Search

Your search keyword '"Zacchello, Franco"' showing total 135 results
Start Over Author "Zacchello, Franco" Language english
135 results on '"Zacchello, Franco"'

25. Metabolomics: moving towards personalized medicine

Author

Reniero Fabiano, Giordano Giuseppe, Carraro Silvia, Baraldi Eugenio, Perilongo Giorgio, and Zacchello Franco

Subjects
Pediatrics, RJ1-570
Abstract

Abstract In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach. Metabolomics is a novel area that promises to contribute significantly to the characterization of various disease phenotypes and to the identification of personal metabolic features that can predict response to therapies. Based on analytical platforms such as mass spectrometry or NMR-based spectroscopy, the metabolomic approach enables a comprehensive overview of the metabolites, leading to the characterization of the metabolic fingerprint of a given sample. These metabolic fingerprints can then be used to distinguish between different disease phenotypes and to predict a drug's effectiveness and/or toxicity. Several studies published in the last few years applied the metabolomic approach in the field of pediatric medicine. Being a highly informative technique that can be used on samples collected non-invasively (e.g. urine or exhaled breath condensate), metabolomics has appeal for the study of pediatric diseases. Here we present and discuss the pediatric clinical studies that have taken the metabolomic approach.

Published
2009
Full Text
View/download PDF

29. Effect of disodium cromoglycate on ventilation and gas exchange during exercise in asthmatic children with a postexertion FEV sub 1 less than 15 percent

Author

Baraldi, Eugenio, Santuz, Pierantonio, Magagnin, Giampiero, Filippone, Marco, and Zacchello, Franco

Subjects
Asthma in children -- Physiological aspects, Cromolyn sodium -- Physiological aspects, Pulmonary gas exchange -- Physiological aspects, Health, Physiological aspects
Abstract

The purpose of this study is to evaluate the effect of disodium cromoglycate (DSCG) on gas exchange and ventilation during incremental exercise in asthmatic children with an [FEV.sub.1] fall less [...]

Published
1994

50. Office spirometry in primary care pediatrics: a pilot study

Author

Zanconato, Stefania, Meneghelli, Giorgio, Braga, Raffaele, Zacchello, Franco, and Baraldi, Eugenio

Subjects
Pulmonary function tests -- Case studies, Spirometry -- Case studies, Pediatrics
Abstract

Objective. The aim of this study was to investigate the validity of office spirometry in primary care 2pediatric practices. Methods. Ten primary care pediatricians undertook a spirometry training program that was led by 2 pediatric pulmonologists from the Pediatric Department of the University of Padova. After the pediatricians' training, children with asthma or persistent cough underwent a spirometric test in the pediatrician's office and at a pulmonary function (PF) laboratory, in the same day in random order. Both spirometric tests were performed with a portable turbine flow sensor spirometer. We assessed the quality of the spirometric tests and compared a range of PF parameters obtained in the pediatricians' offices and in the PF laboratory according to the Bland and Altman method. Results. A total of 109 children (mean age: 10.4 years; range: 6-15) were included in the study. Eighty-five (78%) of the spirometric tests that were performed in the pediatricians' offices met all of the acceptability and reproducibility criteria. The 24 unacceptable test results were attributable largely to a slow start and failure to satisfy end-of-test criteria. Only the 85 acceptable spirometric tests were considered for analysis. The agreement between the spirometric tests that were performed in the pediatrician's office and in the PF laboratory was good for the key parameters (forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow between 25% and 75%). The repeatability coefficient was 0.26 L for forced expiratory volume in 1 second (83 of 85 values fall within this range), 0.30 L for forced vital capacity (81 values fall within this range), and 0.58 L/s for forced expiratory flow between 25% and 75% (82 values fall within this range). In 79% of cases, the primary care pediatricians interpreted the spirometric tests correctly. Conclusions. It seems justifiable to perform spirometry in pediatric primary care, but an integrated approach involving both the primary care pediatrician and certified pediatric respiratory medicine centers is recommended because effective training and quality assurance are vital prerequisites for successful spirometry. office spirometry, primary care pediatrics, asthma, children.

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results