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Objective: This descriptive pilot study aimed at assessing the impact of art contemplation on patients' adaptation to hospital confinement and the factors influencing this effect., Study Design: Artistic photographs were hung on the walls of the ward. Two hundred and thirty-nine (239) consecutive non-bed-constrained patients who stayed in the ward for at least 3 days (original number enrolled in study were males/females: 148/96, age 19-89 years; 5 patients declined to fill out questionnaires) participated in the study., Methods: Patients compiled two questionnaires exploring physical, psychologic, and social/family well-being, relative/friend support, and ward functioning. The self-perceived effect of photographs on the hospitalization distress was assessed. Clinical conditions were evaluated with the Eastern Cooperative Oncology Group (ECOG) performance status., Results: Ninety-seven (97) (40.6%) patients belonged to ECOG stage 0, 101 (42.3%) to stage 1, 37 (15.5%) to stage 2, and 4 (1.7%) to stage 3. Two hundred and thirty-nine patients (239) (92%) looked at and 232 (85.5%) repeatedly contemplated the photographs. For most patients (72%), photographs made their stay in the hospital more pleasant. The ECOG performance status and self-perceived anxiety were the only independent modulators of the probability to obtain a restorative effect from the photographs., Conclusions: Embellishing clinical spaces with photographs has a positive effect on the adaptation to hospitalization in most patients. This effect is influenced by the patients' clinical status and self-perceived anxiety.