diversity of native alleles. When MC was required not to increase and the increase of kinship at native alleles was restricted, the MC levels and the diversity at native alleles were well managed, and the genetic gain was only slightly reduced. However, genetic progress was substantially lower in the scenario that aimed to recover the original genetic background. Truncation selection and traditional OCS selection both reduce the genetic originality of breeds with historical introgression. The inclusion of MC and kinship at native alleles as additional constraints in OCS showed great potential for conservation. Recovery of the original genetic background is possible but requires many generations of selection and reduces the genetic progress in performance traits. Hence, constraining MCs at their current values can be recommended to avoid further reduction of genetic originality., (Copyright © 2017 Wang et al.)
- Published
- 2017
- Full Text
- View/download PDF
32. Novel optimum contribution selection methods accounting for conflicting objectives in breeding programs for livestock breeds with historical migration.
- Author
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Wang Y, Bennewitz J, and Wellmann R
- Subjects
- Animals, Female, Genetic Fitness, Inbreeding, Insemination, Artificial veterinary, Male, Polymorphism, Genetic, Cattle genetics, Selective Breeding
- Abstract
Background: Optimum contribution selection (OCS) is effective for increasing genetic gain, controlling the rate of inbreeding and enables maintenance of genetic diversity. However, this diversity may be caused by high migrant contributions (MC) in the population due to introgression of genetic material from other breeds, which can threaten the conservation of small local populations. Therefore, breeding objectives should not only focus on increasing genetic gains but also on maintaining genetic originality and diversity of native alleles. This study aimed at investigating whether OCS was improved by including MC and modified kinships that account for breed origin of alleles. Three objective functions were considered for minimizing kinship, minimizing MC and maximizing genetic gain in the offspring generation, and we investigated their effects on German Angler and Vorderwald cattle., Results: In most scenarios, the results were similar for Angler and Vorderwald cattle. A significant positive correlation between MC and estimated breeding values of the selection candidates was observed for both breeds, thus traditional OCS would increase MC. Optimization was performed under the condition that the rate of inbreeding did not exceed 1% and at least 30% of the maximum progress was achieved for all other criteria. Although traditional OCS provided the highest breeding values under restriction of classical kinship, the magnitude of MC in the progeny generation was not controlled. When MC were constrained or minimized, the kinship at native alleles increased compared to the reference scenario. Thus, in addition to constraining MC, constraining kinship at native alleles is required to ensure that native genetic diversity is maintained. When kinship at native alleles was constrained, the classical kinship was automatically lowered in most cases and more sires were selected. However, the average breeding value in the next generation was also lower than that obtained with traditional OCS., Conclusions: For local breeds with historical introgressions, current breeding programs should focus on increasing genetic gain and controlling inbreeding, as well as maintaining the genetic originality of the breeds and the diversity of native alleles via the inclusion of MC and kinship at native alleles in the OCS process.
- Published
- 2017
- Full Text
- View/download PDF
33. A unified approach to characterize and conserve adaptive and neutral genetic diversity in subdivided populations.
- Author
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Wellmann R, Bennewitz J, and Meuwissen TH
- Subjects
- Animals, Computer Simulation, Genetics, Population, Adaptation, Biological genetics, Animals, Wild genetics, Conservation of Natural Resources methods, Genetic Drift, Genetic Variation, Livestock genetics, Models, Genetic
- Abstract
As extinction of local domestic breeds and of isolated subpopulations of wild species continues, and the resources available for conservation programs are limited, prioritizing subpopulations for conservation is of high importance to halt the erosion of genetic diversity observed in endangered species. Current approaches usually only take neutral genetic diversity into account. However, adaptation of subpopulations to different environments also contributes to the diversity found in the species. This paper introduces two notions of adaptive variation. The adaptive diversity in a trait is the excess of variance found in genotypic values relative to the variance that would have been expected in the absence of selection. The adaptivity coverage of a set of subpopulations quantifies how well the subpopulations could adapt to a large range of environments within a limited time span. Additionally, genome-based notions of neutral diversities were obtained that correspond to well known pedigree-based definitions. The values of subpopulations for conservation of adaptivity coverage were compared with their conservation values for adaptive diversity and neutral diversities using simulated data. Conservation values for adaptive diversity and neutral diversities were only slightly correlated, but the values for conservation of adaptivity coverage showed a reasonable correlation with both kinds if the time span was chosen appropriately. Hence, maintaining adaptivity coverage is a promising approach to prioritize subpopulations for conservation decisions.
- Published
- 2014
- Full Text
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34. Using genome-wide association analysis to characterize environmental sensitivity of milk traits in dairy cattle.
- Author
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Streit M, Wellmann R, Reinhardt F, Thaller G, Piepho HP, and Bennewitz J
- Subjects
- Animals, Breeding, Cattle, Dairy Products, Polymorphism, Single Nucleotide, Gene-Environment Interaction, Genome-Wide Association Study, Milk Proteins genetics, Quantitative Trait Loci genetics
- Abstract
Genotype-by-environment interaction (GxE) has been widely reported in dairy cattle. One way to analyze GxE is to apply reaction norm models. The first derivative of a reaction norm is the environmental sensitivity (ES). In the present study we conducted a large-scale, genome-wide association analysis to identify single-nucleotide polymorphisms (SNPs) that affect general production (GP) and ES of milk traits in the German Holstein population. Sire estimates for GP and for ES were calculated from approximately 13 million daughter records by the use of linear reaction norm models. The daughters were offspring from 2297 sires. Sires were genotyped for 54k SNPs. The environment was defined as the average milk energy yield performance of the herds at the time during which the daughter observations were recorded. The sire estimates were used as observations in a genome-wide association analysis, using 1797 sires. Significant SNPs were confirmed in an independent validation set (500 sires of the same population). To separate GxE scaling and other GxE effects, the observations were log-transformed in some analyses. Results from the reaction norm model revealed GxE effects. Numerous significant SNPs were validated for both GP and ES. Many SNPs that affect GP also affect ES. We showed that ES of milk traits is a typical quantitative trait, genetically controlled by many genes with small effects and few genes with larger effect. A log-transformation of the observation resulted in a reduced number of validated SNPs for ES, pointing to genes that not only caused scaling GxE effects. The results will have implications for breeding for robustness in dairy cattle.
- Published
- 2013
- Full Text
- View/download PDF
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