8 results on '"Yu, Xixiang"'
Search Results
2. The value of PIVKA-Ⅱ versus AFP for the diagnosis and detection of postoperative changes in hepatocellular carcinoma
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Lee, Qiuyan, Yu, Xixiang, and Yu, Weiwei
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- 2021
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3. Catalytic Synthesis of Atropoisomers via Non‐Canonical Friedel‐Crafts Reactions.
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Ye, Xutong, Yu, Xixiang, Deng, Rui, Zhong, Fangrui, and Wu, Guojiao
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FRIEDEL-Crafts reaction , *ACYLATION , *BRONSTED acids , *ORGANIC synthesis , *ALKENYLATION , *CHIRALITY element - Abstract
The Friedel‐Crafts reaction stands as a powerful synthetic tool for C−H functionalization of aromatic feedstocks, which is conventionally realized through electrophilic alkylation and acylation. The burgeoning interests in axially chiral compounds across diverse fields have spurred extensive exploration of this classic transformation for catalytic atroposelective synthesis. Consequently, the past decade has witnessed the rapid expansion of various non‐canonical Friedel‐Crafts reactions, including electrophilic arylation, alkenylation, halogenation, sulfenylation, and amination of aryl C−H bonds, thereby delving into new chemical spaces. A range of catalytic atroposelective synthetic methods have been devised for these significant arene C−H functionalization. This review provides a comprehensive overview of the cutting‐edge catalytic synthesis of atropoisomers through non‐canonical Friedel‐Crafts reactions, categorized into three parts based on the type of bond formation on the aromatics: C(sp2)−C(sp3) bond formations, C(sp2)−C(sp2) bond formations and C(sp2)−heteroatom bond formations. The richness of electrophiles and the modulation of atroposelectivity by diverse chiral organocatalysts, particularly chiral Brønsted acids, are elucidated. We anticipate that the repertoire of asymmetric Friedel‐Crafts reaction will continue to flourish and to be demonstrated in not only scientific researches but also industrial organic synthesis. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Knockdown of FOXO6 Inhibits Glycolysis and Reduces Cell Resistance to Paclitaxel in HCC Cells via PI3K/Akt Signaling Pathway
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Yu,Xixiang, Gao,Xixi, Mao,Xiaoping, Shi,Zhenjing, Zhu,Bangxuan, Xie,Linqin, Di,Shaodan, and Jin,Limin
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FOXO6 ,paclitaxel ,drug resistance ,PI3K/Akt signaling pathway ,glycolysis ,OncoTargets and Therapy ,digestive system diseases ,hepatocellular carcinoma cells ,Original Research - Abstract
Xixiang Yu,1 Xixi Gao,2 Xiaoping Mao,3 Zhenjing Shi,3 Bangxuan Zhu,1 Linqin Xie,1 Shaodan Di,1 Limin Jin3 1Wenzhou Medical University, Wenzhou No. 3 Clinical College, Wenzhou, Zhejiang Province, People’s Republic of China; 2Qingyuan County People’s Hospital, Qingyuan, Zhejiang Province, People’s Republic of China; 3The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang Province, People’s Republic of ChinaCorrespondence: Limin JinThe Third Affiliated Hospital of Wenzhou Medical University, No. 108, Wansong Road, Ruian, Zhejiang Province, People’s Republic of ChinaTel +86 135 6622 1074Email yinlang25929258258@163.comPurpose: Previous studies have reported that FOXO6 is highly expressed in hepatocellular carcinoma (HCC) tissues and is associated with the prognosis of HCC patients. However, little research has been carried out to explore the role of FOXO6 in glycolysis of HCC cells and paclitaxel resistance. Today, along with the increasing incidence and mortality of HCC, chemotherapy resistance of HCC also poses a serious challenge. Therefore, this study was set out to investigate the effect of FOXO6 on glycolysis and cytotoxicity of paclitaxel in HCC cells and its potential mechanism.Patients and Methods: The levels of FOXO6 mRNA and protein were detected by qRT-PCR and Western blot, respectively. In addition, paclitaxel-resistant cell lines of HCC cells were established, whose activity was assessed by CCK-8 assay, among which the invasion ability was assessed by Transwell and the apoptosis rate by flow cytometry. What is more, glycolysis levels were evaluated by measuring glucose consumption and lactic acid production, and the protein levels of p-PI3K and p-protein kinase B (Akt) were determined by Western blot.Results: Compared with normal human hepatocytes, FOXO6 was highly expressed in HCC cells, which was of high real value for HCC. FOXO6 knockdown inhibited the proliferation and invasion and induced apoptosis of HCC cells. In addition, FOXO6 knockdown suppressed glycolysis, reversed resistance to chemotherapy in Hep3B/PTX cells and inactivated PI3K and Akt proteins, thus inhibiting the PI3K/Akt signaling pathway. Furthermore, it was found that when activated by 740Y-P, PI3K/Akt signaling pathway could resist the effects of FOXO6 knockdown on the cytotoxicity and glycolysis of paclitaxel in HCC cells. Vice versa, inhibition of PI3K/Akt pathway by LY294002 could resist the effect of FOXO6 overexpression on chemotherapy, cytotoxicity and glycolysis of HCC cells.Conclusion: FOXO6 knockdown can inhibit glycolysis of HCC cells and reduce their resistance to chemotherapy by inhibiting the PI3K/Akt signaling pathway, which may be a new target for the treatment of HCC.Keywords: FOXO6, PI3K/Akt signaling pathway, hepatocellular carcinoma cells, glycolysis, paclitaxel, drug resistance
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- 2020
5. Treatment of a non-purulent intracranial venous sinus thrombus using a thrombectomy aspiration system: A case report
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Lee, Qiuyan, Yu, Xixiang, and Yu, Weiwei
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- 2021
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6. Expression Analysis of Long Non-Coding RNA HAR1A and HAR1B in HBV-Induced Hepatocullular Carcinoma in Chinese Patients.
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Shi, Zhenjing, Luo, Ya, Zhu, Minghui, Zhou, Yu, Zheng, Bingru, Wu, Daoyi, Wang, Shuting, Xie, Xiangbang, Lin, Heping, and Yu, Xixiang
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CANCER patients ,CHI-squared test ,COMPARATIVE studies ,CONFIDENCE intervals ,HEPATITIS viruses ,HEPATOCELLULAR carcinoma ,CIRRHOSIS of the liver ,MULTIVARIATE analysis ,POLYMERASE chain reaction ,REGRESSION analysis ,RESEARCH funding ,RNA ,STATISTICS ,DATA analysis ,PROPORTIONAL hazards models ,REVERSE transcriptase polymerase chain reaction ,DATA analysis software ,GENE expression profiling ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,CHRONIC hepatitis B ,LOG-rank test ,ONE-way analysis of variance - Abstract
Objective To determine the clinical relevance of long noncoding RNA (lncRNA) HAR1A and HAR1B expression in hepatocellular carcinoma (HCC). Methods In this study, we enrolled 50 cases of chronic hepatitis B (CHB) without cirrhosis, 50 cases of CHB and liver cirrhosis (LC), and 100 cases of HBV and HCC. The expression profiles of lncRNA HAR1A and HAR1B were analyzed using reverse transcription–quantitative polymerase chain reaction (RT-qPCR). Results The expression levels of HAR1A and HAR1B were significantly lower in the HCC group, compared with the CHB and LC groups (P <.01). HAR1A and HAR1B were negatively associated with histologic grade and TNM (tumor/nodes/metastasis) stage (all P <.05). Univariable multivariable analysis showed that decreased HAR1A (HR = 0.753, P =.02) and HAR1B (HR = 0.551, P =.01) levels were independent predictors for shorter overall survival (OS) in HCC. Conclusion Decreased HAR1A and HAR1B expression in HCC indicates poor prognosis. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Tripterine Treatment Improves Endothelial Progenitor Cell Function via Integrin-Linked Kinase.
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Lu, Chenhui, Yu, Xixiang, Zuo, Keqiang, Zhang, Xiaoping, Cao, Chuanwu, Xu, Jichong, Wang, Shi, Tang, Tao, Ye, Meng, Pei, Erli, Uzan, Georges, Zhi, Kangkang, and Li, Maoquan
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CELL physiology , *STEM cells , *PROGENITOR cells , *ATHEROSCLEROSIS , *CYTOPROTECTION - Abstract
Background/Aims: Atherosclerosis is associated with dysfunction of endothelial progenitor cells (EPCs). Tripterine, a chemical compound derived from the Chinese medicinal plant Tripterygium wilfordii Hook, displays anti-inflammatory properties in several animal models. We hypothesized that tripterine can improve EPC function and thus the efficiency of EPC transplantation. Methods and Results: Tripterine preconditioning (2.5 μM, 4 h) improved EPC proliferation, tube formation, migration, and adhesion, and reduced apoptosis in cells cultured in ox-LDL (200 ug/ml). Tripterine restored integrin-linked kinase (ILK) levels downregulated by ox-LDL in EPCs, suggesting the involvement of the ILK/Akt pathway. Small interfering RNA-mediated depletion of ILK and dominant-negative ILK transduction inhibited the phosphorylation of the ILK downstream signaling targets protein kinase B/ Akt and glycogen synthase kinase 3-beta (GSK-3β), and reduced β-catenin and cyclin D1 expression. In atherosclerotic mice injected with green fluorescent protein-labeled EPCs to evaluate EPC function, tripterine decreased aortic lesions and plaque deposition, and injection of tripterine-treated EPCs restored ILK levels. Conclusion: The present results suggest that tripterine improves vascular function in atherosclerosis by enhancing EPC function through a mechanism involving the ILK signaling pathway. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Identification and validation of a glycolysis-associated multiomics prognostic model for hepatocellular carcinoma.
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Deng T, Ye Q, Jin C, Wu M, Chen K, Yang J, Chen Z, Yu X, Chen G, and Wang Y
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- Aged, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular mortality, Female, Humans, Kaplan-Meier Estimate, Liver Neoplasms metabolism, Male, Middle Aged, Models, Statistical, Prognosis, Risk Assessment, Survival Analysis, Transcriptome, Carcinoma, Hepatocellular diagnosis, Glycolysis, Liver Neoplasms diagnosis
- Abstract
Increased glycolysis has been reported as a major metabolic hallmark in many cancers, and is closely related to malignant behavior of tumors. However, the potential mechanism of glycolysis in hepatocellular carcinoma (HCC) and its prognostic value are not well understood. To address this, we investigated glycolysis-related gene expression data of patients with HCC from TCGA and ICGC. Patients were categorized into three different glycolysis-associated subgroups: Glycolysis-M, Glycolysis-H, and Glycolysis-L. We found that Glycolysis-H combined with Glycolysis-M (Glycolysis-H+M) subgroup was associated with poor overall survival and distinct cancer stem cell characteristics and immune infiltrate patterns. Additionally, multiomics-based analyses were conducted to evaluate genomic patterns of glycolysis subgroups, including their gene mutations, copy number variations, and RNA-sequencing data. Finally, a glycolysis-associated multiomics prognostic model (GMPM) consisting of 19 glycolysis-associated genes was developed. The capability of GMPM in categorizing patients with HCC into high- and low-risk groups was validated with independent HCC datasets. Finally, GMPM was confirmed as an independent risk factor for the prognosis of patients with HCC. We believe that our findings provide new insights into the mechanism of glycolysis and highlight the potential clinical value of GMPM in predicting the prognosis of patients with HCC.
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- 2021
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