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Automated External Defibrillators (AED) incorporate a shock decision algorithm that analyzes the patient's electrocardiogram (EKG), allowing lay persons to provide life saving defibrillation therapy to out-of-hospital cardiac arrest (OHCA) patients. The most accurate shock decision algorithms are based on deep learning, but these algorithms have not been trained and tested using OHCA data. In this study we propose novel deep learning architectures for shock decision algorithms based on convolutional and residual networks. EKG electronic recordings from a cohort of 852 OHCA cases (4216 AED EKG analyses) were used in the study. EKGs were annotated by a pool of six expert clinicians resulting in 3718 nonshockable and 498 shockable EKGs. Data were partitioned patient wise in a stratified way to train and test the models using 10-fold cross validation, and the procedure was repeated 100 times for statistical evaluation. Performance was assessed using sensitivity (shockable), specificity (non-shockable) and accuracy, and the analysis was conducted for EKG segments of decreasing duration. The best model had median (interdecile range) accuracies of 98.6 (98.5-98.7)%, 98.4 (98.2-98.6)%, 98.2 (97.9-98.4)%, and 97.6 (97.4-97.8)%, for 4, 3, 2 and 1 second EKG segments, respectively. The minimum 90% sensitivity and 95% specificity requirements established by the American Heart Association for shock decision algorithms were met, and the best model presented significantly greater accuracy (p