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894 results on '"Wilhelm, Sabine"'

1. Optimizing Smartphone-Delivered Cognitive Behavioral Therapy for Body Dysmorphic Disorder Using Passive Smartphone Data: Initial Insights From an Open Pilot Trial

Author

Weingarden, Hilary, Matic, Aleksandar, Calleja, Roger Garriga, Greenberg, Jennifer L, Harrison, Oliver, and Wilhelm, Sabine

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundSmartphone-delivered cognitive behavioral therapy (CBT) is becoming more common, but research on the topic remains in its infancy. Little is known about how people typically engage with smartphone CBT or which engagement and mobility patterns may optimize treatment. Passive smartphone data offer a unique opportunity to gain insight into these knowledge gaps. ObjectiveThis study aimed to examine passive smartphone data across a pilot course of smartphone CBT for body dysmorphic disorder (BDD), a psychiatric illness characterized by a preoccupation with a perceived defect in physical appearance, to inform hypothesis generation and the design of subsequent, larger trials. MethodsA total of 10 adults with primary diagnoses of BDD were recruited nationally and completed telehealth clinician assessments with a reliable evaluator. In a 12-week open pilot trial of smartphone CBT, we initially characterized natural patterns of engagement with the treatment and tested how engagement and mobility patterns across treatment corresponded with treatment response. ResultsMost participants interacted briefly and frequently with smartphone-delivered treatment. More frequent app usage (r=–0.57), as opposed to greater usage duration (r=–0.084), correlated strongly with response. GPS-detected time at home, a potential digital marker of avoidance, decreased across treatment and correlated moderately with BDD severity (r=0.49). ConclusionsThe sample was small in this pilot study; thus, results should be used to inform the hypotheses and design of subsequent trials. The results provide initial evidence that frequent (even if brief) practice of CBT skills may optimize response to smartphone CBT and that mobility patterns may serve as useful passive markers of symptom severity. This is one of the first studies to examine the value that passively collected sensor data may contribute to understanding and optimizing users’ response to smartphone CBT. With further validation, the results can inform how to enhance smartphone CBT design.

Published
2020
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2. Digital Biomarkers of Social Anxiety Severity: Digital Phenotyping Using Passive Smartphone Sensors

Author

Jacobson, Nicholas C, Summers, Berta, and Wilhelm, Sabine

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundSocial anxiety disorder is a highly prevalent and burdensome condition. Persons with social anxiety frequently avoid seeking physician support and rarely receive treatment. Social anxiety symptoms are frequently underreported and underrecognized, creating a barrier to the accurate assessment of these symptoms. Consequently, more research is needed to identify passive biomarkers of social anxiety symptom severity. Digital phenotyping, the use of passive sensor data to inform health care decisions, offers a possible method of addressing this assessment barrier. ObjectiveThis study aims to determine whether passive sensor data acquired from smartphone data can accurately predict social anxiety symptom severity using a publicly available dataset. MethodsIn this study, participants (n=59) completed self-report assessments of their social anxiety symptom severity, depressive symptom severity, positive affect, and negative affect. Next, participants installed an app, which passively collected data about their movement (accelerometers) and social contact (incoming and outgoing calls and texts) over 2 weeks. Afterward, these passive sensor data were used to form digital biomarkers, which were paired with machine learning models to predict participants’ social anxiety symptom severity. ResultsThe results suggested that these passive sensor data could be utilized to accurately predict participants’ social anxiety symptom severity (r=0.702 between predicted and observed symptom severity) and demonstrated discriminant validity between depression, negative affect, and positive affect. ConclusionsThese results suggest that smartphone sensor data may be utilized to accurately detect social anxiety symptom severity and discriminate social anxiety symptom severity from depressive symptoms, negative affect, and positive affect.

Published
2020
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15. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis

Author

Ramakrishnan, Divya, Farhat, Luis C., Vattimo, Edoardo F.Q., Levine, Jessica L.S., Johnson, Jessica A., Artukoglu, Bekir B., Landeros-Weisenberger, Angeli, Zangen, Abraham, Pelissolo, Antoine, de B. Pereira, Carlos A., Rück, Christian, Costa, Daniel L.C., Mataix-Cols, David, Shannahoff-Khalsa, David, Tolin, David F., Zarean, Elham, Meyer, Elisabeth, Hawken, Emily R., Storch, Eric A., Andersson, Erik, Miguel, Euripedes C., Maina, Giuseppe, Leckman, James F., Sarris, Jerome, March, John S., Diniz, Juliana B., Kobak, Kenneth, Mallet, Luc, Vulink, Nienke C.C., Amiaz, Revital, Fernandes, Rodrigo Yacubian, Shavitt, Roseli G., Wilhelm, Sabine, Golshan, Shahrokh, Tezenas du Montcel, Sophie, Erzegovesi, Stefano, Baruah, Upasana, Greenberg, William M., Kobayashi, Yuki, and Bloch, Michael H.

Published
2024
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41. Defining tic severity and tic impairment in Tourette Disorder

Author

McGuire, Joseph F., Piacentini, John, Storch, Eric A., Ricketts, Emily J., Woods, Douglas W., Peterson, Alan L., Walkup, John T., Wilhelm, Sabine, Ramsey, Kesley, Essoe, Joey K.-Y., Himle, Michael B., Lewin, Adam B., Chang, Susanna, Murphy, Tanya K., McCracken, James T., and Scahill, Lawrence

Published
2021
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43. The efficacy of psychological treatments on body dysmorphic disorder: a meta-analysis and trial sequential analysis of randomized controlled trials.

Author

Liu, Yinong, Lai, Lizu, Wilhelm, Sabine, Phillips, Katharine A., Guo, Yunxiao, Greenberg, Jennifer L., and Ren, Zhihong

Subjects
PREVENTION of mental depression, ANXIETY prevention, PSYCHOTHERAPY, MEDICAL information storage & retrieval systems, RESEARCH funding, EXECUTIVE function, SEX distribution, TREATMENT effectiveness, BODY dysmorphic disorder, META-analysis, RANDOMIZED controlled trials, MEDLINE, QUALITY of life, MEDICAL databases, ONLINE information services, PSYCHOLOGY information storage & retrieval systems
Abstract

This meta-analysis and trial sequential analysis (TSA) of randomized controlled trials (RCTs) on the psychological treatment of body dysmorphic disorder (BDD) was conducted to evaluate the intervention effects and robustness of the evidence. This study included 15 RCTs up until 15 June 2024, with 905 participants. Results showed significant improvements in BDD symptoms (g = −0.97), depression (g = −0.51), anxiety (g = −0.72), insight/delusion (g = −0.57), psychosocial functioning (g = 0.45), and quality of life (g = 0.44), with effects sustained from 1 to 6 months follow-up. RCTs with a waitlist/inactive control reported larger effect sizes for post-intervention BDD symptoms compared to those with a placebo/active control group. In addition, studies with low risk of bias demonstrate larger effect sizes for post-intervention psychosocial functioning compared to studies with some concerns. Notably, the presence of exposure and response prevention in the treatment, as well as the mode of delivery (face-to-face or digital), did not have a significant impact on the intervention outcomes. Females exhibited greater effect sizes in post-intervention BDD symptoms and psychosocial functioning than males. With increasing age, the effect size for insight/delusion symptoms diminished. Longer session duration was associated with larger effect sizes for BDD symptoms, depression at post-treatment, and depression at follow-up. TSA indicated robust evidence for depression at post-treatment and BDD symptoms, while the remaining outcome variables did not meet the desired level of evidence. In conclusion, this study underscores the effectiveness of psychological treatments in reducing BDD symptoms and improving related outcomes, highlighting the need for further research to confirm the impact of these therapies on other outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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44. An Online Mindfulness‐Based Group Intervention for Tics: A Pilot Randomized Controlled Trial.

Author

Reese, Hannah E., Brown, William Alan, Summers, Berta, Hoeppner, Susanne, Miller, Sarah B., and Wilhelm, Sabine

Abstract

Background: Current treatments for Tourette syndrome (TS) and persistent tic disorder (PTD) are often insufficiently effective, inaccessible, and frequently associated with adverse events. Thus, we must continue to develop and test effective, accessible, and safe treatment options. Objective: We aimed to conduct a pilot randomized controlled trial (RCT) comparing a novel, videoconference‐delivered group mindfulness‐based intervention for tics (MBIT) to videoconference‐delivered group psychoeducation, relaxation, and supportive therapy (PRST) for adults with TS or PTD. Methods: Thirty‐two adults with TS or PTD were randomly assigned to receive 8 weeks of either MBIT or PRST. Tic severity, tic‐related impairment, and global improvement were assessed by a trained, independent evaluator who was masked to treatment condition at baseline (week 0), posttreatment (week 9), 1‐month follow‐up, and 6‐month follow‐up. All study procedures were conducted online via secure videoconferencing. Results: Twenty‐eight participants began treatment and were included in analyses. MBIT, relative to PRST, was associated with a significantly greater decline in tic severity (d = 0.85) and tic‐related impairment (d = 0.99) from baseline to posttreatment. Treatment response was significantly higher in MBIT (69%) than in PRST (13%). Neither treatment resulted in serious adverse effects. The durability of treatment outcomes is also reported and discussed. Conclusions: The results from this pilot RCT suggest that videoconference‐delivered group MBIT may be an efficacious, accessible, and safe intervention for adults with tics. Future research is necessary to confirm these preliminary findings. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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48. The Centrality of Doubting and Checking in the Network Structure of Obsessive-Compulsive Symptom Dimensions in Youth

Author

Cervin, Matti, Perrin, Sean, Olsson, Elin, Aspvall, Kristina, Geller, Daniel A., Wilhelm, Sabine, McGuire, Joseph, Lázaro, Luisa, Martínez-González, Agustin E., Barcaccia, Barbara, Pozza, Andrea, Goodman, Wayne K., Murphy, Tanya K., Seçer, İsmail, Piqueras, José A., Rodríguez-Jiménez, Tiscar, Godoy, Antonio, Rosa-Alcázar, Ana I., Rosa-Alcázar, Ángel, Ruiz-García, Beatriz M., Storch, Eric A., and Mataix-Cols, David

Published
2020
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