1. Comparison of the Framingham Risk Score, UKPDS Risk Engine, and SCORE for Predicting Carotid Atherosclerosis and Peripheral Arterial Disease in Korean Type 2 Diabetic Patients
- Author
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Seong-Woo Choi, Young-Hoon Lee, Min-Ho Shin, Jin-Su Choi, Sun-Seog Kweon, Woo-Jun Yun, Jung-Ae Rhee, Hye-Yeon Kim, and Hye-Ran Ahn
- Subjects
medicine.medical_specialty ,Framingham Risk Score ,business.industry ,United Kingdom Prospective Diabetes Study ,Odds ratio ,Type 2 diabetes ,medicine.disease ,Risk Assessment ,Confidence interval ,Surgery ,Peripheral Arterial Disease ,Quartile ,Diabetes Mellitus, Type 2 ,Internal medicine ,Diabetes mellitus ,medicine ,Cardiology ,cardiovascular system ,Original Article ,cardiovascular diseases ,Carotid Artery Thrombosis ,Family Practice ,Risk assessment ,business - Abstract
BACKGROUND To compare the predictability of the Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study (UKPDS) risk engine, and the Systematic Coronary Risk Evaluation (SCORE) for carotid atherosclerosis and peripheral arterial disease in Korean type 2 diabetic patients. METHODS Among 1,275 registered type 2 diabetes patients in the health center, 621 subjects with type 2 diabetes participated in the study. Well-trained examiners measured the carotid intima-media thickness (IMT), carotid plaque, and ankle brachial index (ABI). The subject's 10-year risk of coronary heart disease was calculated according to the FRS, UKPDS, and SCORE risk scores. These three risk scores were compared to the areas under the curve (AUC). RESULTS The odds ratios (ORs) of all risk scores increased as the quartiles increased for plaque, IMT, and ABI. For plaque and IMT, the UKPDS risk score provided the highest OR (95% confidence interval) at 3.82 (2.36, 6.17) and at 6.21 (3.37, 11.45). For ABI, the SCORE risk estimation provided the highest OR at 7.41 (3.20, 17.18). However, no significant difference was detected for plaque, IMT, or ABI (P = 0.839, 0.313, and 0.113, respectively) when the AUCs of the three risk scores were compared. When we graphed the Kernel density distribution of these three risk scores, UKPDS had a higher distribution than FRS and SCORE. CONCLUSION No significant difference was observed when comparing the predictability of the FRS, UKPDS risk engine, and SCORE risk estimation for carotid atherosclerosis and peripheral arterial disease in Korean type 2 diabetic patients.
- Published
- 2011