1,118 results on '"Xin, Yin"'
Search Results
2. Prevalence of turnover intention among emergency nurses worldwide: a meta-analysis
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Hui Ren, Yingchun Xue, Pan Li, Xin Yin, Wenhao Xin, and Hongyan Li
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Meta-analysis ,Emergency department ,Nurses ,Turnover intention ,Prevalence ,Nursing ,RT1-120 - Abstract
Abstract Aim To explore the prevalence of turnover intentions among emergency nurses across the globe, decision-makers should be offered evidence-based assistance. Background and introduction Compared with those of general nurses, the unique work environment and pressure significantly impact emergency nurses’ turnover intention. High personnel turnover intention often hinders the provision of high-quality emergency services. Methods This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Published and unpublished papers were identified through electronic searches of PubMed, Web of Science, EMBASE, CINAHL, and the Cochrane Library from their establishment until February 1, 2023. The literature included in this study may encompass cross-sectional studies and longitudinal studies. Two researchers independently screened the literature, extracted data, and assessed the quality of the included studies while using the tool developed by Hoy and colleagues in 2012. Stata 17.0 was used for all the statistical analyses. Results This study included 12 articles by screening 744 articles, which included a total of 4400 nurses. All studies included in the analysis were cross-sectional. The overall prevalence of turnover intention among emergency nurses was 45%. Further analysis revealed that the turnover intention prevalence among emergency nurses in Asia was 54%, whereas in other regions, it was 38%. The turnover intention among younger nurses (61%) was significantly greater than that among older nurses (30%). Compared with the published scale, the self-developed scale resulted in a higher turnover intention rate of 52%, which was 41%. Conclusion The prevalence of emergency nurses’ turnover intention is relatively high and shows an increasing trend, with noticeable variations across different regions and age groups. Notably, Asian nurses and those younger than 35.6 years exhibit a greater intention to turnover. Patient or public contribution There is no patient or public involvement, as this article is a meta-analysis. Implications for nursing and health policy Nursing managers, administrators, and policymakers must recognize the seriousness of high turnover intentions among emergency nurses and develop effective prevention strategies to address this issue globally.
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- 2024
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3. Glyphosate resistance and no fitness cost in backcross offspring of wild soybean and transgenic soybean with epsps gene
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Laipan Liu, Li Zhang, Zhixiang Fang, Wenjing Shen, Xin Yin, Zhentao Ren, Qi Yu, Jingang Liang, and Biao Liu
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Wild soybean ,Foreign gene ,Backcross progeny ,Fitness ,Glyphosate resistance ,Ecological risk ,Botany ,QK1-989 - Abstract
Abstract Background The commercial utilization of genetically modified soybeans has yielded substantial economic advantages. Nevertheless, the genetic drift towards wild soybeans is one of the main ecological risks that needs to be addressed. Previous experiments demonstrated the absence of fitness cost or florescence overlap in hybrid offspring resulting from the crossbreeding of transgenic soybean GTS40-3-2 and Zhengzhou wild soybeans. In this study, hybrid progeny was systematically crossed with wild soybeans to establish a backcross progeny system. This system was employed to evaluate the ecological risk associated with the backcross progeny of transgenic and wild soybeans. Results The findings indicated that the offspring from the backcross exhibited glyphosate tolerance. Furthermore, the expression of foreign proteins in the backcross offspring was notably lower than in the transgenic soybean, and there was no significant difference when compared to the hybrid progeny. Parameters such as germination rate, aboveground biomass, pods per plant, full seeds per plant, and 100-grain weight exhibited no significant differences between the negative and positive lines of the backcross progenies, and no fitness cost was identified in comparison to wild soybeans. These results underscore the potential for foreign genes to propagate within other wild soybeans, which requires continuous attention. Conclusions The widespread adoption of genetically modified soybeans has undeniably led to substantial economic gains. However, the research findings emphasize the critical importance of addressing the ecological risks posed by genetic drift towards wild soybeans. The backcross progeny system established in this study indicates that the potential for foreign gene dissemination to wild soybean populations warrants continued attention and mitigation strategies.
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- 2024
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4. A topological Hund nodal line antiferromagnet
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Xian P. Yang, Yueh-Ting Yao, Pengyu Zheng, Shuyue Guan, Huibin Zhou, Tyler A. Cochran, Che-Min Lin, Jia-Xin Yin, Xiaoting Zhou, Zi-Jia Cheng, Zhaohu Li, Tong Shi, Md Shafayat Hossain, Shengwei Chi, Ilya Belopolski, Yu-Xiao Jiang, Maksim Litskevich, Gang Xu, Zhaoming Tian, Arun Bansil, Zhiping Yin, Shuang Jia, Tay-Rong Chang, and M. Zahid Hasan
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Science - Abstract
Abstract The interplay of topology, magnetism, and correlations gives rise to intriguing phases of matter. In this study, through state-of-the-art angle-resolved photoemission spectroscopy, density functional theory, and dynamical mean-field theory calculations, we visualize a fourfold degenerate Dirac nodal line at the boundary of the bulk Brillouin zone in the antiferromagnet YMn2Ge2. We further demonstrate that this gapless, antiferromagnetic Dirac nodal line is enforced by the combination of magnetism, space-time inversion symmetry, and nonsymmorphic lattice symmetry. The corresponding drumhead surface states traverse the whole surface Brillouin zone. YMn2Ge2 thus serves as a platform to exhibit the interplay of multiple degenerate nodal physics and antiferromagnetism. Interestingly, the magnetic nodal line displays a d-orbital dependent renormalization along its trajectory in momentum space, thereby manifesting Hund’s coupling. Our findings offer insights into the effect of electronic correlations on magnetic Dirac nodal lines, leading to an antiferromagnetic Hund nodal line.
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- 2024
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5. The reduced cortical bone density in vertebral bodies: risk for osteoporotic fractures? Insights from CT analysis
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Yong Yang, Feng Liao, Xingbo Xing, Nianxi Liao, Dawei Wang, Xin Yin, Yihao Liu, Jidong Guo, Li Li, Huadong Wang, Chunyan Li, and Yang Zheng
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Osteoporotic vertebral fractures ,Cortical bone mineral density ,Cancellous mineral bone density ,Quantitative computed tomography ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background There is a corresponding increase in the prevalence of osteoporosis and related fractures with the aging population on the rise. Furthermore, osteoporotic vertebral compression fractures (OVCF) may contribute to higher patient mortality rates. It is essential to conduct research on risk factors for OVCF and provide a theoretical basis for preventing such fractures. Methods We retrospectively recruited patients who had spine CT for OVCF or back pain. Demographic and CT data were collected. Quantitative computed tomography (QCT) software analyzed the CT data, using subcutaneous fat and paraspinal muscles as reference standards for BMD processing. BMD of cortical and cancellous bones in each patient’s vertebral body was determined. Results In this study, 144 patients were divided into non-OVCF (96) and OVCF (48) groups. Non-OVCF patients had higher cortical BMD of 382.5 ± 52.4 to 444.6 ± 70.1 mg/cm3, with T12 having the lowest BMD (p
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- 2024
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6. A CRISPR/Cas12a-based platform for rapid on-site bovine viral diarrhea virus diagnostics
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Meixi Wang, Jitao Chang, Yuxin Han, Chaonan Wang, Songkang Qin, Jun Wang, Lulu Zhang, Yuanmao Zhu, Fei Xue, Fang Wang, Hongliang Chai, Yulong Wang, Xinjie Wang, and Xin Yin
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Agriculture (General) ,S1-972 - Published
- 2024
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7. The different serum albumin assays influence the prescriptions in children with primary nephrotic syndrome
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Hui Tang, Fei Liu, Guanyu Li, Lijuan Wu, Yue Li, Jiyuan Zeng, Xin Yin, Lei Pi, Xiaoqing Lin, Xiaoyi Cai, Zichuan Xu, Jinling Tang, Yanwei Hu, and Xia Gao
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Medicine ,Science - Abstract
Abstract The differences between the serum albumin determined by bromocresol green (BCG) and immunonephelometry (IN) were inconsistent in past studies, and the samples were all adults. We sought to determine the differences in children and reveal the impacts of these differences on the clinical diagnosis and treatments of primary nephrotic syndrome (PNS). Repeated measurements from 576 PNS children showed that albumin measured by BCG and IN (ALB-B and ALB-I) were 19.95 (11.15) g/L and 15.30 (11.05) g/L, respectively, and the mean difference was 4.68 g/L (P
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- 2024
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8. Conventional superconductivity in the doped kagome superconductor Cs(V0.86Ta0.14)3Sb5 from vortex lattice studies
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Yaofeng Xie, Nathan Chalus, Zhiwei Wang, Weiliang Yao, Jinjin Liu, Yugui Yao, Jonathan S. White, Lisa M. DeBeer-Schmitt, Jia-Xin Yin, Pengcheng Dai, and Morten Ring Eskildsen
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Science - Abstract
Abstract A hallmark of unconventional superconductors is a complex electronic phase diagram where intertwined orders of charge-spin-lattice degrees of freedom compete and coexist. While the kagome metals such as CsV3Sb5 also exhibit complex behavior, involving coexisting charge density wave order and superconductivity, much is unclear about the microscopic origin of the superconducting pairing. We study the vortex lattice in the superconducting state of Cs(V0.86Ta0.14)3Sb5, where the Ta-doping suppresses charge order and enhances superconductivity. Using small-angle neutron scattering, a strictly bulk probe, we show that the vortex lattice exhibits a strikingly conventional behavior. This includes a triangular symmetry with a period consistent with 2e-pairing, a field dependent scattering intensity that follows a London model, and a temperature dependence consistent with a uniform superconducting gap. Our results suggest that optimal bulk superconductivity in Cs(V1−x Ta x )3Sb5 arises from a conventional Bardeen-Cooper-Schrieffer electron-lattice coupling, different from spin fluctuation mediated unconventional copper- and iron-based superconductors.
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- 2024
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9. Enhancing the Interaction of Carbon Nanotubes by Metal–Organic Decomposition with Improved Mechanical Strength and Ultra-Broadband EMI Shielding Performance
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Shi, Yu-Ying, Liao, Si-Yuan, Wang, Qiao-Feng, Xu, Xin-Yun, Wang, Xiao-Yun, Gu, Xin-Yin, Hu, You-Gen, Zhu, Peng-Li, Sun, Rong, and Wan, Yan-Jun
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- 2024
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10. How does psychosocial safety climate cross-level influence work engagement and job burnout: the roles of organization-based self-esteem and psychological detachment
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Tongshuang Yuan, Hui Ren, Xin Yin, Leilei Liang, Junsong Fei, Xiaoying Liu, Chengbin Zheng, Huimin Wang, Jiaying Gao, Songli Mei, and Hongyan Li
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Psychosocial safety climate ,Work engagement ,Job burnout ,Nurses ,Cross-level model ,Nursing ,RT1-120 - Abstract
Abstract Background Existing researches on nurses’ work engagement and job burnout have mostly stayed at the individual level, and limited researches test the cross-level effects of psychosocial safety climate (PSC). The study aimed to explore the cross-level mediating effect of organization-based self-esteem (OBSE) and the moderating effect of psychological detachment between the relationship of PSC and work engagement and job burnout in nurses. Methods The cross-sectional study was conducted during November to December 2022 at a tertiary hospital in a northeastern province of China. Data was collected from 1832 nurses through an online questionnaire. Correlation analyses and hierarchical linear modeling were used to test study hypotheses. Results The results showed that PSC was positively associated with work engagement, and negatively associated with job burnout. OBSE mediated the effect of PSC on work engagement, as well as job burnout. Additionally, psychological detachment played a moderating role between PSC and work engagement, but no moderating effect was found between PSC and job burnout. Conclusions PSC at the organizational level increases work engagement and reduces job burnout by stimulating nurses’ high levels of OBSE. Psychological detachment, as a situational factor, enhances the positive influence of PSC on work engagement. The implementation of measures to improve the PSC levels of the organization, and the levels of OBSE and psychological detachment among nurses could help to promote their good work performance.
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- 2024
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11. Dyadic effects of financial toxicity and social support on the fear of cancer recurrence in breast cancer patients and caregivers: an actor–partner interdependence mediation model
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Hongyan Li, Yabin Sun, Tianye Yang, Xin Yin, Zhu Zhu, Jianjun Shi, Lingling Tong, Jia Yang, and Hui Ren
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Breast cancer ,Fear of cancer recurrence ,Financial toxicity ,Social support ,Actor–partner interdependence mediation model ,Nursing ,RT1-120 - Abstract
Abstract Purpose In this study, the actor–partner interdependence mediation model (APIMeM) was applied to breast cancer patients and their caregivers to assess the factors that affect the fear of cancer recurrence. In particular, the purpose of this study was to evaluate the mediating effect of social support on financial toxicity and the fear of cancer recurrence, providing an effective basis for developing plans to reduce the level of fear of cancer recurrence. Methods This study employed a cross-sectional design, and 405 dyads of breast cancer patients and their caregivers were enrolled. Financial toxicity, social support, and fear of cancer recurrence were assessed by computing comprehensive scores for financial toxicity based on patient-reported outcome measures, the Social Support Rating Scale, and the Fear of Cancer Recurrence Inventory Short Form, respectively. The data were analysed using SPSS 24.0 and AMOS 23.0. Results The results showed that the fear of cancer recurrence of breast cancer patients and their caregivers was significantly related to dyadic financial toxicity and social support. In addition, the financial toxicity of breast cancer patients and their caregivers had significant actor effects and partner effects on the fear of cancer recurrence through dyadic social support. Conclusions The financial toxicity of breast cancer patients and their caregivers could produce actor and partner effects on the fear of cancer recurrence through the mediation of social support, which provided empirical support for improving reducing the level of fear of cancer recurrence among patients and caregivers at the dyadic level.
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- 2024
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12. Multimodal Machine Learning Guides Low Carbon Aeration Strategies in Urban Wastewater Treatment
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Hong-Cheng Wang, Yu-Qi Wang, Xu Wang, Wan-Xin Yin, Ting-Chao Yu, Chen-Hao Xue, and Ai-Jie Wang
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Wastewater treatment ,Multimodal machine learning ,Deep learning ,Aeration control ,Interpretable machine learning ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The potential for reducing greenhouse gas (GHG) emissions and energy consumption in wastewater treatment can be realized through intelligent control, with machine learning (ML) and multimodality emerging as a promising solution. Here, we introduce an ML technique based on multimodal strategies, focusing specifically on intelligent aeration control in wastewater treatment plants (WWTPs). The generalization of the multimodal strategy is demonstrated on eight ML models. The results demonstrate that this multimodal strategy significantly enhances model indicators for ML in environmental science and the efficiency of aeration control, exhibiting exceptional performance and interpretability. Integrating random forest with visual models achieves the highest accuracy in forecasting aeration quantity in multimodal models, with a mean absolute percentage error of 4.4% and a coefficient of determination of 0.948. Practical testing in a full-scale plant reveals that the multimodal model can reduce operation costs by 19.8% compared to traditional fuzzy control methods. The potential application of these strategies in critical water science domains is discussed. To foster accessibility and promote widespread adoption, the multimodal ML models are freely available on GitHub, thereby eliminating technical barriers and encouraging the application of artificial intelligence in urban wastewater treatment.
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- 2024
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13. Effects of Sheep Grazing and Nitrogen Addition on Dicotyledonous Seedling Abundance and Diversity in Alpine Meadows
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Huanhuan Dong, Yuqi Ma, Zuoyi Wang, Yuan Yang, Longxin Zhang, Xin Yin, Honglin Li, Lanping Li, Huakun Zhou, Zhen Ma, and Chunhui Zhang
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annual net primary productivity ,litter ,photosynthetically active radiation ,vegetation diversity ,seedling regeneration ,Ecology ,QH540-549.5 - Abstract
Seedling is a crucial stage in the growth and development of plants, and the expansion and persistence of plant populations can be achieved through seed regeneration. Sheep grazing, fertilization, light, soil moisture, vegetation diversity and biomass, and litter all have potential impacts on species regeneration. We measured vegetation diversity, annual net primary productivity (ANPP), litter, ground photosynthetically active radiation (PAR), and soil moisture of alpine meadows under sheep grazing and nitrogen addition treatments, and studied their effects on the dicotyledonous seedling abundance and diversity using linear regression models (LMs) and structural equation models (SEMs). We found that sheep grazing reduced ANPP, increased vegetation diversity and PAR, and decreased soil moisture. Fertilization increased ANPP and litter, decreased vegetation diversity and PAR, but had no effect on soil moisture. Sheep grazing and fertilization both reduced the abundance of dicotyledonous seedlings, and simultaneously fertilization can reduce the diversity of dicotyledonous seedlings, while sheep grazing had no effect on the diversity of dicotyledonous seedlings. LMs showed that vegetation diversity, ANPP, and litter, rather than light and soil moisture, affected dicotyledonous seedling abundance and diversity. SEMs revealed that sheep grazing and fertilization indirectly influenced seedling regeneration through vegetation diversity rather than ANPP and litter. Our research will increase our understanding of the dicotyledonous plant regeneration process in alpine grasslands and facilitate the development of strategies for management and protection of alpine grassland.
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- 2024
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14. Enhancement of superconductivity and phase diagram of Ta-doped Kagome superconductor CsV3Sb5
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Jinjin Liu, Qing Li, Yongkai Li, Xinwei Fan, Jun Li, Peng Zhu, Hanbin Deng, Jia-Xin Yin, Huaixin Yang, Jianqi Li, Hai-Hu Wen, and Zhiwei Wang
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Medicine ,Science - Abstract
Abstract Kagome superconductors AV3Sb5 (A = K, Rb, and Cs) have attracted enormous interest due to the coexistence of charge density wave (CDW) order, unconventional superconductivity (SC) and anomalous Hall effect (AHE). In this paper, we reported an intensive investigation on Cs(V1−x Ta x )3Sb5 single crystals with systematic Ta doping. Ta was confirmed to be doped into V-site in the Kagome layer from both single crystal X-ray diffraction structural refinement and scanning transmission electron microscopy observation. The highest Ta doping level was found to be about 16%, which is more than twice as much as 7% in Nb-doped CsV3Sb5. With the increase of Ta doping, CDW order was gradually suppressed and finally vanished when the doping level reached to more than 8%. Meanwhile, superconductivity was enhanced with a maximum critical temperature (Tc) of 5.3 K, which is the highest Tc in the bulk crystal of this Kagome system at ambient pressure so far. The μ 0 H c2(T) behavior demonstrates that the system is still a two-band superconductor after Ta doping. Based on the electrical transport measurement, a phase diagram was set up to exhibit the evolution of CDW and SC in the Cs(V1−x Ta x )3Sb5 system. These findings pave a new way to search for new superconductors with higher Tc in the AV3Sb5 family and establish a new platform for tuning and controlling the multiple orders and superconducting states.
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- 2024
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15. MOG-antibody-associated transverse myelitis with the H-sign and unusual MRI enhancement: a case report and literature review
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Lu Zhang, Chuan Feng, Ling He, Shi-Yu Huang, Xin-Yin Liu, and Xiao Fan
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myelin oligodendrocyte glycoprotein ,antibody ,myelitis ,magnetic resonance imaging ,H-sign ,Pediatrics ,RJ1-570 - Abstract
Transverse myelitis is the second most common symptoms in myelin oligodendrocyte antibody-associated diseases (MOGAD), causing obvious clinical manifestation. T2-hyperintense lesions mainly restricted to the gray matter in the spinal cord on axial magnetic resonance imaging, produce the H-sign, which is thought to be the typical finding of MOGAD. Contrast enhancement can be observed in some cases of myelin oligodendrocyte antibody-associated transverse myelitis (MOG-TM). However, reports on the enhancement pattern associated with the H-sign are rarely seen. In this report, we describe a case of pediatric MOG-TM in which the H-sign was observed without enhancement, while the surrounding white matter exhibited enhancement. This pattern contradicts the previously observed gray matter involvement. Then we reviewed the literatures of myelin oligodendrocyte antibody-positive myelitis to focus on the neuroimaging features and discuss the implications of our finding.
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- 2024
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16. A rotor open-phase imbalance protection for variable speed pumped storage unit based on rotation transformation fault component ratio
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Qinghui Lu, Jian Qiao, Xin Yin, Xianggen Yin, Zhichang Liu, Yikai Wang, and Kai Wang
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Variable speed pumped storage unit ,Rotor open-phase imbalance ,Fault component ratio ,Microcomputer protection ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
Doubly-fed variable speed pumped storage unit (VSPSU) adopts slip ring injection AC excitation mode, and its rotor side structure is complex and prone to open-phase faults. It is very important to configure specific open-phase imbalance protection to ensure its safe operation. Traditional doubly-fed motors only stay in the state monitoring stage for rotor electrical imbalance, which cannot meet the requirements of large-capacity VSPSU for fast, real-time, and high-reliability protection. Therefore, this paper proposes a VSPSU rotor open-phase imbalance protection method based on the rotation transformation fault component ratio (FCR). The fundamental frequency component and fault characteristic component of the stator current space vector are extracted by rotation transformation and FCR is calculated, and then different protection action modes are divided according to the amplitude of FCR. To realize the engineering application, a microcomputer protection algorithm suitable for the proposed protection method is further proposed, and then a complete microcomputer protection scheme is formed. Simulation and experiment results show that the proposed protection scheme has high sensitivity and fast action speed. At the same time, the proposed algorithm can be directly embedded in the existing microcomputer protection device to meet the needs of engineering applications.
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- 2024
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17. Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism
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Chu Zhang, Gui Wang, Xin Yin, Lingshan Gou, Mengyuan Guo, Feng Suo, Tao Zhuang, Zhenya Yuan, Yanan Liu, Maosheng Gu, and Ruiqin Yao
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PPP1R3G ,Obesity ,Liver steatosis ,Gut microbiota ,Bile acid metabolism ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Intestinal dysbiosis and disrupted bile acid (BA) homeostasis are associated with obesity, but the precise mechanisms remain insufficiently explored. Hepatic protein phosphatase 1 regulatory subunit 3G (PPP1R3G) plays a pivotal role in regulating glycolipid metabolism; nevertheless, its obesity-combatting potency remains unclear. In this study, a substantial reduction was observed in serum PPP1R3G levels in high-body mass index (BMI) and high-fat diet (HFD)-exposed mice, establishing a positive correlation between PPP1R3G and non-12α-hydroxylated (non-12-OH) BA content. Additionally, hepatocyte-specific overexpression of Ppp1r3g (PPP1R3G HOE) mitigated HFD-induced obesity as evidenced by reduced weight, fat mass, and an improved serum lipid profile; hepatic steatosis alleviation was confirmed by normalized liver enzymes and histology. PPP1R3G HOE considerably impacted systemic BA homeostasis, which notably increased the non-12-OH BAs ratio, particularly lithocholic acid (LCA). 16S ribosomal DNA (16S rDNA) sequencing assay indicated that PPP1R3G HOE reversed HFD-induced gut dysbiosis by reducing the Firmicutes/Bacteroidetes ratio and Lactobacillus population, and elevating the relative abundance of Blautia, which exhibited a positive correlation with serum LCA levels. A fecal microbiome transplantation test confirmed that the anti-obesity effect of hepatic PPP1R3G was gut microbiota-dependent. Mechanistically, PPP1R3G HOE markedly suppressed hepatic cholesterol 7α-hydroxylase (CYP7A1) and sterol-12α-hydroxylase (CYP8B1), and concurrently upregulated oxysterol 7-α hydroxylase and Takeda G protein-coupled BA receptor 5 (TGR5) expression under HFD conditions. Furthermore, LCA administration significantly mitigated the HFD-induced obesity phenotype and elevated non-12-OH BA levels. These findings emphasize the significance of hepatic PPP1R3G in ameliorating diet-induced adiposity and hepatic steatosis through the gut microbiota-BA axis, which may serve as potential therapeutic targets for obesity-related disorders.
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- 2024
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18. Phonon promoted charge density wave in topological kagome metal ScV6Sn6
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Yong Hu, Junzhang Ma, Yinxiang Li, Yuxiao Jiang, Dariusz Jakub Gawryluk, Tianchen Hu, Jérémie Teyssier, Volodymyr Multian, Zhouyi Yin, Shuxiang Xu, Soohyeon Shin, Igor Plokhikh, Xinloong Han, Nicholas C. Plumb, Yang Liu, Jia-Xin Yin, Zurab Guguchia, Yue Zhao, Andreas P. Schnyder, Xianxin Wu, Ekaterina Pomjakushina, M. Zahid Hasan, Nanlin Wang, and Ming Shi
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Science - Abstract
Abstract Charge density wave (CDW) orders in vanadium-based kagome metals have recently received tremendous attention, yet their origin remains a topic of debate. The discovery of ScV6Sn6, a bilayer kagome metal featuring an intriguing $$\sqrt{3}\times\sqrt{3}\times3$$ 3 × 3 × 3 CDW order, offers a novel platform to explore the underlying mechanism behind the unconventional CDW. Here, we combine high-resolution angle-resolved photoemission spectroscopy, Raman scattering and density functional theory to investigate the electronic structure and phonon modes of ScV6Sn6. We identify topologically nontrivial surface states and multiple van Hove singularities (VHSs) in the vicinity of the Fermi level, with one VHS aligning with the in-plane component of the CDW vector near the $$\bar{K}$$ K ¯ point. Additionally, Raman measurements indicate a strong electron-phonon coupling, as evidenced by a two-phonon mode and new emergent modes. Our findings highlight the fundamental role of lattice degrees of freedom in promoting the CDW in ScV6Sn6.
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- 2024
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19. Enhancing the Interaction of Carbon Nanotubes by Metal–Organic Decomposition with Improved Mechanical Strength and Ultra-Broadband EMI Shielding Performance
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Yu-Ying Shi, Si-Yuan Liao, Qiao-Feng Wang, Xin-Yun Xu, Xiao-Yun Wang, Xin-Yin Gu, You-Gen Hu, Peng-Li Zhu, Rong Sun, and Yan-Jun Wan
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EMI shielding ,Mechanical strength ,Carbon nanotubes ,Metal–organic decomposition ,Flexibility ,Technology - Abstract
Highlights A strategy based on metal-organic decomposition is proposed to enhance the tube-tube interactions of carbon nanotubes (CNTs). The robust tube-tube interactions of CNTs enhance both EMI shielding performance and mechanical properties of CNT film. This innovative approach provides an effective way to obtain high-performance CNT film.
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- 2024
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20. Hepatitis E virus infects human testicular tissue and Sertoli cells
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Tianxu Liu, Yalei Cao, Jiaming Weng, Songzhan Gao, Zirun Jin, Yun Zhang, Yuzhuo Yang, He Zhang, Changyou Xia, Xin Yin, Yong Luo, Qiyu He, Hui Jiang, Lin Wang, and Zhe Zhang
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Hepatitis E virus ,chronic hepatitis E ,extrahepatic replication ,human testis ,Sertoli cells ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
ABSTRACTGlobally, hepatitis E virus (HEV) infections are prevalent. The finding of high viral loads and persistent viral shedding in ejaculate suggests that HEV replicates within the human male genital tract, but its target organ is unknown and appropriate models are lacking. We aimed to determine the HEV tropism in the human testis and its potential influence on male reproductive health. We conducted an ex vivo culture of human testis explants and in vitro culture of primary human Sertoli cells. Clinically derived HEV genotype 1 (HEV1) and HEV3 virions, as well as rat-derived HEV-C1, were used for inoculation. Transcriptomic analysis was performed on testis tissues collected from tacrolimus-treated rabbits with chronic HEV3 infection. Our findings reveal that HEV3, but not HEV1 or HEV-C1, can replicate in human testis explants and primary human Sertoli cells. Tacrolimus treatment significantly enhanced the replication efficiency of HEV3 in testis explants and enabled successful HEV1 infection in Sertoli cells. HEV3 infection disrupted the secretion of several soluble factors and altered the cytokine microenvironment within primary human Sertoli cells. Finally, intratesticular transcriptomic analysis of immunocompromised rabbits with chronic HEV infection indicated downregulation of genes associated with spermatogenesis. HEV can infect the human testicular tissues and Sertoli cells, with increased replication efficiency when exposed to tacrolimus treatment. These findings shed light on how HEV may persist in the ejaculate of patients with chronic hepatitis E and provide valuable ex vivo tools for studying countermeasures.
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- 2024
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21. Emergence of novel reassortant H3N3 avian influenza viruses with increased pathogenicity in chickens in 2023
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Qiuyan Mao, Shuning Zhou, Shuo Liu, Cheng Peng, Xin Yin, Jinping Li, Yaxin Zhang, Wanting Zhou, Guangyu Hou, Wenming Jiang, and Hualei Liu
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Published
- 2024
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22. Metabolic profiling and spatial metabolite distribution in wild soybean (G. soja) and cultivated soybean (G. max) seeds
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Xin Yin, Zhentao Ren, Ruizong Jia, Xiaodong Wang, Qi Yu, Li Zhang, Laipan Liu, Wenjing Shen, Zhixiang Fang, Jingang Liang, and Biao Liu
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Glycine soja ,LC-MS/MS ,Soybean seeds ,Nutritional potential ,MALDI-MSI ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Wild soybeans retain many substances significantly reduced or lost in cultivars during domestication. This study utilized LC-MS to analyze metabolites in the seed coats and embryos of wild and cultivated soybeans. 866 and 815 metabolites were identified in the seed extracts of both soybean types, with 35 and 10 significantly differing metabolites in the seed coat and embryos, respectively. The upregulated metabolites in wild soybeans are linked to plant defense, stress responses, and nitrogen cycling. MALDI-MSI results further elucidated the distribution of these differential metabolites in the cotyledons, hypocotyls, and radicles. In addition to their role in physiological processes like growth and response to environmental stimuli, the prevalent terpenoids, lipids, and flavonoids present in wild soybeans exhibit beneficial bioactivities, including anti-inflammatory, antibacterial, anticancer, and cardiovascular disease prevention properties. These findings underscore the potential of wild soybeans as a valuable resource for enhancing the nutritional and ecological adaptability of cultivated soybeans.
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- 2024
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23. A coaxial multi-ring detection method for measuring the pitch and thickness accuracy of cylindrical gears
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Dehai Zhang, Junheng Li, Yanqin Li, Chao Wu, Tao Wang, Zhicheng Zhang, Xin Yin, and Hongshuai Hu
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Control engineering systems. Automatic machinery (General) ,TJ212-225 ,Technology (General) ,T1-995 - Abstract
Performance of gear transmissions affects the performance of mechanical equipment. It is necessary to develop more reliable gear pitch and tooth thickness accuracy detection methods in order to evaluate gear transmission performance and detect gear pitch and tooth thickness accuracy more accurately. Based on the basic theory of gears, binocular vision technology, and statistical principles, a new method that measures gear pitch and tooth thickness using machine vision is proposed: coaxial multi-ring detection (MCD). There is no contact, no damage, and a high degree of efficiency with this method. Using this method, we are able to detect the pitch and thickness accuracy of each gear tooth multiple times within the tooth width range and in multiple directions perpendicular to the gear axis. We statistically analyze the measurement results to determine the gear’s most accurate detection results. The measurement method for gear machining accuracy is investigated using the coaxial multi-ring detection method. The statistical analysis of multiple measurement results is carried out, and the measurement results obtained are highly consistent with those of the gear detection center. In conclusion, the measurement results of this method are highly reliable, and they can be used as a reliable basis for evaluating gear transmission performance.
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- 2024
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24. Influences of elevational gradient on flower size and number of Gentiana lawrencei var. farreri
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Mengyan Wang, Zuoyi Wang, Yuan Yang, Xinquan Zhao, Huakun Zhou, Shurong Zhou, Xin Yin, Yanmei Ren, Huanhuan Dong, Longxin Zhang, Zhen Ma, and Chunhui Zhang
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alpine plant ,climate change ,functional trait ,individual size ,reproductive allocation ,Ecology ,QH540-549.5 - Abstract
Abstract Plants can adapt to environmental changes by adjusting their functional traits and biomass allocation. The size and number of flowers are functional traits related to plant reproduction. Life history theory predicts that there is a trade‐off between flower size and number, and the trade‐off can potentially explain the adaptability of plants. Elevation gradients in mountains provide a unique opportunity to test how plants will respond to climate change. In this study, we tried to better explain the adaptability of the alpine plant Gentiana lawrencei var. farreri in response to climate change. We measured the flower size and number, individual size, and reproductive allocation of G. lawrencei var. farreri during the flowering period along an elevation gradient from 3200 to 4000 m, and explored their relationships using linear mixed‐effect models and the structural equation model. We found that with elevation increasing, individual size and flower number decreased and flower size increased, while reproductive allocation remained unchanged. Individual size positively affected flower number, but was not related to flower size; reproductive allocation positively affected flower size, but was not related to flower number; there is a clear trade‐off between flower size and number. We also found that elevation decreased flower number indirectly via directly reducing individual size. In sum, this study suggests that G. lawrencei var. farreri can adapt to alpine environments by the synergies or trade‐offs among individual size, reproductive allocation, flower size, and flower number. This study increases our understanding of the adaptation mechanisms of alpine plants to climate change in alpine environments.
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- 2024
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25. Exploring COVID-19 causal genes through disease-specific Cis-eQTLs
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Sainan Zhang, Ping Wang, Lei Shi, Chao Wang, Zijun Zhu, Changlu Qi, Yubin Xie, Shuofeng Yuan, Liang Cheng, Xin Yin, and Xue Zhang
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COVID-19 ,Expression quantitative trait loci ,Summary data-based mendelian randomization ,siRNA transfection ,Microbiology ,QR1-502 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Genome-wide association study (GWAS) analysis has exposed that genetic factors play important roles in COVID-19. Whereas a deeper understanding of the underlying mechanism of COVID-19 was hindered by the lack of expression of quantitative trait loci (eQTL) data specific for disease. To this end, we identified COVID-19-specific cis-eQTLs by integrating nucleotide sequence variations and RNA-Seq data from COVID-19 samples. These identified eQTLs have different regulatory effect on genes between patients and controls, indicating that SARS-CoV-2 infection may cause alterations in the human body's internal environment. Individuals with the TT genotype in the rs1128320 region seemed more susceptible to SARS-CoV-2 infection and developed into severe COVID-19 due to the abnormal expression of IFITM1. We subsequently discovered potential causal genes, of the result, a total of 48 genes from six tissues were identified. siRNA-mediated depletion assays in SARS-CoV-2 infection proved that 14 causal genes were directly associated with SARS-CoV-2 infection. These results enriched existing research on COVID-19 causal genes and provided a new sight in the mechanism exploration for COVID-19.
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- 2024
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26. Real-world study of hepatic artery infusion chemotherapy combined with anti-PD-1 immunotherapy for hepatocellular carcinoma patients with portal vein tumor thrombus
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Jinghuan Li, Bing Quan, Wenfeng Liu, Menglong Zhao, Fan Yao, Rongxin Chen, Zhenggang Ren, and Xin Yin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) present a poor prognosis. Current systemic therapies offer limited benefits. Hepatic artery infusion chemotherapy (HAIC) is a local regional treatment for advanced HCC, particularly in selected patients such as patients with PVTT or high intrahepatic tumor burden. Objectives: The purpose of this study is to retrospectively evaluate the efficacy and safety of HAIC combined with anti-PD-1 immunotherapy for HCC patients with PVTT, and explore factors related to survival prognosis, providing clues for treatment decisions for HCC patients. Design: This is a single-center retrospective study conducted over 2 years on consecutive PVTT patients receiving HAIC combined anti-PD-1 antibodies. Methods: The primary endpoint was overall survival (OS). Univariate and multivariate analyses were performed to identify prognostic factors affecting OS. Treatment-associated adverse events were evaluated as well. Results: A total of 119 patients were analyzed. The median OS and PFS were 14.9 months and 6.9 months. A total of 31.1% of grade 3–4 adverse events were reported, with elevated transaminase and total bilirubin being the most common. The independent variables correlated with survival include treatment-related alpha-fetoprotein (AFP) response, the presence of extrahepatic organ metastasis, absolute value of platelet (PLT), neutrophil-to-lymphocyte ratio, and combined usage of tyrosine kinase inhibitors (TKIs). Conclusion: In HCC patients with PVTT, combination therapy with HAIC and anti-PD-1 antibodies might be a promising therapy. The efficacy and safety of this combination protocol on patients with HCC complicated by PVTT warrants further investigation prospectively, especially in combination with TKIs.
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- 2024
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27. Development and application of one-step multiplex Real-Time PCR for detection of three main pathogens associated with bovine neonatal diarrhea
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Chaonan Wang, Fang Wang, Jitao Chang, Zhigang Jiang, Yuxin Han, Meixi Wang, Bo Jing, Aiyun Zhao, and Xin Yin
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neonatal calf diarrhea ,bovine rotavirus ,bovine coronavirus ,Escherichia coli k99 ,real-time PCR ,Microbiology ,QR1-502 - Abstract
IntroductionNeonatal calf diarrhea (NCD) is one of the most common diseases in calves, causing huge economic and productivity losses to the bovine industry worldwide. The main pathogens include bovine rotavirus (BRV), bovine coronavirus (BCoV), and Enterotoxigenic Escherichia coli (ETEC) K99. Since multiple infectious agents can be involved in calf diarrhea, detecting each causative agent by traditional methods is laborious and expensive.MethodsIn this study, we developed a one-step multiplex Real-Time PCR assay to simultaneously detect BRV, BCoV, and E. coli K99+. The assay performance on field samples was evaluated on 1100 rectal swabs of diseased cattle with diarrhea symptoms and compared with the conventional gel-based RT-PCR assay detect BRV, BCoV, and E. coli K99+.ResultsThe established assay could specifically detect the target pathogens without cross-reactivity with other pathogens. A single real-time PCR can detect ~1 copy/µL for each pathogen, and multiplex real-time PCR has a detection limit of 10 copies/µL. Reproducibility as measured by standard deviation and coefficient of variation were desirable. The triple real-time PCR method established in this study was compared with gel-based PT-PCR. Both methods are reasonably consistent, while the real-time PCR assay was more sensitive and could rapidly distinguish these three pathogens in one tube. Analysis of surveillance data showed that BRV and BCoV are major enteric viral pathogens accounting for calves’ diarrhea in China. DiscussionThe established assay has excellent specificity and sensitivity and was suitable for clinical application. The robustness and high-throughput performance of the developed assay make it a powerful tool in diagnostic applications and calf diarrhea research.
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- 2024
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28. Assessment of the impact of climate change on streamflow of Ganjiang River catchment via LSTM-based models
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Chao Deng, Xin Yin, Jiacheng Zou, Mingming Wang, and Yukun Hou
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Climate change ,Monthly runoff prediction ,LSTM-based models ,CMIP6 ,Ganjiang River catchment ,Physical geography ,GB3-5030 ,Geology ,QE1-996.5 - Abstract
Study region: Ganjiang River catchment, China. Study focus: Quantifying the effects of the impacts climate change on streamflow is of great importance for regional water resources management. In this study, four LSTM-based models, i.e., LSTM, Stack-LSTM, Bi-LSTM and CNN-LSTM, were constructed to assess hydrological changes under future climate change based on the bias-corrected Coupled Model Intercomparison Project Phase 6 meteorological data from four shared socioeconomic pathways (SSPs). New hydrological insights for the study region: (1) The Bi-LSTM achieves the best streamflow simulation performance during the validation period of 2006–2016, followed by the LSTM, Satck-LSTM and CNN-LSTM. The climate will get warmer and wetter in future scenarios with mean annual precipitation and temperature increasing by 3.0–6.2% and 8.3–13.4% (compared to baseline period), respectively. (2) The predicted streamflow will have a decrease of 1.5–16.5% during 2026–2075 under all SSP scenarios. The results of LSTM, Stack-LSTM, and Bi-LSTM models show a decrease of 0.27–50% in November to March, indicating that the dry season will become even drier in the future. These results reveal that the hydrological regime of the Ganjiang River is likely to change and will be characterized by greater seasonal uncertainty and more potential for extreme events due to significant warming and wetting over the future periods.
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- 2024
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29. Epigenetic silencing of callose synthase by VIL1 promotes bud-growth transition in lily bulbs
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Pan, Wenqiang, Li, Jingru, Du, Yunpeng, Zhao, Yajie, Xin, Yin, Wang, Shaokun, Liu, Chang, Lin, Zhimin, Fang, Shaozhong, Yang, Yingdong, Zaccai, Michele, Zhang, Xiuhai, Yi, Mingfang, Gazzarrini, Sonia, and Wu, Jian
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- 2023
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30. Prevalence and genetic characterization of hepatitis E virus in domestic Bactrian camels in northern China: Identification of a novel HEV8 subtype
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Gang LU, Xin YIN, Yan-qin LIU, Jin-xin XIE, and Shou-jun LI
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Agriculture (General) ,S1-972 - Published
- 2023
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31. Topological magnetic line defects in Fe(Te, Se) high-temperature superconductors
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Xianxin Wu, Jia-Xin Yin, Chao-Xing Liu, and Jiangping Hu
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Atomic physics. Constitution and properties of matter ,QC170-197 - Abstract
Abstract The realization of Majorana zero modes in condensed matter have been attracting enormous interests from fundamental science such as topological quantum computation. Recently iron based superconductors were identified as a high-temperature platform for realizing topological superconductivity and Majorana modes. As unconventional superconductors, one of the most important characteristics of them is that they are in the vicinity of magnetic states due to the strong Hund’s coupling in iron atoms. Here we propose that the line defects with missing Te/Se anions in Fe(Se, Te) superconductors provide the realization of intrinsic antiferromagnetic (AFM) chains with Rashba spin-orbit coupling. Against conventional wisdom, Majorana zero modes (MZMs) can be robustly generated at these AFM chain ends. These results can consistently explain the recent experimental observation of zero-energy end states in line defects of monolayer Fe(Te, Se)/SrTiO3 by scanning tunneling microscopy (STM) measurements. Our research not only demonstrates an unprecedented interplay among native line defect, emergent magnetism and topological superconductivity but also explores a high-temperature platform for Majorana fermions.
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- 2023
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32. Factors Influencing the Change of Phyllosphere Microbial Community of Three Populus spp. in the Same Habitat
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Xin Yin, Weixi Zhang, Dan Li, Ran Wang, Xinyao Cong, Zhongyi Pang, Yanhui Peng, Yang Ge, Wenxu Zhu, and Changjun Ding
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phyllosphere ,microorganism ,high-throughput sequencing ,leaf characteristics ,bacterial and fungal communities ,Plant ecology ,QK900-989 - Abstract
Plant leaves harbor a rich diversity of bacteria and fungi that, through their interactions with host plants, assume an influential role in plant physiological and metabolic processes. The unique phyllosphere environment of different plant species may shape and select distinct phyllosphere microbial communities. While most academic research has focused on the phyllosphere microorganisms within the same plant variety, there is relatively limited research on the phyllosphere microbial communities between different varieties. Populus L. is a typical tree species in temperate monsoon climates, widely distributed in northern China, and it constitutes a crucial component of China’s forestry resources. For the purpose of this study, we investigated the community structure and diversity of phyllosphere fungi and bacteria in different poplar varieties under identical growth conditions to elucidate the main factors contributing to differences in phyllosphere microbial communities among these varieties. Our findings revealed variations in nitrogen, phosphorus, starch, and soluble sugar contents among the three poplar species studied. Additionally, there were considerable disparities in both abundance and α diversity index of phyllosphere fungal and bacterial communities among these species. At the phylum level, Ascomycota and Basidiomycota have been identified as the dominant fungal communities; while Proteobacteria and Actinomycetes were dominant bacterial communities. The correlation analysis pointed out that chemical traits in the leaves, in particular the total phosphorus and the quantity of soluble sugar, had a significant correlation with the structure and diversity of the microbial community residing in the phyllosphere. Overall, our results demonstrate that even under identical site conditions, each poplar species harbors its own unique phyllosphere microbial community composition as well as distinct leaf characteristics—highlighting host plant diversity as a crucial factor driving differences in phyllosphere microbial composition.
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- 2024
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33. Evaluating an advanced system with flexible dielectric insole and inertial sensors for post-ACL reconstruction assessment
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Li, Haipeng, Wang, Lili, Liu, Di, Lin, Ye, Xin, Yin, Zhang, Qiquan, Shuang, Feng, Huang, Peng, and Chen, Li
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- 2024
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34. Regulating bulb dormancy release and flowering in lily through chemical modulation of intercellular communication
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Zhao, Yajie, Pan, Wenqiang, Xin, Yin, Wu, Jingxiang, Li, Rong, Shi, Jinxin, Long, Shuo, Qu, Lianwei, Yang, Yingdong, Yi, Mingfang, and Wu, Jian
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- 2023
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35. Prevalence of comorbid depression and associated factors among hospitalized patients with type 2 diabetes mellitus in Hunan, China
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Maimaitituerxun, Rehanguli, Chen, Wenhang, Xiang, Jingsha, Kaminga, Atipatsa C., Wu, Xin Yin, Chen, Letao, Yang, Jianzhou, Liu, Aizhong, and Dai, Wenjie
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- 2023
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36. Predictive model for identifying mild cognitive impairment in patients with type 2 diabetes mellitus: A CHAID decision tree analysis
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Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Yu Xie, Fang Xiao, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, and Wenjie Dai
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decision tree ,mild cognitive impairment ,predictor variable ,type 2 diabetes mellitus ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background As the population ages, mild cognitive impairment (MCI) and type 2 diabetes mellitus (T2DM) become common conditions that often coexist. Evidence has shown that MCI could lead to reduced treatment compliance, medication management, and self‐care ability in T2DM patients. Therefore, early identification of those with increased risk of MCI is crucial from a preventive perspective. Given the growing utilization of decision trees in prediction of health‐related outcomes, this study aimed to identify MCI in T2DM patients using the decision tree approach. Methods This hospital‐based case–control study was performed in the Endocrinology Department of Xiangya Hospital affiliated to Central South University between March 2021 and December 2022. MCI was defined based on the Petersen criteria. Demographic characteristics, lifestyle factors, and T2DM‐related information were collected. The study sample was randomly divided into the training and validation sets in a 7:3 ratio. Univariate and multivariate analyses were performed, and a decision tree model was established using the chi‐square automatic interaction detection (CHAID) algorithm to identify key predictor variables associated with MCI. The area under the curve (AUC) value was used to evaluate the performance of the established decision tree model, and the performance of multivariate regression model was also evaluated for comparison. Results A total of 1001 participants (705 in the training set and 296 in the validation set) were included in this study. The mean age of participants in the training and validation sets was 60.2 ± 10.3 and 60.4 ± 9.5 years, respectively. There were no significant differences in the characteristics between the training and validation sets (p > .05). The CHAID decision tree analysis identified six key predictor variables associated with MCI, including age, educational level, household income, regular physical activity, diabetic nephropathy, and diabetic retinopathy. The established decision tree model had 15 nodes composed of 4 layers, and age is the most significant predictor variable. It performed well (AUC = .75 [95% confidence interval (CI): .71–.78] and .67 [95% CI: .61–.74] in the training and validation sets, respectively), was internally validated, and had comparable predictive value compared to the multivariate logistic regression model (AUC = .76 [95% CI: .72–.80] and .69 [95% CI: .62–.75] in the training and validation sets, respectively). Conclusion The established decision tree model based on age, educational level, household income, regular physical activity, diabetic nephropathy, and diabetic retinopathy performed well with comparable predictive value compared to the multivariate logistic regression model and was internally validated. Due to its superior classification accuracy and simple presentation as well as interpretation of collected data, the decision tree model is more recommended for the prediction of MCI in T2DM patients in clinical practice.
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- 2024
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37. Impact of vertical shading designs on the cross-ventilation performance of a high-rise office building
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Xin Yin and Mohammed W. Muhieldeen
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Natural ventilation ,Vertical shading ,Window ,CFD simulation ,Office furniture layout ,Technology - Abstract
Historically, windows shading systems have been part of sustainable design elements that minimize solar heat gain while still allowing fresh air to pass through. However, there is a lack of comprehensive research on the impact of shading systems on natural ventilation in furnished indoor spaces. This study aimed to assess the efficacy of vertical shadings on the cross-ventilation performance in an office building through numerical analysis by utilizing computational fluid dynamics. Site measurements were conducted to compare with the numerical results and were used as boundary conditions for the numerical simulations. The results showed that incorporating vertical shadings with the window has the potential to enhance the ventilation rate when the wind direction ranges from 45° to 90°. Then, different vertical fin settings were applied for various specific window types for further analysis. The initial case (awning window) with central shading resulted in a 30.46 % increase in the airflow rate compared to that in the non-shading scenario. The implementation of vertical shadings for sash windows can be considered to be the most effective combination, which resulted in a 12.04 % increase in the ventilation rate, a reduction of 17.73 % in the velocity non-uniformity coefficient, and a decrease of 31.47 % in the percentage area of the dead zone. Lastly, a first attempt to demonstrate the potential of altering the furniture placement to improve the natural ventilation with window shading systems is presented. The ventilation rates were slightly affected by the placement of furniture, while the local age-of-air surrounding the occupant could be reduced by 56.21 %. This study provides a practical architectural strategy for enhancing indoor natural ventilation behavior through the implementation of window vertical shadings.
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- 2024
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38. Sleep quality and its associated factors among patients with type 2 diabetes mellitus in Hunan, China: a cross-sectional study
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Aizhong Liu, Yu Xie, Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Fang Xiao, Xin Yin Wu, Letao Chen, Jianzhou Yang, and Wenjie Dai
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Medicine - Abstract
Objectives Type 2 diabetes mellitus (T2DM) is a serious public health issue. Compared with the general population, patients with T2DM have a higher risk of poor sleep quality, which could ultimately result in poor prognosis. Therefore, this study aimed to evaluate sleep quality and its associated factors among patients with T2DM in Hunan, China.Design This was a cross-sectional study.Setting A tertiary hospital in Hunan, China.Participants Patients with T2DM hospitalised at the Endocrinology Department were consecutively enrolled between March 2021 and December 2022. Sociodemographic characteristics, lifestyle factors and T2DM-related information were collected retrospectively.Primary and secondary outcome measures Sleep quality was evaluated using the Pittsburgh Sleep Quality Index, with a cut-off value of >7 suggesting poor sleep quality. Multivariate logistic regression analysis was used to determine factors associated with poor sleep quality.Results Of the 1039 participants included, 1001 provided complete data. The mean age of the study sample was 60.24±10.09 years, and 40.5% (95% CI 37.5% to 43.5%) of patients had poor sleep quality. Multivariate logistic regression analysis showed that female sex (adjusted OR (aOR) 1.70, 95% CI 1.25 to 2.29), unmarried status (aOR 1.72, 95% CI 1.05 to 2.83), diabetic retinopathy (aOR 1.38, 95% CI 1.04 to 1.83), diabetic foot (aOR 1.80, 95% CI 1.11 to 2.93) and a per capita monthly household income of >5000 RMB (aOR 0.66, 95% CI 0.47 to 0.93) were associated with poor sleep quality.Conclusions Nearly two-fifths of patients with T2DM reported poor sleep quality in Hunan, China. Sex, marital status, diabetic retinopathy, diabetic foot and household income were independently associated with sleep quality among patients with T2DM in Hunan, China.
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- 2024
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39. Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer
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Tianyi Fang, Xin Yin, Yufei Wang, Lei Zhang, Shuo Yang, Xinju Jiang, and Yingwei Xue
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Gastric cancer ,Adenocarcinoma of esophagogastric junction ,Upper gastric cancer ,Systemic infammation response index ,Platelet–lymphocyte ratio ,Prognosis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Tumor immunity plays an important role in assessing the tumor progression. The purpose of this study was to investigate the prognostic value of combined systemic inflammation response index (SIRI) and platelet–lymphocyte ratio (PLR) of gastroesophageal junction cancer (AEG) and upper gastric cancer (UGC) patients. Methods: In this retrospective study, patients from 2003 to 2014 were divided into training and validation sets. The prognostic accuracy of each variable was compared using time-independent ROC analysis. The scoring system was calculated by cut-off values of SIRI and PLR in 5-year. Kaplan-Meier and Log-rank tests were used to analyze overall survival (OS). Chi-square test was used to analyze the association between clinical characteristics and the scoring system. Univariate and multivariate analyses based on the competitive risk regression model were used to analyze independent predictors of death due to AGC and UGC. R software was used to construct the Nomogram model of risk assessment. Results: Patients with SIRI–PLR = 2 had worse survival time than those with 0 and 1 (P
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- 2024
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40. DDR2/STAT3 Positive Feedback Loop Mediates the Immunosuppressive Microenvironment by Upregulating PD-L1 and Recruiting MDSCs in Oxaliplatin-Resistant HCCSummary
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Wenfeng Liu, Feng Zhang, Bing Quan, Fan Yao, Rongxin Chen, Zhenggang Ren, Ling Dong, and Xin Yin
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DDR2 ,STAT3 ,PD-L1 Upregulation ,MDSCs ,Hepatocellular Carcinoma ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aims: Transcriptome sequencing revealed high expression of DDR2 in oxaliplatin-resistant hepatocellular carcinoma (HCC). This study aimed to explore the role of DDR2 in oxaliplatin resistance and immune evasion in HCC. Methods: Oxaliplatin-resistant HCC cell lines were established. The interaction between DDR2 and STAT3 was investigated, along with the mechanisms involved in DDR2/STAT3-mediated PD-L1 upregulation and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) accumulation both in vitro and in vivo. Results: DDR2 was found to induce the phosphorylation of STAT3, leading to its nuclear translocation. Conversely, the activation of STAT3 enhanced DDR2 expression. A positive feedback loop involving DDR2/STAT3 was identified in oxaliplatin-resistant HCC, which was associated with PD-L1 upregulation and PMN-MDSCs accumulation. Knockdown of DDR2 and STAT3 sensitized oxaliplatin-resistant HCC cells to oxaliplatin and resulted in decreased PMN-MDSCs and increased CD8+ T cells in the tumor microenvironment. Enzyme-linked immunosorbent array and MDSC transwell migration assays indicated that oxaliplatin-resistant HCC cells recruited PMN-MDSCs through CCL20. Dual luciferase reporter assays demonstrated that STAT3 can directly enhance the transcription of PD-L1 and CCL20. Furthermore, treatment with a PD-L1 antibody in combination with CCL20 blockade had significant antitumor effects on oxaliplatin-resistant HCC. Conclusions: Our findings revealed a positive feedback mechanism involving DDR2 and STAT3 that mediates the immunosuppressive microenvironment and promotes oxaliplatin resistance and immune evasion via PD-L1 upregulation and PMN-MDSC recruitment. Targeting the DDR2/STAT3 pathway may be a promising therapeutic strategy to overcome immune escape and chemoresistance in HCC.
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- 2024
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41. Typology and working mechanism of a hybrid power router based on power-frequency transformer electromagnetic coupling with converters
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Jinmu Lai, Xin Yin, Xianggen Yin, Jiaxuan Hu, and Fan Xiao
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Power router ,Power-frequency transformer ,Power electronic converter ,Hybrid ,Working mechanism ,Distribution or transmission of electric power ,TK3001-3521 ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
Abstract The power router (PR) is a promising piece of equipment for realizing multi-voltage level interconnection and flexible power control in the future distribution power grid. In this paper, a hybrid PR (HPR) topology based on power-frequency transformer electromagnetic coupling with converters is proposed for the medium distribution power grid. The power-frequency transformer is used to undertake power transmission, voltage conversion, and other main tasks, while the power electronic converters are combined to achieve active control. Equivalent magnetic and electrical circuit models are established to help discuss the operating principle of the proposed HPR. Additionally, the power flow and control principle of the HPR in different operating conditions are analyzed, with the control system design scheme presented. The theoretical analysis results are verified by MATLAB/Simulink + Plecs simulation and a controller hardware-in-the-loop study, as well as a down-scale experimental test, indicating that the proposed HPR is flexible in active voltage support and current control.
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- 2023
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42. Cancer‐associated fibroblast expression of glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer
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Shuo Yang, Guoli Li, Xin Yin, Yufei Wang, Xinju Jiang, Xiulan Bian, Tianyi Fang, Shengjie Yin, Lei Zhang, and Yingwei Xue
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gastric cancer ,GFPT2 ,cancer‐associated fibroblasts ,immune microenvironment ,prognosis ,Pathology ,RB1-214 - Abstract
Abstract Glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a rate‐limiting enzyme in hexosamine biosynthesis involved in the occurrence and progress of many cancers. What role it plays in gastric cancer (GC) is still unclear. In this study, transcriptome sequencing data from the Harbin Medical University (HMU)‐GC cohort and The Cancer Genome Atlas (TCGA) dataset were combined with the HMU‐TCGA training cohort to analyze the biological function and clinical significance of GFPT2. The correlation of GFPT2 with immune cells and stromal cells was analyzed in the GC immune microenvironment through transcriptome sequencing data and a public single‐cell sequencing database. In cell lines, GC tissues, and the tissue microarray, GFPT2 protein expression was confirmed by western blotting and immunohistochemistry. The mRNA of GFPT2 was highly expressed in the tumor (p
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- 2023
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43. Preparation and properties of transparent poly(aryl ether ketone) films with low dielectric constant
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Huijuan Li, Miao Yi, Xin Yin, Wenliang Wu, and Shiai Xu
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transparency ,low dielectric constant ,soluble ,poly (aryl ether ketone) ,polymer synthesis, molecular engineering ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Chemical technology ,TP1-1185 - Abstract
The objective of this study is to prepare a new poly(aryl ether ketone) (PAEK) with low dielectric constant, high transparency and heat resistance by introducing fluorine atoms and phenolphthalein (PHPH) groups into the polymer backbone. The chemical structure of PAEK random copolymers was characterized by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR) and X-ray diffraction (XRD),, and the molecular weight of PAEK was determined by gel permeation chromatography (GPC). It is found that these random copolymers are soluble in common organic solvents, especially low boiling point solvents, such as CHCl3, tetrahydrofuran (THF) and dimethylacetamide (DMAc). Transparent, uniform and flexible films were prepared by casting from DMAc solvent. The PAEK copolymers exhibit high glass transition temperature (163–220 °C by differential scanning calorimetry (DSC) and 168–227 °C by dynamic mechanical analysis (DMA)) and thermal stability with 5% weight loss temperatures of 461–525 °C. The PAEK films show good mechanical properties with tensile strengths of 50–62 MPa. The dielectric constant (k) is only 2.31–3.08, and the loss tangent is only 0.003–0.009 at 1 MHz. All films exhibit excellent optical transparency, their UV cutoff wavelength is shorter than 386 nm, and the transmittance at 450 nm is higher than 80%.
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- 2023
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44. The Carter administration’s policy towards Afghanistan
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Xin Yin
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“new world order strategy” ,carter administration ,soviet union ,afghanistan ,evolution ,“new cold war” ,“carter doctrine” ,Oriental languages and literatures ,PJ - Abstract
The Carter administration came to power at a crucial period when the relations between the East and the West were shifting from relaxation to re-confrontation. Its policy towards Afghanistan was not only restricted by the situation of U.S.-Soviet Union relations but also exerted a direct influence on the maintenance and transformation of this situation, notably the opening of the “New Cold War” between the East and the West. With the evolution of the Carter administration’s policy towards Afghanistan as the main clue, this paper aims to study the formation background, causes of change and development logic of different US policies towards Afghanistan in this period so as to reveal the internal relationship between the change of the U.S. policy towards Afghanistan and the evolution of the Cold War situation, as well as the essence of the U.S. policy.
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- 2023
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45. Impact of school operating scenarios on COVID-19 transmission under vaccination in the U.S.: an agent-based simulation model
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Xingran Weng, Qiushi Chen, Tarun Kumar Sathapathi, Xin Yin, and Li Wang
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Medicine ,Science - Abstract
Abstract At the height of the COVID-19 pandemic, K-12 schools struggled to safely operate under the fast-changing pandemic situation. However, little is known about the impact of different school operating scenarios considering the ongoing efforts of vaccination. In this study, we deployed an agent-based simulation model to mimic disease transmission in a mid-sized community consisting of 10,000 households. A total of eight school operating scenarios were simulated, in decreasing order of restrictiveness regarding COVID-19 mitigation measures. When masks were worn at school, work, and community environments, increasing in-person education from 50% to 100% would result in only 1% increase in cumulative infections. When there were no masks nor contact tracing while schools were 100% in person, the cumulative infection increased by 86% compared to the scenario when both masking and contact tracing were in place. In the sensitivity analysis for vaccination efficacy, we found that higher vaccination efficacy was essential in reducing overall infections. Our findings showed that full in-person education was safe, especially when contact tracing, masking, and widespread vaccination were in place. If no masking nor contact tracing was practiced, the transmission would rose dramatically but eventually slow down due to herd immunity.
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- 2023
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46. Epidemic trends of dyslipidemia in young adults: a real-world study including more than 20,000 samples
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Liang-Yu Liu, Xiyidan Aimaiti, Ying-Ying Zheng, Xiao-Yu Zhi, Zhi-Long Wang, Xin Yin, Ying Pan, Ting-Ting Wu, and Xiang Xie
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Dyslipidemia ,Young ,Age ,Obesity ,Trend ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background There is an urgent need to learn more about the epidemiological features of dyslipidemia in youth to address the high burden of cardiovascular disease. Methods This experiment was an observational, cross-sectional study. The samples were collected from 22,379 college students at Xinjiang Medical University. Result The overall prevalence of dyslipidemia was 13.17%, which was significantly higher in men (23%) than in women (7.2%), p
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- 2023
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47. Prevalence of Anxiety and Associated Factors Among Inpatients with Type 2 Diabetes Mellitus in China: A Cross-Sectional Study
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Maimaitituerxun, Rehanguli, Chen, Wenhang, Xiang, Jingsha, Xie, Yu, Kaminga, Atipatsa C., Wu, Xin Yin, Chen, Letao, Yang, Jianzhou, Liu, Aizhong, and Dai, Wenjie
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- 2023
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48. Hopf-like Bifurcation Analysis of a Fractional-Order Tumor-Lymphatic Model Involving Two Time Delays
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Xueying Shi, Xiaoping Chen, Chengdai Huang, An Luo, and Xin Yin
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fractional order ,tumor-lymphatic model ,stability ,Hopf-like bifurcation ,two time delays ,Mathematics ,QA1-939 - Abstract
This paper investigates the Hopf-like bifurcation of a fractional tumor-lymphatic model with two time delays. The two time delays are considered as branching parameters, and we analyze their influences on the dynamic properties of the model. Through an examination of the root distribution of the characteristic equation, we derive the properties of the positive steady state and the conditions for the occurrence of Hopf-like bifurcation near the positive equilibrium point. Numerical simulations are demonstrated to support our theoretical results.
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- 2024
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49. Runoff Prediction in Different Forecast Periods via a Hybrid Machine Learning Model for Ganjiang River Basin, China
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Wei Wang, Shinan Tang, Jiacheng Zou, Dong Li, Xiaobin Ge, Jianchu Huang, and Xin Yin
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monthly runoff forecasting ,factor selection ,variable modal decomposition ,principal component analysis ,long short-term memory neural network ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Accurate forecasting of monthly runoff is essential for efficient management, allocation, and utilization of water resources. To improve the prediction accuracy of monthly runoff, the long and short memory neural networks (LSTM) coupled with variational mode decomposition (VMD) and principal component analysis (PCA), namely VMD-PCA-LSTM, was developed and applied at the Waizhou station in the Ganjiang River Basin. The process begins with identifying the main forecasting factors from 130 atmospheric circulation indexes using the PCA method and extracting the stationary components from the original monthly runoff series using the VMD method. Then, the correlation coefficient method is used to determine the lag of the above factors. Lastly, the monthly runoff is simulated by combining the stationary components and key forecasting factors via the LSTM model. Results show that the VMD-PCA-LSTM model effectively addresses the issue of low prediction accuracy at high flows caused by a limited number of samples. Compared to the single LSTM and VMD-LSTM models, this comprehensive approach significantly enhances the model’s predictive accuracy, particularly during the flood season.
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- 2024
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50. Chromosome-level genome assembly of Murraya paniculata sheds light on biosynthesis of floral volatiles
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Tianyu Yang, Xin Yin, Haotong Kang, Danni Yang, Xingyu Yang, Yunqiang Yang, and Yongping Yang
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Murraya paniculata ,Citrus species ,Comparative genomics ,Transposon ,Flower volatiles ,Phenylacetaldehyde ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Murraya paniculata (L.) Jack, commonly called orange jessamine in the family Rutaceae, is an important ornamental plant in tropical and subtropical regions which is famous for its strong fragrance. Although genome assemblies have been reported for many Rutaceae species, mainly in the genus Citrus, full genomic information has not been reported for M. paniculata, which is a prerequisite for in-depth genetic studies on Murraya and manipulation using genetic engineering techniques. Here, we report a high-quality chromosome-level genome assembly of M. paniculata and aim to provide insights on the molecular mechanisms of flower volatile biosynthesis. Results The genome assembly with a contig N50 of 18.25 Mb consists of 9 pseudomolecules and has a total length of 216.86 Mb. Phylogenetic analysis revealed that M. paniculata diverged from the common ancestor approximately 25 million years ago and has not undergone any species-specific whole genome duplication events. Genome structural annotation and comparative genomics analysis revealed that there are obvious differences in transposon contents among the genomes of M. paniculata and Citrus species, especially in the upstream regions of genes. Research on the flower volatiles of M. paniculata and C. maxima at three flowering stages revealed significant differences in volatile composition with the flowers of C. maxima lacking benzaldehyde and phenylacetaldehyde. Notably, there are transposons inserted in the upstream region of the phenylacetaldehyde synthase (PAAS) genes Cg1g029630 and Cg1g029640 in C. maxima, but not in the upstream region of three PAAS genes Me2G_2379, Me2G_2381, and Me2G_2382 in M. paniculata. Our results indicated that compared to the low expression levels of PAAS genes in C. maxima, the higher expression levels of the three PAAS genes in M. paniculata are the main factor affecting the phenylacetaldehyde biosynthesis and causing the content difference of phenylacetaldehyde. The phenylacetaldehyde synthetic activities of the enzymes encoded by M. paniculata PAAS genes were validated by in vitro analyses. Conclusions Our study provides useful genomic resources of M. paniculata for further research on Rutaceae plants, identifies new PAAS genes, and provides insights into how transposons contribute to variations in flower volatiles among Murraya and Citrus plants.
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- 2023
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