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218 results on '"Westphal, Lynn M"'

1. A View from the past into our collective future: the oncofertility consortium vision statement

Author

Woodruff, Teresa K., Ataman-Millhouse, Lauren, Acharya, Kelly S., Almeida-Santos, Teresa, Anazodo, Antoinette, Anderson, Richard A., Appiah, Leslie, Bader, Joy, Becktell, Kerri, Brannigan, Robert E., Breech, Lesley, Bourlon, Maria T., Bumbuliene, Žana, Burns, Karen, Campo-Engelstein, Lisa, Campos, Jacira R., Centola, Grace M., Chehin, Mauricio Barbour, Chen, Diane, De Vos, Michel, Duncan, Francesca E., El-Damen, Ahmed, Fair, Douglas, Famuyiwa, Yemi, Fechner, Patricia Y., Fontoura, Paula, Frias, Olivia, Gerkowicz, Sabrina A., Ginsberg, Jill, Gracia, Clarisa R., Goldman, Kara, Gomez-Lobo, Veronica, Hazelrigg, Brent, Hsieh, Michael H., Hoyos, Luis R., Hoyos-Martinez, Alfonso, Jach, Robert, Jassem, Jacek, Javed, Murid, Jayasinghe, Yasmin, Jeelani, Roohi, Jeruss, Jacqueline S., Kaul-Mahajan, Nalini, Keim-Malpass, Jessica, Ketterl, Tyler G., Khrouf, Mohamed, Kimelman, Dana, Kusuhara, Atsuko, Kutteh, William H., Laronda, Monica M., Lee, Jung Ryeol, Lehmann, Vicky, Letourneau, Joseph M., McGinnis, Lynda K, McMahon, Eileen, Meacham, Lillian R., Mijangos, Monserrat Fabiola Velez, Moravek, Molly, Nahata, Leena, Ogweno, George Moses, Orwig, Kyle E., Pavone, Mary Ellen, Peccatori, Fedro Alessandro, Pesce, Romina Ileana, Pulaski, Hanna, Quinn, Gwendolyn, Quintana, Ramiro, Quintana, Tomas, de Carvalho, Bruno Ramalho, Ramsey-Goldman, Rosalind, Reinecke, Joyce, Reis, Fernando M., Rios, Julie, Rhoton-Vlasak, Alice S., Rodriguez-Wallberg, Kenny A., Roeca, Cassandra, Rotz, Seth J., Rowell, Erin, Salama, Mahmoud, Saraf, Amanda J., Scarella, Anibal, Schafer-Kalkhoff, Tara, Schmidt, Deb, Senapati, Suneeta, Shah, Divya, Shikanov, Ariella, Shnorhavorian, Margarett, Skiles, Jodi L., Smith, James F., Smith, Kristin, Sobral, Fabio, Stimpert, Kyle, Su, H. Irene, Sugimoto, Kouhei, Suzuki, Nao, Thakur, Mili, Victorson, David, Viale, Luz, Vitek, Wendy, Wallace, W. Hamish, Wartella, Ellen A., Westphal, Lynn M., Whiteside, Stacy, Wilcox, Lea H., Wyns, Christine, Xiao, Shuo, Xu, Jing, and Zelinski, Mary

Published
2021
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25. Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion

Author

Mahmoud, Salama, Mitchell, Rod T, Laronda, Monica M., Goldman, Kara, Smith, Kristen, Pavone, Mary Ellen, Brannigan, Robert E., Ataman-Millhouse, Laura, Patrizio, Pasquale, Rodriguez-Wallberg, Kenny A., Okutsu-Horage, Yuki, Susuki, Nao, Lambertini, Matteo, Stern, Catharyn, Gomez-Lobo, Veronica, Maher, Jacqueline Y, Hsieh, M., Moravek, Molly, Anazodo, Antoinette, Westphal, Lynn M., Anderson, Richard A, Wallace, W Hamish B, Nahata, Leena, Whiteside, Stacy, Senapati, Suneeta, Shah, Divya K, Gracia, Clarisa R., Fino, Elizabeth M, Blakemore, Jennifer K, Quinn, Gwendolyn P, Krüssel, Jan-Steffen, Baston-Büst, Dunja-Maria, Liebenthron, Jana, Andersen, Claus Y, Kristensen, Stine Gry, Mamsen, Linn S, Jayasinghe, Yasmin, Su, Irene H, Dolmans, M. M., Dolmans, christiani A, Demeestere, Isabelle, De Vos, Isabelle, Van Moer, E., Isachenko, Vladimir, Isachenko, Evgenia, Mallmann, Peter, Rahimi, Gohar, Valli-pulaski, H, Steimer, S, McMahon, Katherine V., Orwig, Kyle E, Sroga, Julie, Smith, James F., Mok-Lin, Evelyn, Woodruff, Teresa K, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Surgical clinical sciences, Follicle Biology, and Centre for Reproductive Medicine - Gynaecology

Subjects
Male, Lymphoma, Best practice, Optimum resource settings, oncofertility, Oncofertility, breast cancer, Breast cancer, Japan, Neoplasms, Genetics, LYMPHOMA, Humans, Genetics (clinical), Cancer, Leukemia, leukemia, Obstetrics and Gynecology, Fertility Preservation, General Medicine, In Vitro Oocyte Maturation Techniques, Europe, oncology, Oocytes, Female, Childhood cancer, Developmental Biology, reproductive medicine
Abstract

PURPOSE: The main objective of Repro-Can-OPEN Study Part 2 is to learn more about oncofertility practices in optimum resource settings to provide a roadmap to establish oncofertility best practice models. METHODS: As an extrapolation for oncofertility best practice models in optimum resource settings, we surveyed 25 leading and well-resourced oncofertility centers and institutions from the USA, Europe, Australia, and Japan. The survey included questions on the availability and degree of utilization of fertility preservation options in case of childhood cancer, breast cancer, and blood cancer. RESULTS: All surveyed centers responded to all questions. Responses and their calculated oncofertility scores showed three major characteristics of oncofertility practice in optimum resource settings: (1) strong utilization of sperm freezing, egg freezing, embryo freezing, ovarian tissue freezing, gonadal shielding, and fractionation of chemo- and radiotherapy; (2) promising utilization of GnRH analogs, oophoropexy, testicular tissue freezing, and oocyte in vitro maturation (IVM); and (3) rare utilization of neoadjuvant cytoprotective pharmacotherapy, artificial ovary, in vitro spermatogenesis, and stem cell reproductive technology as they are still in preclinical or early clinical research settings. Proper technical and ethical concerns should be considered when offering advanced and experimental oncofertility options to patients. CONCLUSIONS: Our Repro-Can-OPEN Study Part 2 proposed installing specific oncofertility programs for common cancers in optimum resource settings as an extrapolation for best practice models. This will provide efficient oncofertility edification and modeling to oncofertility teams and related healthcare providers around the globe and help them offer the best care possible to their patients.

Published
2021
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40. Euploidy in relation to blastocyst sex and morphology.

Author

Wang, Ange, Kort, Jonathan, Behr, Barry, and Westphal, Lynn M.

Subjects
BLASTOCYST, CELL morphology, PLOIDY, HUMAN in vitro fertilization, PREIMPLANTATION genetic diagnosis
Abstract

Purpose: The objective of our study is to assess the relationship of embryo ploidy status in relation to embryo sex, morphological characteristics, and transfer parameters.Methods: This is a retrospective cohort study at an academic medical center of patients who underwent in vitro fertilization with preimplantation genetic screening (PGS) from 2010 to 2015. Embryos were screened with 24-chromosome preimplantation genetic screening with day 5/6 trophectoderm biopsy. We investigated embryo euploidy in relation to morphology (expansion, inner cell mass, trophectoderm), embryo sex, biopsy day, and blastocyst cohort size. We used multivariate logistic regression to calculate odds ratios of euploidy in relation to these parameters.Results: A total of 1559 embryos from 316 cycles and 233 patients (mean maternal age = 37.8 ± 4.2 years) were included in the analysis. Six hundred and twenty-eight blastocysts (40.3%) were found to be euploid. Expansion (p < 0.001), inner cell mass (ICM) (p < 0.01), and trophectoderm grade (p < 0.001) were significantly associated with embryo ploidy in bivariate models controlling for maternal age, while embryo sex, biopsy day, and blastocyst cohort size were not associated with embryo ploidy. In a multivariate model, we found that maternal age (p < 0.001), higher grade of expansion (p < 0.01), and better quality trophectoderm (p < 0.001 for A compared to C grade) remained significantly associated with increased embryo euploidy, but ICM grade was no longer significant. Embryo sex was not associated with ploidy status, though male embryos were found to be associated with higher trophectoderm scores (p < 0.02).Conclusions: This is the largest study to date to investigate PGS-tested embryo sex and ploidy status. While maternal age and some morphological parameters (expansion, trophectoderm grade) are associated with euploidy in our cohort, other parameters such as embryo sex, biopsy day, and cohort size are not. Though embryo sex was not associated with euploidy, male embryos were found to be associated with higher trophectoderm grades. Additional investigation in larger studies is warranted. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Medical egg freezing: the importance of a patient-centered approach to fertility preservation.

Author

Inhorn, Marcia C., Birenbaum-Carmeli, Daphna, Westphal, Lynn M., Doyle, Joseph, Gleicher, Norbert, Meirow, Dror, Raanani, Hila, Dirnfeld, Martha, and Patrizio, Pasquale

Subjects
FERTILITY preservation, OVUM cryopreservation, PATIENT-centered care, ANTHROPOLOGISTS in medicine, MOTIVATION (Psychology)
Abstract

Purpose: This binational qualitative study of medical egg freezing (MEF) examined women's motivations and experiences, including their perceived needs for patient-centered care in the midst of fertility- and life-threatening diagnoses. Methods: Forty-five women who had undertaken MEF were interviewed in the USA (33 women) and in Israel (12 women) between June 2014 and August 2016. Interviews lasted approximately 1 h and were conducted by two senior medical anthropologists, one in each country. Women were recruited from four American IVF clinics (two academic, two private) and two Israeli clinics (both academic) where MEF is being offered to cancer patients and women with other fertility-threatening medical conditions. Results: Women who undertake MEF view their fertility and future motherhood as important components of their identities and recovery and, thus, are grateful for the opportunity to pursue fertility preservation. However, women who undergo MEF have special needs, given that they tend to be a 'vulnerable' population of young (age < 30), unmarried, resource-constrained women, who are facing not only fertility loss but also the 'double jeopardy' of cancer. Through in-depth, qualitative interviews, these women's MEF stories reveal 10 dimensions of care important to fertility preservation, including five 'system factors' (information, coordination and integration, accessibility, physical comfort, cost) and five 'human factors' (adolescent issues, male partner involvement, family involvement, egg disposition decisions, emotional support). Together, these dimensions of care constitute an important framework that can be best described as 'patient-centered MEF.' Conclusions: Women pursuing MEF have special medical needs and concerns, which require particular forms of patient-centered care. This study outlines 10 dimensions of patient-centered fertility preservation that are appropriate for MEF patients. This approach may help IVF clinics to be better prepared for delivering top-quality care to mostly young, single women facing the daunting prospect of fertility loss and life-threatening medical diagnoses. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Results of a pilot study in the U.S. and Vietnam to assess the utility and acceptability of a multi-level pregnancy test (MLPT) for home monitoring of hCG trends after assisted reproduction.

Author

Shochet, Tara, Comstock, Ioanna A., Nguyen Thi Nhu Ngoc, Westphal, Lynn M., Sheldon, Wendy R., Ly Thai Loc, Blum, Jennifer, Winikoff, Beverly, Blumenthal, Paul D., Ngoc, Nguyen Thi Nhu, and Loc, Ly Thai

Subjects
PREGNANCY tests, CHORIONIC gonadotropins, REPRODUCTIVE health services, REPRODUCTIVE technology, URINALYSIS, EMBRYO transfer, HUMAN reproduction, HUMAN reproductive technology, PILOT projects, PATIENTS' attitudes, PSYCHOLOGY
Abstract

Background: To evaluate the utility and acceptability of using multi-level pregnancy tests (MLPTs) at home to monitor hCG trends following assisted reproductive technology (ART).Methods: One hundred and four women presenting for ART at either Stanford Medicine Fertility and Reproductive Health Clinic (Stanford, CA) or Hung Vuong Hospital (Ho Chi Minh City, Vietnam) participated in this pilot study. Women were asked to perform the MLPT at home, primarily on days when they were also scheduled to receive standard clinic-based serum hCG testing. These tests were administered up to 6 times over the 6-week period following embryo transfer or intrauterine insemination (IUI). Concordance of serial hCG readings for each time point was assessed by comparing trends in urine MLPT results with trends in serum hCG. Stable or increasing hCG level was interpreted as an indication of a progressing pregnancy, while a declining hCG was interpreted as a lack of established or progressing pregnancy. At study end, all participants were asked about the acceptability and convenience of using the MLPT at home for monitoring hCG trends following ART.Results: Data from both urine and serum testing are available for 156 of 179 clinic visits (87.2%). There was high concordance of serial trend results between the two types of tests: among the 156 sets of serum and urine hCG data points, 150 (96.2%) showed a matching trend in hCG pattern and 6 (3.8%) resulted in a discordant trend. Seventy-three percent of women reported being satisfied or very satisfied with using the MLPTs at home. Almost all (96.6%) said that the MLPT was easy or very easy to use.Conclusion: The MLPT offers women and health care providers a client-friendly diagnostic tool to detect very early pregnancy and monitor its progress.Trial Registration: This study was registered on clinicaltrials.gov as NCT01846403 (May 1, 2013), and NCT01919502 (August 5, 2013). [ABSTRACT FROM AUTHOR]

Published
2017
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50. Fertility Issues for Newly Diagnosed Women Interested in Child Bearing: Strategies and Options.

Author

Moayeri, Sharon E. and Westphal, Lynn M.

Abstract

Breast cancer is the most common cancer among reproductive aged women, accounting for 30% of all cancers. In the United States during 2005, more than 210,000 new cases of breast cancer were reported and approximately 11,000 occurred in women younger than 40 years. Among the many concerns experienced by patients with breast cancer, fertility issues can be a particular concern. Identifying this need and offering specialized counseling at the earliest possible point in the patient΄s care can potentially preserve options for future pregnancy in the young woman with breast cancer. [ABSTRACT FROM AUTHOR]

Published
2011
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