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Your search keyword '"Yao, Jian-Zhong"' showing total 18 results
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18 results on '"Yao, Jian-Zhong"'

14. Antitumor Activities and Structure-Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route.

Author

Zhang, Yong-Qiang, Zhang, Huo-Jun, Zhang, Jing, Wang, Juan, Yao, Jian-Zhong, Zhu, Lin-Jian, Zhuang, Chun-Lin, Wang, Sheng-Zheng, Dong, Guo-Qiang, Sheng, Chun-Quan, Miao, Zhen-Yuan, and Zhang, Wan-Nian

Abstract

Based on a new semisynthetic route, a series of phosphotriester 7-alkyl-homocamptothecin derivatives are designed and synthesized. Cytotoxic activity assays show that compounds 12a and 14c with a methyl in position C7 of the homocamptothecin are more potent than the other derivatives and the positive drug irinotecan against A-549, MCF-7, and LOVO cell lines. Moreover, compound 14c shows potent tumour inhibitory activity in a Colo205 xenograft model. [ABSTRACT FROM AUTHOR]

Published
2011
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17. Inversion of secondary chiral alcohols in toluene with the tunable complex of R3NCOOH

Author

Shi, Xiao-Xin, Shen, Chun-Li, Yao, Jian-Zhong, Nie, Liang-Deng, and Quan, Na

Subjects
*CHIRALITY, *ALCOHOLS (Chemical class), *TOLUENE, *ENANTIOMERS, *SULFONATES, *CARBOXYLIC acids, *COMPLEX compounds, *NUCLEOPHILIC reactions
Abstract

Abstract: The SN2 reaction of enantiomerically pure sulfonates with the tunable complex of R3N–R′COOH in toluene has been extensively studied. It was revealed that the molar ratio of the tertiary amines and carboxylic acids in the complex of R3NR′COOH is crucial for the SN2 reaction, and should be tuned for each sulfonate to give the best yield. Fifteen sulfonates 1 and 3–13 (Scheme 2) were prepared and transformed into 22 corresponding inverted esters 2 and 14–24 (Scheme 2) in good to high yields. [Copyright &y& Elsevier]

Published
2010
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18. Benzochloroporphyrin derivative induced cytotoxicity and inhibition of tumor recurrence during photodynamic therapy for osteosarcoma.

Author

Gong HY, Sun MX, Hu S, Tao YY, Gao B, Li GD, Cai ZD, and Yao JZ

Subjects
Animals, Apoptosis drug effects, Bone Neoplasms drug therapy, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Female, Mice, Mice, Inbred C3H, Mice, Nude, Neoplasm Recurrence, Local prevention & control, Osteosarcoma surgery, Photosensitizing Agents chemistry, Photosensitizing Agents toxicity, Porphyrins chemistry, Porphyrins toxicity, Neoplasm Recurrence, Local drug therapy, Osteosarcoma drug therapy, Photochemotherapy, Photosensitizing Agents pharmacology, Porphyrins pharmacology
Abstract

Photodynamic therapy (PDT) is a promising cancer treatment modality that uses dye-sensitized photooxidation of biologic matter in target tissue. This study explored effects of the photosensitizer BCPD-17 during PDT for osteosarcoma. LM-8 osteosarcoma cells were treated with BCPD-17 and cell viability after laser irradiation was assessed in vitro with the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The effects of BCPD-17 during PDT recurrence were then examined on tumor-bearing mice in vivo. BCPD-17 had dose- dependent cytotoxic effects on LM-8 osteosarcoma cells after laser irradiation which also had energy-dependent effects on the cells. The rate of local recurrence was reduced when marginal resection of mice tumors was followed by BCPD-17-mediated PDT. Our results indicated BCPD-17-mediated PDT in combination with marginal resection of tumors is a potentially new effective treatment for osteosarcoma.

Published
2013
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