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722 results on '"ZHU Wenbo"'

1. Challenges of COVID-19 vaccination in patients with cancer

Author

Jia Siyue, Zhu Wenbo, Jiang Hudachuan, and Zhu Fengcai

Subjects
COVID-19, vaccine, clinical trial, patients with cancer, Science, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Patients with cancer are at increased risk of SARA-CoV-2 infection or developing severe COVID-19 cases due to malignancy or immunosuppressive therapy, but they are generally excluded from the target population for COVID-19 vaccination. In general, inactivated vaccines are safe and immunogenic for patients with cancer, but live attenuated vaccines are not recommended. The study suggested that the safety of the mRNA COVID-19 vaccine in patients with cancer is similar to that in healthy people, but immunogenicity is slightly weaker, and a booster dose may be needed. This paper aims to summarize the results of COVID-19 vaccine clinical studies conducted in patients with cancer worldwide and the relevant guidelines released by authorities, so as to provide evidence for promoting COVID-19 vaccination for patients with cancer.

Published
2022
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2. Study on the dynamic natural ventilation rates of occupied residence

Author

Liu Shuwei, Jian Yiwen, Zhu Wenbo, Gu Xundong, Bian Mengmeng, and Liu Zijia

Subjects
Environmental sciences, GE1-350
Abstract

The residential natural ventilation rates have a significant impact on indoor thermal comfort and air quality and building energy consumption. The characteristics of the indoor-outdoor temperature difference and wind pressure change over time, as well as the occupants' window opening behavior and the use of HVAC systems, resulting in the residential air change rate being dynamic with time. Many previous studies of residential ventilation measured the steady-state air change rates, which does not reflect the actual dynamic characteristics. In this study, a field measurement was conducted in a bedroom of one natural ventilation residential building in Beijing with continuously monitoring the CO2 concentration, indoor air temperature, and outdoor meteorological parameters for one year. Using the CO2 released by occupants as a tracer gas, the extended Kalman filter based on the Transient Mass Balance Equation (TMBE) was adopted to calculate the dynamic air change rate. This method can effectively filter the CO2 concentration measurement noise. The trend of air change rate with each influencing factor was analyzed. This study is expected to lay the foundation for future studies of dynamic air change rates in residential buildings.

Published
2022
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9. Chromosome-level genomes of three key Allium crops and their trait evolution

Author

Hao, Fei, Liu, Xue, Zhou, Botong, Tian, Zunzhe, Zhou, Lina, Zong, Hang, Qi, Jiyan, He, Juan, Zhang, Yongting, Zeng, Peng, Li, Qiong, Wang, Kai, Xia, Keke, Guo, Xing, Li, Li, Shao, Wenwen, Zhang, Bohan, Li, Shengkang, Yang, Haifeng, Hui, Linchong, Chen, Wei, Peng, Lixin, Liu, Feipeng, Rong, Zi-Qiang, Peng, Yingmei, Zhu, Wenbo, McCallum, John A., Li, Zhen, Xu, Xun, Yang, Hui, Macknight, Richard C., Wang, Wen, and Cai, Jing

Published
2023
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45. Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells

Author

Lin Yuan, Lin Xi, Ou Yanqiu, Zhou Yuehan, Zhu Wenbo, Leng Tiandong, Lu Huimin, Wu Sihan, Zheng Xiaoke, Shu Minfeng, Xu Dong, Zhou Yuxi, and Yan Guangmei

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Astrocytomas are the most common and aggressive brain tumors characterized by their highly invasive growth. Gain of chromosome 7 with a hot spot at 7q32 appears to be the most prominent aberration in astrocytoma. Previously reports have shown that microRNA-335 (miR-335) resided on chromosome 7q32 is deregulated in many cancers; however, the biological function of miR-335 in astrocytoma has yet to be elucidated. Results We report that miR-335 acts as a tumor promoter in conferring tumorigenic features such as growth and invasion on malignant astrocytoma. The miR-335 level is highly elevated in C6 astrocytoma cells and human malignant astrocytomas. Ectopic expression of miR-335 in C6 cells dramatically enhances cell viability, colony-forming ability and invasiveness. Conversely, delivery of antagonist specific for miR-335 (antagomir-335) to C6 cells results in growth arrest, cell apoptosis, invasion repression and marked regression of astrocytoma xenografts. Further investigation reveals that miR-335 targets disheveled-associated activator of morphogenesis 1(Daam1) at posttranscriptional level. Moreover, silencing of endogenous Daam1 (siDaam1) could mimic the oncogenic effects of miR-335 and reverse the growth arrest, proapoptotic and invasion repression effects induced by antagomir-335. Notably, the oncogenic effects of miR-335 and siDAAM1 together with anti-tumor effects of antagomir-335 are also confirmed in human astrocytoma U87-MG cells. Conclusion These findings suggest an oncogenic role of miR-335 and shed new lights on the therapy of malignant astrocytomas by targeting miR-335.

Published
2011
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