Search

Your search keyword '"Yin, Xiu-Feng"' showing total 8 results
Start Over Author "Yin, Xiu-Feng" Language english
8 results on '"Yin, Xiu-Feng"'

5. Impact of Chemotherapy Delay on Overall Survival for AML with I DH1/2 Mutations: A Study in Adult Chinese Patients

Author

Wang, Jing Han, Guo, Qi, Ma, Zhi Xin, Ma, Qiu Ling, Yu, Meng Xia, Yin, Xiu Feng, Lu, Sha Sha, Xie, Qiong Hong, Jiang, Yue Hong, Shen, Dan, Ma, li Ya, Shi, Hui, Yu, Wen Juan, Lou, Ye Jiang, Li, Ying, Yang, Min, Xu, Gai Xiang, Mao, Li Ping, Li, Jian Hu, Wang, Fan Ping, Wang, Dong Mei, Wei, Ju Ying, Tong, Hong Yan, Huang, Jian, and Jin, Jie

Published
2015
Full Text
View/download PDF

6. Impact of Chemotherapy Delay on Overall Survival for AML with IDH1/2 Mutations: A Study in Adult Chinese Patients.

Author

Wang, Jing-Han, Guo, Qi, Ma, Zhi-Xin, Ma, Qiu-Ling, Yu, Meng-Xia, Yin, Xiu-Feng, Lu, Sha-Sha, Xie, Hong-Qiong, Jiang, Yue-Hong, Shen, Dan, Ma, Li-Ya, Shi, Hui, Yu, Wen-Juan, Lou, Ye-Jiang, Li, Ying, Yang, Min, Xu, Gai-Xiang, Mao, Li-Ping, Li, Jian-Hu, and Wang, Huan-Ping

Subjects
ACUTE myeloid leukemia treatment, ACUTE myeloid leukemia, CANCER chemotherapy, GENETIC mutation, CHINESE people, HEALTH of adults, PATIENTS, DISEASES
Abstract

The effect of time from diagnosis to treatment (TDT) on overall survival of patients with acute myeloid leukemia (AML) remains obscure. Furthermore, whether chemotherapy delay impacts overall survival (OS) of patients with a special molecular subtype has not been investigated. Here, we enrolled 364 cases of AML to assess the effect of TDT on OS by fractional polynomial regression in the context of clinical parameters and genes of FLT3ITD, NPM1, CEBPA, DNMT3a, and IDH1/2 mutations. Results of the current study show IDH1/2 mutations are associated with older age, M0 morphology, an intermediate cytogenetic risk group, and NPM1 mutations. TDT associates with OS for AML patients in a nonlinear pattern with a J shape. Moreover, adverse effect of delayed treatment on OS was observed in patients with IDH1/2 mutations, but not in those with IDH1/2 wildtype. Therefore, initiating chemotherapy as soon as possible after diagnosis might be a potential strategy to improve OS in AML patients with IDH1/2 mutations. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

8. Absence of miR-142 mutation in Chinese patients with acute myeloid leukemia.

Author

Chen, Fei-Fei, Lou, Yin-Jun, Chen, Jian, Jin, Jing, Zhou, Jia-Ni, Yin, Xiu-Feng, Zhu, Zhi-Juan, Hu, Chao, Yu, Meng-Xia, Wang, Huan-Ping, and Jin, Jie

Subjects
ACUTE myeloid leukemia, DNA mutational analysis, GENES, AGE factors in disease, LEUCOCYTES, BONE marrow
Abstract

The article presents a study that analyzed the mutation status of miR-142 in patients with de novo acute myeloid leukemia. The study reveals the characteristics of these patients including median age at diagnosis, median bone marrow blasts, and median white cell count at diagnosis. It highlights the similarity between the mutation rate of other genes studied and samples obtained from archived bone marrow slides and other resources including DNA extracted from bone marrow mononuclear cells.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results