12 results on '"Yeung, Nicole"'
Search Results
2. Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase
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Lin, Hui-Ming, Mak, Blossom, Yeung, Nicole, Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Kwan, Edmond M., Fettke, Heidi, Tran, Ben, Davis, Ian D., Mahon, Kate L., Zhang, Alison, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Crumbaker, Megan, Stricker, Phillip D., Du, Pan, Yu, Jianjun, Jia, Shidong, Scheinberg, Tahlia, Fitzpatrick, Michael, Bonnitcha, Paul, Sullivan, David R., Joshua, Anthony M., Azad, Arun A., Butler, Lisa M., Meikle, Peter J., and Horvath, Lisa G.
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- 2021
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3. Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer
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Lin, Hui-Ming, Huynh, Kevin, Kohli, Manish, Tan, Winston, Azad, Arun A., Yeung, Nicole, Mahon, Kate L., Mak, Blossom, Sutherland, Peter D., Shepherd, Andrew, Mellett, Natalie, Docanto, Maria, Giles, Corey, Centenera, Margaret M., Butler, Lisa M., Meikle, Peter J., and Horvath, Lisa G.
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- 2021
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4. Effect of FAK inhibitor VS‐6063 (defactinib) on docetaxel efficacy in prostate cancer
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Lin, Hui‐Ming, Lee, Brian Y., Castillo, Lesley, Spielman, Calan, Grogan, Judith, Yeung, Nicole K., Kench, James G., Stricker, Phillip D., Haynes, Anne‐Maree, Centenera, Margaret M., Butler, Lisa M., Shreeve, S. Martin, Horvath, Lisa G., and Daly, Roger J.
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- 2018
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5. MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer
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Lin, Hui-Ming, Nikolic, Iva, Yang, Jessica, Castillo, Lesley, Deng, Niantao, Chan, Chia-Ling, Yeung, Nicole K., Dodson, Eoin, Elsworth, Benjamin, Spielman, Calan, Lee, Brian Y., Boyer, Zoe, Simpson, Kaylene J., Daly, Roger J., Horvath, Lisa G., and Swarbrick, Alexander
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- 2018
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6. Birds, barks, and boats in Burrard Inlet : A spatial analysis of winter marine bird communities and recreational disturbances along the Kitsilano shoreline
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Gauk, Jamie, Kwan, Braela, Li, Ada, and Yeung, Nicole
- Abstract
British Columbia’s Burrard Inlet is recognized internationally as an Important Bird Area (IBA) (IBA Canada, 2017). IBAs are crucial for preserving biodiversity because they include globally important bird populations, and they are internationally accepted as effective conservation tools. The Burrard Inlet was established as an IBA due to the potential threats that residential urbanization, commercial and industrial development, as well as recreational activities pose to the integrity of marine bird communities (IBA Canada, 2017). The Kitsilano shoreline, a component of Burrard Inlet, attracts both people and birds alike. With beaches such as Spanish Banks Beach Park, Jericho Beach Park, and Kitsilano Beach Park, the Kitsilano shoreline is a popular destination for beach use among locals and visitors. Additionally, the region is a critical habitat for numerous species of marine birds, many of which are species of interest (IBA Canada, 2017). Burrard Inlet currently supports 1.5% of the global population of Barrow’s Goldeneye, though it has historically supported 4% of the estimated global population (IBA Canada, 2017). Additionally, Burrard Inlet supports over 7,000 Surf Scoters, 100 Great Blue Herons, and 100 to 500 Western Grebes (IBA Canada, 2017). The City of Vancouver is striving to be the greenest city in the world by 2020. The preservation of the city’s bird biodiversity will be instrumental in achieving this, as it will contribute to meeting Goal 6: Access to Nature (Greenest City: 2020 Action Plan, 2012). To accomplish this, efforts to mitigate the impacts of urbanization on native bird species are critical. Increasing human activity pose threats to bird communities along our coasts and beaches, since recreational activities can disrupt the foraging, courting, and resting behaviours of birds. Therefore, it should be of utmost priority to adopt strategies that encourage beach users to engage in recreational activity in a manner that minimizes the disturbance impacts to marine birds (Vancouver Bird Strategy, 2015). The primary goal of this project is to assess the status of marine bird communities along the Kitsilano shoreline. We completed a series of spatial analyses based on field data collection from November 2017 to February 2018. Additionally, we addressed the observed trends between bird distributions and anthropogenic activities using a combination of quantitative analysis and anecdotal observations. The research questions driving this project: 1) What marine bird species are present along the Kitsilano shoreline between November and February? 2) What are the abundances and spatial distributions of the observed marine bird communities? 3) What human recreational activities are present along the shoreline and is there a trend between human disturbances and marine bird distributions?
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- 2018
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7. Plasma lipidomic profiling of chemotherapy-induced peripheral neuropathy.
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Yeung, Nicole, Lin, Hui-Ming, Timmins, Hannah, Li, Tiffany, Goldstein, David, Friedlander, Michael, Harrison, Michelle L., Mahon, Kate Lynette, Meikle, Peter, Park, Susanna, and Horvath, Lisa
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- 2023
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8. Intuition in Organizations: Empirical Research with Training Implications.
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Sinclair, Marta, Bas, Alina, Dorfler, Viktor, Yeung, Nicole, Govender, Sagrie (Chantelle), Williamson, Charmaine, DAvis, Annemarie, Fellnhofer, Katharina, Vincent, Vinod U., and Vincent, Nishani Edirisinghe
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This stream of the 14th annual intuition symposium at AoM showcases new empirical research into the use of intuition in decision making and problem solving. All five contributions are based on findings from recent studies and draw conclusions relevant for intuition training. Bas and Dörfler explore whether knowledge workers in a crisis situation resort to intuition, how it is manifested when they do, and what kind of support they need to improve their performance in this respect. Yeung and Sinclair report a piloted training program for entrepreneurs, applying the body-based focusing method to help them surface intuitive insights and boost their confidence in intuition when making difficult decisions. Govender et al. outline how the reflective practice of pausing can influence strategy making through generation of intuitive metaphors and stimulation of other intuition-related processes. Fellnhofer examines in a study of risky decision making whether intuition can be triggered and measured by visual means, through the use of hidden images. Finally, Vincent and Vincent investigate conditions under which decision makers have the tendency to rely on their intuition or be swayed by data provided by artificial intelligence when dealing with an ill-structured problem. Knowing by Intuiting Author: Alina Bas; U. of Strathclyde Business School Author: Viktor Dorfler; U. of Strathclyde Business School Training Entrepreneurial Intuition - An Action Research Intervention Author: Nicole Yeung; Griffith Business School, Griffith U. Author: Marta Sinclair; Griffith U. Can Pausing Enhance Intuition? Author: Sagrie (Chantelle) Govender; U. of South Africa Author: Charmaine Williamson; U. of South Africa Author: Annemarie DAvis; U. of South Africa How Can Intuition Measurement Inform Training? Author: Katharina Fellnhofer; ETH Zurich, Harvard U. When Do Individuals Rely on Intuition vs. AI when Dealing with Ill-Structured Problems? Author: Vinod U. Vincent; Clayton State U. Author: Nishani Edirisinghe Vincent; U. of Tennessee, Chattanooga [ABSTRACT FROM AUTHOR]
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- 2023
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9. Characteristics of immune-infiltrating cells in the tumor microenvironment of appendiceal cancer with peritoneal disease.
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Strach, Madeleine Cornelia, Yeung, Nicole, Lin, Hui-Ming, Ansari, Nabila, Koh, Cherry, Shin, Joo-Shik, Kench, James, Horvath, Lisa, and Mahon, Kate Lynette
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- 2023
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10. Intuition in Organizations: Developing Intuition in the Digital Age.
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Sinclair, Marta, Baldacchino, Leonie, Bas, Alina, Coleiro, Keith, Dorfler, Viktor, Fellnhofer, Katharina, Dias, Suzi Elen Ferreira, Iizuka, Edson Sadao, Kazuhito Isomura, Izumi Mitsui, Motomasa Murayama, Renold, Ursula, Robinson, Jennifer Llewellen, Sadler-Smith, Eugene, and Yeung, Nicole
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This 13th annual symposium at AoM showcases new intuition research pertinent to the development or training of intuition in different management contexts and organizational processes, as required by current and future workforce. It highlights the relevance of intuition in the digital age and suggests how digital technology can be used for its development. The contribution by Fellenhofer and Renold investigates how intuition could be trained in conjunction with analysis by means of digital tools, such as virtual reality. Sadler-Smith discusses different types of intuition likely to be required in the digital age and proposes type-specific training methods. Bas and Dörfler make a distinction between training needs for the sensing and sensemaking aspects of intuiting under uncertainty. Murayama et al. explain how Japanese companies develop their employees' intuitive skills as part of the 'souji' management practice. Robinson proposes how to develop collective intuition through collective mindfulness utilizing 'deep games.' Dias et al. highlight factors pertinent to intuition training for social entrepreneurs who face tension between commercial and social considerations. Coleiro and Baldacchino outline a training program, tailored to specific needs of various entrepreneurs. Finally, Yeung and Sinclair propose how to use the focusing method to enhance intuitive decision making. * How Can We Train Diverse Cognitive Skills of Tomorrow's Managers with new Technologies? * Presenter: Katharina Fellnhofer; ETH Zurich, Harvard U. * Presenter: Ursula Renold; ETH Zürich, D-MTEC * Developing Intuition in the Digital Age * Presenter: Eugene Sadler-Smith; U. of Surrey * Developing Intuiting for the Conditions of Uncertainty * Presenter: Alina Bas; U. of Strathclyde Business School * Presenter: Viktor Dorfler; U. of Strathclyde Business School * The Power of 'Souji' to Increase Intuitive Familiarity * Presenter: Motomasa Murayama; Komazawa U., Japan * Presenter: Izumi Mitsui; Sonoda Wemen's U. * Presenter: Kazuhito Isomura; CHUO U. * Understanding the Acquisition of Collective Mindfulness: The Implications for Intuition Training * Presenter: Jennifer Llewellen Robinson; Henley Business School, U. of Reading * Understanding Social Entrepreneurs' Obstacles to Applying Intuition * Presenter: Suzi Elen Ferreira Dias; ESPM, Sao Paulo, Brazil * Presenter: Edson Sadao Iizuka; Centro U. FEI * Presenter: Marta Sinclair; Griffith U. * A Training Programme for Entrepreneurial Intuition * Presenter: Keith Coleiro; U. of Malta * Presenter: Leonie Baldacchino; U. of Malta * Training Intuitive Decision Making with Focusing Method * Presenter: Nicole Yeung; Griffith Business School, Griffith U. * Presenter: Marta Sinclair; Griffith U. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.
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Lin, Hui-Ming, Yeung, Nicole, Hastings, Jordan F., Croucher, David R., Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Kwan, Edmond M., Davis, Ian D., Tran, Ben, Mahon, Kate L., Zhang, Alison, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Bastick, Patricia, Crumbaker, Megan L., Joshua, Anthony M., Azad, Arun A., and Meikle, Peter J.
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CYTOKINES , *SURVIVAL , *INTERLEUKINS , *DISEASE progression , *BIOMARKERS , *METASTASIS , *CERAMIDES , *LIPIDS , *PROSTATE tumors , *SPHINGOLIPIDS - Abstract
Simple Summary: Lipids (fatty substances) and cytokines are molecules that affect how the immune response works. The measurement of the amounts of lipids and cytokines in blood might give clues about how prostate cancers grow or respond to treatment. This study looked at the blood levels of lipids and cytokines in men with advanced prostate cancer that was growing despite standard treatment (metastatic castration-resistant prostate cancer, mCRPC). We found that certain lipids were consistently associated with poorer clinical outcome, while cytokines were not. The levels of a type of lipid (ceramide) were associated with some cytokines. This lipid is known to activate the immune system and is associated with poor outcomes in mCRPC. A change in lipid profiles was associated with better response to treatment. Overall, our findings suggest that blood lipids might be more informative than cytokines, might influence the immune response, and might help predict treatment response. Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the interactions between lipid metabolism and immune response in mCRPC by investigating the relationship between the plasma lipidome and cytokines. Plasma samples from two independent cohorts of men with mCRPC (n = 146, 139) having life-prolonging treatments were subjected to lipidomic and cytokine profiling (290, 763 lipids; 40 cytokines). Higher baseline levels of sphingolipids, including ceramides, were consistently associated with shorter overall survival in both cohorts, whereas the associations of cytokines with overall survival were inconsistent. Increasing levels of IL6, IL8, CXCL16, MPIF1, and YKL40 correlated with increasing levels of ceramide in both cohorts. Men with a poor prognostic 3-lipid signature at baseline had a shorter time to radiographic progression (poorer treatment response) if their lipid profile at progression was similar to that at baseline, or their cytokine profile at progression differed to that at baseline. In conclusion, baseline levels of circulating lipids were more consistent as prognostic biomarkers than cytokines. The correlation between circulating ceramides and cytokines suggests the regulation of immune responses by ceramides. The association of treatment response with the change in lipid profiles warrants further research into metabolic interventions. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Intuition in Organizations: New Directions in Intuition Research.
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Akinci, Cinla, Sinclair, Marta, Bas, Alina, Dorfler, Viktor, Dias, Suzi Elen Ferreira, Grant, Michael, Iizuka, Edson Sadao, NIlsson, Fredrik, Nordvall, Anna-Carin, Wang, Xin (Rachel), and Yeung, Nicole
- Abstract
The goal of this symposium is to showcase new directions in intuition research to mark the onset of the 2nd decade of annual intuition events at the Academy of Management meetings. The contributors come from diverse backgrounds, yet all their work demonstrates the presence of intuition in various organizational processes and settings. Grant et al. discuss contextuality of intuition, and caution researchers to take it into consideration before drawing general conclusions. Akinci illustrates this point by outlining unique characteristics of police first responders in their use of intuition. Likewise, Wang clarifies the role of intuition in problem solving of aerospace scientists, with the help of an integrated thematic and unthematic knowledge. Dörfler and Bas explore the usefulness of intuition as opposed to artificial intelligence, and in this context raise the importance of sensing and sensemaking. Yeung and Sinclair investigate the sensing aspect further by reconciling our understanding of intuition and felt sense. Finally, Dias et al. address a general concern how to capture up-to-date thinking of leading intuition researchers, proposing a new method that would reduce time lag in the publication process. The presented topics outline new areas where intuition research may be heading in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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