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9. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia

Author

Messina, C, Valsecchi, MG, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Lombardi, A, Masera, G, and Zanesco, L

Published
1998
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17. Risk management of HBsAg or anti-HCV positive healthcare workers in hospital

Author

Mele, A., Ippolito, G., Craxì, A., Coppola, R.C., Petrosillo, N., Piazza, M., Puro, V., Rizzetto, M., Sagliocca, L., Taliani, G., Zanetti, A., Barni, M., Bianco, E., Bollero, E., Cargnel, A., Cattaneo, M., Chiaramonte, M., Conti, E., D'Amelio, R., De Stefano, D.M., Di Giulio, S., Franco, E., Gallo, G., Levrero, M., Mannella, E., Merli, S., Milazzo, F., Moiraghi, A., Polillo, R., Prati, D., Ragni, P., Sagnelli, E., Scognamiglio, P., Sommella, L., Stroffolini, T., Terrana, T., Tosolini, G., Vitiello, E., Zanesco, L., Ziparo, V., Maffei, C., Moro, M.L., Satolli, R., and Traversa, G.

Published
2001
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18. Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation

Author

Guardiola, Ph., Pasquini, R., Dokal, I., Ortega, J.J., van Weel-Sipman, M., Marsh, J.C.W., Ball, S.E., Locatelli, F., Vermylen, C., Skinner, R., Ljungman, P., Miniero, R., Shaw, P.J., Souillet, G., Michallet, M., Bekassy, A.N., Krivan, G., Di Bartolomeo, P., Heilmann, C., Zanesco, L., Cahn, J.Y., Arcese, W., Bacigalupo, A., and Gluckman, E.

Published
2000
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21. PROSPECTIVE STUDY OF 84 PATIENTS WITH WISKOTT-ALDRICH SYNDROME AND X-RECESSIVE PIASTRINOPENIA: RESULTS OF THE APPLICATION OF COMMON PROTOCOL FOR DIAGNOSIS AND TREATMENT OF WAS/XLT

Author

Soresina, A., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Biondi, A., Mattia, D., Aiuti, A., Maurizio Arico', Azzari, C., Cornelli, P. E., Rossi, P., Martino, S., Specchia, F., Pignata, C., Izzi, G., Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., Plebani, A., Pietrogrande, M. C., Porta, F., Soresina, A., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Biondi, A., De Mattia, D., Aiuti, A., Arico, M., Azzari, C., Cornelli, P. E., Rossi, P., Martino, S., Specchia, F., Pignata, Claudio, Izzi, G., Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., Plebani, A., Pietrogrande, M. C., and Porta, F.

Published
2012

22. The Quality of Life of Children and Adolescents with X-Linked Agammaglobulinemia

Author

Soresina A., Nacinovich R., Bomba M., Cassani M., Molinaro A., Sciotto A., Martino S., Cardinale F., De Mattia D., Putti C., Dellepiane R.M., Felici L., Parrinello G., Neri F., Plebani A., Pierani P., DeMattia D., Martire B., Armenio L., Dammacco F., Ranieri G., Masi M., Miniaci A., Pession A., Rondelli R., Notarangelo L. D., Cao, Cossu F., Del Giacco S., Manconi P., Evangelista I., Magro S., Morgione S., STRISCIUGLIO, PIETRO, Anastasio E., Schillirò G., Paganelli R., Sticca M., Sperlì D., Carpino L., Bernini G., Azzari C., Maggi E., Romagnani S., Matucci A., Vultaggio A., Castagnola E., Gattorno M., Presta G., Civino A., Gambaretto G., Fasoli S., Salpietro C., Pietrogrande M.C., DellePiane R.M., Panisi C., Cambiaghi G., Pietrogrande M., Roncarolo M.G., Aiuti A., Masera G., Biondi A., Sala A., PIGNATA, CLAUDIO, Poggi V., Menna G., Di Nardo R., D'Apuzzo A., Pelliccia A., Correra A., Marone G., SPADARO, GIUSEPPE, Carli M., Zanesco L., Basso G., Putti M.C., Semenzato G., Agostini C., Amato G.M., Aricò M., Trizzino A., Izzi G., Bertolini P., Locatelli F., Zecca M., Rondini G., Marseglia G.L., Maccario R., Bossi G., Favre C., Consolini R., Vecchi V., Sacchini P., Rinaldi G., Ugazio A.G., Rossi P., Livadiotti S., Cancrini C., Finocchi A., Stabile A., Duse M., Iacobini M., Quinti I., Moschese V., Cecere F., Morgese G., Acquaviva A., De Zan G., Strafella S., Tamaro P., Rabusin M., Tovo P.A., Nespoli L., Marinoni M., Porcellini A., Cazzola G.A., Annarosa, Soresina, Renata, Nacinovich, Monica, Bomba, Morena, Cassani, Molinaro, Anna, Antonella, Sciotto, Silvana, Martino, Fabio, Cardinale, Domenico, Mattia, Caterina, Putti, Rosa Maria, Dellepiane, Leonardo, Felici, Giovanni, Parrinello, Francesca, Neri, Alessandro, Plebani, Soresina, A, Nacinovich, R, Bomba, M, Cassani, M, Molinaro, A, Sciotto, A, Martino, S, Cardinale, F, De Mattia, D, Putti, C, Dellepiane, R, Felici, L, Parrinello, G, Neri, F, Plebani, A, Soresina, A., Nacinovich, R., Bomba, M., Cassani, M., Molinaro, A., Sciotto, A., Martino, S., Cardinale, F., De Mattia, D., Putti, C., Dellepiane, R. M., Felici, L., Parrinello, G., Neri, F., Plebani, A., Pierani, P., Demattia, D., Martire, B., Armenio, L., Dammacco, F., Ranieri, G., Masi, M., Miniaci, A., Pession, A., Rondelli, R., Notarangelo, L. D., Cao, Cossu, F., Del Giacco, S., Manconi, P., Evangelista, I., Magro, S., Morgione, S., Strisciuglio, Pietro, Anastasio, E., Schillirò, G., Paganelli, R., Sticca, M., Sperlì, D., Carpino, L., Bernini, G., Azzari, C., Maggi, E., Romagnani, S., Matucci, A., Vultaggio, A., Castagnola, E., Gattorno, M., Presta, G., Civino, A., Gambaretto, G., Fasoli, S., Salpietro, C., Pietrogrande, M. C., Panisi, C., Cambiaghi, G., Pietrogrande, M., Roncarolo, M. G., Aiuti, A., Masera, G., Biondi, A., Sala, A., Pignata, Claudio, Poggi, V., Menna, G., Di Nardo, R., D'Apuzzo, A., Pelliccia, A., Correra, A., Marone, G., Spadaro, Giuseppe, Carli, M., Zanesco, L., Basso, G., Putti, M. C., Semenzato, G., Agostini, C., Amato, G. M., Aricò, M., Trizzino, A., Izzi, G., Bertolini, P., Locatelli, F., Zecca, M., Rondini, G., Marseglia, G. L., Maccario, R., Bossi, G., Favre, C., Consolini, R., Vecchi, V., Sacchini, P., Rinaldi, G., Ugazio, A. G., Rossi, P., Livadiotti, S., Cancrini, C., Finocchi, A., Stabile, A., Duse, M., Iacobini, M., Quinti, I., Moschese, V., Cecere, F., Morgese, G., Acquaviva, A., De Zan, G., Strafella, S., Tamaro, P., Rabusin, M., Tovo, P. A., Nespoli, L., Marinoni, M., Porcellini, A., and Cazzola, G. A.

Subjects
Male, Pediatrics, medicine.medical_specialty, x-linked agammaglobulinemia, Activities of daily living, Adolescent, X-linked agammaglobulinemia, Health Status, Immunology, pedsql 4.0 generic core scale, Quality of life, children, Agammaglobulinemia, Surveys and Questionnaires, Activities of Daily Living, health-related quality of life, parents, medicine, Humans, Immunology and Allergy, PedsQL 4.0 Generic Core Scale, Child, Settore MED/38 - Pediatria Generale e Specialistica, Health related quality of life, quality of live, business.industry, Immunoglobulins, Intravenous, Genetic Diseases, X-Linked, medicine.disease, Socioeconomic Factors, Child, Preschool, Mutation, Quality of Life, Female, X-linked agammaglobulinemia - children - parents - health-related quality of life - PedsQL 4.0 Generic Core Scale, business
Abstract

Introduction: The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases. Discussion: The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed. © 2008 Springer Science+Business Media, LLC.

Published
2009

23. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation

Author

Crocchiolo, R., Zino, E., Vago, L., Oneto, R., Bruno, B., Pollichieni, S., Sacchi, N., Sormani, M. P., Marcon, J., Lamparelli, T., Fanin, R., Garbarino, L., Miotti, V., Bandini, G., Bosi, A., Ciceri, F., Bacigalupo, A., Fleischhauer, K., Midollo Osseo Gruppo Italiano Trapianto, D. I., Terapia Cellulare, Cellule Staminali Ematopoietiche Cse E., Italian Bone Marrow Donor Registry Collaboratori, Scalari P., Bontempelli, M., Prinoth, O., Carcassi, C., Marceno, R., Porfirio, Rombola, G., Lombardo, Ferrioli, G., Poli, F., Scalamogna, M., Mazzi, B., Rossi, F., Mascaretti, L., Albergoni, Salvaneschi, L., Salvaneschi, M., Valentini, Nesci, S., Papola, F., Scatena, Mariotti, Perrone, Laurenti, Grammatico, Paola, Mariani, M., Favoino, B., Guizzardi, Pontiero, Leoni, P., Rambaldi, A., Casini, M., Angelucci, E., Baronciani, D., La Nasa, G., Milone, G., Guidi, S., Van Lint, M. T., Dini, G., Corradini, P., Milani, R., Morra, E., Marenco, P., Deliliers, Lambretenghi G., Onida, F., Marcatti, M., Castagna, L., Pioltelli, P., Selleri, C., Zanesco, L., Scime, R., Musso, M., Alessandrino, E. P., Locatelli, F., Visani, G., Di Bartolomeo, P., Papineschi, F., Favre, C., Iori, A. P., Foa, Roberto, Locasciulli, A., Majolino, I., Majolino, P., Leone, G., Arcese, W., Cerretti, R., Carella, A. M., Cascavilla, N., Lauria, F., Mazza, P., Cerno, M., Benedetti, F., Crocchiolo, R, Zino, E, Vago, L, Oneto, R, Bruno, B, Pollichieni, S, Sacchi, N, Sormani, Mp, Marcon, J, Lamparelli, T, Fanin, R, Garbarino, L, Miotti, V, Bandini, G, Bosi, A, Ciceri, F, Bacigalupo, A, and Fleischhauer, K

Subjects
Adult, Disease-Free Survival, Donor Selection, Female, HLA-DRB1 Chains, Hematologic Neoplasms, Humans, Italy, Male, Middle Aged, Recurrence, Registries, Retrospective Studies, Risk Factors, Survival Rate, Transplantation, Homologous, Algorithms, HLA-DR Antigens, Hematopoietic Stem Cell Transplantation, Tissue Donors, Biochemistry, Immunology, Hematology, Cell Biology, Homologous, medicine.medical_treatment, Human leukocyte antigen, Hematopoietic stem cell transplantation, Medicine, Risk factor, Survival rate, Transplantation, HLA-DPB1, business.industry, Hazard ratio, Confidence interval, business, Settore MED/15 - Malattie del Sangue
Abstract

The importance of donor-recipient human leukocyte antigen (HLA)-DPB1 matching for the clinical outcome of unrelated hematopoietic stem cell transplantation (HSCT) is controversial. We have previously described an algorithm for nonpermissive HLA-DPB1 disparities involving HLA-DPB1*0901,*1001,*1701,*0301,*1401,*4501, based on T-cell alloreactivity patterns. By revisiting the immunogenicity of HLA-DPB1*02, a modified algorithm was developed and retrospectively tested in 621 unrelated HSCTs facilitated through the Italian Registry for onco-hematologic adult patients. The modified algorithm proved to be markedly more predictive of outcome than the original one, with significantly higher KaplanMeier probabilities of 2-year survival in permissive compared with nonpermissive transplantations (55% vs 39%, P = .005). This was the result of increased adjusted hazards of nonrelapse mortality (hazard ratio [HR] = 1.74; confidence interval [CI], 1.19-2.53; P = .004) but not of relapse (HR = 1.02; CI, 0.73-1.42; P = .92). The increase in the hazards of overall mortality by nonpermissive HLA-DPB1 disparity was similar in 10 of 10 (HR = 2.12; CI, 1.23-3.64; P = .006) and 9 of 10 allele-matched transplantations (HR = 2.21; CI, 1.28-3.80; P = .004), both in early-stage and in advanced-stage disease. These data call for revisiting current HLA matching strategies for unrelated HSCT, suggesting that searches should be directed up-front toward identification of HLA-DPB1 permissive, 10 of 10 or 9 of 10 matched donors. (Blood. 2009; 114:1437-1444) RI Porfirio, Berardino/I-1988-2012

Published
2009

24. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation

Author

Crocchiolo, R, Zino, E, Vago, L, Oneto, R, Bruno, B, Pollichieni, S, Sacchi, N, Sormani, Mp, Marcon, J, Lamparelli, T, Fanin, R, Garbarino, L, Miotti, V, Bandini, G, Bosi, A, Ciceri, F, Bacigalupo, A, Fleischhauer, K, Gruppo Italiano Trapianto di Midollo Osseo, Terapia Cellulare, Cellule Staminale Ematopoietiche e., Italian Bone Marrow Donor Registry, Scalari, P, Bontempelli, M, Prinoth, O, Carcassi, C, Marcenò, R, Porfirio, Rombolà, G, Lombardo, Ferrioli, G, Poli, F, Scalamogna, M, Mazzi, B, Rossi, F, Mascaretti, L, Albergoni, Salvaneschi, L, Martinetti, M, Valentini, Renzo, Nesci, S, Papola, F, Scatena, Mariotti, Perrone, Laurenti, Grammatico, P, Mariani, M, Favoino, B, Guizzardi, Pontiero, Leoni, P, Rambaldi, A, Casini, M, Angelucci, E, Baronciani, D, La Nasa, G, Milone, G, Guidi, S, Van Lint MT, Dini, G, Corradini, P, Milani, R, Morra, E, Marenco, P, Lambretenghi Deliliers, G, Onida, F, Marcatti, M, Castagna, L, Pioltelli, P, Selleri, C, Zanesco, L, Scimè, R, Musso, M, Alessandrino, Ep, Locatelli, F, Visani, G, Di Bartolomeo, P, Papineschi, Federico, Favre, C, Iori, Ap, Foà, R, Locasciulli, A, Majolino, I, Majolino, P, Leone, G, Arcese, W, Cerretti, R, Carella, Am, Cascavilla, N, Lauria, F, Mazza, P, Cerno, M, and Benedetti, F.

Published
2009

25. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia. AIEOP/FONOP-TMO group. Associzione Italiana Emato-Oncologia Pediatrica

Author

Messina, C, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Zanesco, L., VALSECCHI, MARIA GRAZIA, Messina, C, Valsecchi, M, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, A, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, and Zanesco, L

Subjects
Male, Antineoplastic Combined Chemotherapy Protocol, Adolescent, Infant, Newborn, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Transplantation, Autologous, Disease-Free Survival, Transplantation, Autologou, childhood lymphoblastic leukemia, meningeal relapse, autologous marrow transplantation, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Meningeal Neoplasms, Humans, Female, Meningeal Neoplasm, Child, Human, Bone Marrow Transplantation
Abstract

The purpose of this study was to assess the role of ABMT in children with ALL who are in 2nd CR after an early isolated CNS relapse. All children experiencing an isolated CNS relapse at 10 AIEOP centers (Associazione Italiana Emato-Oncologia Pediatrica) from 1986 to 1992 were eligible for this study. The series included 69 patients who relapsed within 3 years from diagnosis: 19 underwent ABMT, nine patients underwent ALLO-BMT from an HLA-identical sibling, and 41 received conventional chemotherapy (CHEMO). Statistical analysis was performed using a Cox's regression model, adjusting for the waiting time before transplantation and prognostic factors. The 5 years DFS was 56.3% (s.e. 12.3) for patients in the ABMT group. This compared favorably with the poor result (12.6% (s.e. 5.9)) seen in the CHEMO group. The risk of failures was reduced by one-third in the ABMT group as compared to the CHEMO group in the multivariate analysis (P < 0.01). In the ALLO group four out of nine patients were in CCR 4-5 years post-transplant. This study suggests that ABMT may also represent a valuable therapeutic choice for patients lacking a matched familiar donor in 2nd CR after an early isolated CNS relapse.

Published
1998

26. Application of common recommendations for diagnosis and treatment of Wiskott-Aldrich syndrome and X-recessive piastrinopenia: clinical and immunological characteristics of 65 patients with WAS/XLT

Author

Soresina, S. A., Mazzolari, E., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Izzi, G., Mattia, D., Azzari, C., Cornelli, P. E., PAOLO ROSSI, Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., and Plebani, A.

Published
2008

43. Graft versus host disease and extracorporeal photochemotherapy: A multicenter retrospective pediatric study

Author

Dall Amico, R., Montini, G., Zulian, F., Zanesco, L., Balduzzi, A., Brugiolo, A., Giovanna Giorgiani, Calore, E., Rivabella, L., Faraci, M., Perotti, C., Pillon, M., Cesaro, S., Zacchello, G., Uderzo, C., Lanino, E., Locatelli, F., and Messina, C.

Subjects
photopheresis, hematopoietic stem cell transplant, paediatric, photopheresis, paediatric, hematopoietic stem cell transplant
Published
2001

44. HEMOPOIETIC STEM CELL TRANSPLANTATION IN CHILDHOOD: REPORT FROM THE BONE MARROW TRANSPLANTATION GROUP OF THE ASSOCIAZIONE ITALIANA DI EMATOLOGIA E ONCOLOGIA PEDIATRICA (AIEOP)

Author

Pession, A., Rondelli, R., Paolucci, Paolo, Pastore, G., Dini, G., Bonetti, F., Madon, E., Mandelli, F., Zanesco, L., Uderzo, C., Prete, A., Rabusin, M., Ugazio, A., Di Bartolomeo, P., Favre, C., Faulkner, L. B., Poggi, V., Luksch, R., Donfrancesco, A., Argiolu, F., and La Nasa, G.

Subjects
AIEOP, Bone marrow transplantation, report
Published
2000

49. Fluconazole prophylaxis and Candida fungemia in neutropenic children with malignancies

Author

Simone Cesaro, Rossetti, F., Perilongo, G., Rossi, L., and Zanesco, L.

Subjects
Male, Catheterization, Central Venous, Neutropenia, Adolescent, Candidiasis, Drug Resistance, Microbial, Immunocompromised Host, HEMATOLOGY, Species Specificity, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Candida albicans, Humans, Child, Fluconazole, Fungemia, Bone Marrow Transplantation, Candida
Abstract

From March, 1990 to February, 1992, we administered fluconazole as antifungal prophylaxis at doses of 3-5 mg/kg/day to 40 patients with prolonged and severe neutropenia following intensive chemotherapy. Fungemia was observed in 3 out 40 patients, and all three of them were due to Candida non-albicans strains: two Candida parapsilosis and one Candida guilliermondi. In vitro sensitivity tests showed that all three isolated strains were susceptible to amphotericin. In one case, Candida guilliermondi was tested for sensitivity to fluconazole and found to be resistant. We conclude that fluconazole prophylaxis proved effective in preventing Candida albicans infections, but it could also contribute to the emergence of Candida non-albicans strains. It might be possible that fluconazole at higher doses could prevent the selection of less susceptible Candida strains.

Published
1993

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